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1. 发明授权

US09476811B2 Digital microfluidic devices and methods incorporating a solid phase 有权
标题翻译：数字微流体装置和结合固相的方法
公开(公告)号：US09476811B2
公开(公告)日：2016-10-25
申请号：US13876813
申请日：2011-10-03
申请人： Jared M. Mudrik , Hao Yang , Aaron R. Wheeler
发明人： Jared M. Mudrik , Hao Yang , Aaron R. Wheeler
IPC分类号： G01N27/453 , G01N1/34 , C12N15/10 , B81B1/00 , B01L3/00
CPC分类号： G01N1/34 , B01L3/502753 , B01L3/502792 , B01L2200/0631 , B01L2300/0636 , B01L2300/0816 , B01L2300/089 , B01L2400/0427 , B81B1/00 , C12N15/1003 , C12N15/1006
摘要： Devices and methods are provided for performing droplet-based solid phase processing steps on a digital microfluidic device. A solid phase material, which may be a porous solid phase material such as a porous polymer monolith is formed or located on a digital microfluidic element. The solid phase may be formed by an in-situ method in which the digital microfluidic array is actuated to transport a droplet of solid phase pre-cursor solution to a selected element on the array, and subsequently processed to form a solid phase on the array element. The integration of a solid phase material with a digital microfluidic array enables a wide range of applications including solid phase extraction and sample concentration.
摘要翻译：提供了用于在数字微流体装置上执行基于液滴的固相处理步骤的装置和方法。可以形成或位于数字微流体元件上的固相材料，其可以是多孔固相材料，例如多孔聚合物整料。固相可以通过原位方法形成，其中数字微流体阵列被致动以将液相的固相前体溶液输送到阵列上的所选元素，并且随后被处理以在阵列上形成固相元件。固相材料与数字微流体阵列的集成使得能够广泛应用于固相萃取和样品浓缩。

2. 发明申请

US20130277218A1 DIGITAL MICROFLUIDIC DEVICES AND METHODS INCORPORATING A SOLID PHASE 有权
标题翻译：数字微流体装置和包含固体相的方法
公开(公告)号：US20130277218A1
公开(公告)日：2013-10-24
申请号：US13876813
申请日：2011-10-03
申请人： Jared M. Mudrik , Hao Yang , Aaron R. Wheeler
发明人： Jared M. Mudrik , Hao Yang , Aaron R. Wheeler
IPC分类号： G01N1/34 , B81B1/00
CPC分类号： G01N1/34 , B01L3/502753 , B01L3/502792 , B01L2200/0631 , B01L2300/0636 , B01L2300/0816 , B01L2300/089 , B01L2400/0427 , B81B1/00 , C12N15/1003 , C12N15/1006
摘要： Devices and methods are provided for performing droplet-based solid phase processing steps on a digital microfluidic device. A solid phase material, which may be a porous solid phase material such as a porous polymer monolith is formed or located on a digital microfluidic element. The solid phase may be formed by an in-situ method in which the digital microfluidic array is actuated to transport a droplet of solid phase pre-cursor solution to a selected element on the array, and subsequently processed to form a solid phase on the array element. The integration of a solid phase material with a digital microfluidic array enables a wide range of applications including solid phase extraction and sample concentration.
摘要翻译：提供了用于在数字微流体装置上执行基于液滴的固相处理步骤的装置和方法。可以形成或位于数字微流体元件上的固相材料，其可以是多孔固相材料，例如多孔聚合物整料。固相可以通过原位方法形成，其中数字微流体阵列被致动以将液相的固相前体溶液输送到阵列上的所选元素，并且随后被处理以在阵列上形成固相元件。固相材料与数字微流体阵列的集成使得能够广泛应用于固相萃取和样品浓缩。

3. 发明授权

US08993348B2 Exchangeable carriers pre-loaded with reagent depots for digital microfluidics 有权
标题翻译：可交换运营商预装了数字微流体的试剂库
公开(公告)号：US08993348B2
公开(公告)日：2015-03-31
申请号：US13122311
申请日：2009-09-30
申请人： Aaron R. Wheeler , Irena Barbulovic-Nad , Hao Yang , Mohamed Abdelgawad
发明人： Aaron R. Wheeler , Irena Barbulovic-Nad , Hao Yang , Mohamed Abdelgawad
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： B01L3/502784 , B01L2200/027 , B01L2200/141 , B01L2200/16 , B01L2300/046 , B01L2300/0867 , B01L2300/161 , B01L2400/0427
摘要： The present invention provides exchangeable, reagent pre-loaded carriers (10), preferably in the form of plastic sheets, which can be temporarily applied to an electrode array (16) on a digital microfluidic (DMF) device (14). The carrier (10) facilitates virtually un-limited re-use of the DMF devices (14) avoiding cross-contamination on the electrode array (16) itself, as well as enabling rapid exchange of pre-loaded reagents (12) while bridging the world-to-chip interface of DMF devices (14). The present invention allows for the transformation of DMF into a versatile platform for lab-on-a-chip applications.
摘要翻译：本发明提供可更换的试剂预加载载体（10），优选为塑料片的形式，其可暂时施加到数字微流体（DMF）装置（14）上的电极阵列（16）。载体（10）有助于几乎不受限制地使用DMF装置（14），以避免电极阵列（16）本身上的交叉污染，并且能够快速交换预加载的试剂（12），同时桥接 DMF设备的世界到芯片接口（14）。本发明允许将DMF转化成用于芯片实验室的通用平台。

4. 发明申请

US20110240471A1 EXCHANGEABLE CARRIERS PRE-LOADED WITH REAGENT DEPOTS FOR DIGITAL MICROFLUIDICS 有权
标题翻译：与数字微流控试剂预付的可交换载体
公开(公告)号：US20110240471A1
公开(公告)日：2011-10-06
申请号：US13122311
申请日：2009-09-30
申请人： Aaron R. Wheeler , Irena Barbulovic-Nad , Hao Yang , Mohamed Abdelgawad
发明人： Aaron R. Wheeler , Irena Barbulovic-Nad , Hao Yang , Mohamed Abdelgawad
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01L3/502784 , B01L2200/027 , B01L2200/141 , B01L2200/16 , B01L2300/046 , B01L2300/0867 , B01L2300/161 , B01L2400/0427
摘要： The present invention provides exchangeable, reagent pre-loaded carriers (10), preferably in the form of plastic sheets, which can be temporarily applied to an electrode array (16) on a digital microfluidic (DMF) device (14). The carrier (10) facilitates virtually un-limited re-use of the DMF devices (14) avoiding cross-contamination on the electrode array (16) itself, as well as enabling rapid exchange of pre-loaded reagents (12) while bridging the world-to-chip interface of DMF devices (14). The present invention allows for the transformation of DMF into a versatile platform for lab-on-a-chip applications.
摘要翻译：本发明提供可更换的试剂预加载载体（10），优选为塑料片的形式，其可暂时施加到数字微流体（DMF）装置（14）上的电极阵列（16）。载体（10）有助于几乎不受限制地使用DMF装置（14），以避免电极阵列（16）本身上的交叉污染，并且能够快速交换预加载的试剂（12），同时桥接 DMF设备的世界到芯片接口（14）。本发明允许将DMF转化成用于芯片实验室的通用平台。

5. 发明申请

US20130164856A1 METHOD OF PROCESSING DRIED SAMPLES USING DIGITAL MICROFLUIDIC DEVICE 审中-公开
标题翻译：使用数字微流体装置处理干燥样品的方法
公开(公告)号：US20130164856A1
公开(公告)日：2013-06-27
申请号：US13695869
申请日：2011-04-15
申请人： Mais J. Jebrail , Hao Yang , Aaron R. Wheeler
发明人： Mais J. Jebrail , Hao Yang , Aaron R. Wheeler
IPC分类号： G01N1/28
CPC分类号： B01L3/502792 , B01L3/502753 , B01L3/502784 , B01L2200/0631 , B01L2400/0427 , G01N2001/288 , G01N2001/4061 , H01J49/00 , Y10T436/25
摘要： Methods are provided for the preparation of a sample using a digital microfluidic platform and the optional subsequent mass analysis of an extracted analyte. A sample is dried, optionally on a solid phase support, and contacted with digital microfluidic array. An analyte present within the dried sample is extracted into an extraction solvent by electrically addressing the digital microfluidic array to transport a droplet of extraction solvent to the dried sample spot. The extracted sample may be dried and subsequently processed on the digital microfluidic array for derivatization. The digital microfluidic device may further include an integrated microfluidic channel having an output aperture, and the method may further include contacting a droplet containing extracted analyte with the microfluidic channel and applying a suitable electric field for generating nano-electrospray, thereby enabling the device to be directly interfaced with a mass analysis device.
摘要翻译：提供了使用数字微流体平台制备样品的方法以及提取的分析物的随后的质量分析。将样品干燥，任选地在固相载体上，并与数字微流体阵列接触。将干燥样品中存在的分析物通过电解寻址数字微流体阵列将萃取溶剂的液滴输送到干燥的样品点而提取到萃取溶剂中。提取的样品可以干燥并随后在数字微流体阵列上进行处理以进行衍生。数字微流体装置还可以包括具有输出孔的集成微流体通道，并且该方法还可以包括使含有提取的分析物的液滴与微流体通道接触并施加合适的电场以产生纳米电喷雾，由此使得该装置能够直接与质量分析装置连接。

6. 发明授权

US09039973B2 Hybrid digital and channel microfluidic devices and methods of use thereof 有权
标题翻译：混合数字和通道微流体装置及其使用方法
公开(公告)号：US09039973B2
公开(公告)日：2015-05-26
申请号：US13123463
申请日：2009-10-13
申请人： Michael W. L. Watson , Mohamed Abdelgawad , Mais Jebrail , Hao Yang , Aaron R. Wheeler
发明人： Michael W. L. Watson , Mohamed Abdelgawad , Mais Jebrail , Hao Yang , Aaron R. Wheeler
IPC分类号： B01L99/00 , G01N1/28 , G01N27/62 , B05B5/025 , B23P19/00 , G01N27/447 , G01N35/10 , B01L3/00 , H01J49/04 , H01J49/16
CPC分类号： G01N27/44791 , B01L3/502715 , B01L3/502753 , B01L3/502792 , B01L2200/027 , B01L2300/0816 , B01L2300/089 , B01L2400/0415 , B01L2400/0421 , G01N35/10 , G01N35/1095 , G01N2035/1041 , H01J49/04 , H01J49/0445 , H01J49/165 , H01J49/167 , Y10T29/49826 , Y10T436/25375
摘要： The present invention provides a hybrid digital and channel microfluidic device in the form of an integrated structure in which a droplet may be transported by a digital microfluidic array and transferred to a microfluidic channel. In one aspect of the invention, a hybrid device comprises a first substrate having a digital microfluidic array capable of transporting a droplet to a transfer location, and a second substrate having a microfluidic channel. The first and second substrates are affixed to form a hybrid device in which an opening in the microfluidic channel is positioned adjacent to the transfer location, so that a droplet transported to the transfer location contacts the channel opening and may enter the channel. The invention also provides methods of performing separations using a hybrid digital and channel microfluidic device and methods of assembling a hybrid digital microfluidic device.
摘要翻译：本发明提供了一种集成结构形式的混合数字和通道微流体装置，其中液滴可以通过数字微流体阵列传输并转移到微流体通道。在本发明的一个方面，混合器件包括具有能够将液滴输送到转移位置的数字微流体阵列的第一衬底和具有微流体通道的第二衬底。第一和第二基底被固定以形成混合装置，其中微流体通道中的开口邻近转移位置定位，使得运送到转移位置的液滴接触通道开口并且可进入通道。本发明还提供使用混合数字和通道微流体装置进行分离的方法以及组装混合数字微流体装置的方法。

7. 发明申请

US20120083046A1 HYBRID DIGITAL AND CHANNEL MICROFLUIDIC DEVICES AND METHODS OF USE THEREOF 有权
标题翻译：混合数字和通道微流体装置及其使用方法
公开(公告)号：US20120083046A1
公开(公告)日：2012-04-05
申请号：US13123463
申请日：2009-10-13
申请人： Michael W. L. Watson , Mohamed Abdelgawad , Mais Jebrail , Hao Yang , Aaron R. Wheeler
发明人： Michael W. L. Watson , Mohamed Abdelgawad , Mais Jebrail , Hao Yang , Aaron R. Wheeler
IPC分类号： B01L99/00 , G01N1/28 , G01N27/62 , B05B5/025 , B23P19/00
CPC分类号： G01N27/44791 , B01L3/502715 , B01L3/502753 , B01L3/502792 , B01L2200/027 , B01L2300/0816 , B01L2300/089 , B01L2400/0415 , B01L2400/0421 , G01N35/10 , G01N35/1095 , G01N2035/1041 , H01J49/04 , H01J49/0445 , H01J49/165 , H01J49/167 , Y10T29/49826 , Y10T436/25375
摘要： The present invention provides a hybrid digital and channel microfluidic device in the form of an integrated structure in which a droplet may be transported by a digital microfluidic array and transferred to a microfluidic channel. In one aspect of the invention, a hybrid device comprises a first substrate having a digital microfluidic array capable of transporting a droplet to a transfer location, and a second substrate having a microfluidic channel. The first and second substrates are affixed to form a hybrid device in which an opening in the microfluidic channel is positioned adjacent to the transfer location, so that a droplet transported to the transfer location contacts the channel opening and may enter the channel. The invention also provides methods of performing separations using a hybrid digital and channel microfluidic device and methods of assembling a hybrid digital microfluidic device.
摘要翻译：本发明提供了一种集成结构形式的混合数字和通道微流体装置，其中液滴可以通过数字微流体阵列传输并转移到微流体通道。在本发明的一个方面，混合器件包括具有能够将液滴输送到转移位置的数字微流体阵列的第一衬底和具有微流体通道的第二衬底。第一和第二基底被固定以形成混合装置，其中微流体通道中的开口邻近转移位置定位，使得运送到转移位置的液滴接触通道开口并且可进入通道。本发明还提供使用混合数字和通道微流体装置进行分离的方法以及组装混合数字微流体装置的方法。

8. 发明申请

US20100081578A1 Exchangeable sheets pre-loaded with reagent depots for digital microfluidics 有权
标题翻译：可更换的纸张预装了数字微流体的试剂库
公开(公告)号：US20100081578A1
公开(公告)日：2010-04-01
申请号：US12285326
申请日：2008-10-01
申请人： Aaron R. Wheeler , Irena Barbulovic-Nad , Hao Yang , Mohamed Abdelgawad
发明人： Aaron R. Wheeler , Irena Barbulovic-Nad , Hao Yang , Mohamed Abdelgawad
IPC分类号： C40B30/00 , C40B40/00 , C40B60/12
CPC分类号： B01L3/502784 , B01L2200/027 , B01L2200/141 , B01L2200/16 , B01L2300/046 , B01L2300/0867 , B01L2300/161 , B01L2400/0427
摘要： The present invention provides an exchangeable, reagent pre-loaded sheets which can be temporarily applied to an electrode array on a digital microfluidic device (DMF). The substrate facilitates virtually un-limited re-use of the DMF devices avoiding cross-contamination on the electrode array itself, as well as enabling rapid exchange of pre-loaded reagents while bridging the world-to-chip interface of DMF devices. The present invention allows for the transformation of DMF into a versatile platform for lab-on-a-chip applications.
摘要翻译：本发明提供了可以临时施加到数字微流体装置（DMF）上的电极阵列的可更换的试剂预加载片。基板有助于几何不受限制地重复使用DMF装置，以避免电极阵列本身的交叉污染，并且能够在桥接DMF装置的世界到芯片的界面的同时快速交换预加载的试剂。本发明允许将DMF转化成用于芯片实验室的通用平台。

9. 发明授权

US10232374B2 Method of processing dried samples using digital microfluidic device 有权
公开(公告)号：US10232374B2
公开(公告)日：2019-03-19
申请号：US13695869
申请日：2011-04-15
申请人： Mais J. Jebrail , Hao Yang , Aaron R. Wheeler
发明人： Mais J. Jebrail , Hao Yang , Aaron R. Wheeler
IPC分类号： G01N1/28 , B01L3/00 , H01J49/00 , G01N1/40
摘要： Methods are provided for the preparation of a sample using a digital microfluidic platform and the optional subsequent mass analysis of an extracted analyte. A sample is dried, optionally on a solid phase support, and contacted with digital microfluidic array. An analyte present within the dried sample is extracted into an extraction solvent by electrically addressing the digital microfluidic array to transport a droplet of extraction solvent to the dried sample spot. The extracted sample may be dried and subsequently processed on the digital microfluidic array for derivatization. The digital microfluidic device may further include an integrated microfluidic channel having an output aperture, and the method may further include contacting a droplet containing extracted analyte with the microfluidic channel and applying a suitable electric field for generating nano-electrospray, thereby enabling the device to be directly interfaced with a mass analysis device.

10. 发明授权

US08187864B2 Exchangeable sheets pre-loaded with reagent depots for digital microfluidics 有权
标题翻译：可更换的纸张预装了数字微流体的试剂库
公开(公告)号：US08187864B2
公开(公告)日：2012-05-29
申请号：US12285326
申请日：2008-10-01
申请人： Aaron R. Wheeler , Irena Barbulovic-Nad , Hao Yang , Mohamed Abdelgawad
发明人： Aaron R. Wheeler , Irena Barbulovic-Nad , Hao Yang , Mohamed Abdelgawad
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L3/502784 , B01L2200/027 , B01L2200/141 , B01L2200/16 , B01L2300/046 , B01L2300/0867 , B01L2300/161 , B01L2400/0427
摘要： The present invention provides an exchangeable, reagent pre-loaded sheets which can be temporarily applied to an electrode array on a digital microfluidic device (DMF). The substrate facilitates virtually un-limited re-use of the DMF devices avoiding cross-contamination on the electrode array itself, as well as enabling rapid exchange of pre-loaded reagents while bridging the world-to-chip interface of DMF devices. The present invention allows for the transformation of DMF into a versatile platform for lab-on-a-chip applications.
摘要翻译：本发明提供了可以临时施加到数字微流体装置（DMF）上的电极阵列的可更换的试剂预加载片。基板有助于几何不受限制地重复使用DMF装置，以避免电极阵列本身的交叉污染，并且能够在桥接DMF装置的世界到芯片的界面的同时快速交换预加载的试剂。本发明允许将DMF转化成用于芯片实验室的通用平台。

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