专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08097716B2 Interfering RNA duplex having blunt-ends and 3′-modifications 有权
标题翻译：干扰RNA双链体具有平端和3'-修饰
公开(公告)号：US08097716B2
公开(公告)日：2012-01-17
申请号：US12338601
申请日：2008-12-18
申请人： Jan Weiler , Jonathan Hall , Jean-Charles Bologna , Francois Jean-Charles Natt , Robert Haner
发明人： Jan Weiler , Jonathan Hall , Jean-Charles Bologna , Francois Jean-Charles Natt , Robert Haner
IPC分类号： C07H21/04
CPC分类号： C12N15/111 , C12N2310/14 , C12N2310/311 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2320/51 , C12N2330/30 , C12N2310/3525
摘要： The present invention relates to double-stranded RNA compounds with at least one blunt end comprising at least one 3′-end of formula wherein X is O or S R1 and R2 are independently OH, NH2, SH, alkyl, aryl, alkyl-aryl, aryl-alkyl, where alkyl, aryl, alkyl-aryl, aryl-alkyl can be substituted by additional heteroatoms and functional groups, preferably a heteroatom selected from the group of N, O, or S or a functional group selected from the group OH, NH2, SH, carboxylic acid or ester; or R1 and R2 may be of formula Y-Z where Y is O, N, S and Z is H, alkyl, aryl, alkyl-aryl, aryl-alkyl, where alkyl, aryl, alkyl-aryl, aryl-alkyl can be substituted by additional heteroatoms, preferably a heteroatom selected from the group of N, O, or S; and wherein said double-stranded RNA mediates RNA interference.
摘要翻译：本发明涉及具有至少一个平末端的双链RNA化合物，其至少包含至少一个下式的3'-末端，其中X是O或S 1 R 2，R 2独立地是OH，NH 2，SH，烷基，芳基，烷基 - 芳基芳基 - 烷基，其中烷基，芳基，烷基 - 芳基，芳基 - 烷基可被其它杂原子和官能团取代，优选选自N，O或S的杂原子或选自OH ，NH 2，SH，羧酸或酯; 或者R1和R2可以是式YZ，其中Y是O，N，S和Z是H，烷基，芳基，烷基 - 芳基，芳基 - 烷基，其中烷基，芳基，烷基 - 芳基，芳基 - 烷基可以被另外的杂原子，优选选自N，O或S的杂原子; 并且其中所述双链RNA介导RNA干扰。

2. 发明申请

US20090192113A1 Interfering RNA Duplex Having Blunt-Ends and 3`-Modifications 有权
标题翻译：干扰RNA双链体具有平端和3'-修饰
公开(公告)号：US20090192113A1
公开(公告)日：2009-07-30
申请号：US12338601
申请日：2008-12-18
申请人： Jan Weiler , Jonathan Hall , Jean-Charles Bologna , Francois Jean-Charles Natt , Robert Haner
发明人： Jan Weiler , Jonathan Hall , Jean-Charles Bologna , Francois Jean-Charles Natt , Robert Haner
IPC分类号： A61K31/713 , C07H21/02 , C12N15/00 , C12Q1/68
CPC分类号： C12N15/111 , C12N2310/14 , C12N2310/311 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2320/51 , C12N2330/30 , C12N2310/3525
摘要： The present invention relates to double-stranded RNA compounds with at least one blunt end comprising at least one 3′-end of formula wherein X is O or S R1 and R2 are independently OH, NH2, SH, alkyl, aryl, alkyl-aryl, aryl-alkyl, where alkyl, aryl, alkyl-aryl, aryl-alkyl can be substituted by additional heteroatoms and functional groups, preferably a heteroatom selected from the group of N, O, or S or a functional group selected from the group OH, NH2, SH, carboxylic acid or ester; or R1 and R2 may be of formula Y-Z where Y is O, N, S and Z is H, alkyl, aryl, alkyl-aryl, aryl-alkyl, where alkyl, aryl, alkyl-aryl, aryl-alkyl can be substituted by additional heteroatoms, preferably a heteroatom selected from the group of N, O, or S; and wherein said double-stranded RNA mediates RNA interference.
摘要翻译：本发明涉及具有至少一个平末端的双链RNA化合物，其至少包含至少一个下式的3'-末端，其中X是O或S 1 R 2，R 2独立地是OH，NH 2，SH，烷基，芳基，烷基 - 芳基芳基 - 烷基，其中烷基，芳基，烷基 - 芳基，芳基 - 烷基可被其它杂原子和官能团取代，优选选自N，O或S的杂原子或选自OH ，NH 2，SH，羧酸或酯; 或者R1和R2可以是式YZ，其中Y是O，N，S和Z是H，烷基，芳基，烷基 - 芳基，芳基 - 烷基，其中烷基，芳基，烷基 - 芳基，芳基 - 烷基可以被另外的杂原子，优选选自N，O或S的杂原子; 并且其中所述双链RNA介导RNA干扰。

3. 发明申请

US20070203084A1 Interfering Rna Duplex Having Blunt-Ends And 3'-Modifications 审中-公开
标题翻译：干扰Rna双链体具有平端和3'-修饰
公开(公告)号：US20070203084A1
公开(公告)日：2007-08-30
申请号：US10569927
申请日：2004-08-27
申请人： Jan Weiler , Jonathan Hall , Jean-Charles Bologna , Francois Natt , Robert Haner
发明人： Jan Weiler , Jonathan Hall , Jean-Charles Bologna , Francois Natt , Robert Haner
IPC分类号： A61K48/00 , C12Q1/68 , C07H21/02
CPC分类号： C12N15/111 , C12N2310/14 , C12N2310/311 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2320/51 , C12N2330/30 , C12N2310/3525
摘要： The present invention relates to double-stranded RNA compounds with at least one blunt end comprising at least one 3′-end of Formula (I): wherein X is O or S R1 and R2 are independently OH, NH2, SH, alkyl, aryl, alkyl-aryl, aryl-alkyl, where alkyl, aryl, alkyl-aryl, aryl-alkyl can be substituted by additional heteroatoms and functional groups, preferably a heteroatom selected from the group of N, O, or S or a functional group selected from the group OH, NH2, SH, carboxylic acid or ester; or R1 and R2 may be of formula Y-Z where Y is O, N, S and Z is H, alkyl, aryl, alkyl-aryl, aryl-alkyl, where alkyl, aryl, alkyl-aryl, aryl-alkyl can be substituted by additional heteroatoms, preferably a heteroatom selected from the group of N, O, or S; and wherein said double-stranded RNA mediates RNA interference. Preferred 3′end modifications are: phosphate, phosphorothioate, abasic ribonucleoside, hydroxyphopyl phosphodiester.
摘要翻译：本发明涉及具有至少一个平末端的双链RNA化合物，其包含至少一个式（I）的3'-末端：其中X是O或SR 1和R 2 烷基，芳基，烷基 - 芳基，芳基 - 烷基，其中烷基，芳基，烷基 - 芳基，芳基 - 烷基可被其它杂原子取代和官能团，优选选自N，O或S的杂原子或选自OH，NH 2，SH，羧酸或酯的官能团; 或R 1和R 2可以是式YZ，其中Y是O，N，S和Z是H，烷基，芳基，烷基 - 芳基，芳基 - 烷基，其中烷基，芳基，烷基 - 芳基，芳基 - 烷基可以被另外的杂原子，优选选自N，O或S的杂原子取代; 并且其中所述双链RNA介导RNA干扰。优选的3'末端修饰是：磷酸，硫代磷酸酯，脱碱核糖核苷，羟基hop酰磷酸二酯。

4. 发明申请

US20060135453A1 Down-regulation of target-gene with pei/single-stranded oligoribonucleotide complexes 审中-公开
标题翻译：用pei /单链寡核糖核苷酸复合物下调靶基因
公开(公告)号：US20060135453A1
公开(公告)日：2006-06-22
申请号：US10543362
申请日：2004-01-30
申请人： Jean-Charles Bologna , Jonathan Hall , Francois Natt , Jan Weiler
发明人： Jean-Charles Bologna , Jonathan Hall , Francois Natt , Jan Weiler
IPC分类号： A61K48/00
CPC分类号： C12N15/111 , A61K31/105 , A61K31/7105 , A61K38/00 , A61K47/645 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/53 , C12N2320/32 , C12N2310/3525
摘要： The present invention provides methods for the downregulation of target genes by an RNA interference mechanism using short single stranded RNA and a cationic polymer, such as linear PEI.
摘要翻译：本发明提供了通过使用短单链RNA和阳离子聚合物如线性PEI的RNA干扰机制来下调靶基因的方法。

5. 发明申请

US20080045417A1 Oligonucleotide Microarray 审中-公开
标题翻译：寡核苷酸微阵列
公开(公告)号：US20080045417A1
公开(公告)日：2008-02-21
申请号：US10574305
申请日：2004-10-13
申请人： Jan Weiler , Jonathan Hall , Christoph Wanke , Jorg Bernd Lange , Witold Filipowicz , Fabrice Kolb
发明人： Jan Weiler , Jonathan Hall , Christoph Wanke , Jorg Bernd Lange , Witold Filipowicz , Fabrice Kolb
IPC分类号： C40B30/04 , C40B40/08
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/178
摘要： The present invention relates to oligonucleotide microarrays comprising short chemically modified RNA oligonucleotides and uses of such microarrays in genomics applications. More specifically, the invention provides an oligonucleotide array comprising a surface and a plurality of oligonucleotide, wherein at least one oligonucleotide has at least one modified sugar moiety at the 2'OH position. The microarrays of the invention are more specifically useful to detect small RNAs.
摘要翻译：本发明涉及包含短化学修饰的RNA寡核苷酸的寡核苷酸微阵列和在基因组学应用中这种微阵列的用途。更具体地，本发明提供了包含表面和多个寡核苷酸的寡核苷酸阵列，其中至少一个寡核苷酸在2'OH位置具有至少一个修饰的糖部分。本发明的微阵列更具体地用于检测小RNA。

6. 发明申请

US20100280094A1 COMPOSITIONS AND METHODS TO TREAT MUSCULAR & CARDIOVASCULAR DISORDERS 审中-公开
标题翻译：用于治疗肌肉和心脏血管疾病的组合物和方法
公开(公告)号：US20100280094A1
公开(公告)日：2010-11-04
申请号：US12519323
申请日：2007-12-13
申请人： Iwan Beuvink , Jonathan Hall , Jan Weiler , Christian Schnell , Mathias Mueller , Martina Schinke-Braun , Fabrizio Serluca
发明人： Iwan Beuvink , Jonathan Hall , Jan Weiler , Christian Schnell , Mathias Mueller , Martina Schinke-Braun , Fabrizio Serluca
IPC分类号： A61K31/7088 , C07H21/04 , C07H21/02 , C12N5/07 , C12N15/63 , A61P21/00 , A61P9/00
CPC分类号： C12N15/113 , C12N2310/113 , C12N2310/141
摘要： The present invention relates to a novel microRNA, mir-208-2, implicated in muscular and cardiovascular disorders. The present invention also relates to oligonucleotide therapeutic agents (antisense oligonucleotides and/or double stranded oligonucleotides such as dsRNA) and their use in the treatment of muscular and cardiovascular disorders resulting from dysregulation of mir-208-2.
摘要翻译：本发明涉及涉及肌肉和心血管疾病的新型微小RNA，mir-208-2。本发明还涉及寡核苷酸治疗剂（反义寡核苷酸和/或双链寡核苷酸，例如dsRNA）及其在治疗由mir-208-2失调导致的肌肉和心血管疾病的用途。

7. 发明授权

US5925744A Functional terpyridine-metal complexes, a process for the preparation thereof and oligonucleotide conjugates with terpyridine-metal complexes 失效
标题翻译：功能性三联吡啶金属络合物，其制备方法和与三联吡啶 - 金属络合物的寡核苷酸缀合物
公开(公告)号：US5925744A
公开(公告)日：1999-07-20
申请号：US793530
申请日：1997-07-28
申请人： Robert Haner , Jonathan Hall , Dieter Husken , Uwe Pieles , Heinz Moser
发明人： Robert Haner , Jonathan Hall , Dieter Husken , Uwe Pieles , Heinz Moser
IPC分类号： C12N15/09 , A61K31/70 , A61P35/00 , C07D213/00 , C07D213/50 , C07D213/55 , C07D213/76 , C07D471/22 , C07F5/00 , C07F9/38 , C07H21/00 , C07H21/04 , C12Q1/68 , A61K51/00 , C07C69/96 , C07D213/22
CPC分类号： C07H21/00 , C07D213/00 , C12Q1/6816 , G01N2458/40
摘要： The present invention relates to cyclic terpyridine-lanthanide complexes having 8 nitrogen atoms and 10 carbon atoms in the macrocycle and containing a functional group in the terpyridine moiety. The invention also relates to a process for the preparation of cyclic terpyridine-lanthanide complexes through the condensation of terpyridine hydrazines with pyridine-2,6-dialdehydes or -ketones. The compounds can be complexed with oligonculeotides and are useful in the sequence-specific cleavage of RNA.
摘要翻译： PCT No.PCT / EP95 / 03409 Sec。 371日期1997年7月28日第 102（e）日期1997年7月28日PCT提交1995年8月30日PCT公布。公开号WO96 / 07668 日期：1996年3月14日本发明涉及大环中具有8个氮原子和10个碳原子并在三联吡啶部分含有官能团的环状三联吡啶 - 镧系元素络合物。本发明还涉及通过三联吡啶肼与吡啶-2,6-二醛或酮的缩合制备环状三联吡啶 - 镧系元素络合物的方法。这些化合物可以与寡核苷酸复合，可用于RNA的序列特异性切割。

8. 发明授权

US11707663B1 System for tracking, locating and predicting the position of a ball in a game of baseball or similar 有权
公开(公告)号：US11707663B1
公开(公告)日：2023-07-25
申请号：US18104113
申请日：2023-01-31
申请人： Patricia Hall , Matthew Hall , Jonathan Hall , Joseph Hall
发明人： Patricia Hall , Matthew Hall , Jonathan Hall , Joseph Hall
IPC分类号： A63B71/00 , A63B71/06 , G06V20/40 , G06T7/246 , G06V10/764 , G06T7/292 , A63B102/18
CPC分类号： A63B71/0605 , G06T7/251 , G06T7/292 , G06V10/764 , G06V20/42 , A63B2102/18 , A63B2220/05 , A63B2220/806 , G06T2207/10016 , G06T2207/30201 , G06T2207/30224
摘要： A system for detecting a ball or strike in baseball.

9. 发明申请

US20120058370A1 Flow Battery With Radial Electrolyte Distribution 有权
标题翻译：流动电池与径向电解质分布
公开(公告)号：US20120058370A1
公开(公告)日：2012-03-08
申请号：US12877852
申请日：2010-09-08
申请人： Brad Kell , Rick Winter , Jonathan Hall
发明人： Brad Kell , Rick Winter , Jonathan Hall
IPC分类号： H01M2/38 , H01M2/36
CPC分类号： H01M12/085 , H01M2/38 , H01M4/02 , H01M4/8626 , H01M10/4214 , Y02E60/128
摘要： An electrochemical flow cell includes a permeable electrode, an impermeable electrode located adjacent to and spaced apart from the permeable electrode and a reaction zone electrolyte flow channel located between a first side of the permeable electrode and a first side of the impermeable electrode. The electrochemical flow cell also includes at least one electrolyte flow channel located adjacent to a second side of the permeable electrode, at least one central electrolyte flow conduit extending through a central portion of the permeable electrode and through a central portion of the impermeable electrode and at least one peripheral electrolyte flow inlet/outlet located in a peripheral portion of the electrochemical cell above or below the permeable electrode.
摘要翻译：电化学流动池包括可渗透电极，位于邻近并与透气电极隔开的不渗透电极和位于可渗透电极的第一侧和不可渗透电极的第一侧之间的反应区电解质流动通道。电化学流动池还包括至少一个位于可渗透电极的第二侧附近的电解质流动通道，至少一个中心电解质流动管道，其延伸穿过可渗透电极的中心部分并穿过不可渗透电极的中心部分，并且在位于可渗透电极上方或下方的电化学电池的周边部分中的至少一个外围电解质流入口/出口。

10. 发明授权

US08061691B2 Piston and gas spring assembly including same 有权
标题翻译：活塞和气弹簧组件包括相同
公开(公告)号：US08061691B2
公开(公告)日：2011-11-22
申请号：US12026289
申请日：2008-02-05
申请人： Daniel I Levy , Jonathan Hall
发明人： Daniel I Levy , Jonathan Hall
IPC分类号： F16F9/04
CPC分类号： B60G11/28 , B60G2202/152 , B60G2204/126 , B60G2204/43 , B60G2204/44 , B60G2204/4502 , B60G2206/424 , B60G2206/71 , F16F9/057
摘要： A piston adapted for use in offset mounting conditions includes a piston body having a longitudinally-extending axis. First and second securement features are located at radially outer positions relative to the axis. The first and second securement features are also located on one diametrical side of a midplane of the piston body. A plurality of support walls extends from the diametrically opposite side of the piston body toward the securement features. A gas spring assembly including such a piston is also included.
摘要翻译：适用于偏移安装条件的活塞包括具有纵向延伸轴线的活塞体。第一和第二固定特征位于相对于轴的径向外部位置。第一和第二固定特征也位于活塞体的中平面的一个直径侧上。多个支撑壁从活塞体的径向相对的侧向朝向固定部件延伸。还包括包括这种活塞的气弹簧组件。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式