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1. 发明申请

US20090068244A1 Polymeric/carbon composite materials for use in medical devices 审中-公开
标题翻译：用于医疗器械的聚合物/碳复合材料
公开(公告)号：US20090068244A1
公开(公告)日：2009-03-12
申请号：US11900779
申请日：2007-09-12
申请人： Jan Weber , Thomas J. Holman , Graig L. Kveen
发明人： Jan Weber , Thomas J. Holman , Graig L. Kveen
IPC分类号： A61L27/54 , A61L27/44
CPC分类号： A61L27/443 , C08L25/04
摘要： The invention provides implantable or insertable medical devices, which contain one or more composite regions. These composite regions, in turn, contain polymer and carbon particles. Also, the invention provides composite materials for use in a medical device containing styrene-isobutylene copolymer and carbon nanotubes.
摘要翻译：本发明提供了可植入或可插入的医疗装置，其包含一个或多个复合区域。这些复合区域又包含聚合物和碳颗粒。此外，本发明提供了用于含有苯乙烯 - 异丁烯共聚物和碳纳米管的医疗装置中的复合材料。

2. 发明授权

US07963940B2 Local perfusion device 有权
标题翻译：局部灌注装置
公开(公告)号：US07963940B2
公开(公告)日：2011-06-21
申请号：US11208879
申请日：2005-08-22
申请人： Thomas J. Holman , Jan Weber , Tracee Eidenschink
发明人： Thomas J. Holman , Jan Weber , Tracee Eidenschink
IPC分类号： A61M29/00
CPC分类号： A61F7/12 , A61F2007/0063 , A61F2007/126
摘要： A device for providing a fluid to a target tissue region of a body vessel is described. The device includes an elongate member having a lumen to receive a fluid, and a structure deployable from a distal portion of the elongate member to channel blood flowing in the vessel. Also described are a method of, and a system for, providing a fluid to a target tissue region inside a body.
摘要翻译：描述了一种用于向身体血管的靶组织区域提供流体的装置。该装置包括具有用于容纳流体的内腔的细长构件，以及可从细长构件的远侧部分展开以使在血管中流动的血液通道的结构。还描述了向身体内的靶组织区域提供流体的方法和系统。

3. 发明授权

US07820936B2 Method and apparatus for controlling and adjusting the intensity profile of a laser beam employed in a laser welder for welding polymeric and metallic components 失效
标题翻译：用于控制和调节激光焊接机中用于焊接聚合物和金属部件的激光束的强度分布的方法和装置
公开(公告)号：US07820936B2
公开(公告)日：2010-10-26
申请号：US10883868
申请日：2004-07-02
申请人： Jan Weber , Thomas J. Holman
发明人： Jan Weber , Thomas J. Holman
IPC分类号： B23K26/20
CPC分类号： B29C65/1629 , B23K26/03 , B23K26/032 , B23K26/034 , B23K26/0643 , B23K26/073 , B29C65/1616 , B29C65/1619 , B29C65/1638 , B29C65/1654 , B29C65/1674 , B29C66/1142 , B29C66/301 , B29C66/43 , B29C66/5221 , B29C66/534 , B29C66/71 , B29C66/73116 , B29C66/73132 , B29C66/73921 , B29C66/742 , B29C66/836 , B29C66/91216 , B29C66/91221 , B29C66/91411 , B29C66/91443 , B29C66/91641 , B29C66/961 , B29C66/962 , B29K2023/065 , B29K2023/083 , B29K2027/18 , B29K2067/00 , B29K2075/00 , B29K2305/12 , B29L2031/7542 , B29L2031/7543 , B29K2077/00 , B29K2071/00 , B29K2067/006 , B29K2067/003 , B29K2033/08 , B29K2025/04 , B29K2023/0633 , B29K2023/0625 , B29K2021/003
摘要： A method and apparatus is provided for forming a fusion bond between two materials such as two components of a catheter. The method begins by forming a bond site by positioning a portion of a first body with respect to a portion of a second body so that a fusion bond site is formed. A laser beam is generated that has an intensity profile across its width. The laser beam is directed onto at least a portion of the first and second bodies within the bond site so that a fusion zone having an increased temperature is formed. After the laser beam is generated, the intensity profile of the laser beam that is directed onto the bond site is controllably adjusted by an optical element such as a dynamically-adjustable beam shaping element.
摘要翻译：提供了一种用于在诸如导管的两个部件的两种材料之间形成熔接的方法和装置。该方法开始于通过将第一主体的一部分相对于第二主体的一部分定位，从而形成熔合点位置来形成粘合部位。产生在其宽度上具有强度分布的激光束。激光束被引导到粘结位置内的第一和第二体的至少一部分上，从而形成具有升高的温度的熔融区。在产生激光束之后，通过诸如动态可调整的光束整形元件的光学元件可控地调节被引导到粘结部位上的激光束的强度分布。

4. 发明申请

US20080262412A1 Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 有权
标题翻译：用于与电力源一起递送治疗剂的内部医疗装置
公开(公告)号：US20080262412A1
公开(公告)日：2008-10-23
申请号：US12077603
申请日：2008-03-20
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61N1/30 , A61M25/10
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译：本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。此外，治疗剂源适于将治疗剂引入电场。另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

5. 发明申请

US20080161900A1 MEDICAL DEVICES INCLUDING COMPOSITES 有权
标题翻译：包括复合材料的医疗器械
公开(公告)号：US20080161900A1
公开(公告)日：2008-07-03
申请号：US11763740
申请日：2007-06-15
申请人： Jan Weber , Thomas J. Holman , Tracee Eidenschink
发明人： Jan Weber , Thomas J. Holman , Tracee Eidenschink
IPC分类号： A61F2/82 , A61F2/84
CPC分类号： A61F2/013 , A61F2/06 , A61F2/82 , A61F2002/018 , A61F2230/0006 , A61F2230/0008 , A61F2230/005 , A61F2230/0067 , A61F2230/0069 , A61F2230/0078 , A61F2250/003
摘要： Medical devices, such as endoprostheses, and methods of making the devices are described. In some embodiments, a medical device includes an elongated hollow body formed of a polymeric matrix containing one or more regions of a pre-determined weight percent of carbon nanotubes in general alignment in a pre-determined orientation. The medical device can have a compressed state with a first transverse dimension and an expanded state with a second relatively greater transverse dimension.
摘要翻译：描述医疗装置，例如内用假体，以及制造装置的方法。在一些实施方案中，医疗装置包括由聚合物基质形成的细长中空体，其含有预定重量百分比的碳纳米管的一个或多个区域，以预定方向大致对准。医疗装置可以具有第一横向尺寸的压缩状态和具有第二较大横向尺寸的膨胀状态。

6. 发明授权

US08795348B2 Medical devices and related methods 有权
标题翻译：医疗器械及相关方法
公开(公告)号：US08795348B2
公开(公告)日：2014-08-05
申请号：US11152555
申请日：2005-06-14
申请人： Jan Weber , Thomas J. Holman , Scott Schewe
发明人： Jan Weber , Thomas J. Holman , Scott Schewe
IPC分类号： A61F2/06 , A61M29/00
CPC分类号： A61F2/95 , A61F2/91 , A61F2/958 , A61F2210/0033 , A61F2220/005 , A61F2220/0058 , A61F2250/0018 , A61F2250/0068 , A61M25/09 , A61M25/1006 , A61M25/10186 , A61M2025/1015 , A61M2025/105 , A61M2025/1056 , A61M2025/1068 , A61M2025/1086 , A61M2025/1093
摘要： A medical system including an elongate member and an elongate element associated with the elongate member so that a shape of the elongate member can be altered upon applying energy to the element.
摘要翻译：一种医疗系统，包括细长构件和与细长构件相关联的细长元件，使得在向元件施加能量时可以改变细长构件的形状。

7. 发明授权

US07491188B2 Reinforced and drug-eluting balloon catheters and methods for making same 有权
标题翻译：加强和药物洗脱球囊导管及其制作方法
公开(公告)号：US07491188B2
公开(公告)日：2009-02-17
申请号：US10963272
申请日：2004-10-12
申请人： Thomas J. Holman , Jan Weber , Scott Schewe
发明人： Thomas J. Holman , Jan Weber , Scott Schewe
IPC分类号： A61M29/00
CPC分类号： A61M25/1029 , A61M25/10 , A61M25/1002 , A61M25/1034 , A61M25/1038 , A61M2025/0058 , A61M2025/1031 , A61M2025/105 , A61M2025/1084
摘要： The present invention generally relates to the field of intravascular medical devices, and more specifically to the field of balloon catheters and other similar diagnostic or therapeutic catheters within the body for treatment and diagnosis of diseases. In particular, the present invention relates to reinforced balloon catheters and drug-eluting balloon catheters and corresponding methods for producing same.
摘要翻译：本发明一般涉及血管内医疗装置的领域，更具体地涉及用于治疗和诊断疾病的体内气囊导管和其它类似的诊断或治疗导管领域。特别地，本发明涉及增强气囊导管和药物洗脱球囊导管及其相应的制造方法。

8. 发明授权

US09011516B2 Medical devices including composites 有权
标题翻译：医疗器械包括复合材料
公开(公告)号：US09011516B2
公开(公告)日：2015-04-21
申请号：US11763740
申请日：2007-06-15
申请人： Jan Weber , Thomas J. Holman , Tracee Eidenschink
发明人： Jan Weber , Thomas J. Holman , Tracee Eidenschink
IPC分类号： A61F2/844 , A61F2/01 , A61F2/06 , A61F2/82
CPC分类号： A61F2/013 , A61F2/06 , A61F2/82 , A61F2002/018 , A61F2230/0006 , A61F2230/0008 , A61F2230/005 , A61F2230/0067 , A61F2230/0069 , A61F2230/0078 , A61F2250/003
摘要： Medical devices, such as endoprostheses, and methods of making the devices are described. In some embodiments, a medical device includes an elongated hollow body formed of a polymeric matrix containing one or more regions of a pre-determined weight percent of carbon nanotubes in general alignment in a pre-determined orientation. The medical device can have a compressed state with a first transverse dimension and an expanded state with a second relatively greater transverse dimension.
摘要翻译：描述医疗装置，例如内用假体，以及制造装置的方法。在一些实施方案中，医疗装置包括由聚合物基质形成的细长中空体，其含有预定重量百分比的碳纳米管的一个或多个区域，以预定方向大致对准。医疗装置可以具有第一横向尺寸的压缩状态和具有第二较大横向尺寸的膨胀状态。

9. 发明授权

US08672990B2 Fiber mesh controlled expansion balloon catheter 有权
标题翻译：纤维网控膨胀气囊导管
公开(公告)号：US08672990B2
公开(公告)日：2014-03-18
申请号：US11139253
申请日：2005-05-27
申请人： Thomas J. Holman , Jan Weber
发明人： Thomas J. Holman , Jan Weber
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/90 , A61F2/954 , A61M25/10 , A61M2025/1081 , A61M2025/1084
摘要： A medical device having a catheter shaft having a distal portion and a proximal portion, a medical balloon co-axially mounted on the distal portion of the catheter shaft and a tubular mesh wrapped around the balloon, wherein the mesh strengthens and reinforced the balloon and may be manipulation to dictate the shape of the balloon and to squeeze the balloon down onto the catheter shaft during deflation of the balloon.
摘要翻译：一种具有导管轴的医疗装置，其具有远侧部分和近端部分，同轴地安装在导管轴的远端部分上的医疗气囊和缠绕在气囊上的管状网状物，其中，网状物加强并加强气囊，并且可以操纵以指示气球的形状并且在气球收缩期间将气囊向下挤压到导管轴上。

10. 发明授权

US08048028B2 Reinforced medical balloon 有权
标题翻译：加强医疗气球
公开(公告)号：US08048028B2
公开(公告)日：2011-11-01
申请号：US11060093
申请日：2005-02-17
申请人： Daniel J. Horn , John Jianhua Chen , Jan Weber , Thomas J. Holman
发明人： Daniel J. Horn , John Jianhua Chen , Jan Weber , Thomas J. Holman
IPC分类号： A61M25/10
CPC分类号： A61M25/104 , A61F2002/9583 , A61F2250/0068 , A61L29/126 , A61M2025/1086
摘要： The invention relates to medical balloons, and methods of modifying said balloons by forming a void pattern in their exterior surfaces and filling the voids with a material, such as a fiber or a nanomaterial (e.g., nanotubes, such as carbon nanotubes) and a matrix material, e.g., a polymer.
摘要翻译：本发明涉及医用气囊，以及通过在其外表面上形成空隙图案并用诸如纤维或纳米材料（例如纳米管，例如碳纳米管）和基体材料，例如聚合物。

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