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    • 10. 发明授权
    • Medical devices having inorganic barrier coatings
    • 具有无机屏障涂层的医疗器械
    • US09220818B2
    • 2015-12-29
    • US12501671
    • 2009-07-13
    • Torsten ScheuermannMichael KuehlingJan WeberDominique Seidel
    • Torsten ScheuermannMichael KuehlingJan WeberDominique Seidel
    • A61F2/82A61K9/22A61L27/34A61L31/16A61L31/08A61L31/14
    • A61L31/16A61L31/082A61L31/146A61L2300/608A61L2420/08
    • Medical devices having a barrier layer comprising an inorganic material. The medical device has a reservoir containing a therapeutic agent and the barrier layer is disposed over the reservoir. In one aspect, the barrier layer has one permeability to the therapeutic agent at one portion of the medical device and a different permeability at another portion of the medical device. In another aspect, the dosage amount of the therapeutic agent in the reservoir at one portion of the medical device is different from the dosage amount of the therapeutic agent in the reservoir at another portion of the medical device. In another aspect, a bioresorbable layer is disposed over the barrier layer at one or more portions of the medical device, wherein the bioresorbable layer comprises a bioresorbable material. Also, methods of coating a medical device are disclosed, in which a barrier layer over a medical device is formed using a lithographic etching process where a plurality of particles serve as an etch mask.
    • 具有包含无机材料的阻挡层的医疗装置。 医疗装置具有含有治疗剂的储液器,并且阻挡层设置在贮存器的上方。 在一个方面,阻挡层在医疗装置的一部分处具有对治疗剂的一种渗透性,并且在医疗装置的另一部分具有不同的渗透性。 另一方面,医疗器械的一部分处的储存器中的治疗剂的剂量与医疗器械的另一部分处的储存器中的治疗剂的剂量不同。 在另一方面,生物可再吸收层设置在医疗装置的一个或多个部分的阻挡层之上,其中生物可再吸收层包括生物可再吸收材料。 此外,公开了涂覆医疗装置的方法,其中使用光刻蚀刻工艺形成医疗装置上的阻挡层,其中多个颗粒用作蚀刻掩模。