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1. 发明授权

US07491225B2 System and method for deploying a drug-eluting external body and tissue scaffold 有权
标题翻译：用于部署药物洗脱外部身体和组织支架的系统和方法
公开(公告)号：US07491225B2
公开(公告)日：2009-02-17
申请号：US11059242
申请日：2005-02-16
申请人： Jan Weber , Brian J. Brown , Richard C. Gunderson , Susan Shoemaker
发明人： Jan Weber , Brian J. Brown , Richard C. Gunderson , Susan Shoemaker
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/07 , A61F2/90 , A61F2/91 , A61F2/966 , A61F2002/075 , A61F2002/91541 , A61F2002/91558 , A61F2220/005 , A61F2220/0058 , A61F2230/0054 , A61F2230/0067 , A61F2250/0068
摘要： A medical appliance is provided that includes a self-expanding stent; a sheath adapted to enclose the self-expanding stent in an interior space during deployment; and an external body comprising a bioactive agent attached to the self-expanding stent and adapted to lie outside the interior space of the sheath when the self-expanding stent is enclosed in the sheath. The medical appliance may be deployed in a lumen of a human body and the external body may release the bioactive agent. A method of producing a medical device is provided that includes attaching an external body to a stent and coupling the stent to a delivery arrangement. The external body includes a bioactive agent. A medical device is provided that includes a tissue scaffold; a sheath adapted to enclose the tissue scaffold in an interior space during deployment; and an external body comprising endothelial cells attached to the tissue scaffold and adapted to lie outside the interior space of the sheath when the tissue scaffold is enclosed in the sheath.
摘要翻译：提供了包括自扩张支架的医疗器具; 适于在展开期间将自扩张支架包围在内部空间中的护套; 以及包括附着在自膨胀支架上的生物活性剂的外部本体，并且当所述自扩张支架被包封在所述护套中时适于位于所述护套的内部空间外部。医疗器具可以部署在人体的内腔中，并且外部体可以释放生物活性剂。提供了一种制造医疗装置的方法，其包括将外部主体附接到支架并将支架联接到输送装置。外部身体包括生物活性剂。提供了包括组织支架的医疗装置; 适于在展开期间将组织支架封闭在内部空间中的护套; 以及外部体，其包括附着在所述组织支架上的内皮细胞，并且当所述组织支架被包封在所述鞘中时，所述外部本体适于位于所述鞘的内部空间的外部。

2. 发明授权

US07766896B2 Variable stiffness catheter assembly 有权
标题翻译：可变刚度导管组装
公开(公告)号：US07766896B2
公开(公告)日：2010-08-03
申请号：US11411360
申请日：2006-04-25
申请人： Angela Kornkven Volk , Tracee Eidenschink , Derek Sutermeister , Derek Wise , Richard C. Gunderson , Jan Weber , John Blix , Richard Olson , Karl A. Jagger
发明人： Angela Kornkven Volk , Tracee Eidenschink , Derek Sutermeister , Derek Wise , Richard C. Gunderson , Jan Weber , John Blix , Richard Olson , Karl A. Jagger
IPC分类号： A61M25/00
CPC分类号： A61M25/0054 , A61M25/0009 , A61M25/0045 , A61M25/0053 , A61M25/0138 , A61M25/0158 , A61M25/09 , A61M25/1006 , A61M2025/0024 , A61M2025/0035 , A61M2025/0039 , A61M2025/0058 , A61M2025/0063 , A61M2025/0915 , A61M2025/09175 , Y10T29/49826
摘要： A catheter comprising an outer shaft comprising a first section of electroactive polymer. The first section of electroactive polymer affecting either the flexibility of the catheter or the steerability of the catheter.
摘要翻译：一种导管，其包括包含电活性聚合物的第一部分的外轴。电活性聚合物的第一部分影响导管的柔性或导管的可操纵性。

3. 发明申请

US20080027528A1 Stent retaining mechanisms 有权
标题翻译：支架保持机构
公开(公告)号：US20080027528A1
公开(公告)日：2008-01-31
申请号：US11496249
申请日：2006-07-31
申请人： Karl Jagger , Tracee Eidenschink , Derek Sutermeister , Daniel Gregorich , Yousef Alkhatib , Matt Heidner , Adam Jennings , Richard C. Gunderson , John Blix , Timothy J. Mickley , Richard Olson , Jan Weber , Dominick Godin
发明人： Karl Jagger , Tracee Eidenschink , Derek Sutermeister , Daniel Gregorich , Yousef Alkhatib , Matt Heidner , Adam Jennings , Richard C. Gunderson , John Blix , Timothy J. Mickley , Richard Olson , Jan Weber , Dominick Godin
IPC分类号： A61F2/06
CPC分类号： A61F2/966 , A61F2/95 , A61F2/97 , A61F2002/9583 , A61F2002/9665 , A61F2250/0059
摘要： A catheter system comprises a catheter comprising a distal portion, a proximal portion and an inner shaft. The inner shaft comprises a medical device receiving region for receiving and carrying a medical device. The retaining device is at least partially constructed of an electroactive polymer. The retaining device is located on or adjacent to the medical device receiving region. The electroactive polymer of the retaining device has an activated state and an inactivated state. The retaining device is capable of retaining a medical device to the catheter and releasing the medical device from the catheter by transitioning between the activated state and the inactivated state.
摘要翻译：导管系统包括导管，其包括远侧部分，近端部分和内部轴。内轴包括用于接收和携带医疗装置的医疗装置接收区域。保持装置至少部分地由电活性聚合物构成。保持装置位于或邻近医疗装置接收区域。保持装置的电活性聚合物具有活化状态和失活状态。保持装置能够将医疗装置保持在导管上，并且通过在激活状态和非活动状态之间转换而将医疗装置从导管释放。

4. 发明授权

US08439961B2 Stent retaining mechanisms 有权
标题翻译：支架保持机构
公开(公告)号：US08439961B2
公开(公告)日：2013-05-14
申请号：US11496249
申请日：2006-07-31
申请人： Karl A. Jagger , Tracee Eidenschink , Derek Sutermeister , Daniel Gregorich , Yousef Alkhatib , Matt Heidner , Adam Jennings , Richard C. Gunderson , John Blix , Timothy J. Mickley , Richard Olson , Jan Weber , Dominick Godin
发明人： Karl A. Jagger , Tracee Eidenschink , Derek Sutermeister , Daniel Gregorich , Yousef Alkhatib , Matt Heidner , Adam Jennings , Richard C. Gunderson , John Blix , Timothy J. Mickley , Richard Olson , Jan Weber , Dominick Godin
IPC分类号： A61F2/06
CPC分类号： A61F2/966 , A61F2/95 , A61F2/97 , A61F2002/9583 , A61F2002/9665 , A61F2250/0059
摘要： A catheter system comprises a catheter comprising a distal portion, a proximal portion and an inner shaft. The inner shaft comprises a medical device receiving region for receiving and carrying a medical device. The retaining device is at least partially constructed of an electroactive polymer. The retaining device is located on or adjacent to the medical device receiving region. The electroactive polymer of the retaining device has an activated state and an inactivated state. The retaining device is capable of retaining a medical device to the catheter and releasing the medical device from the catheter by transitioning between the activated state and the inactivated state.
摘要翻译：导管系统包括导管，其包括远侧部分，近端部分和内部轴。内轴包括用于接收和携带医疗装置的医疗装置接收区域。保持装置至少部分地由电活性聚合物构成。保持装置位于或邻近医疗装置接收区域。保持装置的电活性聚合物具有活化状态和失活状态。保持装置能够将医疗装置保持在导管上，并且通过在激活状态和非活动状态之间转换而将医疗装置从导管释放。

5. 发明申请

US20100030315A1 BIFURCATION CATHETER ASSEMBLY AND METHODS 有权
标题翻译：分岔管总成及方法
公开(公告)号：US20100030315A1
公开(公告)日：2010-02-04
申请号：US12183162
申请日：2008-07-31
申请人： Richard C. Gunderson , Rick Noddin , Adam Jennings
发明人： Richard C. Gunderson , Rick Noddin , Adam Jennings
IPC分类号： A61F2/84 , A61M25/10 , B23P11/00
CPC分类号： A61M25/104 , A61F2/856 , A61F2/954 , A61F2/958 , A61F2002/821 , A61M25/1011 , A61M25/1029 , A61M25/1036 , A61M2025/1045 , Y10T29/49826 , Y10T29/49925
摘要： A catheter assembly includes a main catheter branch and a side catheter branch. The main catheter branch includes a main balloon, a side balloon and a side inflation member. The side inflation member intersects the side balloon at a location on the side balloon that is offset laterally from a central line passing from a distal most point on the side balloon to a proximal most point on the side balloon. The side balloon is configured to extend radially outward relative to the main balloon when the side balloon is inflated. The side catheter branch can be centrally aligned with the side balloon central line and be positioned laterally adjacent to the side inflation lumen.
摘要翻译：导管组件包括主导管分支和侧导管分支。主导管分支包括主气囊，侧气囊和侧充气构件。侧膨胀构件在侧气球的位置处与侧气球相交，该侧气球从侧气囊上的最远点到侧气球的最近点从中心线横向偏移。侧气囊被构造成当侧气囊膨胀时相对于主气囊径向向外延伸。侧导管分支可以与侧球囊中心线居中对准并且被定位成侧向邻近侧向充气腔。

6. 发明授权

US07641647B2 Medical device with modified marker band 失效
标题翻译：带修改标记带的医疗器械
公开(公告)号：US07641647B2
公开(公告)日：2010-01-05
申请号：US10749499
申请日：2003-12-29
申请人： Richard C. Gunderson
发明人： Richard C. Gunderson
IPC分类号： A61M25/098
CPC分类号： A61M25/0108 , A61B90/39 , A61F2250/0098 , A61M25/0012 , A61M2025/09075 , A61M2025/1079
摘要： A marker band and medical devices such as catheters and guidewires that include a marker band. A marker band may include a generally cylindrical body portion having one or more slots or openings defined therein. The marker band is configured for being secured to a medical device. Methods of making and using a marker band and a medical device having a marker band are also disclosed.
摘要翻译：标记带和包括标记带的导管和导线等医疗装置。标记带可以包括具有限定在其中的一个或多个狭槽或开口的大致圆柱形主体部分。标记带被配置为固定到医疗装置。还公开了制造和使用标记带的方法和具有标记带的医疗装置。

7. 发明申请

US20080086081A1 Medical balloon incorporating electroactive polymer and methods of making and using the same 有权
标题翻译：含有电活性聚合物的医用气囊及其制造和使用方法
公开(公告)号：US20080086081A1
公开(公告)日：2008-04-10
申请号：US11496248
申请日：2006-07-31
申请人： Tracee Eidenschink , Derek Wise , Derek Sutermeister , Yousef Alkhatib , Daniel Gregorich , Adam Jennings , Matt Heidner , Dominick Godin , Richard C. Gunderson , John Blix , Karl A. Jagger , Angela Kornkven Volk
发明人： Tracee Eidenschink , Derek Wise , Derek Sutermeister , Yousef Alkhatib , Daniel Gregorich , Adam Jennings , Matt Heidner , Dominick Godin , Richard C. Gunderson , John Blix , Karl A. Jagger , Angela Kornkven Volk
IPC分类号： A61M29/00
CPC分类号： A61M25/104 , A61M25/1038 , A61M2025/0058 , A61M2025/1031 , A61M2025/1081 , A61M2025/1086 , A61M2025/1088 , Y10S310/80
摘要： An expandable medical balloon having at least one static state, at least one expanded state, and at least one deflated state, the expandable medical balloon including at least one active region, the at least one active region including electroactive polymer.
摘要翻译：一种具有至少一种静态，至少一种膨胀状态和至少一种放气状态的可膨胀医用气囊，所述可扩张医用气囊包括至少一个活性区，所述至少一个活性区包括电活性聚合物。

8. 发明申请

US20080021532A1 Delivery of cardiac stimulation devices 有权
标题翻译：输送心脏刺激装置
公开(公告)号：US20080021532A1
公开(公告)日：2008-01-24
申请号：US11490916
申请日：2006-07-21
申请人： Graig L. Kveen , Douglas R. Saholt , Roger Hastings , Richard C. Gunderson
发明人： Graig L. Kveen , Douglas R. Saholt , Roger Hastings , Richard C. Gunderson
IPC分类号： A61N1/00
CPC分类号： A61N1/0573 , A61M25/0082 , A61M2025/0095 , A61N1/362 , A61N1/37205 , A61N1/37288 , A61N1/3756
摘要： Some embodiments of an electrical stimulation system employ wireless electrode assemblies to provide pacing therapy, defibrillation therapy, or other stimulation therapy. In certain embodiments, the wireless electrode assemblies may include a guide wire channel so that each electrode assembly can be advanced over a guide wire instrument through the endocardium. For example, a distal tip portion of a guide wire instrument can penetrate through the endocardium and into the myocardial wall of a heart chamber, and the electrode assembly may then be advanced over the guide wire and into the heart chamber wall. In such circumstances, the guide wire instrument (and other portions of the delivery system) can be retracted from the heart chamber wall, thereby leaving the electrode assembly embedded in the heart tissue.
摘要翻译：电刺激系统的一些实施例采用无线电极组件来提供起搏治疗，除颤疗法或其它刺激疗法。在某些实施例中，无线电极组件可以包括引导线通道，使得每个电极组件可以通过心内膜在导丝器械上前进。例如，导丝器械的远侧末端部分可以穿透心内膜并进入心脏室的心肌壁，然后可以将电极组件推进到导丝上并进入心室壁。在这种情况下，引导线器械（和输送系统的其它部分）可以从心室壁缩回，从而使电极组件嵌入在心脏组织中。

9. 发明授权

US06019779A Multi-filar coil medical stent 有权
标题翻译：多线圈医疗支架
公开(公告)号：US06019779A
公开(公告)日：2000-02-01
申请号：US169246
申请日：1998-10-09
申请人： Michael S. Thorud , Richard C. Gunderson
发明人： Michael S. Thorud , Richard C. Gunderson
IPC分类号： A61F2/06 , A61F2/84 , A61F2/88 , A61M29/00 , A61M5/00
CPC分类号： A61F2/88 , A61F2/95 , A61F2002/9511
摘要： Multi-filar, open and closed coil, tubular medical stents that are introduced to a site in a body lumen and released to expand at the site to provide a passageway through the stent lumen are disclosed. Each stent filar is a coil wound in substantially the same pitch through the majority of its length between the ends thereof. The coils are attached together at least at one coil end to form an end of the stent and wound in an interleaved manner such that the adjacent coils are substantially evenly spaced apart or in close contact in the released state and do not cross over one another. In one open coil stent embodiment, both ends of each coil are attached in respective first and second common attachment junctions, and the resulting coils have relatively even predetermined spacing between adjacent coil turns through the majority of the length of the stent between the first and last coil turns when the stent is released. Preferably, the first and second stent ends are formed by attaching the coil ends in common, and the stent ends are squared by decreasing the pitch of the first coil turn extending from the stent end such that the spacing of the stent end from the adjacent coil is reduced from the predetermined spacing. Additionally, multi-filar closed coil stent embodiments are disclosed having only one end of each coil attached in common and adjacent coil turns in substantial mutual and overlying contact in the restrained state during implantation and non-overlying contact in the released state. Preferably each common attachment junction of attached coil ends and each free coil end is formed into an enlarged stent end in at least one dimension for ease of attachment to and release from a stent delivery catheter. The common attachment junction can be snared or grasped by a stent retrieval system and retracted from the body lumen.
摘要翻译：公开了多丝状，开放和闭合的线圈，被引入到体腔内的位置并被释放以在现场扩张以提供通过支架内腔的通道的管状医疗支架。每个支架丝是在其端部之间的大部分长度上以基本上相同的间距缠绕的线圈。线圈至少在一个线圈端连接在一起以形成支架的端部并以交错的方式缠绕，使得相邻的线圈在释放状态下基本均匀地间隔开或紧密接触，并且不会彼此交叉。在一个开放式线圈支架实施例中，每个线圈的两端都附接在相应的第一和第二公共连接接头中，并且所得到的线圈在相邻的线圈之间具有相对均匀的预定间隔，通过支架的大部分长度在第一和最后当支架释放时，线圈转弯。优选地，第一和第二支架端部通过将线圈端部共同地附接而形成，并且支架端部通过减小从支架端部延伸的第一线圈匝的间距而平坦，使得支架端部与相邻线圈的间隔从预定间隔减小。此外，公开了多丝状闭合线圈支架实施例，其中每个线圈的一端仅在共同的和相邻的线圈匝中以处于释放状态的植入期间的非限制性接触中的实质上相互和上覆接触相接触。优选地，连接的线圈端部和每个自由线圈端部的每个常见附接接头在至少一个维度上形成为扩大的支架端部，以便于附接到支架输送导管和从支架输送导管释放。常见的附着连接点可被支架取出系统卷入或抓住并从体腔缩回。

10. 发明授权

US5383467A Guidewire catheter and apparatus for diagnostic imaging 失效
标题翻译：导丝导管和诊断成像装置
公开(公告)号：US5383467A
公开(公告)日：1995-01-24
申请号：US977985
申请日：1992-11-18
申请人： Michael L. Auer , Victor I. Chornenky , Peter T. Fettig , Richard C. Gunderson , Jeffrey A. McBroom , James S. Sharrow
发明人： Michael L. Auer , Victor I. Chornenky , Peter T. Fettig , Richard C. Gunderson , Jeffrey A. McBroom , James S. Sharrow
IPC分类号： A61B5/00 , A61B18/24 , A61B6/00
CPC分类号： A61B5/0084 , A61B18/245 , A61B5/6851 , A61B5/0066 , A61B5/0086
摘要： A catheter comprising a unitary guidewire and single mode optical fiber is used to illuminate human body channels, such as a tissue mass within a blood vessel, for purposes of diagnosis. A low coherent light source illuminates the tissue and provides a reference beam. Illumination that is reflected from the tissue is combined with the reference beam in an interferometer process. The path length of the reference beam is changed in a known manner in order to provide a known reference to the distance inside of the tissue from which reflected radiation is being received, thus providing information as to both the nature and the geometry of the tissue. A high signal to noise ratio is provided.
摘要翻译：为了诊断目的，包括单一导丝和单模光纤的导管用于照亮人体通道，例如血管内的组织块。低相干光源照亮组织并提供参考光束。在干涉仪工艺中将从组织反射的照明与参考光束组合。以已知的方式改变参考光束的路径长度，以提供已知的参考反射辐射被接收的组织内的距离，从而提供关于组织的性质和几何形状的信息。提供了高信噪比。

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