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1. 发明申请

US20090200165A1 USE OF POLYMER REAGENTS TO MODULATE AND CONTROL ELECTROKINETIC FLOWS IN A MICRO- OR NANOFLUIDIC DEVICE 审中-公开
标题翻译：聚合物试剂在微波或纳米级器件中调节和控制电动力流动的应用
公开(公告)号：US20090200165A1
公开(公告)日：2009-08-13
申请号：US11994267
申请日：2006-06-28
申请人： Jan Sudor , Françoise Vinet , Anne-Marie Gue , Daniel Esteve
发明人： Jan Sudor , Françoise Vinet , Anne-Marie Gue , Daniel Esteve
IPC分类号： B01D57/02
CPC分类号： C03C17/3405 , C03C17/004 , C03C2218/11 , C03C2218/31 , G01N27/44752
摘要： The invention concerns the field of microfluidics and in particular that of electrophoresis on a micro- or nanofluidic device. More particularly, the invention concerns the use of a reactive polymer coating adapted to be submitted to a phase separation under the influence of an external stimulation of chemical or physical type, to modulate the electrokinetic flows (electroosmotic or electrophoretic flows during electrophoresis for example) in a micro- or nanofluidic device. The invention also concerns a method for varying the electrokinetic flows in such a device using said coating, as well as the micro- or nanofluidic devices comprising at least one channel or one capillary tube whereof the inner surface is covered at least partly with such a coating.
摘要翻译：本发明涉及微流体领域，特别涉及微流体或纳流体装置上的电泳领域。更具体地说，本发明涉及适用于在化学或物理类型的外部刺激的影响下进行相分离的反应性聚合物涂层的用途，以调节动电流（例如电泳期间的电渗或电泳流）微流体或纳流体装置。本发明还涉及一种用于使用所述涂层改变这种装置中的电动动力流动的方法，以及包括至少一个通道或一个毛细管的微流体或纳流体装置，其中内表面至少部分地被这样的涂层。

2. 发明申请

US20080206752A1 Method For the Photochemical Attachment of Biomolecules to a Substrate 审中-公开
标题翻译：生物分子对底物的光化学附着的方法
公开(公告)号：US20080206752A1
公开(公告)日：2008-08-28
申请号：US11815935
申请日：2005-02-10
申请人： Maxime Balakirev , Jan Sudor , Francois Chatelain , Xavier Coqueret
发明人： Maxime Balakirev , Jan Sudor , Francois Chatelain , Xavier Coqueret
IPC分类号： C12Q1/68 , C12N9/96
CPC分类号： C08J7/18 , G01N33/54353
摘要： Methods and devices for attaching biomolecules to a solid substrate surface for example to the inner surface of a capillary. In particular, the invention relates to compounds and methods for creating patterned arrays of biomolecules inside fused silica capillaries so that a plurality of bioassays can be conducted simultaneously.
摘要翻译：将生物分子附着到固体基底表面的方法和装置，例如连接到毛细管的内表面。特别地，本发明涉及用于在熔融二氧化硅毛细管内产生生物分子的图案化阵列的化合物和方法，以便同时进行多个生物测定。

3. 发明申请

US20070178465A1 N,n-dimethylacrylamide-based high molecular weight polymer 审中-公开
标题翻译： N，n-二甲基丙烯酰胺类高分子量聚合物
公开(公告)号：US20070178465A1
公开(公告)日：2007-08-02
申请号：US10592795
申请日：2005-03-10
申请人： Jan Sudor , Valessa Barbier
发明人： Jan Sudor , Valessa Barbier
IPC分类号： C12Q1/68 , G01N33/53 , C08G63/91
CPC分类号： C08F265/10
摘要： The invention relates to water-soluble N,N-dialkylacrylamide-based high molecular weight random polymers and monomers laterally functionalised by molecules of interest and to the use thereof for preparing solid supports provided with at least one surface on which said polymers are adsorbed. Said invention also relates to the thus modified solid supports, to a method for the production thereof and to different uses thereof, in particular for immobilising molecules of interest or for carrying out chemical, biochemical or biological reactions.
摘要翻译：本发明涉及水溶性N，N-二烷基丙烯酰胺基高分子量无规聚合物和由目标分子横向功能化的单体，以及其用于制备固体载体的用途，所述固体载体具有吸附所述聚合物的至少一个表面。所述发明还涉及如此改性的固体支持物，其生产方法及其不同用途，特别是用于固定目标分子或用于进行化学，生化或生物反应。

4. 发明授权

US06830670B1 Heat-sensitive medium for separating species in a separating channel and use thereof 失效
标题翻译：用于在分离通道中分离物质的热敏介质及其用途
公开(公告)号：US06830670B1
公开(公告)日：2004-12-14
申请号：US09869382
申请日：2001-10-01
申请人： Jean-Louis Viovy , Dominique Hourdet , Jan Sudor
发明人： Jean-Louis Viovy , Dominique Hourdet , Jan Sudor
IPC分类号： G01N27447
CPC分类号： G01N27/44747
摘要： A medium comprises an electrolyte wherein is dissolved at least an assembly of block copolymers characterized in that the block copolymers: are present in the electrolyte at a concentration level to provide the medium with the property of reversibly passing from a state of viscosity V1, obtained at a temperature T1, to a viscosity state V2 greater by at least 100% than V1, obtained at a temperature T2, and comprise in their structure at least: two non-contiguous polymeric segments having in the electrolyte a lower critical solubility temperature (LCST) and having an average number of atoms along their skeleton more than 50; and a polymeric segment soluble in the electrolyte at temperatures T1 and T2. The invention also concerns the use of the medium for separating analytes.
摘要翻译：介质包括电解质，其中至少溶解了嵌段共聚物的组合物，其特征在于所述嵌段共聚物以浓度水平存在于所述电解质中，以提供介质具有从粘度V1的状态可逆地通过的性质温度T1，在温度T2下达到比V1大至少100％的粘度状态V2，并且在其结构中包括至少两个在电解液中具有较低临界溶解度温度（LCST）的非连续聚合物链段，并且沿其骨架的平均原子数大于50; 和在温度T1和T2下可溶于电解质的聚合物链段。本发明还涉及介质用于分离分析物的用途。

5. 发明授权

US06709692B2 Surface absorbing polymers and the uses thereof to treat hydrophobic or hydrophilic surfaces 失效
标题翻译：表面吸附聚合物及其用途来处理疏水或亲水表面
公开(公告)号：US06709692B2
公开(公告)日：2004-03-23
申请号：US09975192
申请日：2001-10-10
申请人： Jan Sudor
发明人： Jan Sudor
IPC分类号： A61L3108
CPC分类号： G01N33/54393
摘要： The invention provides methods for the treatment of surfaces using surface adsorbing polymers, methods for decreasing the adsorption of organic materials onto the surface of treated devices or vessels, methods for performing fluid operations involving the treatment of surfaces, and apparatus and systems comprising the treated surfaces. Further, the present invention provides a method for treating the surface of microfluidics channel wherein the microfluidics surface is coated for deactivation and wherein this coating can be easily regenerated. The present invention also provides a method for treating the surface of a plastic device. The surface adsorbing polymers of the invention are particularly stable at temperatures and conditions required for biochemical reactions, especially in applications involving temperature cycling or polymerization of polynucleotides or polypeptides.
摘要翻译：本发明提供了使用表面吸附聚合物处理表面的方法，减少有机材料吸附到经处理的装置或容器的表面上的方法，用于执行包括处理表面的流体操作的方法以及包括处理表面的装置和系统。此外，本发明提供了一种处理微流体通道表面的方法，其中微流体表面被涂覆以失活，并且其中该涂层可以容易地再生。本发明还提供了一种处理塑料装置表面的方法。本发明的表面吸附聚合物在生化反应所需的温度和条件下特别稳定，特别是在涉及温度循环或聚合多核苷酸或多肽的应用中。

6. 发明授权

US07449304B2 Method for enhancing the efficiency of an enzymatic process for removal of contaminating nucleotides 失效
标题翻译：提高去除污染核苷酸酶解过程效率的方法
公开(公告)号：US07449304B2
公开(公告)日：2008-11-11
申请号：US10493976
申请日：2002-10-14
申请人： Jan Sudor
发明人： Jan Sudor
IPC分类号： C12Q1/42
CPC分类号： C12N9/16
摘要： This invention relates to methods for enhancing the efficiency of biological processes that involve successive enzymatic reactions. More specifically, the invention relates to methods for enhancing the efficiency of an enzymatic purification process by increasing the temperature between successive enzymatic purification steps.
摘要翻译：本发明涉及提高涉及连续酶反应的生物过程效率的方法。更具体地，本发明涉及通过增加连续的酶促纯化步骤之间的温度来提高酶促纯化方法的效率的方法。

7. 发明申请

US20060057681A1 Method for enhancing the effciency of an enzymatic purification process 失效
标题翻译：提高酶促纯化过程效率的方法
公开(公告)号：US20060057681A1
公开(公告)日：2006-03-16
申请号：US10493976
申请日：2002-10-14
申请人： Jan Sudor
发明人： Jan Sudor
IPC分类号： C12P19/34
CPC分类号： C12N9/16
摘要： This invention relates to methods for enhancing the efficiency of biological processes that involve successive enzymatic reactions. More specifically, the invention relates to methods for enhancing the efficiency of an enzymatic purification process by increasing the temperature between successive enzymatic purification steps.
摘要翻译：本发明涉及提高涉及连续酶反应的生物过程效率的方法。更具体地，本发明涉及通过增加连续的酶促纯化步骤之间的温度来提高酶促纯化方法的效率的方法。

8. 发明授权

US5292416A Pulsed-field separation of polysaccharides in capillaries 失效
标题翻译：毛细血管中多糖的脉冲场分离
公开(公告)号：US5292416A
公开(公告)日：1994-03-08
申请号：US975314
申请日：1992-11-13
申请人： Milos V. Novotny , Jan Sudor
发明人： Milos V. Novotny , Jan Sudor
IPC分类号： B01D57/02 , G01N27/447 , C25B7/00
CPC分类号： G01N27/44773
摘要： Polysaccharides are separated in a capillary using pulsed-field electrophoresis.
摘要翻译：使用脉冲场电泳在毛细管中分离多糖。

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