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1. 发明授权

US09671392B2 Multisensor array for detection of analytes or mixtures thereof in gas or liquid phase 有权
公开(公告)号：US09671392B2
公开(公告)日：2017-06-06
申请号：US13637641
申请日：2011-03-31
申请人： Jan Oskar Jeppsen , Natalie Kostesha , Carsten Johnsen , Kent Albin Nielsen , Anja Boisen , Mogens Havsteen Jakobsen
发明人： Jan Oskar Jeppsen , Natalie Kostesha , Carsten Johnsen , Kent Albin Nielsen , Anja Boisen , Mogens Havsteen Jakobsen
IPC分类号： G01N33/52 , C40B40/04 , C07D495/04 , G01N31/22 , G01N33/53 , G01N33/94
CPC分类号： G01N33/521 , C07D495/04 , C40B40/04 , G01N31/22 , G01N33/5308 , G01N33/94
摘要： The present invention relates to a multisensor array for detection of analytes in the gas phase or in the liquid phase, comprising at least two different chemo-selective compounds represented by the general formula (I) wherein the hetero atoms X1-X4 and the substituents R1-R4 are defined in the specification and the dashed bonds represent independently of each other either a single bond or a double bond. Said chemo-selective compounds are capable of individually changing physicochemical properties when exposed to analytes or analyte mixtures and these changes can be detected by a transducer or an array of transducers. The present invention does also relate to the use of at least two different chemo-selective compounds in a sensor array, a method for preparation of such sensor arrays and the use of said sensor arrays. Furthermore the present invention relates to methods for detecting and identifying analytes or mixtures thereof in the gas phase or in the liquid phase.

2. 发明申请

US20130096030A1 MULTISENSOR ARRAY FOR DETECTION OF ANALYTES OR MIXTURES THEREOF IN GAS OR LIQUID PHASE 有权
标题翻译：用于检测气体或液相中分析物或其混合物的多传感器阵列
公开(公告)号：US20130096030A1
公开(公告)日：2013-04-18
申请号：US13637641
申请日：2011-03-31
申请人： Jan Oskar Jeppesen , Natalie Kostesha , Carsten Johnsen , Kent Albin Nielsen , Anja Boisen , Mogens Havsteen Jakobsen
发明人： Jan Oskar Jeppesen , Natalie Kostesha , Carsten Johnsen , Kent Albin Nielsen , Anja Boisen , Mogens Havsteen Jakobsen
IPC分类号： G01N33/52
CPC分类号： G01N33/521 , C07D495/04 , C40B40/04 , G01N31/22 , G01N33/5308 , G01N33/94
摘要： The present invention relates to a multisensor array for detection of analytes in the gas phase or in the liquid phase, comprising at least two different chemo-selective compounds represented by the general formula (I) wherein the hetero atoms X1-X4 and the substituents R1-R4 are defined in the specification and the dashed bonds represent independently of each other either a single bond or a double bond. Said chemo-selective compounds are capable of individually changing physicochemical properties when exposed to analytes or analyte mixtures and these changes can be detected by a transducer or an array of transducers. The present invention does also relate to the use of at least two different chemo-selective compounds in a sensor array, a method for preparation of such sensor arrays and the use of said sensor arrays. Furthermore the present invention relates to methods for detecting and identifying analytes or mixtures thereof in the gas phase or in the liquid phase.
摘要翻译：本发明涉及用于检测气相或液相中分析物的多传感器阵列，其包含由通式（I）表示的至少两种不同的化学选择性化合物，其中杂原子X 1 -X 4和取代基R 1 -R4在说明书中定义，虚线键彼此独立地表示单键或双键。所述化学选择性化合物当暴露于分析物或分析物混合物时能够单独改变物理化学性质，并且这些变化可以由换能器或换能器阵列检测。本发明还涉及在传感器阵列中使用至少两种不同的化学选择性化合物，制备这种传感器阵列的方法以及所述传感器阵列的使用。此外，本发明涉及在气相或液相中检测和鉴定分析物或其混合物的方法。

3. 发明授权

US06881549B2 Method for introduction of reporter groups into bacterial lipopolysaccharide-derived carbohydrates and the subsequent coupling of such derivatives onto solid surfaces 失效
标题翻译：将报告基团引入到细菌脂多糖衍生的碳水化合物中的方法以及随后将这些衍生物偶联到固体表面上
公开(公告)号：US06881549B2
公开(公告)日：2005-04-19
申请号：US10132795
申请日：2002-04-25
申请人： Mogens Havsteen Jakobsen , Ulrik Boas , Eva Irene Stenbaek Jauh , Peter M. H. Heegaard
发明人： Mogens Havsteen Jakobsen , Ulrik Boas , Eva Irene Stenbaek Jauh , Peter M. H. Heegaard
IPC分类号： C07B61/00 , C07H21/00 , G01N33/543 , G01N33/569 , C07H1/00 , C07H15/00 , G01N33/544 , G01N33/573
CPC分类号： G01N33/56916 , C07B2200/11 , C07H21/00 , G01N33/54353 , G01N33/56911 , G01N2333/255 , G01N2400/50
摘要： The present invention provides a method for immobilizing a polysaccharide (PS) to a solid surface, said polysaccharide having a keto-carboxy group (—C(═O)—COOH) or a ketal or hemiketal group corresponding thereto, e.g. derived from KDO (2-keto-3-deoxy-D-manno-octonic acid)), the method comprising the steps of: (a) forming a covalent bond between the carboxy group of the polysaccharide and a reporter molecule (RM), thereby forming a polysaccharide-reporter molecule conjugate (PS-RM), said reporter molecule comprising a recognition/substrate site (e.g. biotin or an anthraquinone); and (b) immobilizing the polysaccharide-report molecule conjugate by forming a specific bond (e.g. by photocoupling or formation of an affinity pair) between the recognition/substrate site of said reporter molecule and a reception/reagent site of the solid surface. The present invention also provides a solid surface thus obtainable and the use of such solid surfaces for diagnostic purposes, e.g. for the detection of bacterial infections from Gram-negative bacteria that are human or veterinary pathogens, e.g. enterobacteria, respiratory bacteria, urogenitial bacteria, and neuropathogenic bacteria such as Salmonella sp., Actinobacillus sp.
摘要翻译：本发明提供了一种将多糖（PS）固定在固体表面上的方法，所述多糖具有酮羧基（-C（ - ） - -COOH）或对应于其的缩酮或半缩酮基，例如。衍生自KDO（2-酮-3-脱氧-D-壬烯 - 辛辛酸）），该方法包括以下步骤：（a）在多糖的羧基与报告分子（RM）之间形成共价键，从而形成多糖 - 报告分子缀合物（PS-RM），所述报告分子包含识别/底物位点（例如生物素或蒽醌）; 和（b）通过在所述报告分子的识别/底物部位和固体表面的接收/试剂部位之间形成特定键（例如通过光耦合或形成亲和力对）来固定多糖报告分子缀合物。本发明还提供了如此获得的固体表面和用于诊断目的的这种固体表面的用途，例如，用于检测来自作为人或兽医病原体的革兰氏阴性细菌的细菌感染。肠细菌，呼吸细菌，泌尿生殖细菌和神经病原菌如沙门氏菌属，放线杆菌属

4. 发明授权

US06635434B1 Immunoassay for pesticides and their degradation products 失效
标题翻译：农药及其降解产物的免疫测定
公开(公告)号：US06635434B1
公开(公告)日：2003-10-21
申请号：US09621025
申请日：2000-07-21
申请人： Mogens Havsteen Jakobsen , Leif Bruun , Brian Pedersen
发明人： Mogens Havsteen Jakobsen , Leif Bruun , Brian Pedersen
IPC分类号： G01N33533
CPC分类号： G01N33/5308 , C07K16/44 , C07K17/02 , Y10S436/815
摘要： A hapten-polymer carrier complex was found to be useful for immunoassay purposes, specifically ELISAs, for the detection of pesticides and their degradation products in hydrosoil and ground water. The degradation products of Casoron G® (also known as dichlorobenzonitrile and dichlorbenil) and Prefix® (also known as chlorthiamid and dichlorobenzthiamide) are analytes detected with high specificity and sensitivity, particularly the degradation product BAM (2,6-dichlorobenzamide). The polymer carrier complex is bound to the hapten via a linker unit, strategically positioned meta to the amide or amide derivative of BAM.
摘要翻译：发现半抗原 - 聚合物载体复合物可用于免疫测定目的，特别是用于在水土和地下水中检测农药及其降解产物的ELISA。 Casoron G（也称为二氯苄腈和二氯苯乙烯）和前缀（也称为氯化喹啉和二氯苯甲硫氨酸）的降解产物是以高特异性和灵敏度检测的分析物，特别是降解产物BAM（2,6-二氯苯甲酰胺）。聚合物载体复合物通过连接单元与半抗原结合，其策略性地定位于BAM的酰胺或酰胺衍生物。

5. 发明授权

US06436653B1 Method for introduction of reporter groups into bacterial lipopolysaccharide-derived carbohydrates and the subsequent coupling of such derivatives onto solid surfaces 失效
标题翻译：将报告基团引入到细菌脂多糖衍生的碳水化合物中的方法以及随后将这些衍生物偶联到固体表面上
公开(公告)号：US06436653B1
公开(公告)日：2002-08-20
申请号：US09460543
申请日：1999-12-14
申请人： Mogens Havsteen Jakobsen , Ulrik Boas , Eva Irene Stenbaek Jauho , Peter M. H. Heegaard
发明人： Mogens Havsteen Jakobsen , Ulrik Boas , Eva Irene Stenbaek Jauho , Peter M. H. Heegaard
IPC分类号： G01N33569
CPC分类号： G01N33/56916 , C07B2200/11 , C07H21/00 , G01N33/54353 , G01N33/56911 , G01N2333/255 , G01N2400/50
摘要： The present invention provides a method for immobilizing a polysaccharide (PS) to a solid surface, said polysaccharide having a keto-carboxy group (—C(═O)—COOH) or a ketal or hemiketal group corresponding thereto, e.g. derived from KDO (2-keto-3-deoxy-D-manno-octonic acid)), the method comprising the steps of: (a) forming a covalent bond between the carboxy group of the polysaccharide and a reporter molecule (RM), thereby forming a polysaccharide-reporter molecule conjugate (PS-RM), said reporter molecule comprising a recognition/substrate site (e.g. biotin or an anthraquinone); and (b) immobilizing the polysaccharide-report molecule conjugate by forming a specific bond (e.g. by photocoupling or formation of an affinity pair) between the recognition/substrate site of said reporter molecule and a reception/reagent site of the solid surface. The present invention also provides a solid surface thus obtainable and the use of such solid surfaces for diagnostic purposes, e.g. for the detection of bacterial infections from Gram-negative bacteria that are human or veterinary pathogens, e.g. enterobacteria, respiratory bacteria, urogenitial bacteria, and neuropathogenic bacteria such as Salmonella sp., Actinobacillus sp.
摘要翻译：本发明提供一种将多糖（PS）固定在固体表面上的方法，所述多糖具有酮羧基（-C（= O）-COOH）或对应于其的缩酮或半缩酮基，例如。衍生自KDO（2-酮-3-脱氧-D-壬烯 - 辛辛酸）），该方法包括以下步骤：（a）在多糖的羧基与报告分子（RM）之间形成共价键，从而形成多糖 - 报告分子缀合物（PS-RM），所述报告分子包含识别/底物位点（例如生物素或蒽醌）; 和（b）通过在所述报告分子的识别/底物部位和固体表面的接收/试剂部位之间形成特定键（例如通过光耦合或形成亲和力对）来固定多糖报告分子缀合物。本发明还提供了如此获得的固体表面和用于诊断目的的这种固体表面的用途，例如，用于检测来自作为人或兽医病原体的革兰氏阴性细菌的细菌感染。肠细菌，呼吸细菌，泌尿生殖细菌和神经病原菌如沙门氏菌属，放线杆菌属

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