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1. 发明申请

US20060249457A1 Matrix for separation of polyethers and method of separation 审中-公开
标题翻译：用于分离聚醚的基质和分离方法
公开(公告)号：US20060249457A1
公开(公告)日：2006-11-09
申请号：US10558103
申请日：2004-09-06
申请人： James Van Alstine , Jan Bergström , Henrik Ihre , Tobias Söderman
发明人： James Van Alstine , Jan Bergström , Henrik Ihre , Tobias Söderman
IPC分类号： B01D15/08
CPC分类号： B01J20/3278 , B01D15/32 , B01D15/362 , B01D15/38 , B01D15/424 , B01J20/286 , B01J20/288 , B01J20/321 , B01J20/3212 , B01J20/327 , B01J20/328
摘要： The present invention relates to a separation matrix comprised of a support to the surfaces of which polymer chains have been coupled, wherein each polymer chain presents recurring proton-donating groups and at least the surface of the support is substantially hydrophilic. In the most advantageous embodiment, the support is porous cross-linked agarose, the polymers are poly(acrylic acid) and the proton-donating groups are carboxyl groups. The matrix is useful e.g. to remove PEG from pegylated and/or native compounds in a liquid. Accordingly, the invention also encompasses a method, such as a chromatographic method, wherein the separation matrix according to the invention is used, for example as a pre-treatment of a reaction mixture that comprises unreacted PEG, pegylated proteins and native proteins.
摘要翻译：本发明涉及一种分离基质，其由其上已经连接有聚合物链的表面的载体组成，其中每个聚合物链呈现重复的质子供体基团，并且载体的至少表面基本上是亲水的。在最有利的实施方案中，载体是多孔交联琼脂糖，聚合物是聚（丙烯酸），质子供体基团是羧基。该矩阵是有用的。以从液体中的聚乙二醇化和/或天然化合物中除去PEG。因此，本发明还包括诸如色谱方法的方法，其中使用根据本发明的分离基质，例如作为包含未反应的PEG，聚乙二醇化蛋白质和天然蛋白质的反应混合物的预处理。

2. 发明授权

US06878555B2 Method and instrumentation for micro dispensation of droplets 失效
标题翻译：用于微量分配液滴的方法和仪器
公开(公告)号：US06878555B2
公开(公告)日：2005-04-12
申请号：US10004424
申请日：2001-12-06
申请人： Per Andersson , Gérald Jesson , Tobias Söderman , Jan Sjöberg
发明人： Per Andersson , Gérald Jesson , Tobias Söderman , Jan Sjöberg
IPC分类号： G01N35/00 , B01F5/06 , B01F13/00 , B01F15/02 , B01J4/02 , B01L3/00 , B05B3/10 , B67D20060101 , G01N1/10 , G01N35/08 , G01N35/10 , G01N37/00
CPC分类号： B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0059 , B01F15/0201 , B01F15/0233 , B01L3/5027 , B01L2200/027 , B01L2200/0605 , B01L2200/142 , B01L2300/0806 , B01L2300/16 , B01L2400/0409 , B01L2400/0418 , B01L2400/0633 , B01L2400/0688 , G01N35/00069 , Y10T436/111666 , Y10T436/115831 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： A method for dispensing droplets of a liquid to a microsystem in the form of a disc comprising a target area (TA0I) in its surface, said disc preferably being a microfluidic disc comprising a microchannel structure with an inlet port that is a target area (TA0I). The method is characterized by comprising the steps of: i) providing (1) said disc which has a triggering mark, and (2) a dispenser arrangement comprising: a) a spinner for rotating the disc around its axis, b) a drop dispenser permitting dispensation of droplets to inlet port I, c) a fixed trigger position outside the disc, and d) a controller which is capable of triggering the dispensation of a droplet into (TA0I) as a function of the triggering mark passing the trigger position, ii) placing the disc in the spinner and programming the controller with values for dispensing parameters that will give dispensation of the droplets to TA0I, iii) dispensing the droplets. The invention also comprises the dispenser arrangement as such.
摘要翻译：一种用于将液体的液滴分配成包括其表面中的目标区域（TA0I）的圆盘形式的微系统的液体的方法，所述盘优选地是包括具有入口端口的微通道结构的微流体盘，目标区域（TA <0> I）。该方法的特征在于包括以下步骤：i）提供（1）具有触发标记的所述盘，和（2）分配器装置，其包括：a）旋转器，用于围绕其轴线旋转盘，b）液滴分配器允许将液滴分配到入口端口I，c）盘之外的固定触发位置，以及d）控制器，该控制器能够根据触发标记通过所述触发标记触发液滴分配到（TA0）触发位置，ii）将盘放置在旋转器中并用控制器编程用于分配参数的值，分配参数将分配到TA 0，i）分配液滴。本发明还包括分配器装置。

3. 发明申请

US20090308470A1 SPINNER HOME SEQUENCE 有权
标题翻译：旋转式家庭系列
公开(公告)号：US20090308470A1
公开(公告)日：2009-12-17
申请号：US11916012
申请日：2006-05-31
申请人： Mårten Bergström , Robert Bielik , Tobias Söderman , Agneta Ohlström
发明人： Mårten Bergström , Robert Bielik , Tobias Söderman , Agneta Ohlström
IPC分类号： F17D3/00 , G01B11/14
CPC分类号： G01N35/00732 , B01L3/5027 , B01L2200/025 , B01L2300/021 , B01L2300/0806 , G01N35/1011 , G01N2035/1034 , Y10T137/86389
摘要： The present invention relates to a method for determining the identity of a microfluidic device and a home position by means of a set of home position marks on the microfluidic device, which is of the type used in a microfluidic system. Said method comprises following phases: a microfluidic device scanning phase, wherein a microfluidic device is scanned for mark identifiers; a microfluidic device identifying phase, wherein at least one a characteristic feature of the set of home marks is/are determined and used for identifying the identity of the microfluidic device; a home position determining phase, wherein the home position is determined by the use of at least a subset of the home position marks identified during said previous phases. The present invention relates to a set of home marks, a microfluidic device carrying such a set of home marks, a microfluidic system, a computer program product and a computer program on a computer usable medium.
摘要翻译：本发明涉及一种通过微流体装置上的一组原始位置标记来确定微流体装置和原始位置的身份的方法，其是在微流体系统中使用的类型。所述方法包括以下阶段：微流体装置扫描阶段，其中扫描微流体装置用于标记识别符; 微流体装置识别阶段，其中确定并且使用该组归属标记中的至少一个特征特征来识别微流体装置的身份; 原始位置确定阶段，其中通过使用在所述先前阶段期间识别的原始位置标记的至少一个子集来确定原始位置。本发明涉及一套家用商标，一种在这种计算机可用介质上携带这样的家庭标记的微流体装置，微流体系统，计算机程序产品和计算机程序。

4. 发明授权

US08600684B2 Spinner home sequence 有权
标题翻译：旋转器主序列
公开(公告)号：US08600684B2
公开(公告)日：2013-12-03
申请号：US11916012
申请日：2006-05-31
申请人： Agneta Ohlström , Mårten Bergström , Tobias Söderman , Robert Bielik
发明人： Agneta Ohlström , Mårten Bergström , Tobias Söderman , Robert Bielik
IPC分类号： F17D3/00 , G01B11/14
CPC分类号： G01N35/00732 , B01L3/5027 , B01L2200/025 , B01L2300/021 , B01L2300/0806 , G01N35/1011 , G01N2035/1034 , Y10T137/86389
摘要： The present invention relates to a method for determining the identity of a microfluidic device and a home position by means of a set of home position marks on the microfluidic device, which is of the type used in a microfluidic system. Said method comprises following phases: a microfluidic device scanning phase, wherein a microfluidic device is scanned for mark identifiers; a microfluidic device identifying phase, wherein at least one a characteristic feature of the set of home marks is/are determined and used for identifying the identity of the microfluidic device; a home position determining phase, wherein the home position is determined by the use of at least a subset of the home position marks identified during said previous phases. The present invention relates to a set of home marks, a microfluidic device carrying such a set of home marks, a microfluidic system, a computer program product and a computer program on a computer usable medium.
摘要翻译：本发明涉及一种通过微流体装置上的一组原始位置标记来确定微流体装置和原始位置的身份的方法，其是在微流体系统中使用的类型。所述方法包括以下阶段：微流体装置扫描阶段，其中扫描微流体装置用于标记识别符; 微流体装置识别阶段，其中确定并且使用该组归属标记中的至少一个特征特征来识别微流体装置的身份; 原始位置确定阶段，其中通过使用在所述先前阶段期间识别的原始位置标记的至少一个子集来确定原始位置。本发明涉及一套家用商标，一种在这种计算机可用介质上携带这样的家庭标记的微流体装置，微流体系统，计算机程序产品和计算机程序。

5. 发明授权

US07616791B2 Confidence determination 有权
标题翻译：信心决心
公开(公告)号：US07616791B2
公开(公告)日：2009-11-10
申请号：US10555009
申请日：2004-06-30
申请人： Tobias Söderman , Mats Inganäs
发明人： Tobias Söderman , Mats Inganäs
IPC分类号： G06K9/00
CPC分类号： G06T7/0004 , B01L3/5027 , G06N3/02 , G06T7/0012 , G06T2207/10008 , G06T2207/20084
摘要： The present invention relates to a method, a system, a neural network and a computer program product for determining the quality of an analytical process, preferably the confidence value. The analytical process is performed in a microchannel structure of a microfluidic device, from which data information of the analytic process is acquired by scanning at least one search area of the microchannel structure for signal data. The search area comprises the result of the analytical process and the acquired data information is stored as an image, one image for each scanned search area.
摘要翻译：本发明涉及用于确定分析过程的质量的方法，系统，神经网络和计算机程序产品，优选地是置信度值。分析过程在微流体装置的微通道结构中进行，通过扫描用于信号数据的微通道结构的至少一个搜索区域，从中获得分析过程的数据信息。搜索区域包括分析处理的结果，并且获取的数据信息被存储为图像，每个扫描搜索区域存储一个图像。

6. 发明授权

US07148264B2 Method of producing macroporous cross-linked polymer particles 有权
标题翻译：生产大孔交联聚合物颗粒的方法
公开(公告)号：US07148264B2
公开(公告)日：2006-12-12
申请号：US10915290
申请日：2004-08-09
申请人： Tobias Söderman , Anders Larsson , Philippe Busson
发明人： Tobias Söderman , Anders Larsson , Philippe Busson
IPC分类号： C08F16/32
CPC分类号： G01N30/482 , B01D15/325 , B01J20/26 , B01J20/261 , B01J20/267 , B01J20/285 , B01J20/287 , B01J20/30 , B01J2220/54 , C08F283/06 , C08F216/125
摘要： The present invention relates to a method of producing one or more macroporous cross-linked polymer particles, which comprises polymerization and cross-linking of divinyl ether monomers in an inert solvent, in which method the polymerization is free radical initiated. The invention also relates to particles so produced, which are useful as separation medium e.g. in RPC or, after suitable derivatization, in other chromatographic methods.
摘要翻译：本发明涉及一种制备一种或多种大孔交联聚合物颗粒的方法，其包括在惰性溶剂中聚合和交联二乙烯基醚单体，其中聚合是自由基引发的。本发明还涉及如此制备的颗粒，其可用作分离介质，例如在RPC中，或在适当的衍生化后，在其他色谱方法中。

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