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1. 发明申请

US20070009606A1 Manufacturing process, such as three dimensional printing, including binding of water-soluble material followed by softening and flowing and forming films of organic-solvent-soluble material 审中-公开
标题翻译：制造工艺，如三维印刷，包括水溶性材料的结合，然后软化和流动，形成有机溶剂可溶性材料的薄膜
公开(公告)号：US20070009606A1
公开(公告)日：2007-01-11
申请号：US11127298
申请日：2005-05-12
申请人： James Serdy , Emanuel Sachs , Thomas West , Sunil Saini , Jie Cai , Andrea Caruso , John Sharobiem , Peter Materna
发明人： James Serdy , Emanuel Sachs , Thomas West , Sunil Saini , Jie Cai , Andrea Caruso , John Sharobiem , Peter Materna
IPC分类号： A61K9/50
CPC分类号： A61L27/56 , A61F2/28 , A61F2002/30062 , A61F2002/30224 , A61F2002/30225 , A61F2002/30785 , A61F2002/30985 , A61F2210/0004 , A61F2230/0069 , A61F2310/00293 , A61F2310/00353 , A61L27/54 , A61L2300/412 , A61L2300/434 , A61L2300/602 , B33Y10/00 , B33Y70/00 , B33Y80/00 , Y10T428/15 , Y10T428/24273 , Y10T428/31504
摘要： The invention includes biostructures which may be characterized as having substantially all of the organic-solvent-soluble material in the form of a network of irregularly shaped perforated films. The biostructure may further include particles of a substantially-insoluble material, which may be a member of the calcium phosphate family. The biostructure may be osteoconductive. The biostructure may further contain an Active Pharmaceutical Ingredient or other bioactive substance. The API may be a substance which stimulates the production of bone morphogenetic protein, such as Lovastatin or related substances, thereby making the biostructure effectively osteoinductive. One or more of the polymers may have a resorption rate in the human body such as to control the release of the API. Methods of manufacture are also disclosed.
摘要翻译：本发明包括生物结构，其可以被表征为具有基本上所有有机溶剂可溶性材料形式的不规则形状的穿孔膜的网络。生物结构可以进一步包括可以是磷酸钙家族成员的基本不溶物质的颗粒。生物结构可能是骨传导的。生物结构还可含有活性药物成分或其他生物活性物质。 API可以是刺激骨形态发生蛋白（例如洛伐他汀或相关物质）生产的物质，从而使生物结构有效地成骨诱导。一种或多种聚合物可能在人体内具有吸收速率，以便控制API的释放。还公开了制造方法。

2. 发明申请

US20050281856A1 Implantable biostructure comprising an osteoconductive member and an osteoinductive material 审中-公开
标题翻译：包括骨传导构件和骨诱导材料的可植入生物结构
公开(公告)号：US20050281856A1
公开(公告)日：2005-12-22
申请号：US11125336
申请日：2005-05-10
申请人： Jonathan McGlohorn , Sunil Saini , Andrea Caruso , Thomas West , Peter Materna , John Sharobiem , Thomas Bradbury
发明人： Jonathan McGlohorn , Sunil Saini , Andrea Caruso , Thomas West , Peter Materna , John Sharobiem , Thomas Bradbury
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61K31/724 , A61L27/36 , A61L27/42 , A61L27/56
CPC分类号： A61F2/28 , A61F2/30744 , A61F2/30767 , A61F2002/2835 , A61F2002/30059 , A61F2002/30062 , A61F2002/30153 , A61F2002/30154 , A61F2002/30179 , A61F2002/30224 , A61F2002/30225 , A61F2002/30235 , A61F2002/30261 , A61F2002/30263 , A61F2002/30271 , A61F2002/30604 , A61F2002/30677 , A61F2002/30772 , A61F2002/30785 , A61F2002/30795 , A61F2002/30807 , A61F2002/30813 , A61F2002/30815 , A61F2002/30822 , A61F2002/30957 , A61F2002/30985 , A61F2210/0004 , A61F2230/0019 , A61F2230/0021 , A61F2230/0058 , A61F2230/0069 , A61F2230/0082 , A61F2230/0084 , A61F2310/00293 , A61K31/724 , A61L27/3608 , A61L27/365 , A61L27/425 , A61L27/56
摘要： The present invention is directed to a biostructure comprising an osteoconductive member and an osteoinductive material. The osteoinductive material may be located within a cavity in the osteoconductive material. In one aspect of the invention the osteoinductive material is demineralized bone matrix and the osteoconductive member comprises tricalcium phosphate.
摘要翻译：本发明涉及包括骨传导构件和骨诱导材料的生物结构。骨诱导材料可以位于骨传导材料的腔内。在本发明的一个方面，骨诱导材料是去矿物质骨基质，并且骨传导性构件包括磷酸三钙。

3. 发明申请

US20050177237A1 Spinal cage insert, filler piece and method of manufacturing 审中-公开
标题翻译：脊柱笼插件，填料片及其制造方法
公开(公告)号：US20050177237A1
公开(公告)日：2005-08-11
申请号：US10966109
申请日：2004-10-18
申请人： Ben Shappley , Timothy Pryor , John Blum , Thomas Bradbury , Peter Materna , Jonathan McGlohorn , Thomas West , Sunil Saini , Thomas Hatcher , Ali Recber
发明人： Ben Shappley , Timothy Pryor , John Blum , Thomas Bradbury , Peter Materna , Jonathan McGlohorn , Thomas West , Sunil Saini , Thomas Hatcher , Ali Recber
IPC分类号： A61F20060101 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46 , B29C67/04
CPC分类号： A61F2/28 , A61F2/30744 , A61F2/4455 , A61F2002/2835 , A61F2002/30059 , A61F2002/30062 , A61F2002/30153 , A61F2002/30154 , A61F2002/30224 , A61F2002/30225 , A61F2002/30235 , A61F2002/30263 , A61F2002/30271 , A61F2002/30354 , A61F2002/30403 , A61F2002/30599 , A61F2002/30772 , A61F2002/30785 , A61F2002/30807 , A61F2002/30813 , A61F2002/30815 , A61F2002/30822 , A61F2002/30957 , A61F2002/30985 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2230/0019 , A61F2230/0021 , A61F2230/0069 , A61F2230/0082 , A61F2230/0084 , A61F2250/0063 , A61F2310/00293
摘要： A spinal cage insert for a spinal cage is provided. The spinal cage insert has a shape suitable to be inserted into and fit closely in an interior of the spinal cage. The insert may comprise a member of the calcium phosphate family. The spinal cage insert may be made to a desired shape of porous ceramic, and it may include channels and/or surface features. Various shapes of filler pieces are also provided, wherein the filler pieces may be suitable to augment external regions of vertebrae which have been fused to each other so as to promote build-up of bone. The spinal cage insert and/or the filler pieces may be osteoconductive and may also contain osteoinductive substances or material. The articles may also contain cavities suitable for containing particles of demineralized bone matrix (DBM). Methods of use and methods of manufacturing the spinal cage insert and filler pieces are also provided.
摘要翻译：提供了一种用于脊柱笼的脊柱插入物。脊柱插入物具有适于插入并紧密配合在脊柱内部的形状。插入物可以包含磷酸钙家族的成员。脊柱笼插入件可以制成所需形状的多孔陶瓷，并且其可以包括通道和/或表面特征。还提供了各种形状的填充片，其中填充片可以适合于增加彼此融合的椎骨的外部区域，以促进骨的积聚。脊柱插入物和/或填充片可以是骨传导的并且还可以含有骨诱导物质或材料。制品还可以包含适于含有软化骨基质（DBM）颗粒的空腔。还提供了使用方法和制造脊柱笼插入件和填充件的方法。

4. 发明申请

US20050027366A1 Bone void filler and method of manufacture 失效
标题翻译：骨空隙填料及其制造方法
公开(公告)号：US20050027366A1
公开(公告)日：2005-02-03
申请号：US10837541
申请日：2004-04-30
申请人： Sunil Saini , Jonathan McGlohorn , Qing Liu , Mahesh Krishnan , Jaedeok Yoo , Thomas West
发明人： Sunil Saini , Jonathan McGlohorn , Qing Liu , Mahesh Krishnan , Jaedeok Yoo , Thomas West
IPC分类号： A61B17/00 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/46 , A61L24/00 , A61L27/12 , A61L27/56 , A61L27/58
CPC分类号： A61L24/0036 , A61B2017/00004 , A61F2/28 , A61F2/30771 , A61F2/3094 , A61F2/4601 , A61F2002/2835 , A61F2002/2842 , A61F2002/30062 , A61F2002/30135 , A61F2002/30154 , A61F2002/30168 , A61F2002/30172 , A61F2002/30179 , A61F2002/3028 , A61F2002/30599 , A61F2002/30611 , A61F2002/30772 , A61F2002/30785 , A61F2002/3082 , A61F2002/30822 , A61F2002/30957 , A61F2210/0004 , A61F2230/0004 , A61F2230/0021 , A61F2230/0043 , A61F2230/0052 , A61F2230/0058 , A61F2230/0063 , A61F2250/0063 , A61F2310/00293 , A61L24/0063 , A61L27/12 , A61L27/56 , A61L27/58 , A61L2430/02 , B33Y80/00
摘要： Bone void filler pieces that are conducive to packing or nesting when a plurality of pieces are located in a cavity in random orientation. The bone void filler of the present invention includes a higher bulk packing density and a porosity of less than 80% to provide a better match native bone ingrowth rate. Further, the bone void filler includes a bi-modal pore distribution with a high frequency of smaller pores to enhance the density characteristic of the bone void filler pieces. A method of manufacturing the bone void filler pieces includes a precursor powder composition suitable to form a ceramic matrix; the preform is converted by chemical reaction to a final composition. The preform further includes the use of a porogen that decomposes to gaseous decomposition products upon heating.
摘要翻译：当多个片段以随机取向位于空腔中时，有利于包装或嵌套的骨空隙填充片。本发明的骨空隙填料包括较高的本体填充密度和小于80％的孔隙率，以提供更好的天然骨向内生长速率。此外，骨隙填料包括具有较高孔隙率的高频率的双峰分布，以增强骨空隙填充片的密度特性。制造骨空隙填充片的方法包括适于形成陶瓷基质的前体粉末组合物; 预成型件通过化学反应转化成最终组合物。预型件还包括使用在加热时分解成气态分解产物的致孔剂。

5. 发明申请

US20050061241A1 Three-dimensional printing apparatus and methods of manufacture including sterilization or disinfection, for example, using ultraviolet light 失效
标题翻译：三维印刷装置和制造方法，包括例如使用紫外线的灭菌或消毒
公开(公告)号：US20050061241A1
公开(公告)日：2005-03-24
申请号：US10891440
申请日：2004-07-14
申请人： Thomas West , Qing Liu , Peter Materna , Alfred Litwak , Christopher Gaylo
发明人： Thomas West , Qing Liu , Peter Materna , Alfred Litwak , Christopher Gaylo
IPC分类号： A61L2/10 , A61L2/20 , B29C35/08 , B29C67/00 , B05C5/00
CPC分类号： A61L2/208 , A61L2/10 , A61L2/206 , B29C64/165 , B29C2035/0827 , B29C2791/005 , B33Y10/00 , B33Y30/00 , B33Y40/00
摘要： The invention includes a three-dimensional printing (3DP) machine that has at least one ultraviolet (UV) light source directed at powder or slurry being processed by the 3DP machine and/or directed at any of various surfaces or machine components, in a manner suitable to kill or damage microorganisms to a desired extent. The UV light sources may be either stationary or movable, and may be either pulsed or substantially continuous, and may operate in any desired sequence and timing with respect to other operations performed by the machine. The invention may include ultraviolet illumination in such a way as to interact with powder to sterilize or disinfect powder either while the powder is stationary or, alternatively, as powder is being moved from one place to another within the 3DP machine, or both. The invention also includes methods of performing three-dimensional printing using such illumination. The invention also includes the combination of other methods of sterilization or disinfection with the use of ultraviolet light. The invention also includes the use of ultraviolet light sources for a combination of polymerization/cross-linking in addition to sterilization/disinfection.
摘要翻译：本发明包括三维打印（3DP）机器，其具有至少一个紫外线（UV）光源，其以粉末或浆料的形式被3DP机器处理和/或以各种表面或机器部件的任何一种方式适合杀死或损害微生物至所需程度。 UV光源可以是静止的或可移动的，并且可以是脉冲的或基本上连续的，并且可以相对于由机器执行的其它操作以任何期望的顺序和定时操作。本发明可以包括紫外线照射，以便与粉末相互作用以在粉末静止时或者当粉末在3DP机器内从一个位置移动到另一个位置时消除粉末或二者兼而有之。本发明还包括使用这种照明进行三维打印的方法。本发明还包括灭菌或消毒的其它方法与紫外线的组合。本发明还包括除灭菌/消毒之外使用紫外光源用于聚合/交联的组合。

6. 发明申请

US20060110357A1 Bone putty composition that maintains granule suspension at reduced temperatures 审中-公开
标题翻译：在降低温度下保持颗粒悬浮的骨腻子组合物
公开(公告)号：US20060110357A1
公开(公告)日：2006-05-25
申请号：US11004878
申请日：2004-12-07
申请人： Peter Materna , Thomas West , Thomas Bradbury
发明人： Peter Materna , Thomas West , Thomas Bradbury
IPC分类号： A61K31/765 , A61K33/42
CPC分类号： A61K31/765 , A61L24/0031 , A61L24/0084 , A61L24/02 , A61L27/12 , A61L27/46 , A61L27/52 , A61L2430/02
摘要： The invention is directed to a bone putty composition comprising a carrier formulation comprising water and a carrier substance, and granules wherein said bone putty composition exhibits gel-like Theological properties throughout the temperature range between about body temperature and temperatures approaching about 0° C. The bone putty composition further exhibits reverse phase Theological behavior in at least a portion of the same temperature range. The granules may comprise tricalcium phosphate (hereinafter “TCP”) or other calcium phosphates, they may be porous, and they are suspended in the carrier formulation. In one embodiment of the invention, the bone putty composition withstands exposure to certain temperatures below about room temperature without precipitation of the granules from suspension.
摘要翻译：本发明涉及包含含有水和载体物质的载体制剂和颗粒的骨腻子组合物，其中所述骨腻子组合物在约体温和接近约0℃的温度范围内表现出凝胶状神经学性质。骨腻子组合物在相同温度范围的至少一部分中进一步显示反相的神学行为。颗粒可以包括磷酸三钙（以下称为“TCP”）或其它磷酸钙，它们可以是多孔的，并且它们悬浮在载体制剂中。在本发明的一个实施方案中，骨腻子组合物经受暴露于低于约室温的某些温度，而不会使颗粒从悬浮液中沉淀。

7. 发明申请

US20050007430A1 Method and system of printheads using electrically conductive solvents 审中-公开
标题翻译：使用导电溶剂的打印头的方法和系统
公开(公告)号：US20050007430A1
公开(公告)日：2005-01-13
申请号：US10808726
申请日：2004-03-24
申请人： Charles Rowe , Peter Materna , Thomas West
发明人： Charles Rowe , Peter Materna , Thomas West
IPC分类号： B41J2/02 , C09D11/00 , H01B1/12 , B41J2/17
CPC分类号： C09D11/36 , B41J2/02 , C09D11/38 , H01B1/122
摘要： A composition having an electrical conductivity sufficient to enable droplets to be easily charged when printing through a continuous jet with deflection printhead. The composition may include a halogenated hydrocarbon solvent, a co-solvent that is miscible with the halogenated hydrocarbon solvent, and a conductivity enhancing substance. The halogenated hydrocarbon solvent may be chloroform, and the co-solvent may be an alcohol, such as methanol or ethanol. The conductivity enhancing substance may be a salt that dissociates upon dissolution to form ions, or may be an acid or a polymer. The conductivity enhancing substance may be chosen to be benign if left in a printed product. The conductivity enhancing substance may be chosen to be volatile so as to be able to evaporate from whatever it is printed upon, and specifically may be chosen to be a liquid at room temperature. The conductivity enhancing substance may be chosen so as to comprise only carbon, oxygen, hydrogen and nitrogen, and in particular may be an ammonium salt; elements commonly found in bodily tissue. Alternatively, the conductivity enhancing substance may be chosen so as to contain ions of metals but only of certain specific metals.
摘要翻译：具有足够的电导率的组合物，以便当通过具有偏转打印头的连续射流打印时能够使液滴容易地充电。组合物可以包括卤代烃溶剂，可与卤代烃溶剂混溶的共溶剂和导电性增强物质。卤代烃溶剂可以是氯仿，共溶剂可以是醇，如甲醇或乙醇。电导率增强物质可以是在溶解时离解形成离子的盐，或者可以是酸或聚合物。如果留在印刷产品中，则导电性增强物质可以选择为良性的。电导率增强物质可以选择为挥发性的，以便能够从其印刷的任何物质蒸发，并且具体地可以在室温下选择为液体。电导率增强物质可以选择为仅包含碳，氧，氢和氮，特别是铵盐; 通常在身体组织中发现的元素。或者，可以选择导电性增强物质以包含金属的离子，但仅包含某些特定的金属。

8. 发明申请

US20050234813A1 Network auctioning apparatus, system and method of use thereof 审中-公开
标题翻译：网络拍卖装置，系统及其使用方法
公开(公告)号：US20050234813A1
公开(公告)日：2005-10-20
申请号：US11156697
申请日：2005-06-20
申请人： Andrew West , Thomas West , Thomas West
发明人： Andrew West , Thomas West , Thomas West
IPC分类号： G06Q30/00 , G07F17/40 , G06F17/60
CPC分类号： G07F17/40 , G06Q20/10 , G06Q30/0613 , G06Q30/08 , G06Q40/04
摘要： The invention provides an apparatus comprising a hand-portable remote auction terminal operatively connected to an agent via a network, wherein the hand-portable remote auction terminal includes governing protocol executably operable to initiate conferencing with the agent and can also facilitate interactive screening during receipt of goods into a network auction. A method that facilitates the exchange of goods, through a network auction via a network, and systems employing the apparatus are also disclosed.
摘要翻译：本发明提供了一种装置，其包括经由网络可操作地连接到代理的便携式远程拍卖终端，其中手持式远程拍卖终端包括可执行地操作以启动与代理会议的管理协议，并且还可以在接收到货物进入网络拍卖。还公开了通过网络进行网络拍卖以及采用该装置的系统来促进商品交换的方法。

9. 发明申请

US20170203411A9 Method and Systems to Control Optical Transmissivity of a Polish Pad Material 有权
公开(公告)号：US20170203411A9
公开(公告)日：2017-07-20
申请号：US14626256
申请日：2015-02-19
申请人： Thomas West, Inc.
发明人： Thomas West , Gary Quigley , Pepito Galvez , Peter McKeever , Suli Holani
IPC分类号： B24D13/14 , B24D11/00
CPC分类号： B24D13/14 , B24D11/001
摘要： A method and systems for controlling optical transmissivity of a polish pad material are provided. The method and systems may include adjusting control parameters to determine the optical transmissivity of a polish pad material. The control parameters may also include pre-processing controls, casting controls, and/or curing controls. Methods and systems also provided for assembling a polish pad that controls the optical transmissivity of the polish pad. Additionally, a polish pad with a controlled optical transmissivity is provided.

10. 发明申请

US20140287663A1 Multilayer Polishing Pads Made by the Methods for Centrifugal Casting of Polymer Polish Pads 审中-公开
标题翻译：由聚合物抛光垫离心铸造方法制成的多层抛光垫
公开(公告)号：US20140287663A1
公开(公告)日：2014-09-25
申请号：US14297177
申请日：2014-06-05
申请人： THOMAS WEST, INC.
发明人： Thomas West , Long Nguyen , Gary Quigley , Pepito Galvez , Suli Holani , Kevin Song , Jorge Craik , Matt Richardson , Peter McKeever
IPC分类号： B24B37/22 , B29C41/04
摘要： A method for making a multilayer polishing pad includes rotating a cylinder about a central axis. The cylinder encloses in an interior space a single polymer mixture that phase separates under centrifugal force. The method also includes forming the polishing pad from at least some of a polymer formed after the polymer mixture has reacted. The method includes forming at least two distinct layers in the polishing pad by casting and gelling sequentially at least two different polymers.
摘要翻译：制造多层抛光垫的方法包括使圆筒围绕中心轴旋转。气缸在内部空间中封闭单个聚合物混合物，在离心力下相分离。该方法还包括从聚合物混合物反应后形成的聚合物中的至少一些形成抛光垫。该方法包括通过依次浇铸和胶凝至少两种不同的聚合物在抛光垫中形成至少两个不同的层。

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