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1. 发明申请

US20060198558A1 METHOD AND APPARATUS FOR CORRECTING CROSSTALK AND SPATIAL RESOLUTION FOR MULTICHANNEL IMAGING 有权
标题翻译：用于校正多通道成像的波形和空间分辨率的方法和装置
公开(公告)号：US20060198558A1
公开(公告)日：2006-09-07
申请号：US11419138
申请日：2006-05-18
申请人： James Riley , Keith Frost
发明人： James Riley , Keith Frost
IPC分类号： G06K9/32
CPC分类号： G06K9/00503 , G01J3/28 , G01J3/2803 , G01J3/32 , G01J3/36 , G01N15/147 , G01N15/1475 , G06K9/00127 , G06T5/50 , G06T7/32 , G06T7/33 , G06T2207/10036
摘要： A multi-channel imaging system generates an ensemble of images for each field of view of an object. Each image in the ensemble is intended to contain information from only one source among a plurality of sources for the object. However, due to crosstalk, at least a portion of the signal from a first source appears in a channel intended for a second source. Because the accuracy of the correction will be degraded if the images in an ensemble are spatially misaligned with respect to one another, the spatial offset between images is determined and a correction is applied to substantially eliminate the offset. Then, a correction to the signals is determined to substantially reduce the contributions to the signal in a channel from the signals in other channels. The signal processing can be employed to process the output signals for each of a plurality of different disclosed imaging systems.
摘要翻译：多通道成像系统为对象的每个视野生成图像集合。集合中的每个图像旨在包含来自对象的多个源中的一个源的信息。然而，由于串扰，来自第一源的信号的至少一部分出现在用于第二源的通道中。因为如果一个组合中的图像相对于彼此在空间上不对准，校正的精度将会降低，所以确定图像之间的空间偏移并且应用校正以基本上消除偏移。然后，确定对信号的校正，以从其它通道中的信号基本上减少对信道中的信号的贡献。信号处理可用于处理多个不同公开的成像系统中的每一个的输出信号。

2. 发明申请

US20060002634A1 Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging 有权
公开(公告)号：US20060002634A1
公开(公告)日：2006-01-05
申请号：US11224200
申请日：2005-09-12
申请人： James Riley , Keith Frost
发明人： James Riley , Keith Frost
IPC分类号： G06K9/32
CPC分类号： G06K9/00503 , G01J3/28 , G01J3/2803 , G01J3/32 , G01J3/36 , G01N15/147 , G01N15/1475 , G06K9/00127 , G06T5/50 , G06T7/32 , G06T7/33 , G06T2207/10036
摘要： A multichannel imaging system generates an ensemble of images for each field of view of an object. Each image in the ensemble is intended to contain information from only one source among a plurality of sources for the object. However, due to crosstalk, at least a portion of the signal from a first source appears in a channel intended for a second source. Because the accuracy of the correction will be degraded if the images in an ensemble are spatially misaligned with respect to one another, the spatial offset between images is determined and a correction is applied to substantially eliminate the offset. Then, a correction to the signals is determined to substantially reduce the contributions to the signal in a channel from the signals in other channels. The signal processing can be employed to process the output signals for each of a plurality of different disclosed imaging systems.

3. 发明申请

US20070069182A1 Corrosion inhibitor compositions and associated methods 审中-公开
标题翻译：腐蚀抑制剂组合物及相关方法
公开(公告)号：US20070069182A1
公开(公告)日：2007-03-29
申请号：US11234997
申请日：2005-09-26
申请人： Juanita Cassidy , Chad Kiser , Jim Lane , Keith Frost
发明人： Juanita Cassidy , Chad Kiser , Jim Lane , Keith Frost
IPC分类号： C23F11/00
CPC分类号： C23F11/04 , C09K8/54 , C23F11/122 , C23F11/184
摘要： Corrosion inhibitor compositions may include certain combinations of the following components: a group 15 metal source, a cinnamaldehyde compound, an additional aldehyde compound, an acetylenic compound, a surfactant, an iodide source, and a solvent. Certain embodiments may omit one or more of these components. The inhibitor corrosion compositions may possess desirable environmental properties particularly for use in downhole environments. The corrosion inhibitor compositions herein do not require the presence of quaternary ammonium compounds or “Mannich” condensation compounds.
摘要翻译：腐蚀抑制剂组合物可以包括以下组分的某些组合：第15族金属源，肉桂醛化合物，另外的醛化合物，炔属化合物，表面活性剂，碘化物源和溶剂。某些实施例可以省略这些组件中的一个或多个。抑制剂腐蚀组合物可具有期望的环境特性，特别用于井下环境中。本文的腐蚀抑制剂组合物不需要季铵化合物或“曼尼希”缩合化合物的存在。

4. 发明申请

US20060148658A1 Compositions for reducing the viscosity of treatment fluids 有权
标题翻译：用于降低处理液粘度的组合物
公开(公告)号：US20060148658A1
公开(公告)日：2006-07-06
申请号：US11030403
申请日：2005-01-06
申请人： Robert Hanes , Richard Pauls , David Griffin , Keith Frost , John Terracina
发明人： Robert Hanes , Richard Pauls , David Griffin , Keith Frost , John Terracina
IPC分类号： C09K8/00 , E21B43/00
CPC分类号： C09K8/68 , C09K8/64 , C09K8/703 , C09K8/706 , C09K2208/26
摘要： In one embodiment, the present invention provides a viscosified treatment fluid composition comprising a base fluid, a gelling agent, and a breaker composition that comprises an oxidizing breaker and a breaker activator that comprises a metal and a protein. In another embodiment, the present invention provides a viscosified treatment fluid composition comprising a base fluid, a gelling agent, and a breaker composition that comprises an oxidizing breaker and a breaker activator that comprises iron. In an embodiment, the present invention provides a breaker composition comprising an oxidizing breaker and a breaker activator that comprises a metal and a protein.
摘要翻译：在一个实施方案中，本发明提供了一种增稠的处理流体组合物，其包含基础流体，胶凝剂和破坏剂组合物，其包含氧化破坏剂和包含金属和蛋白质的破坏剂活化剂。在另一个实施方案中，本发明提供了一种粘稠的处理流体组合物，其包含基础流体，胶凝剂和破坏剂组合物，其包含氧化破坏剂和包含铁的破坏剂活化剂。在一个实施方案中，本发明提供了包含氧化破坏剂和包含金属和蛋白质的破坏剂活化剂的断路器组合物。

5. 发明申请

US20050127271A1 Auto focus for a flow imagin system 有权
标题翻译：自动对焦一个流量想象系统
公开(公告)号：US20050127271A1
公开(公告)日：2005-06-16
申请号：US11045675
申请日：2005-01-28
申请人： William Ortyn , Michael Seo , David Basiji , Keith Frost , David Perry
发明人： William Ortyn , Michael Seo , David Basiji , Keith Frost , David Perry
IPC分类号： G01N15/10 , G01N15/14 , G02B27/00 , G06T7/20 , G01N21/00 , G01N15/06 , G02B7/04
CPC分类号： G06T7/20 , G01N15/1459 , G01N15/1463 , G01N2015/1018 , G01N2015/1443 , G01N2015/1447 , G01N2015/1452 , G01N2015/1497 , G02B27/0012 , G06K9/00134
摘要： A pair of optical gratings are used to modulate light from an object, and the modulated light from either grating is used to determine the velocity of the object. Each optical grating is offset from a reference focal point by the same distance, one grating being offset in a positive direction, the other in a negative direction. Signals produced in response to the modulated light can be processed to determine a direction in which a primary collection lens should be moved in order to improve a focus of the imaging system on the object. The lens is moved incrementally in the direction so determined, and the process is repeated until an optimal focus is achieved. In a preferred embodiment, the signals are weighted, so that the optical grating disposed closest to the optimal focus position contributes the most to velocity detection.
摘要翻译：一对光栅用于调制来自物体的光，并且来自任一光栅的调制光用于确定物体的速度。每个光栅从参考焦点偏移相同的距离，一个光栅在正方向偏移，另一个光栅在负方向上偏移。可以处理响应于调制光产生的信号以确定主收集透镜应该移动的方向，以便改善成像系统对物体的焦点。透镜在如此确定的方向上逐渐移动，并重复该过程，直到达到最佳聚焦。在优选实施例中，对信号进行加权，使得最靠近最佳聚焦位置布置的光栅最有助于速度检测。

6. 发明申请

US20120244550A1 IMAGE-BASED QUANTITATION OF MOLECULAR TRANSLOCATION 有权
标题翻译：基于图像的分子量转移定量
公开(公告)号：US20120244550A1
公开(公告)日：2012-09-27
申请号：US13436371
申请日：2012-03-30
申请人： Thaddeus C. George , David A. Basiji , Keith Frost , Brian E. Hall , William E. Ortyn , Michael J. Seo
发明人： Thaddeus C. George , David A. Basiji , Keith Frost , Brian E. Hall , William E. Ortyn , Michael J. Seo
IPC分类号： G01N21/64 , C12Q1/02
CPC分类号： G01N33/56966
摘要： The use of an imaging system, cell compartment markers, and molecular markers in methods for correlating the movement of molecules within a cell to a particular compartment are provided, including measuring and correlating molecule movement in adherent and non-adherent cells.
摘要翻译：提供了在将细胞内的分子运动与特定隔室相关联的方法中使用成像系统，细胞室标记和分子标记，包括测量和关联粘附和非贴壁细胞中的分子运动。

7. 发明授权

US08005314B2 Extended depth of field imaging for high speed object analysis 有权
公开(公告)号：US08005314B2
公开(公告)日：2011-08-23
申请号：US11609269
申请日：2006-12-11
申请人： William Ortyn , David Basiji , Keith Frost , Luchuan Liang , Richard Bauer , Brian Hall , David Perry
发明人： William Ortyn , David Basiji , Keith Frost , Luchuan Liang , Richard Bauer , Brian Hall , David Perry
IPC分类号： G06K9/40 , G06K9/64 , G03H1/00 , G02B3/10 , G02B13/06
CPC分类号： G02B27/0075 , G01N15/147 , G01N15/1475 , G01N21/6458 , G01N2015/1452 , G02B21/365 , G02B27/0012
摘要： A high speed, high-resolution flow imaging system is modified to achieve extended depth of field imaging. An optical distortion element is introduced into the flow imaging system. Light from an object, such as a cell, is distorted by the distortion element, such that a point spread function (PSF) of the imaging system is invariant across an extended depth of field. The distorted light is spectrally dispersed, and the dispersed light is used to simultaneously generate a plurality of images. The images are detected, and image processing is used to enhance the detected images by compensating for the distortion, to achieve extended depth of field images of the object. The post image processing preferably involves de-convolution, and requires knowledge of the PSF of the imaging system, as modified by the optical distortion element.

8. 发明授权

US09528989B2 Image-based quantitation of molecular translocation 有权
标题翻译：基于图像的分子易位定量
公开(公告)号：US09528989B2
公开(公告)日：2016-12-27
申请号：US13436371
申请日：2012-03-30
申请人： Thaddeus C. George , David A. Basiji , Keith Frost , Brian E. Hall , William E. Ortyn , Michael J. Seo
发明人： Thaddeus C. George , David A. Basiji , Keith Frost , Brian E. Hall , William E. Ortyn , Michael J. Seo
IPC分类号： G06K9/00 , G01N33/569
CPC分类号： G01N33/56966
摘要： The use of an imaging system, cell compartment markers, and molecular markers in methods for correlating the movement of molecules within a cell to a particular compartment are provided, including measuring and correlating molecule movement in adherent and non-adherent cells.
摘要翻译：提供了在将细胞内的分子运动与特定隔室相关联的方法中使用成像系统，细胞室标记和分子标记，包括测量和关联粘附和非贴壁细胞中的分子运动。

9. 发明申请

US20070114030A1 Methods of modifying particulate surfaces to affect acidic sites thereon 有权
标题翻译：改性颗粒表面以影响其上的酸性位点的方法
公开(公告)号：US20070114030A1
公开(公告)日：2007-05-24
申请号：US11284392
申请日：2005-11-21
申请人： Bradley Todd , Keith Frost , Jimmie Waver , Bessie Citrowske
发明人： Bradley Todd , Keith Frost , Jimmie Waver , Bessie Citrowske
IPC分类号： E21B43/267 , E21B43/22
CPC分类号： C09K8/805 , C01P2002/02 , C01P2004/84 , C09C3/12 , Y10S507/904 , Y10S507/924
摘要： Methods comprising: providing a treatment fluid that comprises a base fluid and a least a plurality of coated particulates, the coated particulates having been treated with a surface modification agent and coated with a hydrolysable coating; placing the treatment fluid into a subterranean formation via a well bore. Also provided are methods comprising: treating a particulate with a surface modification agent; coating the particulate with a hydrolysable coating that has an initial degradation rate to produce a coated particulate; placing the particulate in a subterranean formation; and allowing the hydrolysable coating to degrade at a second degradation rate that is slower than its initial degradation rate.
摘要翻译：方法包括：提供包含基础流体和至少多个涂覆颗粒的处理流体，所述涂覆的颗粒已用表面改性剂处理并涂覆有可水解涂层; 通过井眼将处理流体置于地层中。还提供的方法包括：用表面改性剂处理颗粒; 用具有初始降解速率的可水解涂层涂覆颗粒以产生涂覆的颗粒; 将颗粒置于地层中; 并且使可水解涂层以比其初始降解速率慢的第二降解速率降解。

10. 发明申请

US20050034868A1 Orthoester compositions and methods of use in subterranean applications 有权
标题翻译：在地下应用中使用的异构体组合物和方法
公开(公告)号：US20050034868A1
公开(公告)日：2005-02-17
申请号：US10752752
申请日：2004-01-07
申请人： Keith Frost , Gary Funkhouser , Bessie Nita Citrowske , Brad Todd
发明人： Keith Frost , Gary Funkhouser , Bessie Nita Citrowske , Brad Todd
IPC分类号： C09K8/52 , E21B43/25
CPC分类号： C09K8/805 , C09K8/52 , Y10S507/906 , Y10S507/924 , Y10T428/2991 , Y10T428/2993 , Y10T428/2996
摘要： The present invention relates to methods and compositions for treating subterranean formations, and more specifically, to improved methods and compositions for generating acids for use downhole, for example, to at least partially degrade the acid-soluble portions of filter cakes deposited in subterranean formations. In one embodiment, the present invention provides a method of degrading an acid-soluble portion of a filter cake comprising contacting the acid-soluble portion of the filter cake with an acid generated from an orthoester.
摘要翻译：本发明涉及用于处理地下地层的方法和组合物，更具体地，涉及用于产生在井下使用的酸的改进的方法和组合物，例如至少部分地降解沉积在地下地层中的滤饼的酸溶性部分。在一个实施方案中，本发明提供降解滤饼的酸溶性部分的方法，包括使滤饼的酸溶性部分与由原酸酯产生的酸接触。

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