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1. 发明授权

US06296667B1 Bone substitutes 失效
公开(公告)号：US06296667B1
公开(公告)日：2001-10-02
申请号：US08944006
申请日：1997-10-01
申请人： James R. Johnson , Jeffrey G. Marx , Wesley D. Johnson
发明人： James R. Johnson , Jeffrey G. Marx , Wesley D. Johnson
IPC分类号： A61F236
CPC分类号： A61F2/28 , A61F2/30767 , A61F2/36 , A61F2/367 , A61F2/389 , A61F2002/2817 , A61F2002/30092 , A61F2002/30884 , A61F2002/30968 , A61F2210/0014 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00131 , A61F2310/00179 , A61F2310/00203 , A61F2310/00239 , A61F2310/00293 , A61L27/425 , A61L27/427 , A61L27/56 , A61L2400/18 , A61L2430/02
摘要： A strong, porous article useful as a bone substitute material. The article comprises a continuous strong framework structure having struts defining interstices which interconnect throughout the bulk volume, and may have ceramic or osteoconductive material occupying at least a portion of the same bulk volume as the framework structure. Either as a coating on the strong framework struts or between the framework struts and the ceramic or osteoconductive—osteoinductive materials is a resilient material which serves to distribute stresses within the article.

2. 发明授权

US6136029A Bone substitute materials 失效
标题翻译：骨替代材料
公开(公告)号：US6136029A
公开(公告)日：2000-10-24
申请号：US942557
申请日：1997-10-01
申请人： Wesley D. Johnson , James R. Johnson , Jeffrey G. Marx
发明人： Wesley D. Johnson , James R. Johnson , Jeffrey G. Marx
IPC分类号： A61L27/00 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/36 , A61F2/38 , A61L27/42 , A61L27/56
CPC分类号： A61F2/28 , A61F2/30767 , A61L27/425 , A61L27/427 , A61L27/56 , A61F2/36 , A61F2/367 , A61F2/389 , A61F2002/2817 , A61F2002/30092 , A61F2002/30884 , A61F2002/30968 , A61F2210/0014 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00131 , A61F2310/00179 , A61F2310/00203 , A61F2310/00239 , A61F2310/00293 , A61L2430/02
摘要： A strong, porous article useful as a bone substitute material and having an outer surface defining a shape having a bulk volume and having open interconnecting interstices extending throughout said volume and opening through said surface. The article comprises a continuous strong framework structure having interstices which interconnect throughout the bulk volume and a second continuous material occupying at least a portion of the same bulk volume as the framework structure. The second material comprises an osteoinductive and/or osteoconductive composition. This composition may be present in one of several forms. One of these is as a coating on the surface of the framework structure. A second form is in the form of a composite, intimately mixed with the framework material within the framework struts. The third form is as a porous mass within the interstices of the framework structure, having pores which are interconnecting with themselves, and with the interstices of the framework structure. Desirably, the porous osteoinductive or osteoconductive composition extends throughout said bulk volume. In a preferred embodiment, the framework structure is formed of a ceramic material. In a further embodiment, the framework structure may be further structurally reinforced with a dense material component integrally affixed thereto.
摘要翻译：用作骨替代材料并具有限定具有本体体积的形状的外表面并且具有贯穿所述体积延伸并且穿过所述表面的开放互连间隙的强的多孔制品。该制品包括具有互连整个本体体积的间隙的连续强框架结构和占据框架结构相同体积体积的至少一部分的第二连续材料。第二种材料包括骨诱导和/或骨传导性组合物。该组合物可以以几种形式之一存在。其中之一是作为框架结构表面上的涂层。第二种形式是复合物的形式，与框架支柱内的框架材料密切混合。第三种形式是在框架结构的空隙内形成多孔质量，具有与其自身相互连接的孔隙以及框架结构的间隙。期望地，多孔骨诱导或骨传导性组合物延伸贯穿整个体积。在优选实施例中，框架结构由陶瓷材料形成。在另一个实施例中，框架结构可以进一步在结构上用与其一体地固定的致密材料部件加强。

3. 发明授权

US06527810B2 Bone substitutes 有权
标题翻译：骨替代品
公开(公告)号：US06527810B2
公开(公告)日：2003-03-04
申请号：US09740807
申请日：2000-12-21
申请人： James R. Johnson , Jeffrey G. Marx , Wesley D. Johnson
发明人： James R. Johnson , Jeffrey G. Marx , Wesley D. Johnson
IPC分类号： A61F228
CPC分类号： A61F2/28 , A61F2/30767 , A61F2/36 , A61F2/367 , A61F2/389 , A61F2002/2817 , A61F2002/30092 , A61F2002/30884 , A61F2002/30968 , A61F2210/0014 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00131 , A61F2310/00179 , A61F2310/00203 , A61F2310/00239 , A61F2310/00293 , A61L27/425 , A61L27/427 , A61L27/56 , A61L2400/18 , A61L2430/02
摘要： A strong, porous article useful as a bone substitute material. The article comprises a continuous strong framework structure having struts defining interstices which interconnect throughout the bulk volume, and may have ceramic or osteoconductive material occupying at least a portion of the same bulk volume as the framework structure. Either as a coating on the strong framework struts or between the framework struts and the ceramic or osteoconductive-osteoinductive materials is a resilient material which serves to distribute stresses within the article.
摘要翻译：用作骨替代材料的强力多孔制品。该制品包括连续的强骨架结构，其具有限定在整个本体体积上互连的间隙的支柱，并且可以具有占据与框架结构相同的体积体积的至少一部分的陶瓷或骨传导材料。作为在强框架支柱上的框架或框架支柱和陶瓷或骨传导 - 骨诱导材料之间的涂层是用于在制品内分布应力的弹性材料。

4. 发明授权

US07740897B2 Process for producing rigid reticulated articles 有权
标题翻译：刚性网状制品的制造方法
公开(公告)号：US07740897B2
公开(公告)日：2010-06-22
申请号：US11245369
申请日：2005-10-06
申请人： Jeffrey G. Marx , Bradley R. Heckendorf , James R. Johnson , John Jeffrey Venarsky
发明人： Jeffrey G. Marx , Bradley R. Heckendorf , James R. Johnson , John Jeffrey Venarsky
IPC分类号： A61F2/28 , A61L27/32 , B05D3/02
CPC分类号： A61L27/425 , A61L27/306 , A61L27/32 , A61L27/427 , A61L27/56
摘要： A method for forming a ceramic article useful as a bone substitute and having an outer surface defining a shape having a bulk volume and having open, interconnecting openings extending throughout the volume and opening through the surface, includes, providing an organic open-pore structure, coating surface of pores of the structure with a ceramic slip, pyrolyzing the organic structure to leave a ceramic structure having struts defining a plurality of interconnecting interstices, and providing within the interstices a porous osteoconductive composition exposed to the interconnecting openings. In a preferred embodiment, the ceramic slip includes a strong, supportive ceramic material and a separate osteoconductive material.
摘要翻译：一种用于形成可用作骨替代物并且具有限定具有本体体积的形状的外表面并且具有贯穿整个体积延伸并且穿过该表面的开口的开放互连开口的陶瓷制品的方法包括提供有机开孔结构，用陶瓷滑动涂覆结构的孔的表面，热解有机结构以留下具有限定多个互连间隙的支柱的陶瓷结构，并在空隙内提供暴露于互连开口的多孔骨传导组合物。在优选实施例中，陶瓷滑移包括强的支撑陶瓷材料和单独的骨传导材料。

5. 发明授权

US06977095B1 Process for producing rigid reticulated articles 失效
标题翻译：刚性网状制品的制造方法
公开(公告)号：US06977095B1
公开(公告)日：2005-12-20
申请号：US09440144
申请日：1999-11-15
申请人： Jeffrey G. Marx , Bradley R. Heckendorf , James R. Johnson , John Jeffrey Venarsky
发明人： Jeffrey G. Marx , Bradley R. Heckendorf , James R. Johnson , John Jeffrey Venarsky
IPC分类号： A61L27/30 , A61L27/32 , A61L27/42 , A61L27/56 , B05D3/00
CPC分类号： A61L27/425 , A61L27/306 , A61L27/32 , A61L27/427 , A61L27/56
摘要： A process for producing a rigid reticulated article involves coating a reticulated substrate which has open, interconnected porosity with a first dispersion comprising a ceramic or metal powder to form a first coating thereon; drying the coated reticulated substrate; contacting the coated reticulated substrate with one or more additional dispersions in succession to form one or more additional coatings thereon; drying the additional coatings between the steps of contacting; heating the coated reticulated substrate to pyrolyze organic components; and sintering the coated reticulated substrate to form a reticulated article, wherein each dispersion has a viscosity less than that of all preceding dispersions. A rigid reticulated article includes inner, intermediate and outer sintered layers of material in which the inner and outer layers are of different composition and the intermediate layer is a composite of the inner and outer layers.
摘要翻译：用于生产刚性网状制品的方法包括用具有开放的互连多孔性的网状基底涂覆包含陶瓷或金属粉末的第一分散体以在其上形成第一涂层; 干燥涂覆的网状基材; 使涂覆的网状基材与一种或多种另外的分散体连续接触以在其上形成一种或多种另外的涂层; 在接触步骤之间干燥附加的涂层; 加热涂覆的网状基底以热解有机组分; 并烧结涂覆的网状基底以形成网状制品，其中每种分散体的粘度小于所有先前分散体的粘度。刚性网状制品包括材料的内部，中间和外部烧结层，其中内层和外层具有不同的组成，中间层是内层和外层的复合材料。

6. 发明申请

US20120022568A1 Instrument for Use in Bone and Method of Use 审中-公开
标题翻译：用于骨骼和使用方法的仪器
公开(公告)号：US20120022568A1
公开(公告)日：2012-01-26
申请号：US13035650
申请日：2011-02-25
申请人： Antony Koblish , Jeffrey G. Marx , Theodore D. Clineff , Stephen G. Gara , Troy Wilford , Paul Tashjian , Maarten Persenaire , Dean Entrekin , Erik M. Erbe
发明人： Antony Koblish , Jeffrey G. Marx , Theodore D. Clineff , Stephen G. Gara , Troy Wilford , Paul Tashjian , Maarten Persenaire , Dean Entrekin , Erik M. Erbe
IPC分类号： A61B17/34
CPC分类号： A61B17/1617 , A61B10/025 , A61B10/0275 , A61B17/1671
摘要： Instrument for creating voids and channels in bone; and for obtaining samples of bone tissue. The instruments are suitable for reducing fractures in bone and for compacting the bone to create a barrier for leakage upon material injection. The instruments may also be used for bone biopsy and for obtaining samples of bone tissue. Methods for using these instruments are also disclosed.
摘要翻译：用于在骨骼中创建空洞和通道的仪器; 并用于获得骨组织样品。该仪器适用于减少骨中的骨折并压实骨骼，以在材料注射时产生渗漏的屏障。这些器械也可用于骨活检和获得骨组织样品。还公开了使用这些仪器的方法。

7. 发明申请

US20140164797A1 PORTABLE ELECTRICAL DEVICE CHARGING SYSTEM AND METHOD USING THERMAL ENERGY 审中-公开
标题翻译：便携式电气装置充电系统和使用热能的方法
公开(公告)号：US20140164797A1
公开(公告)日：2014-06-12
申请号：US14100185
申请日：2013-12-09
申请人： Jeffrey G. Marx , Lance A. Marx
发明人： Jeffrey G. Marx , Lance A. Marx
IPC分类号： H02J7/00 , G06F1/26 , F21L4/08
CPC分类号： H02J7/32 , F21L4/085
摘要： A portable electrical device charging system and method for using thermal energy, especially for use in the field or as part of military operations, is disclosed. The inventive electrical device charging system has one or more thermal electric generators attached, physically connected to, or incorporated within a container or pouch that is used to heat packaged meals-ready-to-eat (“MRE”). With the generation of heat to cook the MRE, the heat transfer through the container or pouch activates the thermal electric generators which generates electricity, in the form of an electric current, that can be used to charge any electrical device including an electrical storage device. More particularly, the generated electrical current may be used to charge radios, batteries, cell phones, personal data assistant devices, tablets, cameras, flashlights, or any other similar device.
摘要翻译：公开了一种用于使用热能的便携式电气装置充电系统和方法，特别是用于现场或军事作业的一部分。本发明的电气设备充电系统具有一个或多个热发电机，其连接到物理上连接到或结合在容器或小袋中，用于加热包装即食即食（“MRE”）。通过产生热量来烹调MRE，通过容器或小袋的热传递激活了以电流形式发电的热发电机，其可用于对包括电存储装置的任何电气装置充电。更具体地，所产生的电流可用于对无线电装置，电池，手机，个人数据助理装置，平板电脑，照相机，手电筒或任何其它类似装置充电。

8. 发明授权

US08876911B2 Delivery device for biological composites and method of preparation thereof 有权
标题翻译：生物复合材料输送装置及其制备方法
公开(公告)号：US08876911B2
公开(公告)日：2014-11-04
申请号：US11384576
申请日：2006-03-20
申请人： James P. Murphy , Charanpreet S. Bagga , Robert J. Chiasera, Jr. , Erik M. Erbe , Jeffrey G. Marx
发明人： James P. Murphy , Charanpreet S. Bagga , Robert J. Chiasera, Jr. , Erik M. Erbe , Jeffrey G. Marx
IPC分类号： A61M31/00 , A61F2/28 , A61L27/46 , A61L27/56 , A61L27/54 , A61B17/88 , A61M25/00 , A61M5/34
CPC分类号： A61L27/46 , A61B17/8816 , A61B17/8825 , A61L27/54 , A61L27/56 , A61L2300/00 , A61M5/34 , A61M25/0097
摘要： An apparatus for the delivery of a biological composite and a method, kit, and system for preparing a biological composite is described herein. The biological composite includes both inorganic and biological materials.
摘要翻译：本文描述了用于递送生物复合材料的装置和用于制备生物复合材料的方法，试剂盒和系统。生物复合材料包括无机和生物材料。

9. 发明授权

US07045125B2 Biologically active composites and methods for their production and use 有权
公开(公告)号：US07045125B2
公开(公告)日：2006-05-16
申请号：US10035797
申请日：2001-10-23
申请人： Erik M. Erbe , Jeffrey G. Marx
发明人： Erik M. Erbe , Jeffrey G. Marx
IPC分类号： A01N63/00
CPC分类号： A61L27/56 , A61L27/46 , A61L27/54 , A61L2300/252 , A61L2300/406 , A61L2300/414 , A61L2300/64
摘要： Biologically active composites containing calcium phosphate, more specifically beta-tri-calcium phosphate, and methods of preparing the same are disclosed herein. Also disclosed are methods of restoring an osseous void and complimentary kits for the disclosed composites.

10. 发明授权

US07052517B2 Delivery device for biological composites and method of preparation thereof 有权
公开(公告)号：US07052517B2
公开(公告)日：2006-05-30
申请号：US10818419
申请日：2004-04-05
申请人： James P. Murphy , Charanpreet S. Bagga , Robert J. Chiasera, Jr. , Erik M. Erbe , Jeffrey G. Marx
发明人： James P. Murphy , Charanpreet S. Bagga , Robert J. Chiasera, Jr. , Erik M. Erbe , Jeffrey G. Marx
IPC分类号： A61F2/28
CPC分类号： A61L27/46 , A61B17/8816 , A61B17/8825 , A61L27/54 , A61L27/56 , A61L2300/00 , A61M5/34 , A61M25/0097
摘要： An apparatus for the delivery of a biological composite and a method, kit, and system for preparing a biological composite is described herein. The biological composite includes both inorganic and biological materials.

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