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1. 发明申请

US20100158850A1 DENDRIMER BASED MODULAR PLATFORMS 审中-公开
标题翻译：基于DENDRIMER的模块化平台
公开(公告)号：US20100158850A1
公开(公告)日：2010-06-24
申请号：US12645081
申请日：2009-12-22
申请人： James R. Baker, JR. , Mark M. Banaszak Holl , Xue-min Cheng , Baohua Huang , Daniel McNemy , Douglas G. Mullen , Thommey Thomas
发明人： James R. Baker, JR. , Mark M. Banaszak Holl , Xue-min Cheng , Baohua Huang , Daniel McNemy , Douglas G. Mullen , Thommey Thomas
IPC分类号： A61K31/74 , C08G69/00
CPC分类号： A61K31/74 , A61K31/00 , A61K45/06 , A61K47/551 , A61K47/59 , A61K47/595 , C08G73/0206 , C08G73/028 , C08G81/00 , C08G83/003 , C08L79/02 , C08L101/005 , A61K2300/00
摘要： The present invention relates to novel therapeutic and diagnostic dendrimer based modular platforms (e.g., drug delivery platforms). In particular, the dendrimer based modular platforms are configured such that two or more dendrimers (e.g., PAMAM dendrimers) are coupled together (e.g., via a cycloaddition reaction) wherein each of the coupled dendrimers is functionalized (e.g., functionalized for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy). In some embodiments, the present invention provides dendrimer based modular platforms having coupled dendrimers (e.g., two or more coupled dendrimers) wherein each dendrimer is conjugated to one or more functional groups (e.g., therapeutic agent, imaging agent, targeting agent, triggering agent) (e.g., for specific targeting and/or therapeutic use of the dendrimer based modular platform). In some embodiments, the functional groups are conjugated to the dendrimers via a linker and/or a triggering agent. In addition, the present invention is directed to methods of synthesizing dendrimer based modular platforms, compositions comprising the dendrimer based modular platforms, as well as systems and methods utilizing the dendrimer based modular platforms (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, etc.)).
摘要翻译：本发明涉及新颖的基于树枝状大分子的模块化平台（例如药物递送平台）。特别地，基于树枝状聚合物的模块化平台被配置为使得两个或更多个树枝状聚合物（例如，PAMAM树枝状聚合物）偶联在一起（例如，通过环加成反应），其中每个偶联的树枝状聚合物被官能化（例如，功能化用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测对治疗的响应）。在一些实施方案中，本发明提供了具有结合的树枝状大分子（例如两个或更多个偶联的树枝状大分子）的树枝状大分子模块化平台，其中每个树枝状聚合物与一个或多个官能团（例如，治疗剂，成像剂，靶向剂，引发剂）（例如，用于基于树枝状聚合物的模块化平台的特异性靶向和/或治疗用途）。在一些实施方案中，官能团通过接头和/或引发剂与树枝状聚合物缀合。此外，本发明涉及基于树枝状聚合物的模块化平台的方法，包含基于树枝状聚合物的模块化平台的组合物以及利用基于树枝状聚合物的模块化平台的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送治疗剂，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗中等））。

2. 发明申请

US20120232225A1 SYNTHESIS AND ISOLATION OF DENDRIMER SYSTEMS 审中-公开
标题翻译： DENDRIMER系统的合成和分离
公开(公告)号：US20120232225A1
公开(公告)日：2012-09-13
申请号：US13392421
申请日：2010-07-23
申请人： James R. Baker, JR. , Mark M. Banaszak Holl , Douglas Gurnett Mullen , Bradford G. Orr , Ankur Desai , Leonard M. Sander , Jack Neel Waddell
发明人： James R. Baker, JR. , Mark M. Banaszak Holl , Douglas Gurnett Mullen , Bradford G. Orr , Ankur Desai , Leonard M. Sander , Jack Neel Waddell
IPC分类号： C08G63/91
CPC分类号： C08G83/004
摘要： The present invention relates to novel methods of synthesis and isolation of dendrimer systems. In particular, the present invention is directed to novel dendrimer conjugates with defined and limited numbers of ligand conjugates and high levels of structural uniformity, methods of synthesizing the same, compositions comprising the conjugates, as well systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)).
摘要翻译：本发明涉及树枝状大分子体系的合成和分离的新方法。特别地，本发明涉及具有限定数量和限定数量的配体缀合物和高水平结构均匀性的新型树状聚合物缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，诊断和/或治疗设置（例如，用于递送治疗剂，成像和/或靶向剂（例如，在疾病（例如，癌症）诊断和/或治疗，疼痛治疗等中））。

3. 发明申请

US20120277376A1 DENDRIMER CONJUGATES 有权
标题翻译： DENDRIMER联合
公开(公告)号：US20120277376A1
公开(公告)日：2012-11-01
申请号：US13547929
申请日：2012-07-12
申请人： James R. Baker, JR. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
发明人： James R. Baker, JR. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
IPC分类号： C08G69/48
CPC分类号： C07D305/08
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.
摘要翻译：本发明涉及新的治疗和诊断树枝状大分子。特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。

4. 发明申请

US20090287005A1 DENDRIMER CONJUGATES 有权
标题翻译： DENDRIMER联合
公开(公告)号：US20090287005A1
公开(公告)日：2009-11-19
申请号：US12403179
申请日：2009-03-12
申请人： James R. Baker, JR. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
发明人： James R. Baker, JR. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
IPC分类号： C07D305/08
CPC分类号： C07D305/08
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.
摘要翻译：本发明涉及新的治疗和诊断树枝状大分子。特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。

5. 发明申请

US20100160299A1 DENDRIMER CONJUGATES 有权
标题翻译： DENDRIMER联合
公开(公告)号：US20100160299A1
公开(公告)日：2010-06-24
申请号：US12570977
申请日：2009-09-30
申请人： James R. Baker, JR. , Xue-min Cheng , Abraham F.L. Van Der Spek , Baohua Mark Huang , Thommey P. Thomas
发明人： James R. Baker, JR. , Xue-min Cheng , Abraham F.L. Van Der Spek , Baohua Mark Huang , Thommey P. Thomas
IPC分类号： A61K31/5513 , C07D489/02 , A61K31/485 , C07D243/24 , C07D413/06 , A61K31/5377
CPC分类号： A61K47/483 , A61K31/485 , A61K47/595
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.
摘要翻译：本发明涉及新的治疗和诊断树枝状大分子。特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。

6. 发明申请

US20120259098A1 DENDRIMER COMPOSITIONS AND METHODS OF SYNTHESIS 有权
标题翻译： DENDRIMER组合物和合成方法
公开(公告)号：US20120259098A1
公开(公告)日：2012-10-11
申请号：US13502004
申请日：2010-10-07
申请人： James R. Baker, JR. , Baohua Huang
发明人： James R. Baker, JR. , Baohua Huang
IPC分类号： C07K17/02 , C07D311/82 , C07C57/12 , C07K1/04 , C07H1/00 , C07H21/04 , C07D219/08 , B82Y15/00
CPC分类号： A61K47/48207 , A61K47/595 , A61K49/0002 , A61K49/0043 , A61K49/0054 , A61K49/124 , A61K51/065 , C08G73/028
摘要： The present invention relates to novel dendrimer compounds and methods of synthesizing the same. In particular, the present invention is directed to novel polyamidoamine (PAMAM) dendrimers, novel dendrimer branching units, methods for synthesizing such novel PAMAM dendrimers and functionalized dendrimers, as well as systems and methods utilizing the dendrimers (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease diagnosis and/or therapy, etc.))).
摘要翻译：本发明涉及新颖的树枝状大分子化合物及其合成方法。特别地，本发明涉及新颖的聚酰胺胺（PAMAM）树枝状大分子，新型树枝状大分子支化单元，合成这种新型PAMAM树枝状聚合物和官能化树枝状聚合物的方法，以及利用树枝状大分子的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送治疗剂，成像和/或靶向剂（例如，在疾病诊断和/或治疗等中））。

7. 发明申请

US20140093537A1 IMMUNOGENIC COMPOSITIONS COMPRISING NANOEMULSION AND METHODS OF ADMINISTERING THE SAME 审中-公开
标题翻译：包含纳米微粒的免疫组合物及其施用方法
公开(公告)号：US20140093537A1
公开(公告)日：2014-04-03
申请号：US14042128
申请日：2013-09-30
申请人： James R. Baker, JR. , Douglas Smith , Ali I. Fattom , Jakub Simon
发明人： James R. Baker, JR. , Douglas Smith , Ali I. Fattom , Jakub Simon
IPC分类号： A61K39/245 , A61K39/02 , A61K39/145 , A61K39/155 , A61K39/00 , A61K39/12
CPC分类号： A61K39/245 , A61K39/00 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/155 , A61K2039/543 , A61K2039/545 , A61K2039/55566 , C12N2710/16634 , C12N2730/10134 , C12N2760/18534
摘要： The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides immunogenic nanoemulsion compositions and methods of administering the same (e.g., via a heterologous prime/boost protocol (e.g., utilizing the same nanoemulsion in each the prime and boost administrations)) to induce immune responses (e.g., innate and/or adaptive immune responses (e.g., for generation of host immunity against an environmental pathogen)). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
摘要翻译：本发明提供了用于刺激免疫应答的方法和组合物。特别地，本发明提供免疫原性纳米乳剂组合物及其施用方法（例如，通过异源原始/加强方案（例如，在每次初次和加强施用中利用相同的纳米乳剂））诱导免疫应答（例如，先天性和/或适应性免疫应答（例如，用于产生针对环境病原体的宿主免疫））。本发明的组合物和方法尤其可用于临床（例如治疗和预防性药物（例如疫苗接种））和研究应用。

8. 发明申请

US20130273113A1 IMMUNOGENIC APOPTOSIS INDUCING COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：免疫组织化学诱导组合物及其使用方法
公开(公告)号：US20130273113A1
公开(公告)日：2013-10-17
申请号：US13836617
申请日：2013-03-15
申请人： James R. Baker, JR. , Paul Makidon , Andrzej Myc
发明人： James R. Baker, JR. , Paul Makidon , Andrzej Myc
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K39/12 , A61K2039/543 , A61K2039/55566 , C12N2730/10134
摘要： The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses (e.g., immunologic cell death/apoptosis (e.g., for the induction of innate and/or adaptive immune responses)). Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., for infectious disease, cancer, autoimmunity, and/or tissue injury (e.g., via alteration of host immune responses))) and research applications.
摘要翻译：本发明提供了用于刺激免疫应答的方法和组合物。特别地，本发明提供纳米乳剂组合物及其使用于诱导免疫应答的方法（例如，免疫细胞死亡/凋亡（例如，用于诱导先天和/或适应性免疫应答））。本发明的组合物和方法尤其可用于临床（例如治疗和预防性药物（例如用于感染性疾病，癌症，自身免疫和/或组织损伤（例如通过改变宿主免疫应答）））和研究应用。

9. 发明申请

US20120276182A1 METHODS OF TREATING FUNGAL, YEAST AND MOLD INFECTIONS 审中-公开
标题翻译：治疗真菌，YEAST和模具感染的方法
公开(公告)号：US20120276182A1
公开(公告)日：2012-11-01
申请号：US13544789
申请日：2012-07-09
申请人： James R. Baker, JR. , Mary R. Flack , Susan M. Ciotti , Joyce A. Sutcliffe
发明人： James R. Baker, JR. , Mary R. Flack , Susan M. Ciotti , Joyce A. Sutcliffe
IPC分类号： A61K47/44 , A61K31/513 , A61K38/12 , A61K31/7048 , A61K9/107 , A61K31/4164 , A61K31/5375 , B82Y5/00
CPC分类号： A61K31/00 , A61K9/0014 , A61K9/1075 , A61K47/183 , A61K47/186 , A61K47/26 , A61K47/44 , Y10S977/906
摘要： The present invention relates to methods for treating and completely curing fungal, yeast, and/or mold infections in human subjects comprising topically administering to a human subject in need thereof an antifungal nanoemulsion composition.
摘要翻译：本发明涉及用于治疗和完全治愈人类受试者真菌，酵母和/或霉菌感染的方法，包括向有需要的人受试者局部施用抗真菌纳米乳剂组合物。

10. 发明申请

US20120259114A1 MULTIFUNCTIONAL SMALL MOLECULES 有权
标题翻译：多功能小分子
公开(公告)号：US20120259114A1
公开(公告)日：2012-10-11
申请号：US13504046
申请日：2010-09-30
申请人： James R. Baker, JR. , Hong Zong , Thommey P. Thomas
发明人： James R. Baker, JR. , Hong Zong , Thommey P. Thomas
IPC分类号： C07D405/14
CPC分类号： C08G83/003 , A61K47/551 , A61K47/595
摘要： The present invention relates to dendrimer synthesis. Specifically, the present invention relates to triazine scaffolds capable of click chemistry for one-step synthesis of functionalized dendrimers, and methods of making and using the same.
摘要翻译：本发明涉及树枝状大分子合成。具体地，本发明涉及能够进行功能化树枝状大分子的一步合成的点击化学的三嗪支架及其制造和使用方法。

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