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1. 发明申请

US20100158850A1 DENDRIMER BASED MODULAR PLATFORMS 审中-公开
标题翻译：基于DENDRIMER的模块化平台
公开(公告)号：US20100158850A1
公开(公告)日：2010-06-24
申请号：US12645081
申请日：2009-12-22
申请人： James R. Baker, JR. , Mark M. Banaszak Holl , Xue-min Cheng , Baohua Huang , Daniel McNemy , Douglas G. Mullen , Thommey Thomas
发明人： James R. Baker, JR. , Mark M. Banaszak Holl , Xue-min Cheng , Baohua Huang , Daniel McNemy , Douglas G. Mullen , Thommey Thomas
IPC分类号： A61K31/74 , C08G69/00
CPC分类号： A61K31/74 , A61K31/00 , A61K45/06 , A61K47/551 , A61K47/59 , A61K47/595 , C08G73/0206 , C08G73/028 , C08G81/00 , C08G83/003 , C08L79/02 , C08L101/005 , A61K2300/00
摘要： The present invention relates to novel therapeutic and diagnostic dendrimer based modular platforms (e.g., drug delivery platforms). In particular, the dendrimer based modular platforms are configured such that two or more dendrimers (e.g., PAMAM dendrimers) are coupled together (e.g., via a cycloaddition reaction) wherein each of the coupled dendrimers is functionalized (e.g., functionalized for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy). In some embodiments, the present invention provides dendrimer based modular platforms having coupled dendrimers (e.g., two or more coupled dendrimers) wherein each dendrimer is conjugated to one or more functional groups (e.g., therapeutic agent, imaging agent, targeting agent, triggering agent) (e.g., for specific targeting and/or therapeutic use of the dendrimer based modular platform). In some embodiments, the functional groups are conjugated to the dendrimers via a linker and/or a triggering agent. In addition, the present invention is directed to methods of synthesizing dendrimer based modular platforms, compositions comprising the dendrimer based modular platforms, as well as systems and methods utilizing the dendrimer based modular platforms (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, etc.)).
摘要翻译：本发明涉及新颖的基于树枝状大分子的模块化平台（例如药物递送平台）。特别地，基于树枝状聚合物的模块化平台被配置为使得两个或更多个树枝状聚合物（例如，PAMAM树枝状聚合物）偶联在一起（例如，通过环加成反应），其中每个偶联的树枝状聚合物被官能化（例如，功能化用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测对治疗的响应）。在一些实施方案中，本发明提供了具有结合的树枝状大分子（例如两个或更多个偶联的树枝状大分子）的树枝状大分子模块化平台，其中每个树枝状聚合物与一个或多个官能团（例如，治疗剂，成像剂，靶向剂，引发剂）（例如，用于基于树枝状聚合物的模块化平台的特异性靶向和/或治疗用途）。在一些实施方案中，官能团通过接头和/或引发剂与树枝状聚合物缀合。此外，本发明涉及基于树枝状聚合物的模块化平台的方法，包含基于树枝状聚合物的模块化平台的组合物以及利用基于树枝状聚合物的模块化平台的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送治疗剂，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗中等））。

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