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1. 发明授权

US07863430B2 Construct capable of release in closed circular form from a larger nucleotide sequence permitting site specific expression and/or developmentally regulated expression of selected genetic sequences 有权
标题翻译：能够以允许位点特异性表达和/或发育调节所选遗传序列表达的较大核苷酸序列以闭环形式释放的构建体
公开(公告)号：US07863430B2
公开(公告)日：2011-01-04
申请号：US10168653
申请日：2001-03-28
申请人： James Langham Dale , Benjamin Dugdale , Greg John Hafner , Scott Richard Hermann , Douglas Kenneth Becker , Robert Maxwell Harding , Srimek Chowpongpang
发明人： James Langham Dale , Benjamin Dugdale , Greg John Hafner , Scott Richard Hermann , Douglas Kenneth Becker , Robert Maxwell Harding , Srimek Chowpongpang
IPC分类号： C07H21/04 , C12N5/04 , A01H1/00
CPC分类号： C12N15/8282 , C12N15/79 , C12N15/8203 , C12N15/8216 , C12N15/8257 , C12N15/8263 , C12N15/8283
摘要： The present invention relates generally to constructs and in particular genetic constructs comprising polynucleotide sequences capable of release in covalently closed, circular form from a larger nucleotide sequence such as a genome of a eukaryotic cell. Preferably, once released, a polynucleotide sequence is reconstituted in a form which permits expression of the polynucleotide sequence. In one embodiment, the reconstituted polynucleotide sequence comprises a coding sequence with all or part of an extraneous nucleotide such as an intronic sequence or other splice signal inserted therein. Expression and in particular transcription of the coding sequence involves splicing out the extraneous sequence. The release and circularization is generally in response to a stimulus such as a protein-mediated stimulus. More particularly, the protein is a viral or prokaryotic or eukaryotic derived protein or developmentally and/or tissue specific regulated protein.
摘要翻译：本发明一般涉及构建体，特别是涉及能够从较大核苷酸序列例如真核细胞的基因组以共价闭合的环形形式释放的多核苷酸序列的遗传构建体。优选地，一旦释放，以允许多核苷酸序列表达的形式重构多核苷酸序列。在一个实施方案中，重构的多核苷酸序列包含具有全部或部分外来核苷酸（例如插入其中的内含子序列或其它剪接信号）的编码序列。表达，特别是编码序列的转录涉及剪接外来序列。释放和环化通常响应于诸如蛋白质介导的刺激的刺激。更具体地，蛋白质是病毒或原核或真核衍生的蛋白质或发育和/或组织特异性调节蛋白。

2. 发明授权

US08829170B2 Construct capable of release in closed circular form from a larger nucleotide sequence permitting site specific expression and/or developmentally regulated expression of selected genetic sequences 有权
标题翻译：能够以允许位点特异性表达和/或发育调节所选遗传序列表达的较大核苷酸序列以闭环形式释放的构建体
公开(公告)号：US08829170B2
公开(公告)日：2014-09-09
申请号：US12948005
申请日：2010-11-17
申请人： James Langham Dale , Benjamin Dugdale , Greg John Hafner , Scott Richard Hermann , Douglas Kenneth Becker , Robert Maxwell Harding , Srimek Chowpongpang
发明人： James Langham Dale , Benjamin Dugdale , Greg John Hafner , Scott Richard Hermann , Douglas Kenneth Becker , Robert Maxwell Harding , Srimek Chowpongpang
IPC分类号： C07H21/04
CPC分类号： C12N15/8282 , C12N15/79 , C12N15/8203 , C12N15/8216 , C12N15/8257 , C12N15/8263 , C12N15/8283
摘要： The present invention relates generally to constructs and in particular genetic constructs comprising polynucleotide sequences capable of release in covalently closed, circular form from a larger nucleotide sequence such as, but not limited to, a genome of a eukaryotic cell. Preferably, once released, a polynucleotide sequence is reconstituted in a form which permits expression of the polynucleotide sequence. In one embodiment, the reconstituted polynucleotide sequence comprises a coding sequence with all or part of an extraneous nucleotide such as, but not limited to, an intronic sequence or other splice signal inserted therein. Expression and in particular transcription of the coding sequence involves splicing out the extraneous sequence. The release and circularization is generally in response to a stimulus such as a protein-mediated stimulus. More particularly, the protein is a viral or prokaryotic or eukaryotic derived protein or developmentally and/or tissue specific regulated protein.
摘要翻译：本发明一般涉及构建体，特别是包含能够以较大核苷酸序列（例如但不限于真核细胞的基因组）以共价闭合的环形形式释放的多核苷酸序列的遗传构建体。优选地，一旦释放，以允许多核苷酸序列表达的形式重构多核苷酸序列。在一个实施方案中，重构的多核苷酸序列包含具有全部或部分外来核苷酸的编码序列，例如但不限于插入其中的内含子序列或其他剪接信号。表达，特别是编码序列的转录涉及剪接外来序列。释放和环化通常响应于诸如蛋白质介导的刺激的刺激。更具体地，蛋白质是病毒或原核或真核衍生的蛋白质或发育和/或组织特异性调节蛋白。

3. 发明申请

US20110119782A1 CONSTRUCT CAPABLE OF RELEASE IN CLOSED CIRCULAR FORM FROM A LARGER NUCLEOTIDE SEQUENCE PERMITTING SITE SPECIFIC EXPRESSION AND/OR DEVELOPMENTALLY REGULATED EXPRESSION OF SELECTED GENETIC SEQUENCES 有权
标题翻译：从大型核素序列允许位置封闭的通用形式释放的构建体特异性表达和/或开发的所选择的遗传序列的调控表达
公开(公告)号：US20110119782A1
公开(公告)日：2011-05-19
申请号：US12948005
申请日：2010-11-17
申请人： James Langham Dale , Benjamin Dugdale , Greg John Hafner , Scott Richard Hermann , Douglas Kenneth Becker , Robert Maxwell Harding , Srimek Chowpongpang
发明人： James Langham Dale , Benjamin Dugdale , Greg John Hafner , Scott Richard Hermann , Douglas Kenneth Becker , Robert Maxwell Harding , Srimek Chowpongpang
IPC分类号： C12N15/63 , C12N15/82 , A01H5/00 , A01K67/027
CPC分类号： C12N15/8282 , C12N15/79 , C12N15/8203 , C12N15/8216 , C12N15/8257 , C12N15/8263 , C12N15/8283
摘要： The present invention relates generally to constructs and in particular genetic constructs comprising polynucleotide sequences capable of release in covalently closed, circular form from a larger nucleotide sequence such as, but not limited to, a genome of a eukaryotic cell. Preferably, once released, a polynucleotide sequence is reconstituted in a form which permits expression of the polynucleotide sequence. In one embodiment, the reconstituted polynucleotide sequence comprises a coding sequence with all or part of an extraneous nucleotide such as, but not limited to, an intronic sequence or other splice signal inserted therein. Expression and in particular transcription of the coding sequence involves splicing out the extraneous sequence. The release and circularization is generally in response to a stimulus such as a protein-mediated stimulus. More particularly, the protein is a viral or prokaryotic or eukaryotic derived protein or developmentally and/or tissue specific regulated protein.
摘要翻译：本发明一般涉及构建体，特别是包含能够以较大核苷酸序列（例如但不限于真核细胞的基因组）以共价闭合的环形形式释放的多核苷酸序列的遗传构建体。优选地，一旦释放，以允许多核苷酸序列表达的形式重构多核苷酸序列。在一个实施方案中，重构的多核苷酸序列包含具有全部或部分外来核苷酸的编码序列，例如但不限于插入其中的内含子序列或其他剪接信号。表达，特别是编码序列的转录涉及剪接外来序列。释放和环化通常响应于诸如蛋白质介导的刺激的刺激。更具体地，蛋白质是病毒或原核或真核衍生的蛋白质或发育和/或组织特异性调节蛋白。

4. 发明授权

US6127604A Intergenic regions of banana bunchy top virus 失效
标题翻译：香蕉束顶病毒的基因间区域
公开(公告)号：US6127604A
公开(公告)日：2000-10-03
申请号：US973068
申请日：1998-03-12
申请人： James Langham Dale , Robert Maxwell Harding , Benjamin Dugdale , Peter Ronald Beetham , Gregory John Hafner , Douglas Kenneth Becker
发明人： James Langham Dale , Robert Maxwell Harding , Benjamin Dugdale , Peter Ronald Beetham , Gregory John Hafner , Douglas Kenneth Becker
IPC分类号： A01H5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/82 , C12R1/92 , C12N5/14
CPC分类号： C12N15/8223 , C12N15/8216 , C12N15/8222
摘要： The invention relates a DNA molecule which is a partial fragment of an intergenic region of a BBTV component or alternatively which DNA molecule is derived from said intergenic region whereby the DNA molecule is capable of promoting, enhancing, regulating, or modifying transcription of a non-BBTV gene.
摘要翻译： PCT No.PCT / AU96 / 00335 Sec。 371日期1998年3月12日 102（e）1998年3月12日PCT PCT 1996年5月31日PCT公布。出版物WO96 / 38554 日期1996年12月5日本发明涉及一种DNA分子，其是BBTV组分的基因间区域的部分片段，或者该DNA分子来源于所述基因间区域，由此DNA分子能够促进，增强，调节或修饰非BBTV基因的转录。

5. 发明授权

US09416365B2 TaBV transcriptional control element, chimeric constructs and uses therefor 有权
标题翻译： TaBV转录控制元件，嵌合构建物及其用途
公开(公告)号：US09416365B2
公开(公告)日：2016-08-16
申请号：US12570431
申请日：2009-09-30
申请人： James Langham Dale , Robert Maxwell Harding , Douglas Kenneth Becker , Gregory John Hafner , Ilin Yang
发明人： James Langham Dale , Robert Maxwell Harding , Douglas Kenneth Becker , Gregory John Hafner , Ilin Yang
IPC分类号： C12N15/82 , C07K14/005
CPC分类号： C12N15/8216 , C07K14/005 , C12N15/8222 , C12N15/8223 , C12N2730/00022
摘要： This invention discloses a constitutive promoter for expression of foreign or endogenous coding sequences in plants, including dicotyledonous and monocotyledonous plants. The invention also discloses a chimeric nucleic acid construct comprising the promoter of the invention operably linked to a foreign or endogenous polynucleotide that codes for a protein of interest or a transcript capable of modulating expression of a target gene. The invention further discloses transformed plant cells, as well as differentiated plants and plant parts, containing the construct. Methods for diagnosis and treatment of viral infections, especially badnaviral infections, are also disclosed.
摘要翻译：本发明公开了一种用于在植物中表达外源或内源编码序列的组成型启动子，包括双子叶植物和单子叶植物。本发明还公开了一种嵌合核酸构建体，其包含可操作地连接到编码目标蛋白质的外源或内源多核苷酸的本发明启动子或能够调节靶基因表达的转录物。本发明还公开了转化的植物细胞，以及含有该构建体的分化植物和植物部分。还公开了用于诊断和治疗病毒感染，特别是恶毒病毒感染的方法。

6. 发明授权

US10415047B2 TaBV transcriptional control elements, chimeric constructs and uses therefor 有权
公开(公告)号：US10415047B2
公开(公告)日：2019-09-17
申请号：US15194766
申请日：2016-06-28
申请人： James Langham Dale , Robert Maxwell Harding , Douglas Kenneth Becker , Gregory John Hafner , Ilin Yang
发明人： James Langham Dale , Robert Maxwell Harding , Douglas Kenneth Becker , Gregory John Hafner , Ilin Yang
IPC分类号： C12N15/82 , C07K14/005
摘要： This invention discloses a constitutive promoter from the Taro bacilliform virus (TaBV) for expression of foreign or endogenous coding sequences in plants, including dicotyledonous and monocotyledonous plants. The invention also discloses a chimeric nucleic acid construct comprising the promoter of the invention operably linked to a foreign or endogenous polynucleotide that codes for a protein of interest or a transcript capable of modulating expression of a target gene. The invention further discloses transformed plant cells, as well as differentiated plants and plant parts, containing the construct. Methods for diagnosis and treatment of viral infections, especially badnaviral infections, are also disclosed.

7. 发明授权

US07598366B2 TaBV transcriptional control elements, chimeric constructs and uses therefor 有权
标题翻译： TaBV转录控制元件，嵌合构建物及其用途
公开(公告)号：US07598366B2
公开(公告)日：2009-10-06
申请号：US10521571
申请日：2003-07-17
申请人： James Langham Dale , Robert Maxwell Harding , Douglas Kenneth Becker , Gregory John Hafner , Ilin Yang
发明人： James Langham Dale , Robert Maxwell Harding , Douglas Kenneth Becker , Gregory John Hafner , Ilin Yang
IPC分类号： C12N15/82 , C12N5/04 , C07H21/04 , A01H5/00
CPC分类号： C12N15/8216 , C07K14/005 , C12N15/8222 , C12N15/8223 , C12N2730/00022
摘要： This invention discloses a constitutive promoter from the Taro bacilliform virus (TaBV) for expression of foreign or endogenous coding sequences in plants, including dicotyledonous and monocotyledonous plants. The invention also discloses a chimeric nucleic acid construct comprising the promoter of the invention operably linked to a foreign or endogenous polynucleotide that codes for a protein of interest or a transcript capable of modulating expression of a target gene. The invention further discloses transformed plant cells, as well as differentiated plants and plant parts, containing the construct. Methods for diagnosis and treatment of viral infections, especially badnaviral infections, are also disclosed.
摘要翻译：本发明公开了一种用于在植物中表达外源或内源编码序列的Taro杆菌病毒（TaBV）的组成型启动子，包括双子叶植物和单子叶植物。本发明还公开了一种嵌合核酸构建体，其包含可操作地连接到编码目标蛋白质的外源或内源多核苷酸的本发明启动子或能够调节靶基因表达的转录物。本发明还公开了转化的植物细胞，以及含有该构建体的分化植物和植物部分。还公开了用于诊断和治疗病毒感染，特别是恶毒病毒感染的方法。

8. 发明申请

US20100281566A1 TRANSCRIPTIONAL CONTROL ELEMENT, CHIMERIC CONSRUCTS AND USES THEREFOR 有权
标题翻译：转运控制元件，其中的重要事项及其用途
公开(公告)号：US20100281566A1
公开(公告)日：2010-11-04
申请号：US12570431
申请日：2009-09-30
申请人： James Langham Dale , Robert Maxwell Harding , Douglas Kenneth Becker , Gregory John Hafner , Ilin Yang
发明人： James Langham Dale , Robert Maxwell Harding , Douglas Kenneth Becker , Gregory John Hafner , Ilin Yang
IPC分类号： C12N15/82 , C12Q1/70 , C12Q1/02 , C12N5/10 , C12N15/63 , A61K38/16 , C07K7/08 , C07K7/06 , C07K14/005 , A01H5/00 , A61P31/12
CPC分类号： C12N15/8216 , C07K14/005 , C12N15/8222 , C12N15/8223 , C12N2730/00022
摘要： This invention discloses a constitutive promoter for expression of foreign or endogenous coding sequences in plants, including dicotyledonous and monocotyledonous plants. The invention also discloses a chimeric nucleic acid construct comprising the promoter of the invention operably linked to a foreign or endogenous polynucleotide that codes for a protein of interest or a transcript capable of modulating expression of a target gene. The invention further discloses transformed plant cells, as well as differentiated plants and plant parts, containing the construct. Methods for diagnosis and treatment of viral infections, especially badnaviral infections, are also disclosed.
摘要翻译：本发明公开了一种用于在植物中表达外源或内源编码序列的组成型启动子，包括双子叶植物和单子叶植物。本发明还公开了一种嵌合核酸构建体，其包含可操作地连接到编码目标蛋白质的外源或内源多核苷酸的本发明启动子或能够调节靶基因表达的转录物。本发明还公开了转化的植物细胞，以及含有该构建体的分化植物和植物部分。还公开了用于诊断和治疗病毒感染，特别是恶毒病毒感染的方法。

9. 发明授权

US5756708A DNA sequences of banana bunchy top virus 失效
标题翻译：香蕉束顶病毒的DNA序列
公开(公告)号：US5756708A
公开(公告)日：1998-05-26
申请号：US202186
申请日：1994-02-24
申请人： Mirko Karan , Thomas Michael Burns , James Langham Dale , Robert Maxwell Harding
发明人： Mirko Karan , Thomas Michael Burns , James Langham Dale , Robert Maxwell Harding
IPC分类号： C07K14/01 , C12N15/11 , C12N15/34
CPC分类号： C07K14/005 , C12N2750/00021 , C12N2750/00022
摘要： The invention provides DNA molecules consisting essentially of a nucleotide sequence or part thereof which are asosciated with the genome of banana bunchy top virus (BBTV) as illustrated in FIGS. 1 through 8 (SEQ ID NOS: 49-54, 27-37, 55-60, 38-48, and 9-23, respectively) of the specification attached herewith.
摘要翻译：本发明提供了基本上由与如图1和2所示的香蕉束顶病毒（BBTV）的基因组一致的核苷酸序列或其部分组成的DNA分子。 1至8（分别为SEQ ID NO：49-54,27-37,55-60,38-48和9-23）。

10. 发明授权

US5856092A Detection of a nucleic acid sequence or a change therein 失效
标题翻译：检测核酸序列或其中的变化
公开(公告)号：US5856092A
公开(公告)日：1999-01-05
申请号：US429659
申请日：1995-04-27
申请人： James Langham Dale , Peter Timms , Terence Patrick Walsh
发明人： James Langham Dale , Peter Timms , Terence Patrick Walsh
IPC分类号： C12Q1/68 , C07H21/00 , C12N15/00 , C12P19/34
CPC分类号： C12Q1/6827
摘要： A method for detecting a specific polynucleotide sequence in a material is disclosed. The method includes exposing said material to an oligonucleotide primer having a sequence complementary to part of said specific polynucleotide sequence wherein said primer binds to part of said polynucleotide sequence when present in said material. Primer bound to the polynucleotide sequence is extended wherein any extended primer includes a detectable element and/or a separation element. Any extended primer is then separated into a fraction wherein said fraction does not have detectable element not included in said extended primer. One then determines whether any extended primer is present in said fraction by assaying said fraction for said extended primer wherein the presence of said extended primer is indicative of the presence of the specific polynucleotide sequence in said material and the absence of said extended primer is indicative of the presence of the specific polynucleotide sequences in said material and the absence of said extended primer in said fraction is indicative of the absence of the specific polynucleotide sequence in said material.
摘要翻译：公开了一种用于检测材料中特定多核苷酸序列的方法。该方法包括将所述材料暴露于具有与所述特异性多核苷酸序列的一部分互补的序列的寡核苷酸引物，其中当存在于所述材料中时，所述引物与部分所述多核苷酸序列结合。与多核苷酸序列结合的引物延伸，其中任何延伸的引物包括可检测元件和/或分离元件。然后将任何延伸的引物分离成其中所述级分不具有未包含在所述延伸引物中的可检测元件的级分。然后通过测定所述延伸引物的所述级分来确定所述级分中是否存在任何延伸引物，其中所述延伸引物的存在指示所述材料中特异性多核苷酸序列的存在，并且所述延伸引物不存在指示所述材料中特定多核苷酸序列的存在和所述级分中不存在所述延伸引物指示所述材料中不存在特异性多核苷酸序列。

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