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1. 发明授权

US07402616B2 Fusible conductive ink for use in manufacturing microfluidic analytical systems 有权
标题翻译：用于制造微流体分析系统的可熔导电油墨
公开(公告)号：US07402616B2
公开(公告)日：2008-07-22
申请号：US10957470
申请日：2004-09-30
申请人： James Iain Rodgers , Margaret Maclennan , James Moffat , Alan McNeilage
发明人： James Iain Rodgers , Margaret Maclennan , James Moffat , Alan McNeilage
IPC分类号： C09D11/00 , C09D11/10
CPC分类号： C09D11/102
摘要： A fusible conductive ink for use in manufacturing microfluidic analytical systems includes micronised powder containing platinum and carbon, poly(bisphenol A-co-epichlorohydrin)-glycidyl end capped polymer, and a solvent. In addition, the ratio of micronised powder to poly(bisphenol A-co-epichlorohydrin)-glycidyl end capped polymer is in the range of 3:1 to 1:3. The fusible conductive inks can be employed in the manufacturing of microfluidic systems to form electrodes, electrically conductive traces and/or electrically conductive contact pads.
摘要翻译：用于制造微流体分析系统的可熔性导电油墨包括含有铂和碳的微粉化粉末，聚（双酚A共 - 表氯醇） - 缩水甘油基封端的聚合物和溶剂。此外，微粉化粉末与聚（双酚A-共 - 表氯醇） - 缩水甘油基封端聚合物的比例在3:1至1:3的范围内。可熔融导电油墨可用于制造微流体系统以形成电极，导电迹线和/或导电接触焊盘。

2. 发明授权

US07465380B2 Water-miscible conductive ink for use in enzymatic electrochemical-based sensors 有权
标题翻译：用于酶电化学传感器的水溶性导电油墨
公开(公告)号：US07465380B2
公开(公告)日：2008-12-16
申请号：US11118947
申请日：2005-04-28
申请人： James Iain Rodgers , Zuifang Liu , Alan Watson McNeilage , Margaret MacLennan , James Moffat , Geoffrey Lillie , Michael MacDonald
发明人： James Iain Rodgers , Zuifang Liu , Alan Watson McNeilage , Margaret MacLennan , James Moffat , Geoffrey Lillie , Michael MacDonald
IPC分类号： G01N27/327 , H01M4/88
CPC分类号： C12Q1/004
摘要： A water-miscible conductive ink for use in enzymatic electrochemical-based sensors includes a conductive material, an enzyme, a mediator and a binding agent. The conductive material, enzyme, mediator, and binding agent are formulated as a water-miscible aqueous-based dispersion wherein the binding agent becomes operatively water-insoluble upon drying.
摘要翻译：用于酶电化学传感器的水混溶性导电油墨包括导电材料，酶，介体和粘合剂。将导电材料，酶，介体和结合剂配制成水混溶性水基分散体，其中粘合剂在干燥时变得可操作地不溶于水。

3. 发明授权

US07588670B2 Enzymatic electrochemical-based sensor 有权
标题翻译：酶电化学传感器
公开(公告)号：US07588670B2
公开(公告)日：2009-09-15
申请号：US11118507
申请日：2005-04-28
申请人： James Iain Rodgers , Zuifang Liu , Alan Watson McNeilage , Margaret MacLennan , James Moffat , Geoffrey Lillie , Michael MacDonald
发明人： James Iain Rodgers , Zuifang Liu , Alan Watson McNeilage , Margaret MacLennan , James Moffat , Geoffrey Lillie , Michael MacDonald
IPC分类号： G01N27/327
CPC分类号： C12Q1/004
摘要： An enzymatic electrochemical-based sensor includes a substrate and a conductive layer formed from a dried water-miscible conductive ink. The water-miscible conductive ink used to form the conductive layer includes a conductive material, an enzyme, a mediator, and a binding agent and is formulated such that the water-miscible conductive ink is a water-miscible aqueous-based dispersion and the binding agent became operatively water-insoluble upon drying.
摘要翻译：酶电化学传感器包括基材和由干燥的水混溶性导电油墨形成的导电层。用于形成导电层的与水可混溶的导电油墨包括导电材料，酶，介体和粘合剂，并且被配制成使得水混溶性导电油墨是水混溶性的基于水的分散体和结合试剂在干燥时变得可操作地不溶于水。

4. 发明授权

US06990849B2 Microfluidic analytical system with position electrodes 有权
标题翻译：具有位置电极的微流体分析系统
公开(公告)号：US06990849B2
公开(公告)日：2006-01-31
申请号：US10811446
申请日：2004-03-26
申请人： Sebastian Bohm , James Iain Rodgers , Alan McNeilage , James Moffat , Matthias Stiene , Tanja Richter
发明人： Sebastian Bohm , James Iain Rodgers , Alan McNeilage , James Moffat , Matthias Stiene , Tanja Richter
IPC分类号： G01N11/00 , G01N33/487 , G01N15/06 , G01N33/00 , C12M1/34
CPC分类号： G01N27/3271 , A61B5/14532 , B01L3/502715 , B01L2200/143 , B01L2300/0645 , B01L2300/0806 , B01L2300/0816 , B01L2400/0409 , G01F1/708 , G01F22/00
摘要： A microfluidic analytical system for monitoring an analyte (for example, glucose) in a liquid sample (e.g., ISF) includes an analysis module with at least one micro-channel for receiving and transporting a liquid sample, at least one analyte sensor for measuring an analyte in the liquid sample and at least one position electrode. The analyte sensor(s) and position electrode(s) are in operative communication with the micro-channel. The microfluidic system also includes a meter configured for measuring an electrical characteristic (such as impedance or resistance) of the position electrode(s). Moreover, the measured electrical characteristic is dependent on the position of the liquid sample in the micro-channel that is in operative communication with the position electrode for which an electrical characteristic is measured.
摘要翻译：用于监测液体样品（例如，ISF）中的分析物（例如葡萄糖）的微流体分析系统包括具有至少一个用于接收和输送液体样品的微通道的分析模块，至少一个分析物传感器，用于测量液体样品中的分析物和至少一个位置电极。分析物传感器和位置电极与微通道可操作地通信。微流体系统还包括配置用于测量位置电极的电特性（例如阻抗或电阻）的仪表。此外，所测量的电特性取决于与测量电特性的位置电极可操作地连通的微通道中的液体样品的位置。

5. 发明授权

US08936713B2 Fill sufficiency method and system 有权
标题翻译：填充充足的方法和系统
公开(公告)号：US08936713B2
公开(公告)日：2015-01-20
申请号：US12965680
申请日：2010-12-10
申请人： James Iain Rodgers , Leanne Mills , Marco Cardosi , Chris Leach , James Moffat
发明人： James Iain Rodgers , Leanne Mills , Marco Cardosi , Chris Leach , James Moffat
IPC分类号： G01N27/327
CPC分类号： G01N27/3274
摘要： Described and illustrated herein are one exemplary method and a measurement system having a meter and a test strip. The test strip has a first working electrode, reference electrode and second working electrode. In this method, acceptable fill data from known first current and known second current are used to predict an estimated second current at proximate the second time period (for a given batch of test strips) during the test sequence. The estimated second current at proximate the second time interval is then compared with a measured actual second current at proximate the second time interval during an actual test to determine if the measured actual second current is substantially equal to or within an acceptable percent deviation from the estimated second current so as to determine sufficient volume of a physiological fluid sample in the test strip.
摘要翻译：本文描述和示出了具有仪表和测试条的一个示例性方法和测量系统。测试条具有第一工作电极，参考电极和第二工作电极。在该方法中，使用来自已知第一电流和已知第二电流的可接受的填充数据来预测在测试序列期间接近第二时间段（对于给定批次的测试条）的估计的第二电流。然后在实际测试期间，将接近第二时间间隔的估计的第二电流与接近第二时间间隔的测量的实际第二电流进行比较，以确定测量的实际第二电流是否基本上等于或在与估计的以确定测试条中的生理液体样本的足够体积。

6. 发明授权

US07572356B2 Electrochemical-based sensor with a redox polymer and redox enzyme entrapped by a dialysis membrane 有权
标题翻译：电化学传感器与氧化还原聚合物和氧化还原酶被透析膜截留
公开(公告)号：US07572356B2
公开(公告)日：2009-08-11
申请号：US10931724
申请日：2004-08-31
申请人： James Iain Rodgers , Zuifang Liu , Geoffrey Lillie
发明人： James Iain Rodgers , Zuifang Liu , Geoffrey Lillie
IPC分类号： G01N27/327
CPC分类号： C12Q1/004
摘要： An electrochemical-based sensor includes an electrode with at least one electrode surface, a film disposed on the electrode surface, and a dialysis membrane disposed on the film. The film includes a redox enzyme and a hydrophilic redox polymer (i.e., a polymer with an attached redox mediator(s)). In addition, the dialysis membrane serves to entrap the redox polymer and redox enzyme in the vicinity of the electrode. Such entrapment is accomplished by employing a redox enzyme and a hydrophilic redox polymer of a sufficiently high molecular weight that they do not pass through the dialysis membrane.
摘要翻译：电化学传感器包括具有至少一个电极表面的电极，设置在电极表面上的膜和设置在膜上的透析膜。该膜包括氧化还原酶和亲水性氧化还原聚合物（即具有附着的氧化还原介体的聚合物）。此外，透析膜用于在电极附近截留氧化还原性聚合物和氧化还原酶。通过使用氧化还原酶和足够高分子量的亲水性氧化还原聚合物，它们不通过透析膜来实现这种捕获。

7. 发明授权

US08932449B2 Analytical test strip with an electrode having electrochemically active and inert areas of a predetermined size and distribution 有权
标题翻译：分析测试条，其具有具有预定尺寸和分布的电化学活性和惰性区域的电极
公开(公告)号：US08932449B2
公开(公告)日：2015-01-13
申请号：US13554378
申请日：2012-07-20
申请人： Gavin Macfie , Craig Redpath , James Iain Rodgers , Neil Whitehead
发明人： Gavin Macfie , Craig Redpath , James Iain Rodgers , Neil Whitehead
IPC分类号： G01N27/00 , G01N27/327
CPC分类号： G01N27/3272
摘要： An electrochemical-based analytical test strip for the determination of an analyte (e.g., glucose) in a bodily fluid sample (such as a whole blood sample) includes an electrically insulating base layer and a patterned conductor layer (for example, a gold patterned conductor layer) disposed over the electrically-insulating layer. The patterned conductor layer includes at least one electrode with the electrode having electrochemically inert areas and an electrochemically active area(s). Moreover, the electrochemically inert areas and electrochemically active area(s) are of a predetermined size and a predetermined distribution such that electrochemical response of the electrode during use of the electrochemical-based analytical test strip is essentially equivalent to a predetermined electrochemical response.
摘要翻译：用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）的基于电化学的分析测试条包括电绝缘基底层和图案化的导体层（例如，金图案化导体层）设置在电绝缘层上。图案化导体层包括至少一个电极，其中电极具有电化学惰性区域和电化学活性区域。此外，电化学惰性区域和电化学活性区域具有预定尺寸和预定分布，使得在使用电化学基分析测试条期间电极的电化学响应基本上等于预定的电化学响应。

8. 发明授权

US08940141B2 Analytical test strip with an electrode having electrochemically active and inert areas of a predetermined size and distribution 有权
公开(公告)号：US08940141B2
公开(公告)日：2015-01-27
申请号：US12783437
申请日：2010-05-19
申请人： Gavin Macfie , Craig Redpath , James Iain Rodgers , Neil Whitehead
发明人： Gavin Macfie , Craig Redpath , James Iain Rodgers , Neil Whitehead
IPC分类号： C12M1/00 , G01N27/26 , G01N33/487 , G01N27/327
CPC分类号： G01N27/3272
摘要： An electrochemical-based analytical test strip for the determination of an analyte (e.g., glucose) in a bodily fluid sample (such as a whole blood sample) includes an electrically insulating base layer and a patterned conductor layer (for example, a gold patterned conductor layer) disposed over the electrically-insulating layer. The patterned conductor layer includes at least one electrode with the electrode having electrochemically inert areas and an electrochemically active area(s). Moreover, the electrochemically inert areas and electrochemically active area(s) are of a predetermined size and a predetermined distribution such that electrochemical response of the electrode during use of the electrochemical-based analytical test strip is essentially equivalent to a predetermined electrochemical response.

9. 发明申请

US20110284393A1 ANALYTICAL TEST STRIP WITH AN ELECTRODE HAVING ELECTROCHEMICALLY ACTIVE AND INERT AREAS OF A PREDETERMINED SIZE AND DISTRIBUTION 有权
标题翻译：具有预计尺寸和分布的电化学活性和惰性区域的电极的分析测试条
公开(公告)号：US20110284393A1
公开(公告)日：2011-11-24
申请号：US12783437
申请日：2010-05-19
申请人： Gavin MACFIE , Craig Redpath , James Iain Rodgers , Neil Whitehead
发明人： Gavin MACFIE , Craig Redpath , James Iain Rodgers , Neil Whitehead
IPC分类号： G01N27/26 , G01N33/50
CPC分类号： G01N27/3272
摘要： An electrochemical-based analytical test strip for the determination of an analyte (e.g., glucose) in a bodily fluid sample (such as a whole blood sample) includes an electrically insulating base layer and a patterned conductor layer (for example, a gold patterned conductor layer) disposed over the electrically-insulating layer. The patterned conductor layer includes at least one electrode with the electrode having electrochemically inert areas and an electrochemically active area(s). Moreover, the electrochemically inert areas and electrochemically active area(s) are of a predetermined size and a predetermined distribution such that electrochemical response of the electrode during use of the electrochemical-based analytical test strip is essentially equivalent to a predetermined electrochemical response.
摘要翻译：用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）的基于电化学的分析测试条包括电绝缘基底层和图案化的导体层（例如，金图案化导体层）设置在电绝缘层上。图案化导体层包括至少一个电极，其中电极具有电化学惰性区域和电化学活性区域。此外，电化学惰性区域和电化学活性区域具有预定尺寸和预定分布，使得在使用电化学基分析测试条期间电极的电化学响应基本上等于预定的电化学响应。

10. 发明授权

US07351770B2 Ionic hydrophilic high molecular weight redox polymers for use in enzymatic electrochemical-based sensors 有权
标题翻译：用于酶电化学传感器的离子型亲水性高分子量氧化还原聚合物
公开(公告)号：US07351770B2
公开(公告)日：2008-04-01
申请号：US10957441
申请日：2004-09-30
申请人： Zuifang Liu , James Iain Rodgers , Geoffrey Lillie , Marco Fabio Cardosi
发明人： Zuifang Liu , James Iain Rodgers , Geoffrey Lillie , Marco Fabio Cardosi
IPC分类号： C08F271/02
CPC分类号： C12Q1/004
摘要： Ionic hydrophilic high molecular weight redox polymers for use in enzymatic electrochemical-based sensors include a hydrophilic polymer (such as a hydrophilic polymer backbone) with ionic portions (e.g., cationic monomers incorporated in the hydrophilic polymer backbone) and a plurality of attached redox mediators. The redox mediators can be, for example, covalently attached to the hydrophilic polymer in a pendant manner. An exemplary cationic hydrophilic high molecular weight redox polymer is synthesized by co-polymerization of a hydrophilic acrylamide monomer, [2-(acryloyloxy)ethyl]trimethyl ammonium chloride and vinyl ferrocene.
摘要翻译：用于酶电化学传感器的离子型亲水性高分子量氧化还原聚合物包括具有离子部分的亲水性聚合物（例如亲水性聚合物主链）（例如并入亲水性聚合物主链中的阳离子单体）和多个附着的氧化还原介体。氧化还原介体可以例如以悬挂的方式与亲水性聚合物共价连接。通过亲水丙烯酰胺单体[2-（丙烯酰氧基）乙基]三甲基氯化铵和乙烯基二茂铁的共聚合来合成示例性的阳离子亲水性高分子量氧化还原聚合物。

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