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1. 发明授权

US09314458B2 Topical use of ingenol-3-angelate or a salt thereof to treat skin cancer 有权
标题翻译：局部使用美沙芬-3-安息香酸盐或其盐治疗皮肤癌
公开(公告)号：US09314458B2
公开(公告)日：2016-04-19
申请号：US13034172
申请日：2011-02-24
申请人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
发明人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
IPC分类号： A61P35/00 , A61P17/04 , A61P31/22 , A61K31/455 , A61K31/22 , A61K36/47
CPC分类号： A61K31/455 , A61K31/22 , A61K36/47 , C07C69/533 , Y02A50/401 , Y02A50/402 , Y02A50/409 , Y02A50/414 , Y02A50/415 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , Y02A50/491 , Y02A90/26
摘要： The present invention relates generally to chemical agents useful in the treatment and prophylaxis of inflammatory conditions or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammalian animal including human and primate, non-mammalian animal and avian species. More particularly, the present invention provides a chemical agent of the macrocyclic diterpene family obtaining from a member of the Euphorbiaceae family of plants or botanical or horticultural relatives thereof or derivatives or chemical analogs or chemically synthetic forms of the agents for use in the treatment or prophylaxis of an inflammatory condition or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammal, animal or avian species. The present invention further contemplates a method for the prophylaxis or treatment of mammalian, animal or avian subjects for inflammatory conditions including chronic or transitory inflammatory conditions or for ameliorating the symptoms of an inflammatory condition by the topical or systemic administration of a macrocyclic diterpene obtainable from a member of the Euphorbiaceae family or botanical or horticultural relatives thereof or a derivative, chemical analog or chemically synthetic form of the agent. The chemical agent of the present invention may be in the form of a purified compound, mixture of compounds, a precursor form of one or more of the compounds capable of chemical transformation into a therapeutically active agent or be in the form of a chemical fraction, sub-fraction or preparation or extract of the plant.
摘要翻译：本发明一般涉及用于治疗和预防炎性病症或改善由哺乳动物（包括人类和灵长类，非哺乳动物和禽类）物种中的炎性病症引起或促进的症状的化学试剂。更具体地说，本发明提供了从大戟科植物或植物或园艺亲属的成员获得的大环二萜类家族化学试剂或衍生物或化学类似物或用于治疗或预防的药剂的化学合成形式的炎性病症或改善由哺乳动物，动物或禽类物种中的炎性病症引起或促进的症状。本发明进一步考虑了一种用于预防或治疗哺乳动物，动物或禽类受试者的炎症性疾病的方法，包括慢性或短暂性炎性病症或通过局部或全身给予大环二萜来改善炎症状态的症状，所述大环二萜可从大戟科（Euphorbiaceae）家族的成员或植物或园艺亲属或衍生物，化学类似物或化学合成形式的药剂。本发明的化学试剂可以是纯化的化合物，化合物的混合物，能够化学转化成治疗活性剂或以化学级分形式的一种或多种化合物的前体形式，子部分或植物的制备或提取物。

2. 发明授权

US07449492B2 Therapeutic agents—I 有权
标题翻译：治疗剂 - I
公开(公告)号：US07449492B2
公开(公告)日：2008-11-11
申请号：US10315288
申请日：2002-12-09
申请人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
发明人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
IPC分类号： A61K31/21
CPC分类号： A61K31/455 , A61K31/22 , A61K36/47 , C07C69/533 , Y02A50/401 , Y02A50/402 , Y02A50/409 , Y02A50/414 , Y02A50/415 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , Y02A50/491 , Y02A90/26
摘要： The present invention relates generally to chemical agents useful in the treatment and prophylaxis of infection by pathogenic or potentially pathogenic entities, or entities capable of opportunistic infection in mammals, including humans and primates, non-mammalian animals and avian species. More particularly, the present invention provides a chemical agent of the macrocyclic diterpene family obtainable from a member of the Euphorbiaceae family of plants or botanical or horticultural relatives thereof or derivatives or chemical analogues or chemically synthetic forms of the agents for use in the treatment or prophylaxis of infection by pathogenic entities in mammalian, animal and avian subjects. The present invention further contemplates a method for the prophylaxis and/or treatment in mammalian, animal or avian subjects of infection or potential infection by pathogenic entities by the topical or systemic administration of a macrocyclic diterpene obtainable from a member of the Euphorbiaceae family of plants or their botanical or horticultural derivatives or a derivative, chemical analogue or chemically synthetic form of the agent. The chemical agent of the present invention may be in the form of a purified compound, mixture of compounds, a precursor form of one or more of the compounds capable of chemical transformation into a therapeutically active agent or in the form of a chemical fraction, sub-fraction, preparation or extract of the plant.
摘要翻译：本发明一般涉及用于治疗和预防致病或潜在致病实体或能够在包括人和灵长类动物，非哺乳动物和禽类物种在内的哺乳动物中机会感染的实体的感染的化学试剂。更具体地说，本发明提供了一种可从植物或植物或园艺亲属的大戟科家族成员获得的大环二萜类化合物或用于治疗或预防的药剂的衍生物或化学类似物或化学合成形式在哺乳动物，动物和禽类受试者中感染病原体。本发明进一步考虑了一种通过局部或全身施用可从植物大戟科植物的成员获得的大环二萜在哺乳动物，动物或禽类受试者中预防和/或治疗感染或潜在感染的方法，或其植物或园艺衍生物或衍生物，化学类似物或化学合成形式的药剂。本发明的化学试剂可以是纯化合物的形式，化合物的混合物，能够化学转化成治疗活性剂或以化学级分形式的一种或多种化合物的前体形式 - 植物的分离，制备或提取。

3. 发明授权

US07838555B2 Macrocyclic diterpenes for the treatment and prophylaxis of acne vulgaris 有权
标题翻译：用于治疗和预防寻常型痤疮的大环二萜类
公开(公告)号：US07838555B2
公开(公告)日：2010-11-23
申请号：US10315318
申请日：2002-12-09
申请人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
发明人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
IPC分类号： A61K31/21
CPC分类号： A61K31/455 , A61K31/22 , A61K36/47 , C07C69/533 , Y02A50/401 , Y02A50/402 , Y02A50/409 , Y02A50/414 , Y02A50/415 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , Y02A50/491 , Y02A90/26
摘要： The present invention relates to the treatment of acne vulgaris in a subject by administering to the subject an ingenane of the formula wherein R24-R26 are herein defined.
摘要翻译：本发明涉及通过向受试者施用下式其中R 24 -R 26在本文中定义的甲氰菊酯来治疗受试者中的寻常痤疮。

4. 发明申请

US20110213002A1 MACROCYCLIC DITERPENES FOR TREATING CONDITIONS ASSOCIATED WITH PROTEIN KINASE C 有权
标题翻译：用于处理与蛋白激酶C相关的条件的大分子化合物
公开(公告)号：US20110213002A1
公开(公告)日：2011-09-01
申请号：US13034172
申请日：2011-02-24
申请人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
发明人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
IPC分类号： A61K31/465 , A61K31/22 , A61P11/06 , A61P9/00 , A61P7/00 , A61P25/28 , A61P25/24 , A61P3/10 , A61P25/00 , A61P19/00 , A61P31/12 , A61P17/06 , A61K31/122
CPC分类号： A61K31/455 , A61K31/22 , A61K36/47 , C07C69/533 , Y02A50/401 , Y02A50/402 , Y02A50/409 , Y02A50/414 , Y02A50/415 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , Y02A50/491 , Y02A90/26
摘要： The present invention relates generally to chemical agents useful in the treatment and prophylaxis of inflammatory conditions or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammalian animal including human and primate, non-mammalian animal and avian species. More particularly, the present invention provides a chemical agent of the macrocyclic diterpene family obtaining from a member of the Euphorbiaceae family of plants or botanical or horticultural relatives thereof or derivatives or chemical analogues or chemically synthetic forms of the agents for use in the treatment or prophylaxis of an inflammatory condition or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammal, animal or avian species. The present invention further contemplates a method for the prophylaxis or treatment of mammalian, animal or avian subjects for inflammatory conditions including chronic or transitory inflammatory conditions or for ameliorating the symptoms of an inflammatory condition by the topical or systemic administration of a macrocyclic diterpene obtainable from a member of the Euphorbiaceae family or botanical or horticultural relatives thereof or a derivative, chemical analogue or chemically synthetic form of the agent. The chemical agent of the present invention may be in the form of a purified compound, mixture of compounds, a precursor form of one or more of the compounds capable of chemical transformation into a therapeutically active agent or be in the form of a chemical fraction, sub-fraction or preparation or extract of the plant.
摘要翻译：本发明一般涉及用于治疗和预防炎性病症或改善由哺乳动物（包括人类和灵长类，非哺乳动物和禽类）物种中的炎性病症引起或促进的症状的化学试剂。更具体地说，本发明提供从大戟科植物或植物或园艺亲属的成员获得的大环二萜类家族化学试剂或用于治疗或预防的药剂的衍生物或化学类似物或化学合成形式的炎性病症或改善由哺乳动物，动物或禽类物种中的炎性病症引起或促进的症状。本发明进一步考虑了一种用于预防或治疗哺乳动物，动物或禽类受试者的炎症性疾病的方法，包括慢性或短暂性炎性病症或通过局部或全身给予大环二萜来改善炎症状态的症状，所述大环二萜可从大戟科的成员或植物或园艺亲属或衍生物，化学类似物或化学合成形式的药剂。本发明的化学试剂可以是纯化的化合物，化合物的混合物，能够化学转化成治疗活性剂或以化学级分形式的一种或多种化合物的前体形式，子部分或植物的制备或提取物。

5. 发明申请

US20100048698A1 MACROCYCLIC DITERPENES FOR TREATING CONDITIONS ASSOCIATED WITH PROTEIN KINASE C 审中-公开
标题翻译：用于处理与蛋白激酶C相关的条件的大分子化合物
公开(公告)号：US20100048698A1
公开(公告)日：2010-02-25
申请号：US12543087
申请日：2009-08-18
申请人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
发明人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
IPC分类号： A61K31/215 , A61P29/00
CPC分类号： A61K31/455 , A61K31/22 , A61K36/47 , C07C69/533 , Y02A50/401 , Y02A50/402 , Y02A50/409 , Y02A50/414 , Y02A50/415 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/483 , Y02A50/491 , Y02A90/26
摘要： The present invention relates generally to chemical agents useful in the treatment and prophylaxis of inflammatory conditions or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammalian animal including human and primate, non-mammalian animal and avian species. More particularly, the present invention provides a chemical agent of the macrocyclic diterpene family obtaining from a member of the Euphorbiaceae family of plants or botanical or horticultural relatives thereof or derivatives or chemical analogues or chemically synthetic forms of the agents for use in the treatment or prophylaxis of an inflammatory condition or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammal, animal or avian species. The present invention further contemplates a method for the prophylaxis or treatment of mammalian, animal or avian subjects for inflammatory conditions including chronic or transitory inflammatory conditions or for ameliorating the symptoms of an inflammatory condition by the topical or systemic administration of a macrocyclic diterpene obtainable from a member of the Fuphorbiaceae family or botanical or horticultural relatives thereof or a derivative, chemical analogue or chemically synthetic form of the agent. The chemical agent of the present invention may be in the form of a purified compound, mixture of compounds, a precursor form of one or more of the compounds capable of chemical transformation into a therapeutically active agent or be in the form of a chemical fraction, sub-fraction or preparation or extract of the plant.
摘要翻译：本发明一般涉及用于治疗和预防炎性病症或改善由哺乳动物（包括人类和灵长类，非哺乳动物和禽类）物种中的炎性病症引起或促进的症状的化学试剂。更具体地说，本发明提供从大戟科植物或植物或园艺亲属的成员获得的大环二萜类家族化学试剂或用于治疗或预防的药剂的衍生物或化学类似物或化学合成形式的炎性病症或改善由哺乳动物，动物或禽类物种中的炎性病症引起或促进的症状。本发明进一步考虑了一种用于预防或治疗哺乳动物，动物或禽类受试者的炎症性疾病的方法，包括慢性或短暂性炎性病症或通过局部或全身给予大环二萜来改善炎症状态的症状，所述大环二萜可从大戟科（Fuphorbiaceae）家族的成员或其植物或园艺亲属，或代理人的衍生，化学类似物或化学合成形式。本发明的化学试剂可以是纯化的化合物，化合物的混合物，能够化学转化成治疗活性剂或以化学级分形式的一种或多种化合物的前体形式，子部分或植物的制备或提取物。

6. 发明授权

US07378445B2 Treatment of prostate cancer 有权
标题翻译：前列腺癌的治疗
公开(公告)号：US07378445B2
公开(公告)日：2008-05-27
申请号：US11324587
申请日：2006-01-03
申请人： James Harrison Aylward , Peter Gordon Parsons
发明人： James Harrison Aylward , Peter Gordon Parsons
IPC分类号： A61K31/22 , C07C69/52
CPC分类号： A61K36/47 , A61K31/222 , A61K31/235 , A61K31/455 , A61K47/54 , A61K47/548
摘要： A chemical agent of the diterpene family obtained from a member of the Euphorbiaceae family of plants for use in the treatment of prophylaxis of prostate cancer or a related cancer or condition.
摘要翻译：从用于治疗前列腺癌或相关癌症或病症的大戟科植物家族的成员获得的二萜家族的化学试剂。

7. 发明授权

US6159957A Method of treatment or inhibition of tumors using pyridyl-substituted metal-diphosphine complexes 失效
标题翻译：使用吡啶基取代的金属 - 二膦配合物治疗或抑制肿瘤的方法
公开(公告)号：US6159957A
公开(公告)日：2000-12-12
申请号：US376643
申请日：1999-08-18
申请人： Susan Jane Berners-Price , Richard John Bowen , Peter Gordon Parsons
发明人： Susan Jane Berners-Price , Richard John Bowen , Peter Gordon Parsons
IPC分类号： A61K31/695 , A61K31/675 , A61P35/00 , C07F9/50 , C07F9/58
CPC分类号： A61K31/675 , C07F9/5059 , C07F9/5068 , C07F9/58 , Y10T428/12396 , Y10T428/12444
摘要： A method of treatment or inhibition of tumors involves administering a compound to a subject. The compound is one in which one or more of the eight phenyl substituents in the compound [M(dppe).sub.2 ].sup.+, in which M is selected from Au(I), Ag(I) and Cu(I), is substituted by 2, 3, or 4 pyridyl substituents. The compound has anti-tumor activity and an octanol/water partition coefficient between 0.01 and 25.5. The compound has selective toxicity to cancer cells, including cisplatin resistant human carcinoma cells lines.
摘要翻译：治疗或抑制肿瘤的方法包括向受试者施用化合物。化合物是其中M选自Au（I），Ag（I）和Cu（I）的化合物[M（dppe）2] +中的八个苯基取代基中的一个或多个被化合物取代为 2,3或4个吡啶基取代基。该化合物具有抗肿瘤活性，辛醇/水分配系数在0.01至25.5之间。该化合物对癌细胞具有选择性毒性，包括耐受顺铂的人类癌细胞系。

8. 发明授权

US06218378B1 Anti-tumor agents comprising pyridyl-substituted metal-diphosphine complex 失效
标题翻译：抗肿瘤剂包括吡啶基取代的金属 - 二膦配合物
公开(公告)号：US06218378B1
公开(公告)日：2001-04-17
申请号：US08860518
申请日：1997-08-22
申请人： Susan Jane Berners-Price , Richard John Bowen , Peter Gordon Parsons
发明人： Susan Jane Berners-Price , Richard John Bowen , Peter Gordon Parsons
IPC分类号： A01N5502
CPC分类号： A61K31/675 , C07F9/5059 , C07F9/5068 , C07F9/58 , Y10T428/12396 , Y10T428/12444
摘要： A method of treatment or inhibition of tumors including the steps of: (i) exchanging one or more of the eight phenyl substituents in the compound [M(dppe)2]+ where M is selected from Au(I), Ag(I) and Cu(I) by 2, 3, or 4 pyridyl substituents to provide a compound having anti-tumor activity and an octanol/water partition coefficient between 0.01 and 25.5; and (ii) administering said compound to a subject requiring treatment which compound has selective toxicity to cancer cells including cisplatin resistant human carcinoma cell lines. The invention also includes within its scope compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are the same or different and may be selected from phenyl, 4-pyridyl, 3-pyridyl, 2-pyridyl wherein each of the 4-pyridyl, 3-pyridyl and 2-pyridyl may optionally be substituted; A is selected from —(CH2)— wherein n is 2 or 3 or cis —CH═CH— or (a) where R9 represents carboxylate and in such case R1, R2, R3, R4, R5, R6, R7 and R8, may be all phenyl; M is Au(I), Ag(I) or Cu(I); X is monovalent anion such as nitrate or bromide, chloride, iodine or any other non-toxic anion; with the following provisos: (i) R1 through R8 cannot be all phenyl; (ii) when R1 through R8 is 2-pyridyl, and A is —(CH2)2—, M cannot be Au(I); or (iii) when R1 through R8 is the same and is 4-pyridyl, X is Cl and A is —(CH2)2—, M cannot be Au(I).
摘要翻译：一种治疗或抑制肿瘤的方法，包括以下步骤：（i）在化合物[M（dppe）2] +中交换一个或多个八个苯基取代基，其中M选自Au（I），Ag（I）和Cu（I）2,3或4个吡啶基取代基，以提供具有抗肿瘤活性和辛醇/水分配系数在0.01至25.5之间的化合物; 和（ii）向需要治疗的受试者施用所述化合物，所述化合物对包括顺铂耐药性人癌细胞系的癌细胞具有选择性毒性。本发明还包括其范围内的式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8相同或不同，并且可以选自苯基，4-吡啶基，3-吡啶基， - 吡啶基，其中每个4-吡啶基，3-吡啶基和2-吡啶基可任选被取代; A选自 - （CH 2） - ，其中n为2或3或顺式-CH = CH-或（a）其中R9表示羧酸盐，在这种情况下，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8，可能全部为苯基; M是Au（I），Ag（I）或Cu（I）; X是一价阴离子，如硝酸盐或溴化物，氯化物，碘或任何其他无毒阴离子; 具有以下条件：（i）R 1至R 8不能全部为苯基; （ii）当R 1至R 8为2-吡啶基且A为 - （CH 2）2 - 时，M不能为Au（I）; 或（iii）当R 1至R 8相同且为4-吡啶基时，X为Cl且A为 - （CH 2）2 - ，M不能为Au（I）。

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