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    • 2. 发明授权
    • Method to control plant pests, improve plant productivity and other purposes
    • 控制植物害虫的方法,提高植物生产力和其他目的
    • US06646000B1
    • 2003-11-11
    • US09610920
    • 2000-07-06
    • Will H. Hartfeldt
    • Will H. Hartfeldt
    • A01N5502
    • A01N61/00A01N33/22Y10S514/97Y10S514/973A01N2300/00A01N25/30A01N37/02A01N59/20
    • A method of treating plant and animal systems and inanimate surfaces for the purposes of controlling plant pests, introducing pesticides and nutrients into plants, mitigating frost damage to plants, increasing crop yields, controlling certain plant diseases, controlling arthropod, bacterial, fungal, mycoplasma, rickettsia, and viral pests of animals and humans, and disinfecting inanimate surfaces. The method utilizes the unique multi-directional dispersion property of the tannate complex of picro ammonium formate and the tannate complex of picro cupric ammonium formate, in aqueous solution, combined with a minor amount of a surfactant sufficient to prevent formation of ammonium picrate, to penetrate plant and animal systems and inanimate surfaces and travelling multidirectionally therein. The method is carried out by introducing a small but effective amount of the tannate complex to the plant or animal system or inanimate surface.
    • 一种处理植物和动物系统和无生命表面的方法,用于控制植物害虫,将农药和营养物质引入植物中,减轻对植物的霜冻损害,增加作物产量,控制某些植物病害,控制节肢动物,细菌,真菌,支原体, 立克次体和动物和人类的病毒性害虫,以及消毒无生命的表面。 该方法利用了独特的多氨基甲酸铵复合物的多向分散性质,并且在水溶液中与微量甲酸铵形成的鞣酸复合物与少量足以防止形成苦味酸铵的表面活性剂结合,渗透 植物和动物系统和无生命的表面,并在其中多向行进。 该方法通过将少量但有效量的鞣酸复合物引入植物或动物系统或无生命的表面来进行。
    • 5. 发明授权
    • Delivery of nucleic acids by porphyrins
    • 通过卟啉递送核酸
    • US06620805B1
    • 2003-09-16
    • US08616141
    • 1996-03-14
    • Garry B. TakleShaji T. George
    • Garry B. TakleShaji T. George
    • A01N5502
    • A61K47/546
    • Efficient methods and compositions are provided for the targeted delivery of effective concentrations of compounds, including nucleic acid molecules and oligonucleotides such as EGSs, ribozymes and antisense, proteins, peptides, carbohydrate, and synthetic organic and inorganic molecules, or combinations thereof, to cells, especially hepatocytes. In the preferred embodiment, the compound is an negatively charged oligonucleotide which binds in a stoichiometric ratio to a water soluble, positively charged macrocycle such as a porphyrin, which targets and protects the oligonucleotide. The porphyrin protects the compound to be delivered and delivers the compound preferentially to certain cells and tissue types. In another embodiment, the porphyrin has anti-human hepatitis virus activity, when administered alone, which is significantly enhanced when in combination with an antiviral compound, especially an oligonucleotide.
    • 提供了有效的方法和组合物,用于靶向递送有效浓度的化合物,包括核酸分子和寡核苷酸,例如EGS,核酶和反义,蛋白质,肽,碳水化合物和合成的有机和无机分子或其组合, 特别是肝细胞。 在优选实施方案中,化合物是以化学计量比与以水溶性,带正电荷的大环化合物(例如靶向和保护寡核苷酸的卟啉)结合的带负电荷的寡核苷酸。 卟啉保护待递送的化合物,并将化合物优先递送至某些细胞和组织类型。 在另一个实施方案中,当单独施用时,卟啉具有抗人肝炎病毒活性,当与抗病毒化合物,特别是寡核苷酸组合时,其显着增强。
    • 10. 发明授权
    • Liposoluble platinum (II) complex and preparation thereof
    • 脂溶性铂(II)络合物及其制备
    • US06613799B1
    • 2003-09-02
    • US06836524
    • 1986-03-05
    • Mitsuaki MaedaTakuma Sasaki
    • Mitsuaki MaedaTakuma Sasaki
    • A01N5502
    • C07F15/0093
    • New derivatives of platinum (II) complex are herein provided, which are liposoluble and applicable as antimicrobial agents and anticancer agents specific to the affected parts of patients and selectively transferred to the parts if they are used in combination with a contrast medium such as lipiodol, the derivatives being represented by the following general formula: (wherein R1 and R2 may be identical or different with each other and represent an ammine optionally substituted with an organic substituent and they may be bonded together through a bivalent organic group and R3 is a saturated or unsaturated higher fatty acid, these derivatives being prepared by nitrifying a cis-dichloro-di-(substituted or unsubstituted)-ammine platinum (II) and then reacting the resulting aqua type product with a corresponding alkali metal salt of higher fatty acid.
    • 本文提供了铂(II)络合物的新衍生物,它们是脂溶性的并且可应用于作为患者受影响部位特异的抗微生物剂和抗癌剂,并且如果它们与造影剂如碘油, 衍生物由以下通式表示:(其中R 1和R 2可以相同或不同,表示任选被有机取代基取代的氨基,并且它们可以通过二价有机基团键合在一起,并且R 3是饱和或 不饱和高级脂肪酸,这些衍生物通过硝化顺式 - 二氯 - 二 - (取代或未取代)的氨铂(II)制备,然后使所得水型产物与相应的高级脂肪酸的碱金属盐反应制备。