专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07897796B2 Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins 有权
标题翻译：使用聚乙烯亚胺键合树脂对紫杉烷类和紫杉烷类混合物进行纯化
公开(公告)号：US07897796B2
公开(公告)日：2011-03-01
申请号：US11764362
申请日：2007-06-18
申请人： James H. Johnson , T. G. Sambandam , Barry J. Hand , Christopher D. Howe , Roland R. Franke , Brian A. Bucher , John S. Juchum , Rex T. Gallagher , Marc A. Plante , Edward M. Desimone, III , Dong S. Yang
发明人： James H. Johnson , T. G. Sambandam , Barry J. Hand , Christopher D. Howe , Roland R. Franke , Brian A. Bucher , John S. Juchum , Rex T. Gallagher , Marc A. Plante , Edward M. Desimone, III , Dong S. Yang
IPC分类号： C07D305/00
CPC分类号： C07D305/14 , B01D15/3804 , B01D15/424
摘要： This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.
摘要翻译：本发明涉及一种用于从包含紫杉烷类的材料中分离和/或纯化一种或多种紫杉烷的方法。在一个实施方案中，该方法包括以下步骤：（a）用附着在固体基质上的含氨基物质如聚乙烯亚胺键合的二氧化硅色谱树脂处理含紫杉烷的材料; （b）从树脂中洗脱所需的紫杉烷化合物; 和（c）回收洗脱的紫杉烷化合物。

2. 发明申请

US20100145080A1 PURIFICATION OF TAXANES 有权
标题翻译：净化紫杉醇
公开(公告)号：US20100145080A1
公开(公告)日：2010-06-10
申请号：US12705247
申请日：2010-02-12
申请人： James H. Johnson , T.G. Sambandam , Barry J. Hand , Christopher D. Howe , Roland R. Franke , Brian A. Bucher , John S. Juchum , Rex T. Gallagher , Marc A. Plante , Edward M. Desimone, III , Dong S. Yang
发明人： James H. Johnson , T.G. Sambandam , Barry J. Hand , Christopher D. Howe , Roland R. Franke , Brian A. Bucher , John S. Juchum , Rex T. Gallagher , Marc A. Plante , Edward M. Desimone, III , Dong S. Yang
IPC分类号： C07D305/14
CPC分类号： C07D305/14 , C07B2200/13 , C07D407/12
摘要： Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.
摘要翻译：公开了一种使紫杉烷结晶的方法，其包括将紫杉烷和二氯甲烷组合以获得溶液并向溶液中加入抗溶剂以获得结晶紫杉烷，其中所述反溶剂选自己烷和庚烷。

3. 发明授权

US06956123B2 Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins 有权
标题翻译：使用聚乙烯亚胺键合树脂对紫杉烷类和紫杉烷类混合物进行纯化
公开(公告)号：US06956123B2
公开(公告)日：2005-10-18
申请号：US10664539
申请日：2003-09-18
申请人： James H. Johnson , T. G. Sambandan , Barry J. Haad , Christopher D. Howe , Roland R. Franke , Brian A. Bucher , John S. Juchum , Rex T. Gallagher , Marc A. Plant , Edward M. De Simone, III , Dong S. Yang
发明人： James H. Johnson , T. G. Sambandan , Barry J. Haad , Christopher D. Howe , Roland R. Franke , Brian A. Bucher , John S. Juchum , Rex T. Gallagher , Marc A. Plant , Edward M. De Simone, III , Dong S. Yang
IPC分类号： C07D20060101 , C07D305/14
CPC分类号： C07D305/14 , B01D15/3804 , B01D15/424
摘要： This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.
摘要翻译：本发明涉及一种用于从包含紫杉烷类的材料中分离和/或纯化一种或多种紫杉烷的方法。在一个实施方案中，该方法包括以下步骤：（a）用附着在固体基质上的含氨基物质如聚乙烯亚胺键合的二氧化硅色谱树脂处理含紫杉烷的材料; （b）从树脂中洗脱所需的紫杉烷化合物; 和（c）回收洗脱的紫杉烷化合物。

4. 发明申请

US20080051589A1 Methods And Compositions For Converting Taxane Amides To Paclitaxel Or Other Taxanes 有权
标题翻译：将紫杉烷酰胺转化为紫杉醇或其他紫杉烷的方法和组合物
公开(公告)号：US20080051589A1
公开(公告)日：2008-02-28
申请号：US10522696
申请日：2003-08-04
申请人： Dasheng Wang , Rex T. Gallagher , John S. Juchum , James H. Johnson
发明人： Dasheng Wang , Rex T. Gallagher , John S. Juchum , James H. Johnson
IPC分类号： C07D305/14
CPC分类号： C07D305/14 , C07F7/1804 , Y02P20/55
摘要： The invention relates to methods and compositions for converting taxane amides to paclitaxel or other taxanes. In one alternative embodiment, the present invention comprises; (i) selectively protecting at least one OH group of a taxane amide; (ii) contacting the taxane amide with a transition metal compound to reduce the amide; (iii) contacting the reduced amide with an agent capable of substantially removing the transition metal; (iv) contacting the reduced amide with a hydrolyzing amount of acid to form a taxane amine salt in solution; (v) adding a sufficient amount of solvent to solidify the amine salt; and (vi) converting the taxane amine salt into paclitaxel or other taxanes.
摘要翻译：本发明涉及将紫杉烷酰胺转化为紫杉醇或其他紫杉烷的方法和组合物。在一个替代实施例中，本发明包括：（i）选择性保护紫杉烷酰胺的至少一个OH基团; （ii）使紫杉烷酰胺与过渡金属化合物接触以还原酰胺; （iii）使还原酰胺与能够基本除去过渡金属的试剂接触; （iv）使还原酰胺与水解量的酸接触以在溶液中形成紫杉烷胺盐; （v）加入足够量的溶剂以固化胺盐; 和（vi）将紫杉烷胺盐转化成紫杉醇或其他紫杉烷。

5. 发明授权

US07605278B2 Methods and compositions for converting taxane amides to paclitaxel or other taxanes 有权
标题翻译：将紫杉烷酰胺转化为紫杉醇或其他紫杉烷的方法和组合物
公开(公告)号：US07605278B2
公开(公告)日：2009-10-20
申请号：US10522696
申请日：2003-08-04
申请人： Dasheng Wang , Rex T. Gallagher , John S. Juchum , James H. Johnson
发明人： Dasheng Wang , Rex T. Gallagher , John S. Juchum , James H. Johnson
IPC分类号： C07D305/14 , C07D493/00
CPC分类号： C07D305/14 , C07F7/1804 , Y02P20/55
摘要： The invention relates to methods and compositions for converting taxane amides to paclitaxel or other taxanes. In one alternative embodiment, the present invention comprises; (i) selectively protecting at least one OH group of a taxane amide; (ii) contacting the taxane amide with a transition metal compound to reduce the amide; (iii) contacting the reduced amide with an agent capable of substantially removing the transition metal; (iv) contacting the reduced amide with a hydrolyzing amount of acid to form a taxane amine salt in solution; (v) adding a sufficient amount of solvent to solidify the amine salt; and (vi) converting the taxane amine salt into paclitaxel or other taxanes.
摘要翻译：本发明涉及将紫杉烷酰胺转化为紫杉醇或其他紫杉烷的方法和组合物。在一个替代实施例中，本发明包括：（i）选择性保护紫杉烷酰胺的至少一个OH基团; （ii）使紫杉烷酰胺与过渡金属化合物接触以还原酰胺; （iii）使还原酰胺与能够基本除去过渡金属的试剂接触; （iv）使还原酰胺与水解量的酸接触以在溶液中形成紫杉烷胺盐; （v）加入足够量的溶剂以固化胺盐; 和（vi）将紫杉烷胺盐转化成紫杉醇或其他紫杉烷。

6. 发明授权

US07220872B2 Conversion of taxane molecules 有权
标题翻译：紫杉烷分子的转化
公开(公告)号：US07220872B2
公开(公告)日：2007-05-22
申请号：US10510120
申请日：2003-04-05
申请人： James H. Johnson , Rex T. Gallagher , Roland R. Franke
发明人： James H. Johnson , Rex T. Gallagher , Roland R. Franke
IPC分类号： C07D305/00 , C07D407/00 , C07D493/00
CPC分类号： C07D305/14
摘要： The invention provides methods and compositions for reductively deoxygenating an amide group at a C-3′ position of a taxane molecule followed by subsequent intra-molecular acyl migration of an acyl group to the C-3′ position.
摘要翻译：本发明提供了用于在紫杉烷分子的C-3'位置还原性脱氧酰胺基团的方法和组合物，随后将酰基分子内酰基迁移至C-3'位置。

7. 发明授权

US07176325B2 Selective acylation of secondary hydroxyl groups 有权
标题翻译：仲羟基的选择性酰化
公开(公告)号：US07176325B2
公开(公告)日：2007-02-13
申请号：US10510063
申请日：2003-04-05
申请人： James H. Johnson , Richard J. Pariza , Rex T. Gallagher
发明人： James H. Johnson , Richard J. Pariza , Rex T. Gallagher
IPC分类号： C07D305/00 , C07D407/00 , C07D493/00
CPC分类号： C07D305/14
摘要： The invention provides methods and compositions for selectively acylating a specific hydroxyl group in a molecule of interest containing at least two unprotected secondary hydroxyl groups. Although the methods and compositions of the invention have general applicability, they are particularly useful in the selective acylation of taxane molecules.
摘要翻译：本发明提供用于选择性酰化目标分子中特定羟基的方法和组合物，其含有至少两个未被保护的仲羟基。尽管本发明的方法和组合物具有一般适用性，但它们在紫杉烷分子的选择性酰化中特别有用。

8. 发明授权

US07832681B2 Dispenser for coiled materials 有权
标题翻译：盘管材料分配器
公开(公告)号：US07832681B2
公开(公告)日：2010-11-16
申请号：US12226477
申请日：2007-04-10
申请人： James H. Johnson
发明人： James H. Johnson
IPC分类号： B65H16/02
CPC分类号： H02G11/02 , B65H49/305
摘要： The dispenser for coiled materials (10, 10a) allows the installation of a coil of material (C) without unrolling the material and then rewinding it onto the dispenser A rotationally stationary base (12) has a rotating reel mounted on the base. The reel has a permanently installed flange and a removable flange (26) secured to the assembly by an axle. The removable flange (26) includes a spring to hold the removable flange securely against the coil of material (C) between the flanges (22, 26), thereby precluding significant looseness or play of a partially depleted coil. The assembly is preferably sufficiently narrow axially to permit passage between conventionally spaced sixteen-inch ′ on-center wall studs. The removable flange (26) may be removed, along with any centering guides, and a larger spool of material placed upon the permanent flange. A roll-around caddy may be used for dispensing larger and heavier coiled material.
摘要翻译：用于盘绕材料（10,10a）的分配器允许在不展开材料的情况下安装线圈（C），然后将其重新卷绕到分配器上。旋转固定基座（12）具有安装在基座上的旋转卷轴。卷轴具有永久安装的凸缘和通过轴固定到组件的可移除凸缘（26）。可移除凸缘（26）包括弹簧，以将可移除凸缘牢固地保持抵靠在凸缘（22,26）之间的材料线圈（C）上，从而排除部分耗尽的线圈的显着的松动或冲击。组件优选地轴向地足够窄，以允许在常规间隔开的十六英寸的中心壁柱之间通过。可拆卸的凸缘（26）可以与任何定心导向件一起移除，并且更大的卷轴材料放置在永久凸缘上。卷绕球罐可用于分配较大和较重的盘绕材料。

9. 发明申请

US20080275778A1 Method of Community Service and Disaster Relief 审中-公开
标题翻译：社区服务和救灾方法
公开(公告)号：US20080275778A1
公开(公告)日：2008-11-06
申请号：US11996693
申请日：2006-07-25
申请人： James H. Johnson
发明人： James H. Johnson
IPC分类号： G09F9/37 , G06Q30/00
CPC分类号： G09F19/22 , E04H1/1222 , G06Q30/0241 , G06Q99/00
摘要： The present invention relates to a method of community service including the steps of providing a site placement for a storage structure and allowing a relief organization to stage disaster relief supplies in that storage structure in anticipation of a possible disaster.
摘要翻译：本发明涉及一种社区服务的方法，包括以下步骤：提供用于存储结构的站点布置，并允许救援组织在预期可能发生的灾难的情况下，在该存储结构中进行救灾物资。

10. 再颁专利

USRE44976E1 Speed and acceleration monitoring device using visible laser beams 有权
标题翻译：使用可见激光束的速度和加速度监测装置
公开(公告)号：USRE44976E1
公开(公告)日：2014-07-01
申请号：US09667693
申请日：2000-09-22
申请人： James H. Johnson , John DiDomenico
发明人： James H. Johnson , John DiDomenico
IPC分类号： G01F3/36
CPC分类号： G01P3/68
摘要： Apparatus for obtaining the speed and acceleration of a motor vehicle in which the speed and acceleration are used in combination with exhaust emissions data obtained from the motor vehicle to analyze information about the pollutants being dispersed into the air by the motor vehicle. The apparatus includes a first radiation source producing a visible laser beam received by a first detector and a second radiation source producing a visible laser beam received by a second detector. The first and second radiation sources are arranged along the roadway with a known spacing and at a height so that the visible laser beams are interrupted by the front and rear wheels of the motor vehicle as it passes along the roadway. The detectors provide output pulses indicating whether the visible laser beams are interrupted and the time of the occurrence of each of the pulses is measured and recorded. An analyzer then calculates the speed and acceleration from the known spacing distance and the stored time measurements.
摘要翻译：用于获得使用速度和加速度的机动车辆的速度和加速度与从机动车获得的废气排放数据相结合的装置，用于分析由机动车辆分散到空气中的污染物的信息。该装置包括产生由第一检测器接收的可见激光束的第一辐射源和产生由第二检测器接收的可见激光束的第二辐射源。第一和第二辐射源沿着道路以已知的间距和高度布置，使得当机动车辆的前轮和后轮沿着道路通过时，可见的激光束被中断。检测器提供指示可见激光束是否中断的输出脉冲，并且测量和记录每个脉冲的发生时间。然后分析仪从已知间距和存储的时间测量值计算速度和加速度。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式