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1. 发明申请

US20070129418A1 Ophthalmic compositions for treating ocular hypertension 有权
公开(公告)号：US20070129418A1
公开(公告)日：2007-06-07
申请号：US11641212
申请日：2006-12-19
申请人： James Doherty , Meng-Hsin Chen , Luping Liu , Swaminathan Natarajan , Robert Tynebor
发明人： James Doherty , Meng-Hsin Chen , Luping Liu , Swaminathan Natarajan , Robert Tynebor
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07F9/65038 , C07D231/56
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

2. 发明申请

US20060154897A1 Ophthalmic compositions for treating ocular hypertension 审中-公开
公开(公告)号：US20060154897A1
公开(公告)日：2006-07-13
申请号：US10528982
申请日：2003-11-04
申请人： James Doherty , Meng-Hsin Chen , Luping Liu , Swaminathan Natarajan , Robert Tynebor
发明人： James Doherty , Meng-Hsin Chen , Luping Liu , Swaminathan Natarajan , Robert Tynebor
IPC分类号： A61K31/675 , A61K31/4439 , A61K31/416 , C07D403/02 , C07D231/56 , C07F9/6503
CPC分类号： C07D401/06 , C07D231/56
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

3. 发明申请

US20070010491A1 Ophthalmic compositions for treating ocular hypertension 有权
标题翻译：用于治疗高眼压症的眼用组合物
公开(公告)号：US20070010491A1
公开(公告)日：2007-01-11
申请号：US10569921
申请日：2004-08-31
申请人： Meng Hsin Chen , James Doherty , Luping Liu , Swaminathan Natarajan , Robert Tynebor
发明人： Meng Hsin Chen , James Doherty , Luping Liu , Swaminathan Natarajan , Robert Tynebor
IPC分类号： A61K31/4439 , A61K31/675
CPC分类号： C07D401/06 , C07F9/65038 , C07F9/65583
摘要： This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans, or a pharmaceutically acceptable salt, in vivo hydrolysable ester, enantiomer, diastereomer or mixture thereof: formula (II) represents C6-10 aryl or C3-10 heterocyclyl, said aryl or heterocyclyl optionally substituted with 1-3 groups selected from Ra; Z represents (CH2)nPO(OR)(OR*).
摘要翻译：本发明涉及式（I）的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛中眼内压升高的其它病症。本发明还涉及这些化合物对哺乳动物物种，特别是人类或其药学上可接受的盐，体内可水解的酯，对映异构体，非对映体或其混合物的眼睛的神经保护作用的用途：式（II）所述芳基或杂环基任选被1-3个选自R a，R b，R 3，R 3，R 3， Z表示（CH 2）n PO（OR）（OR *）。

4. 发明申请

US20060020000A1 Ophthalmic compositions for treating ocular hypertension 失效
公开(公告)号：US20060020000A1
公开(公告)日：2006-01-26
申请号：US10530840
申请日：2003-11-04
申请人： James Doherty , Meng-Hsin Chen , Luping Liu , Swaminathan Natarajan , Dong Ming Shen , Robert Tynebor
发明人： James Doherty , Meng-Hsin Chen , Luping Liu , Swaminathan Natarajan , Dong Ming Shen , Robert Tynebor
IPC分类号： A61K31/427 , A61K31/416 , C07D417/02 , C07D231/04
CPC分类号： C07D417/14 , C07D231/56 , C07D401/06 , C07D403/06 , C07D417/12
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

5. 发明申请

US20060148805A1 Opthalmic compositions for treating ocular hypertension 审中-公开
标题翻译：用于治疗高眼压症的眼用组合物
公开(公告)号：US20060148805A1
公开(公告)日：2006-07-06
申请号：US10561571
申请日：2004-06-25
申请人： Meng Hsin Chen , James Doherty , Luping Liu , Swaminathan Natarajan , Dong-Ming Shen , Min Shu
发明人： Meng Hsin Chen , James Doherty , Luping Liu , Swaminathan Natarajan , Dong-Ming Shen , Min Shu
IPC分类号： A61K31/522 , A61K31/503 , A61K31/498 , A61K31/4184 , C07D473/10 , C07D471/02 , C07D487/02
CPC分类号： C07D235/12 , C07D235/08 , C07D235/16 , C07D405/04 , C07D471/04
摘要： This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
摘要翻译：本发明涉及有效的钾通道阻滞剂或其制剂在治疗青光眼和导致患者眼睛中眼内压升高的其它病症中的用途。本发明还涉及这些化合物对哺乳动物物种尤其是人的眼睛的神经保护作用的用途。

6. 发明申请

US20070027188A1 Ophthalmic compositions for treating ocular hypertension 失效
标题翻译：用于治疗高眼压症的眼用组合物
公开(公告)号：US20070027188A1
公开(公告)日：2007-02-01
申请号：US10570231
申请日：2004-08-31
申请人： Meng Chen , James Doherty , Luping Liu , Swaminathan Natarajan , Robert Tynebor
发明人： Meng Chen , James Doherty , Luping Liu , Swaminathan Natarajan , Robert Tynebor
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D401/06
摘要： This invention relates to potent potassium channel blocker compounds of structural Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
摘要翻译：本发明涉及结构式I的有效钾通道阻断剂化合物或其用于治疗青光眼的其它制剂及导致患者眼睛中眼内压升高的其它病症本发明还涉及这些化合物在使用中提供对哺乳动物物种，特别是人类的眼睛的神经保护作用。

7. 发明申请

US20050256117A1 Ophthalmic compositions for treating ocular hypertension 审中-公开
公开(公告)号：US20050256117A1
公开(公告)日：2005-11-17
申请号：US10511636
申请日：2003-06-11
申请人： Meng Hsin Chen , Luping Liu , Peter Meinke , Ravi Natarajan , William Parsons , Dong-Ming Shen , Min Shu , John Stelmach , Harold Wood , Fengqi Zhang , David Wisnoski , James Doherty
发明人： Meng Hsin Chen , Luping Liu , Peter Meinke , Ravi Natarajan , William Parsons , Dong-Ming Shen , Min Shu , John Stelmach , Harold Wood , Fengqi Zhang , David Wisnoski , James Doherty
IPC分类号： A61K9/08 , A61K9/10 , A61K31/404 , A61K31/41 , A61K31/427 , A61K31/4439 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/7056 , A61K45/00 , A61K47/36 , A61P3/10 , A61P9/06 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/06 , A61P27/12 , A61P43/00 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/18 , C07D401/06 , C07D403/10 , C07D409/12 , C07D413/02 , C07D417/02 , C07D417/12 , C07D417/14 , C07H15/26 , C07D43/02
CPC分类号： C07D401/06 , C07D209/12 , C07D209/18 , C07D403/10 , C07D409/12 , C07D417/12 , C07D417/14 , C07H15/26
摘要： This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

8. 发明申请

US20070129372A1 P38 kinase inhibiting agents 失效
标题翻译： P38激酶抑制剂
公开(公告)号：US20070129372A1
公开(公告)日：2007-06-07
申请号：US11602782
申请日：2006-11-21
申请人： Meng-Hsin Chen , James Doherty , Robert Tynebor
发明人： Meng-Hsin Chen , James Doherty , Robert Tynebor
IPC分类号： A61K31/503 , C07D487/04
CPC分类号： C07D455/02 , C07D471/04
摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要翻译：由化学式（I）或其药学上可接受的盐描述的化合物是p38的抑制剂，可用于治疗炎症，例如治疗类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和其他关节炎病症; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。

9. 发明申请

US20050176723A1 (Halo-benzo carbonyl)heterobicyclic p38 kinase inhibiting agents 失效
标题翻译：（卤代 - 苯并羰基）杂双环p38激酶抑制剂
公开(公告)号：US20050176723A1
公开(公告)日：2005-08-11
申请号：US10517754
申请日：2003-06-06
申请人： James Doherty , Swaminathan Natarajan , John Stelmach
发明人： James Doherty , Swaminathan Natarajan , John Stelmach
IPC分类号： A61K31/519 , A61K31/5377 , A61P1/04 , A61P9/10 , A61P11/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P33/06 , A61P37/06 , A61P39/02 , A61P43/00 , C07D471/04 , C07D487/02 , C07D519/00
CPC分类号： C07D471/04
摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要翻译：由化学式（I）或其药学上可接受的盐描述的化合物：（I）是p38的抑制剂，可用于治疗炎症，例如治疗类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和其他关节炎病症 ; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。

10. 发明授权

US09165466B2 Method of speeding call flow 有权
标题翻译：加速呼叫流程的方法
公开(公告)号：US09165466B2
公开(公告)日：2015-10-20
申请号：US13160853
申请日：2011-06-15
申请人： Ki Hak Yi , Christopher N. Shamoun , James Doherty
发明人： Ki Hak Yi , Christopher N. Shamoun , James Doherty
IPC分类号： H04L12/66 , G08G1/0968 , H04W76/02 , H04W4/04
CPC分类号： G08G1/096811 , H04W4/046 , H04W76/15
摘要： A system and method for communicating between a vehicle and a central facility includes initiating at a vehicle a request for turn-by-turn directions; establishing a packet-switched call between the vehicle and a central facility using a wireless carrier system and a mobile dialed number (MDN) associated with the vehicle; receiving determined route information at the vehicle from the central facility via the packet-switched call; offering a vehicle occupant a service option that uses a circuit-switched call; and if the vehicle occupant accepts the service option, directing the wireless carrier system to establish the circuit-switched call using the MDN while maintaining the packet-switched call in a dormant state.
摘要翻译：用于在车辆和中央设施之间进行通信的系统和方法包括在车辆上启动对逐个方向的请求; 使用与车辆相关联的无线载波系统和移动拨号号码（MDN）在车辆和中央设施之间建立分组交换呼叫; 从中央设施经由分组交换呼叫在车辆处接收确定的路线信息; 为车辆乘客提供使用电路交换呼叫的服务选项; 并且如果车辆乘客接受服务选项，则指示无线运营商系统使用MDN建立电路交换呼叫，同时保持分组交换呼叫处于休眠状态。

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