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1. 发明申请

US20050256117A1 Ophthalmic compositions for treating ocular hypertension 审中-公开
公开(公告)号：US20050256117A1
公开(公告)日：2005-11-17
申请号：US10511636
申请日：2003-06-11
申请人： Meng Hsin Chen , Luping Liu , Peter Meinke , Ravi Natarajan , William Parsons , Dong-Ming Shen , Min Shu , John Stelmach , Harold Wood , Fengqi Zhang , David Wisnoski , James Doherty
发明人： Meng Hsin Chen , Luping Liu , Peter Meinke , Ravi Natarajan , William Parsons , Dong-Ming Shen , Min Shu , John Stelmach , Harold Wood , Fengqi Zhang , David Wisnoski , James Doherty
IPC分类号： A61K9/08 , A61K9/10 , A61K31/404 , A61K31/41 , A61K31/427 , A61K31/4439 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/7056 , A61K45/00 , A61K47/36 , A61P3/10 , A61P9/06 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/06 , A61P27/12 , A61P43/00 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/18 , C07D401/06 , C07D403/10 , C07D409/12 , C07D413/02 , C07D417/02 , C07D417/12 , C07D417/14 , C07H15/26 , C07D43/02
CPC分类号： C07D401/06 , C07D209/12 , C07D209/18 , C07D403/10 , C07D409/12 , C07D417/12 , C07D417/14 , C07H15/26
摘要： This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

2. 发明申请

US20060116366A1 Spirocyclic ureas, compositions containing such compounds and methods of use 审中-公开
标题翻译：螺环脲，含有这些化合物的组合物和使用方法
公开(公告)号：US20060116366A1
公开(公告)日：2006-06-01
申请号：US10537187
申请日：2003-11-26
申请人： Emma Parmee , Fengqi Zhang , Dong-Ming Shen , John Stelmach
发明人： Emma Parmee , Fengqi Zhang , Dong-Ming Shen , John Stelmach
IPC分类号： A61K31/551 , A61K31/519
CPC分类号： C07D403/12 , C07D235/02 , C07D239/70 , C07D471/10
摘要： The present invention relates to spirocyclic ureas, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
摘要翻译：本发明涉及螺环脲，含有这些化合物的组合物和治疗方法该化合物是胰高血糖素受体拮抗剂，因此可用于治疗，预防或延缓2型糖尿病的发作。

3. 发明申请

US20050176723A1 (Halo-benzo carbonyl)heterobicyclic p38 kinase inhibiting agents 失效
标题翻译：（卤代 - 苯并羰基）杂双环p38激酶抑制剂
公开(公告)号：US20050176723A1
公开(公告)日：2005-08-11
申请号：US10517754
申请日：2003-06-06
申请人： James Doherty , Swaminathan Natarajan , John Stelmach
发明人： James Doherty , Swaminathan Natarajan , John Stelmach
IPC分类号： A61K31/519 , A61K31/5377 , A61P1/04 , A61P9/10 , A61P11/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P33/06 , A61P37/06 , A61P39/02 , A61P43/00 , C07D471/04 , C07D487/02 , C07D519/00
CPC分类号： C07D471/04
摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要翻译：由化学式（I）或其药学上可接受的盐描述的化合物：（I）是p38的抑制剂，可用于治疗炎症，例如治疗类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和其他关节炎病症 ; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。

4. 发明申请

US20190224522A1 Lateral Tilting Treadmill Systems 审中-公开
公开(公告)号：US20190224522A1
公开(公告)日：2019-07-25
申请号：US16260967
申请日：2019-01-29
申请人： John Stelmach , Matthew Sommerfield , Brendan Haentjens
发明人： John Stelmach , Matthew Sommerfield , Brendan Haentjens
IPC分类号： A63B22/02 , A63B21/00 , A63B24/00
摘要： A lateral tilting system comprising one or more crossbeams that are each pivotably supported by a respective base member for pivotable motion about a common longitudinal axis. A drive mechanism is operably connected to a drive shaft to mechanically drive pivotable motion of the crossbeams about the axis, and resulting lateral tilt of an associated treadmill deck. A control system may be included to receive a user's input for controlling an oscillation rate or other parameter of the lateral tilting, and optionally longitudinal incline of the treadmill deck. A novel treadmill including a lateral tilting system and a lateral tilting accessory for conventional exercise equipment are provided also.

5. 发明申请

US20100089087A1 Cold Probe for Cooling Liquids 失效
标题翻译：冷却液冷探头
公开(公告)号：US20100089087A1
公开(公告)日：2010-04-15
申请号：US12250097
申请日：2008-10-13
申请人： John Stelmach
发明人： John Stelmach
IPC分类号： F25D3/00 , F25B21/02
CPC分类号： F25D15/00
摘要： A chilled probe for quickly and conveniently cooling a liquid is positioned to permit a user to insert the probe into the liquid to be cooled. Feedback, in the form of an indication of a representative liquid temperature, is also provided to increase the value of the method and apparatus. Individual sleeves are conveniently provided on a roll to keep the chilled probe from coming into direct contact with the liquid, thereby avoiding contamination between liquid samples being cooled.
摘要翻译：用于快速方便地冷却液体的冷冻探针被定位成允许使用者将探针插入待冷却的液体中。还提供了以代表性液体温度指示的形式的反馈，以增加方法和装置的价值。单独的套筒方便地设置在卷筒上，以保持冷冻的探针与液体直接接触，从而避免被冷却的液体样品之间的污染。

6. 发明申请

US20090261106A1 Apparatus for Holding Trash Can Liners in Place 审中-公开
标题翻译：用于将垃圾桶装入的设备
公开(公告)号：US20090261106A1
公开(公告)日：2009-10-22
申请号：US12107275
申请日：2008-04-22
申请人： John Stelmach
发明人： John Stelmach
IPC分类号： B65F1/06 , B65D25/14 , B65D25/20
CPC分类号： B65F1/06
摘要： A device for holding in place a flexible bag, such as a plastic garbage bag, that is attached to the outside wall of a trash can, or molded into the top portion of a trash can. The invention is a resilient one piece clamp formed of an elastomeric material. The clamp has complementary projections and indentations respectively on mating surfaces of the first and second portions of the clamp that hold the bag in place. The present invention can have two embodiments: one being a clamp attached to adhesive material that attaches to the outside wall of a trash can, the other embodiment is where the entire garbage can and clamp is of one piece construction.
摘要翻译：用于保持附接到垃圾桶的外壁的塑料垃圾袋的柔性袋（例如塑料垃圾袋）的装置，或者模制到垃圾桶的顶部。本发明是由弹性体材料形成的弹性单件夹具。夹具在夹具的第一部分和第二部分的配合表面上分别具有互补的突出和凹陷，以将袋保持在适当位置。本发明可以具有两个实施例：一个是附接到粘附材料的夹具，其附接到垃圾桶的外壁，另一个实施例是整个垃圾桶和夹具是一体式结构。

7. 发明申请

US20080085926A1 Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use 有权
标题翻译：胰高血糖素受体拮抗剂化合物，含有这些化合物的组合物和使用方法
公开(公告)号：US20080085926A1
公开(公告)日：2008-04-10
申请号：US11906374
申请日：2007-10-02
申请人： John Stelmach , Emma Parmee , James Tata , Keith Rosauer , Ronald Kim , Amy Bittner , Jiang Chang , Christopher Sinz
发明人： John Stelmach , Emma Parmee , James Tata , Keith Rosauer , Ronald Kim , Amy Bittner , Jiang Chang , Christopher Sinz
IPC分类号： A61K31/404 , A61P3/04 , A61P3/10 , A61P9/10 , C07D209/04
CPC分类号： C07D209/18
摘要： Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了胰高血糖素受体拮抗剂化合物。该化合物可用于治疗2型糖尿病及相关病症。还包括药物组合物和治疗方法。

8. 发明授权

US07353775B1 Animal accommodation station 失效
标题翻译：动物住宿站
公开(公告)号：US07353775B1
公开(公告)日：2008-04-08
申请号：US10932699
申请日：2004-09-02
申请人： John Stelmach
发明人： John Stelmach
IPC分类号： A01K5/00
CPC分类号： A01K5/0114 , A01K1/04
摘要： An animal accommodation station includes a base positionable upon a selected surface and supporting a shaft in an upright position. A canopy is carried at the upper end of the shaft. At an intermediate location, a cantilevered beam extends radially from the shaft. Food receptacles are detachably carried by the beam. A collar, rotatably coupled with the shaft intermediate the base and the beam, supports a radially extending arm having a free end to which is attached an animal leash.
摘要翻译：动物容纳站包括可在选定的表面上定位的基座，并且支撑竖直位置的轴。在轴的上端承载一个顶盖。在中间位置，悬臂梁从轴径向延伸。食物容器可以由梁可拆卸地承载。一个可转动地连接在基座和梁上的轴的轴环支撑一个具有自由端的径向延伸的臂，该自由端连接着动物皮带。

9. 发明申请

US20170197110A1 Lateral Tilting Treadmill Systems 审中-公开
公开(公告)号：US20170197110A1
公开(公告)日：2017-07-13
申请号：US15405003
申请日：2017-01-12
申请人： John Stelmach , Matthew Sommerfield , Brendan Haentjens
发明人： John Stelmach , Matthew Sommerfield , Brendan Haentjens
IPC分类号： A63B22/02 , A63B21/00 , A63B24/00
CPC分类号： A63B22/0235 , A63B21/4035 , A63B22/0015 , A63B22/0023 , A63B22/025 , A63B22/04 , A63B22/0605 , A63B22/0664 , A63B22/16 , A63B24/0087 , A63B69/0057 , A63B2225/09
摘要： A lateral tilting system comprising one or more crossbeams that are each pivotably supported by a respective base member for pivotable motion about a common longitudinal axis. A drive mechanism is operably connected to a drive shaft to mechanically drive pivotable motion of the crossbeams about the axis, and resulting lateral tilt of an associated treadmill deck. A control system may be included to receive a user's input for controlling an oscillation rate or other parameter of the lateral tilting, and optionally longitudinal incline of the treadmill deck. A novel treadmill including a lateral tilting system and a lateral tilting accessory for conventional exercise equipment are provided also.

10. 发明授权

US08114038B2 Oral hygiene apparatus 失效
标题翻译：口腔卫生仪器
公开(公告)号：US08114038B2
公开(公告)日：2012-02-14
申请号：US12103279
申请日：2008-04-15
申请人： John Stelmach
发明人： John Stelmach
IPC分类号： A61H13/00
CPC分类号： A61H13/005 , A61C17/0214
摘要： A method and apparatus for oral hygiene, in particular having an oral hygiene device similar to a WATER PIK® brand device which has a pump with an inlet port and an outlet nozzle. A reservoir is placed in a sink above a drain and below a faucet and water from the faucet is adjusted for temperature and flows into the reservoir and over and into the drain of the sink. A conduit is provided between the inlet of the pump and the outlet of the reservoir so that, in use, a person can first adjust the temperature of the water in the reservoir and then turn on the pump and use the oral hygiene device as with any other oral hygiene apparatus while either allowing the water to continue to flow from the faucet at the desired temperature; or, if desired, to stop the flow and put medication into the container before use so that the water and medication solution is used rather than just water.
摘要翻译：一种用于口腔卫生的方法和装置，特别是具有类似于具有入口和出口喷嘴的泵的WATER PIK品牌装置的口腔卫生装置。将水箱放置在排水沟上方的水槽中并在水龙头下方，并且从水龙头的水被调节温度并流入储存器中并且进入水槽的排水沟。在泵的入口和储存器的出口之间设置导管，使得在使用中，人可以首先调节储存器中的水的温度，然后打开泵并使用口腔卫生装置，如同任何同时允许水在所需温度下继续从水龙头流出; 或者如果需要，在使用之前停止流动并将药物放入容器中，以使用水和药物溶液而不仅仅是水。

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