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1. 发明授权

US06659934B1 Automated system for the radiation treatment of a desired area within the body of a patient 有权
标题翻译：用于辐射治疗患者体内所需区域的自动化系统
公开(公告)号：US06659934B1
公开(公告)日：2003-12-09
申请号：US09469510
申请日：1999-12-22
申请人： James D. Hughett , Robert Michael Webster , Douglas Layland Armstrong , Byron Lee Boylston , Gregg T. Juett , Richard A. Hillstead , Jack C. Griffis, III , Andrew L. Lerohl , Mark Dehdashtian , Marvin A. Guiles
发明人： James D. Hughett , Robert Michael Webster , Douglas Layland Armstrong , Byron Lee Boylston , Gregg T. Juett , Richard A. Hillstead , Jack C. Griffis, III , Andrew L. Lerohl , Mark Dehdashtian , Marvin A. Guiles
IPC分类号： A61N500
CPC分类号： A61N5/1007 , A61N2005/1008
摘要： A transfer device usable in a system for intraluminal treatment of a selected site in a body of a patient in which the transfer device comprises an integral pump for pressurizing and circulating fluid through a fluid path defined by the transfer device and associated catheter. A removable fluid cartridge is provided including a reservoir from which fluid is drawn by the pump and into which fluid is returned after being circulated through the fluid path. The pump may be a peristaltic pump and the fluid cartridge may include an elongated fluid pick-up having an inlet through which fluid is introduced into the transfer device. The fluid pick-up is sized in length so that the inlet is always submerged in the fluid regardless of the orientation of the transfer device.
摘要翻译：一种可用于管腔内治疗患者体内的选定部位的系统中的转移装置，其中所述转运装置包括用于通过由所述输送装置和相关导管限定的流体路径加压和循环流体的整体泵。提供了可拆卸的流体盒，其包括储存器，流体由泵从该容器中被抽出，并且在通过流体路径循环之后流体返回到储存器中。泵可以是蠕动泵，并且流体盒可以包括具有入口的细长流体拾取器，流体通过入口引入到输送装置中。流体拾取器的长度尺寸使得入口总是浸没在流体中，而与传送装置的取向无关。

2. 发明授权

US07311656B2 Automated system for the radiation treatment of a desired area within the body of a patient 有权
标题翻译：用于辐射治疗患者体内所需区域的自动化系统
公开(公告)号：US07311656B2
公开(公告)日：2007-12-25
申请号：US10694289
申请日：2003-10-27
申请人： James D. Hughett , Robert Michael Webster , Douglas Layland Armstrong , Byron Lee Boylston , Gregg T. Juett , Richard A. Hillstead , Jack C. Griffis, III , Andrew L. Lerohl , Mark Dehdashtian , Marvin A. Guiles
发明人： James D. Hughett , Robert Michael Webster , Douglas Layland Armstrong , Byron Lee Boylston , Gregg T. Juett , Richard A. Hillstead , Jack C. Griffis, III , Andrew L. Lerohl , Mark Dehdashtian , Marvin A. Guiles
IPC分类号： A61N5/00
CPC分类号： A61N5/1007 , A61N2005/1008
摘要： A transfer device usable in a system for intraluminal treatment of a selected site in a body of a patient in which the transfer device comprises an integral pump for pressurizing and circulating fluid through a fluid path defined by the transfer device and associated catheter. A removable fluid cartridge is provided including a reservoir from which fluid is drawn by the pump and into which fluid is returned after being circulated through the fluid path. The pump may be a peristaltic pump and the fluid cartridge may include an elongated fluid pick-up having an inlet through which fluid is introduced into the transfer device. The fluid pick-up is sized in length so that the inlet is always submerged in the fluid regardless of the orientation of the transfer device. A removable treatment cartridge having a lumen forming part of the fluid path may also be provided, and a storage sleeve for the treatment cartridge may be of a radiation-blocking material, such as quartz. Further, the treatment cartridge may have a memory for storing and indicating selected information about the treating element.
摘要翻译：一种可用于管腔内治疗患者体内的选定部位的系统中的转移装置，其中所述转运装置包括用于通过由所述输送装置和相关导管限定的流体路径加压和循环流体的整体泵。提供了可拆卸的流体盒，其包括储存器，流体由泵从该容器中被抽出，并且在通过流体路径循环之后流体返回到储存器中。泵可以是蠕动泵，并且流体盒可以包括具有入口的细长流体拾取器，流体通过入口引入到输送装置中。流体拾取器的长度尺寸使得入口总是浸没在流体中，而与传送装置的取向无关。还可以设置具有形成流体路径的一部分的内腔的可移除处理盒，并且用于处理盒的存储套筒可以是诸如石英的辐射阻挡材料。此外，治疗盒可以具有用于存储和指示关于治疗元件的选定信息的存储器。

3. 发明授权

US07066873B2 Automated system for the radiation treatment of a desired area within the body of a patient 失效
标题翻译：用于辐射治疗患者体内所需区域的自动化系统
公开(公告)号：US07066873B2
公开(公告)日：2006-06-27
申请号：US10694097
申请日：2003-10-27
申请人： James D. Hughett , Robert Michael Webster , Douglas Layland Armstrong , Byron Lee Boylston , Gregg T. Juett , Richard A. Hillstead , Jack C. Griffis, III , Andrew L. Lerohl , Mark Dehdashtian , Marvin A. Guiles
发明人： James D. Hughett , Robert Michael Webster , Douglas Layland Armstrong , Byron Lee Boylston , Gregg T. Juett , Richard A. Hillstead , Jack C. Griffis, III , Andrew L. Lerohl , Mark Dehdashtian , Marvin A. Guiles
IPC分类号： A61M3/00 , A61N5/00
CPC分类号： A61N5/1007 , A61N2005/1008
摘要： A transfer device usable in a system for intraluminal treatment of a selected site in a body of a patient in which the transfer device comprises an integral pump for pressurizing and circulating fluid through a fluid path defined by the transfer device and associated catheter. A removable fluid cartridge is provided including a reservoir from which fluid is drawn by the pump and into which fluid is returned after being circulated through the fluid path. The pump may be a peristaltic pump and the fluid cartridge may include an elongated fluid pick-up having an inlet through which fluid is introduced into the transfer device. The fluid pick-up is sized in length so that the inlet is always submerged in the fluid regardless of the orientation of the transfer device. A removable treatment cartridge having a lumen forming part of the fluid path may also be provided, and a storage sleeve for the treatment cartridge may be of a radiation-blocking material, such as quartz. Further, the treatment cartridge may have a memory for storing and indicating selected information about the treating element.
摘要翻译：一种可用于管腔内治疗患者体内的选定部位的系统中的转移装置，其中所述转运装置包括用于通过由所述输送装置和相关导管限定的流体路径加压和循环流体的整体泵。提供了可拆卸的流体盒，其包括储存器，流体由泵从该容器中被抽出，并且在通过流体路径循环之后流体返回到储存器中。泵可以是蠕动泵，并且流体盒可以包括具有入口的细长流体拾取器，流体通过入口引入到输送装置中。流体拾取器的长度尺寸使得入口总是浸没在流体中，而与传送装置的取向无关。还可以设置具有形成流体路径的一部分的内腔的可移除处理盒，并且用于处理盒的存储套筒可以是诸如石英的辐射阻挡材料。此外，治疗盒可以具有用于存储和指示关于治疗元件的选定信息的存储器。

4. 发明申请

US20110196186A1 METHODS AND APPARATUS EMPLOYING IONIZING RADIATION FOR TREATMENT OF CARDIAC ARRHYTHMIA 审中-公开
标题翻译：使用离子辐射治疗心脏病的方法和装置
公开(公告)号：US20110196186A1
公开(公告)日：2011-08-11
申请号：US13090782
申请日：2011-04-20
申请人： RAOUL BONAN , Charles E. Larsen , Roelof Trip , Douglas B. Schumer , Jack C. Griffis, III , Andrew L. Lerohl
发明人： RAOUL BONAN , Charles E. Larsen , Roelof Trip , Douglas B. Schumer , Jack C. Griffis, III , Andrew L. Lerohl
IPC分类号： A61N5/00
CPC分类号： A61N5/1002 , A61B2017/003 , A61B2018/00363 , A61B2018/00559 , A61B2018/00577 , A61M25/0147 , A61M2025/0034 , A61M2025/004
摘要： Method and apparatus are disclosed employing ionizing radiation. for forming lines of ablation or lesions in cardiac tissue to treat atrial fibrillation or other electrophysiological problems with the heart. The apparatus may include a catheter in which the radiation source is advanced hydraulically after the catheter is in place within the heart. Various fixation devices are also disclosed for fixing the location of the catheter within the heart.
摘要翻译：公开了使用电离辐射的方法和装置。用于在心脏组织中形成消融线或病变线以治疗心房颤动或其他心脏电生理问题。该装置可以包括导管，其中在导管在心脏内部就位之后，辐射源以液压方式前进。还公开了各种固定装置，用于将导管的位置固定在心脏内。

5. 发明授权

US07182725B2 Methods and apparatus employing ionizing radiation for treatment of cardiac arrhythmia 有权
公开(公告)号：US07182725B2
公开(公告)日：2007-02-27
申请号：US10252731
申请日：2002-09-23
申请人： Raoul Bonan , Charles E. Larsen , Roelof Trip , Douglas B. Schumer , Jack C. Griffis, III , Andrew L. Lerohl
发明人： Raoul Bonan , Charles E. Larsen , Roelof Trip , Douglas B. Schumer , Jack C. Griffis, III , Andrew L. Lerohl
IPC分类号： A61N5/00
CPC分类号： A61N5/1002 , A61B2017/003 , A61B2018/00363 , A61B2018/00559 , A61B2018/00577 , A61M25/0147 , A61M2025/0034 , A61M2025/004
摘要： Method and apparatus are disclosed employing ionizing radiation for forming lines of ablation or lesions in cardiac tissue to treat atrial fibrillation or other electrophysiological problems with the heart. The apparatus may include a catheter in which the radiation source is advanced hydraulically after the catheter is in place within the heart. Various fixation devices are also disclosed for fixing the location of the catheter within the heart.

6. 发明授权

US08012078B2 Methods and apparatus employing ionizing radiation for treatment of cardiac arrhythmia 有权
标题翻译：使用电离辐射治疗心律失常的方法和装置
公开(公告)号：US08012078B2
公开(公告)日：2011-09-06
申请号：US11709652
申请日：2007-02-22
申请人： Raoul Bonan , Charles E. Larsen , Roelof Trip , Douglas B. Schumer , Jack C. Griffis, III , Andrew L. Lerohl
发明人： Raoul Bonan , Charles E. Larsen , Roelof Trip , Douglas B. Schumer , Jack C. Griffis, III , Andrew L. Lerohl
IPC分类号： A61N5/00
CPC分类号： A61N5/1002 , A61B2017/003 , A61B2018/00363 , A61B2018/00559 , A61B2018/00577 , A61M25/0147 , A61M2025/0034 , A61M2025/004
摘要： Method and apparatus are disclosed employing ionizing radiation for forming lines of ablation or lesions in cardiac tissue to treat atrial fibrillation or other electrophysiological problems with the heart. The apparatus may include a catheter in which the radiation source is advanced hydraulically after the catheter is in place within the heart. Various fixation devices are also disclosed for fixing the location of the catheter within the heart.
摘要翻译：公开了使用电离辐射在心脏组织中形成消融线或病变线的方法和装置，以治疗心脏颤动或其他心脏电生理问题。该装置可以包括导管，其中在导管在心脏内部就位之后，辐射源以液压方式前进。还公开了各种固定装置，用于将导管的位置固定在心脏内。

7. 外观设计

USD681811S1 Suture anchor device 有权
公开(公告)号：USD681811S1
公开(公告)日：2013-05-07
申请号：US29403322
申请日：2011-10-04
申请人： Jack C. Griffis, III , Kenneth A. Gall , Christopher M. Yakacki
设计人： Jack C. Griffis, III , Kenneth A. Gall , Christopher M. Yakacki

8. 发明授权

US08152755B1 System and method for delivering a therapeutic agent with finesse 有权
标题翻译：用于递送治疗剂的系统和方法
公开(公告)号：US08152755B1
公开(公告)日：2012-04-10
申请号：US12731019
申请日：2010-03-24
申请人： Michael L. Wach , W. Robert Taylor , Jack C. Griffis, III , Raymond P. Vito
发明人： Michael L. Wach , W. Robert Taylor , Jack C. Griffis, III , Raymond P. Vito
IPC分类号： A61M37/00 , A61M31/00
CPC分类号： A61M25/00 , A61M5/178 , A61M25/0026 , A61M25/007 , A61M2206/20
摘要： A catheter for delivering a therapeutic agent to a target site of a human or animal subject can include a substantially flexible and biocompatible catheter body having a proximal end and a distal end. An eductor can be located at the distal end of the catheter body, and a first lumen within the catheter body for housing the therapeutic agent can be in fluid communication with the eductor. A second lumen, also in fluid communication with the first lumen, can extend from the proximal end of the catheter body towards the eductor and can have an output port at the distal end of the catheter body. The eductor can be operable to induce the therapeutic agent to flow from the first lumen out of the output port in response to fluid flowing through the second lumen.
摘要翻译：用于将治疗剂递送到人或动物受试者的靶位点的导管可以包括具有近端和远端的基本上柔性且生物相容的导管主体。喷射器可以位于导管主体的远端，并且用于容纳治疗剂的导管主体内的第一腔可以与喷射器流体连通。也与第一腔流体连通的第二腔可以从导管主体的近端延伸到喷射器，并且可以在导管主体的远端具有输出端口。喷射器可操作以响应于流体流过第二腔而致使治疗剂从第一腔流出输出端口。

9. 发明申请

US20110077735A1 SCLERAL PROSTHESIS FOR TREATING PRESBYOPIA AND OTHER EYE DISORDERS AND RELATED DEVICES AND METHODS 有权
标题翻译：治疗前列腺炎和其他眼病的SCLERAL PROSTHESIS及相关设备和方法
公开(公告)号：US20110077735A1
公开(公告)日：2011-03-31
申请号：US12960917
申请日：2010-12-06
申请人： Jack C. Griffis, III
发明人： Jack C. Griffis, III
IPC分类号： A61F2/16
CPC分类号： A61F2/147 , A61F2/148 , A61F2210/0023
摘要： One example scleral prosthesis includes a first free end and a second free end, each wider than a middle portion of the scleral prosthesis. Multiple first portions form the first end of the scleral prosthesis. The first portions are separated along at least half of a length of the scleral prosthesis. Multiple second portions may form the second end of the scleral prosthesis, and the second portions may be separated along less than a quarter of the length of the scleral prosthesis. An implantation device can be used to facilitate implantation of a scleral prosthesis. The implantation device includes a first end portion configured to be inserted into a scleral tunnel of an eye. The implantation device also includes a second end portion configured to receive the scleral prosthesis. A rod with a tapered and rounded end can be partially inserted into the first end portion of the implantation device.
摘要翻译：一个例子是巩膜假体包括第一自由端和第二自由端，每个宽度大于巩膜假体的中间部分。多个第一部分形成巩膜假体的第一端。第一部分沿巩膜假体长度的至少一半分开。多个第二部分可以形成巩膜假体的第二端，并且第二部分可以沿着巩膜假体的长度的小于四分之一分开。可以使用植入装置来促进巩膜假体的植入。植入装置包括构造成插入到眼睛的巩膜隧道中的第一端部。植入装置还包括构造成接收巩膜假体的第二端部。具有锥形和圆形端的杆可以部分地插入植入装置的第一端部。

10. 发明申请

US20110054436A1 Method and system for maintaining aseptic conditions in the storage of biologics 审中-公开
标题翻译：维持生物制品储存无菌条件的方法和系统
公开(公告)号：US20110054436A1
公开(公告)日：2011-03-03
申请号：US12806541
申请日：2010-08-16
申请人： Jack C. Griffis, III , Minh Vo
发明人： Jack C. Griffis, III , Minh Vo
IPC分类号： A61J1/22
CPC分类号： A61J1/2096 , A61J1/2037 , A61J9/00
摘要： Technologies are generally described for the storage of biologics and other fluid materials while maintaining aseptic conditions. A system may include a storage body providing a reservoir for containing the materials. A cap may couple to the storage body forming a fluid-tight seal. A port may be provided for transferring the materials. A seal, or valve, may be provided within the port. The seal may be configured to close off the reservoir unless acted upon to release the materials through the port. A movable member may make up part of the storage body. The movable member may be configured to change a reservoir volume of the storage body in response to changes in a volume of the materials. The reservoir may become smaller as the materials are released. Multi-dose volumes of fluid materials may be stored for repeated access with reduced risk of contamination and reduction in shelf life.
摘要翻译：技术通常被描述为用于储存生物制剂和其它流体材料，同时保持无菌条件。系统可以包括提供用于容纳材料的储存器的存储体。盖可以连接到存储体，形成流体密封。可以提供用于传送材料的端口。密封件或阀门可以在端口内提供。密封件可以被配置为关闭储存器，除非作用于通过端口释放材料。可移动部件可以构成存储体的一部分。可移动构件可以被配置为响应于材料体积的变化而改变存储体的储存器容积。当材料被释放时，储存器可能变小。多剂量的流体材料可以被存储以用于重复进入，降低污染的风险和降低保质期。

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