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    • 1. 发明申请
    • Method and system for maintaining aseptic conditions in the storage of biologics
    • 维持生物制品储存无菌条件的方法和系统
    • US20110054436A1
    • 2011-03-03
    • US12806541
    • 2010-08-16
    • Jack C. Griffis, IIIMinh Vo
    • Jack C. Griffis, IIIMinh Vo
    • A61J1/22
    • A61J1/2096A61J1/2037A61J9/00
    • Technologies are generally described for the storage of biologics and other fluid materials while maintaining aseptic conditions. A system may include a storage body providing a reservoir for containing the materials. A cap may couple to the storage body forming a fluid-tight seal. A port may be provided for transferring the materials. A seal, or valve, may be provided within the port. The seal may be configured to close off the reservoir unless acted upon to release the materials through the port. A movable member may make up part of the storage body. The movable member may be configured to change a reservoir volume of the storage body in response to changes in a volume of the materials. The reservoir may become smaller as the materials are released. Multi-dose volumes of fluid materials may be stored for repeated access with reduced risk of contamination and reduction in shelf life.
    • 技术通常被描述为用于储存生物制剂和其它流体材料,同时保持无菌条件。 系统可以包括提供用于容纳材料的储存器的存储体。 盖可以连接到存储体,形成流体密封。 可以提供用于传送材料的端口。 密封件或阀门可以在端口内提供。 密封件可以被配置为关闭储存器,除非作用于通过端口释放材料。 可移动部件可以构成存储体的一部分。 可移动构件可以被配置为响应于材料体积的变化而改变存储体的储存器容积。 当材料被释放时,储存器可能变小。 多剂量的流体材料可以被存储以用于重复进入,降低污染的风险和降低保质期。
    • 3. 发明申请
    • Catheter for treatment of total occlusions and methods for manufacture and use of the catheter
    • 用于治疗全部闭塞的导管以及制造和使用导管的方法
    • US20060264821A1
    • 2006-11-23
    • US11291758
    • 2005-12-01
    • Minh VoCory Anderson
    • Minh VoCory Anderson
    • A61M31/00
    • A61M25/0015A61M25/0009A61M25/0043A61M2025/1052
    • A catheter for treatment of chronic total occlusions includes an occlusion breach device, a catheter body made of a temperature-dependent softening, shape-memory, thermoplastic polymer having a first flexible state and a second stiff state. The catheter body has a heat transfer conduit and a conduit for slidably receiving the breach device. A heat-transferring device selectively changes a temperature of the heat transfer conduit to, thereby, change stiffness of the catheter body between the two states. To treat a CTO with the catheter, it is warmed above the glass-transition temperature and below the melting-temperature to make the catheter flexible. The catheter has a shape when inserted at the occlusion site and is cooled to, thereby, stiffen. Breaching of the occlusion is assisted with the stiff catheter. The catheter is removed by warming the polymer. Also provided is a method for manufacturing such a selectively stiffening catheter.
    • 用于治疗慢性完全闭塞的导管包括闭塞突破装置,由温度依赖性软化形状记忆体形成的导管体,具有第一柔性状态和第二僵硬状态的热塑性聚合物。 导管主体具有传热导管和用于可滑动地接收突破装置的导管。 传热装置选择性地改变传热管道的温度,从而改变导管体在两种状态之间的刚度。 为了用导管治疗CTO,将其温度高于玻璃化转变温度并低于熔融温度,以使导管变得柔软。 导管在插入位置时具有形状并被冷却,从而变硬。 使用刚性导管辅助阻塞闭塞。 通过加热聚合物去除导管。 还提供了制造这种选择性加强导管的方法。
    • 4. 发明授权
    • Catheter for treatment of total occlusions and methods for manufacture and use of the catheter
    • 用于治疗全部闭塞的导管以及制造和使用导管的方法
    • US07399291B2
    • 2008-07-15
    • US11291758
    • 2005-12-01
    • Minh VoCory Anderson
    • Minh VoCory Anderson
    • A61F7/12A61F7/00A61M29/00
    • A61M25/0015A61M25/0009A61M25/0043A61M2025/1052
    • A catheter for treatment of chronic total occlusions includes an occlusion breach device, a catheter body made of a temperature-dependent softening, shape-memory, thermoplastic polymer having a first flexible state and a second stiff state. The catheter body has a heat transfer conduit and a conduit for slidably receiving the breach device. A heat-transferring device selectively changes a temperature of the heat transfer conduit to, thereby, change stiffness of the catheter body between the two states. To treat a CTO with the catheter, it is warmed above the glass-transition temperature and below the melting-temperature to make the catheter flexible. The catheter has a shape when inserted at the occlusion site and is cooled to, thereby, stiffen. Breaching of the occlusion is assisted with the stiff catheter. The catheter is removed by warming the polymer. Also provided is a method for manufacturing such a selectively stiffening catheter.
    • 用于治疗慢性完全闭塞的导管包括闭塞突破装置,由温度依赖性软化形状记忆体形成的导管体,具有第一柔性状态和第二僵硬状态的热塑性聚合物。 导管主体具有传热导管和用于可滑动地接收突破装置的导管。 传热装置选择性地改变传热管道的温度,从而改变导管体在两种状态之间的刚度。 为了用导管治疗CTO,将其温度高于玻璃化转变温度并低于熔融温度,以使导管变得柔软。 导管在插入位置时具有形状并被冷却,从而变硬。 使用刚性导管辅助阻塞闭塞。 通过加热聚合物去除导管。 还提供了制造这种选择性加强导管的方法。