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1. 发明申请

US20060198866A1 Thermoplastic fluoropolymer-coated medical devices 有权
标题翻译：热塑性含氟聚合物涂层医疗器械
公开(公告)号：US20060198866A1
公开(公告)日：2006-09-07
申请号：US11378401
申请日：2006-03-16
申请人： James Chang , Robert Cleek , Edward Cully , Michael Vonesh
发明人： James Chang , Robert Cleek , Edward Cully , Michael Vonesh
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61L27/34 , C08L101/04
摘要： A medical device provided with at least a partial surface coating of a thermoplastic copolymer of tetrafluoroethylene and perfluoroalkylvinylether that is free of cross-linking monomers and curing agents. The fluoropolymer coating is preferably an amorphous thermoplastic, is highly inert and biocompatible, has elastomeric characteristics that provide desirable mechanical properties such as good flexibility and durability. These characteristics allow the coating to be considered “functionally transparent” because it withstands mechanical deformations required for the assembly, deployment, expansion, and placement of medical devices, without any adverse effect on the mechanical and biological functionality of the coated device. Further, its inertness, derived from the perfluorocarbon structure, contributes to its functionally transparent nature. The coating can be provided with various liquid or solid additives, can be loaded with large quantities of additives including a wide range of therapeutic agents, and has excellent drug elution characteristics when elutable additives are used. The desirable mechanical characteristics are surprising given the absence of cross-linking monomers and curing agents that would otherwise render such materials inadequately biocompatible. The perfluoroalkylvinylether may be perfluoromethylvinylether, perfluoroethylvinylether or perfluoropropylvinylether.
摘要翻译：一种医疗装置，其具有不含交联单体和固化剂的四氟乙烯和全氟烷基乙烯基醚的热塑性共聚物的至少部分表面涂层。含氟聚合物涂层优选为无定形热塑性塑料，具有高度惰性和生物相容性，具有提供所需机械性能（例如良好的柔韧性和耐久性）的弹性体特性。这些特性使得涂层被认为是“功能上透明的”，因为它可以承受医疗装置的组装，展开，膨胀和放置所需的机械变形，而不会对涂覆装置的机械和生物功能产生任何不利影响。此外，其衍生自全氟化碳结构的惰性有助于其功能上的透明性。该涂层可以提供各种液体或固体添加剂，可以加载大量的添加剂，包括广泛的治疗剂，并且当使用可洗脱添加剂时具有优异的药物洗脱特性。鉴于不存在交联单体和固化剂，否则将使得这些材料生物相容性不足，理想的机械特性令人惊奇。全氟烷基乙烯基醚可以是全氟甲基乙烯基醚，全氟乙基乙烯基醚或全氟丙基乙烯基醚。

2. 发明申请

US20060025852A1 Bioabsorbable self-expanding endolumenal devices 审中-公开
标题翻译：生物可吸收的自扩张腔内装置
公开(公告)号：US20060025852A1
公开(公告)日：2006-02-02
申请号：US10910502
申请日：2004-08-02
申请人： Joseph Armstrong , Paul Begovac , Robert Cleek , Edward Cully , Charles Flynn , Byron Hayes , Ryan Peterson , Michael Vonesh , Charles White
发明人： Joseph Armstrong , Paul Begovac , Robert Cleek , Edward Cully , Charles Flynn , Byron Hayes , Ryan Peterson , Michael Vonesh , Charles White
IPC分类号： A61F2/06
CPC分类号： A61F2/01 , A61B17/12022 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/91 , A61F2/915 , A61F2002/016 , A61F2002/018 , A61F2002/30062 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2210/0004 , A61F2210/0076 , A61F2220/0016 , A61F2230/005 , A61F2230/0054 , A61F2230/0069 , A61F2230/008 , A61F2250/003 , A61L31/06 , A61L31/148 , C08L67/04
摘要： The present invention is directed to bioabsorbable self-expanding medical devices for use inside or outside body conduits that self-expand at, or below, normal human body temperature without requisite for a polymeric thermal transition
摘要翻译：本发明涉及用于在正常人体温度下或在正常人体温度下自身膨胀而在聚合物热转变条件下自身膨胀的身体管道内部或外部的生物可吸收自扩张医疗装置

3. 发明申请

US20050175709A1 Therapeutic microparticles 审中-公开
标题翻译：治疗性微粒
公开(公告)号：US20050175709A1
公开(公告)日：2005-08-11
申请号：US11008820
申请日：2004-12-09
申请人： Ace Baty , Robert Cleek , Daniel Davidson , Melissa Matzen , Michael Vonesh , Joshua Williams
发明人： Ace Baty , Robert Cleek , Daniel Davidson , Melissa Matzen , Michael Vonesh , Joshua Williams
IPC分类号： A61B17/12 , A61B17/42 , A61F2/02 , A61K9/14 , A61K47/48 , A61L24/00 , A61L24/04
CPC分类号： A61L24/0042 , A61B17/12022 , A61B17/12109 , A61B17/12186 , A61B2017/1205 , A61B2017/4216 , A61L24/001 , A61L24/046 , A61L2430/36 , C08L69/00
摘要： Biodegradable, compression resistant microparticles adapted for injection through a catheter system, such as is useful for selective embolization procedures. The microparticles can optimally be neutrally buoyant relative to a target bodily fluid. Various active agents may be included in the microparticles, such an anesthetic which can reduce pain during an embolization procedure. The invention further comprises methods and equipment for testing and delivering compression resistant microparticles.
摘要翻译：适于通过导管系统注射的可生物降解，抗压缩的微粒，例如可用于选择性栓塞程序。微粒可以相对于目标体液最佳地为中性浮力。可以在微粒中包括各种活性剂，这种麻醉剂可以在栓塞过程中减轻疼痛。本发明还包括用于测试和递送抗压缩微粒的方法和设备。

4. 发明申请

US20070264302A1 Immobilized biologically active entities having high biological activity following mechanical manipulation 有权
标题翻译：机械操作后具有高生物活性的固定生物活性物质
公开(公告)号：US20070264302A1
公开(公告)日：2007-11-15
申请号：US11433250
申请日：2006-05-12
申请人： Robert Cleek , Michael Daly , Krzysztof Pietrzak
发明人： Robert Cleek , Michael Daly , Krzysztof Pietrzak
IPC分类号： A61F2/02 , A61K31/727
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/222 , A61L2300/236 , A61L2300/252 , A61L2300/416 , Y10T428/31544 , C08L79/02
摘要： The present invention is directed to immobilized biologically active entities that retain significant biological activity following mechanical manipulation of a substrate material to which the entities are immobilized.
摘要翻译：本发明涉及固定化的生物活性物质，其在机械操作实体所固定的基底材料之后保持显着的生物学活性。

5. 发明申请

US20070264301A1 Immobilized biologically active entities having a high degree of biological activity following sterilization 有权
标题翻译：灭菌后具有高度生物活性的固定生物活性物质
公开(公告)号：US20070264301A1
公开(公告)日：2007-11-15
申请号：US11433105
申请日：2006-05-12
申请人： Robert Cleek , Michael Daly , Krzysztof Pietrzak
发明人： Robert Cleek , Michael Daly , Krzysztof Pietrzak
IPC分类号： A61F2/00 , A61K31/727
CPC分类号： A61L33/0011 , A61L2/206
摘要： The present invention is directed to immobilized biologically active entities that retain significant biological activity following sterilization of the immobilized biologically active entities.
摘要翻译：本发明涉及在固定的生物活性物质灭菌后保持显着的生物活性的固定的生物活性物质。

6. 发明申请

US20080089919A1 Immobilized Biologically Active Entities Having a High Degree of Biological Activity 有权
标题翻译：具有高度生物活性的固定生物活性物质
公开(公告)号：US20080089919A1
公开(公告)日：2008-04-17
申请号：US11938162
申请日：2007-11-09
申请人： Robert Cleek , Michael Daly , Krzysztof Pietrzak
发明人： Robert Cleek , Michael Daly , Krzysztof Pietrzak
IPC分类号： A61F2/00 , A61K31/727
CPC分类号： A61L31/16 , A61K31/727 , A61K38/1709 , A61L27/20 , A61L27/34 , A61L27/54 , A61L31/042 , A61L33/0011 , A61L33/0029 , A61L2300/222 , A61L2300/236 , A61L2300/416 , A61L2300/42 , A61L2300/45 , C08L5/02 , C08L5/10
摘要： The present invention relates to immobilized biologically active entities having heparin cofactor II binding activity.
摘要翻译：本发明涉及具有肝素辅因子II结合活性的固定生物活性物质。

7. 发明申请

US20070264308A1 Immobilized Biologically Active Entities Having High Biological Activity Following Mechanical Manipulation 有权
标题翻译：机械操作后具有高生物活性的固定生物活性物质
公开(公告)号：US20070264308A1
公开(公告)日：2007-11-15
申请号：US11747163
申请日：2007-05-10
申请人： Robert Cleek , Michael Daly , Krzysztof Pietrzak
发明人： Robert Cleek , Michael Daly , Krzysztof Pietrzak
IPC分类号： A61L27/00 , B32B27/00
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/222 , A61L2300/236 , A61L2300/252 , A61L2300/416 , Y10T428/31544 , C08L79/02
摘要： The present invention relates to immobilized biologically active entities that retain significant biological activity following mechanical manipulation of a substrate material to which the entities are immobilized.
摘要翻译：本发明涉及固定化的生物活性实体，其在机械操作实体所固定的基底材料之后保持显着的生物学活性。

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