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1. 发明申请

US20080311569A1 METHOD FOR QUANTITATIVE MEASUREMENT OF GENE EXPRESSION FOR INDENTIFYING INDIVIDUALS AT RISK FOR BRONCHOGENIC CARCINOMA 有权
标题翻译：基因表达定量测定方法，用于在BRC发生癌症风险中鉴别个体
公开(公告)号：US20080311569A1
公开(公告)日：2008-12-18
申请号：US11757705
申请日：2007-06-04
申请人： James C. Willey , David A. Weaver , Erin L. Crawford
发明人： James C. Willey , David A. Weaver , Erin L. Crawford
IPC分类号： C12Q1/68
CPC分类号： G01N33/57423 , C12Q1/686 , C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , C12Q2545/101 , C12Q2521/107
摘要： A method measure expression of multiple target genes in a progenitor cell for bronchogenic carcinoma comprising the use of reverse transcription-polymerase chain reaction (RT-PCR) to allow simultaneous expression measurement of the multiple target genes is disclosed.
摘要翻译：一种测量支气管癌的祖细胞中多个靶基因的表达的方法，包括使用逆转录聚合酶链反应（RT-PCR）以允许多个靶基因的同时表达测量。

2. 发明申请

US20120322071A9 METHOD FOR QUANTITATIVE MEASUREMENT OF GENE EXPRESSION FOR INDENTIFYING INDIVIDUALS AT RISK FOR BRONCHOGENIC CARCINOMA 有权
标题翻译：基因表达定量测定方法，用于在BRC发生癌症风险中鉴别个体
公开(公告)号：US20120322071A9
公开(公告)日：2012-12-20
申请号：US11757705
申请日：2007-06-04
申请人： James C. Willey , David A. Weaver , Erin L. Crawford
发明人： James C. Willey , David A. Weaver , Erin L. Crawford
IPC分类号： C12Q1/68
CPC分类号： G01N33/57423 , C12Q1/686 , C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , C12Q2545/101 , C12Q2521/107
摘要： A method measure expression of multiple target genes in a progenitor cell for bronchogenic carcinoma comprising the use of reverse transcription-polymerase chain reaction (RT-PCR) to allow simultaneous expression measurement of the multiple target genes is disclosed.
摘要翻译：一种测量支气管癌的祖细胞中多个靶基因的表达的方法，包括使用逆转录聚合酶链反应（RT-PCR）以允许多个靶基因的同时表达测量。

3. 发明授权

US5876978A Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction 失效
标题翻译：使用多重竞争性逆转录酶 - 聚合酶链反应定量测量基因表达的方法
公开(公告)号：US5876978A
公开(公告)日：1999-03-02
申请号：US876766
申请日：1997-06-16
申请人： James C. Willey , Erin L. Crawford , Jeffery P. DeMuth , Clara M. Jackson , David A. Weaver
发明人： James C. Willey , Erin L. Crawford , Jeffery P. DeMuth , Clara M. Jackson , David A. Weaver
IPC分类号： C12N15/09 , B01D57/02 , B01L3/00 , B01L7/00 , C12M1/00 , C12M1/34 , C12M1/36 , C12M1/38 , C12M1/40 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N35/10 , G01N37/00 , C12P19/34
CPC分类号： C12Q1/6851 , B01D57/02 , C12Q1/686
摘要： A method and apparatus for quantitative measurement of gene expression through multiplex competitive reverse transcriptase polymerase chain reaction amplification are disclosed. The method and apparatus are especially useful for analysis of small specimens of cells and tissues.
摘要翻译：公开了通过多重竞争性逆转录聚合酶链反应扩增定量测量基因表达的方法和装置。该方法和装置对于细胞和组织的小标本的分析特别有用。

4. 发明授权

US08722331B2 Method for selecting a treatment for non-small cell lung cancer using gene expression profiles 有权
标题翻译：使用基因表达谱选择非小细胞肺癌治疗的方法
公开(公告)号：US08722331B2
公开(公告)日：2014-05-13
申请号：US10508932
申请日：2003-03-27
申请人： Jeffrey P. Demuth , Erin L. Crawford , James C. Willey , David A. Weaver , Kristy A. Warner , Timothy G. Graves
发明人： Jeffrey P. Demuth , Erin L. Crawford , James C. Willey , David A. Weaver , Kristy A. Warner , Timothy G. Graves
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , C12Q1/6886 , C12Q2565/501 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , C12Q2545/107
摘要： The present invention identifies and quantifies changes in gene expression associated with non-small cell lung cancer NSCLC by examining gene expression in tissue from normal lung and diseased lung. The present invention also identifies and quantifies expression profiles which serve as useful diagnostic markers as well as markers that are useful to monitor disease states, disease progression, drug toxicity, drug efficacy and drug metabolism.
摘要翻译：本发明通过检查来自正常肺和患病肺的组织中的基因表达来鉴定和量化与非小细胞肺癌NSCLC相关的基因表达的变化。本发明还鉴定和量化用作有用的诊断标志物的表达谱以及可用于监测疾病状态，疾病进展，药物毒性，药物功效和药物代谢的标志物。

5. 发明授权

US08563238B2 Method for quantitative measurement of gene expression for identifying individuals at risk for bronchogenic carcinoma 有权
标题翻译：定量测定支气管癌危险性个体的基因表达方法
公开(公告)号：US08563238B2
公开(公告)日：2013-10-22
申请号：US11757705
申请日：2007-06-04
申请人： James C. Willey , David A. Weaver , Erin L. Crawford
发明人： James C. Willey , David A. Weaver , Erin L. Crawford
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： G01N33/57423 , C12Q1/686 , C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , C12Q2545/101 , C12Q2521/107
摘要： A method measure expression of multiple target genes in a progenitor cell for bronchogenic carcinoma comprising the use of reverse transcription-polymerase chain reaction (RT-PCR) to allow simultaneous expression measurement of the multiple target genes is disclosed.
摘要翻译：一种测量支气管癌的祖细胞中多个靶基因的表达的方法，包括使用逆转录聚合酶链反应（RT-PCR）以允许多个靶基因的同时表达测量。

6. 发明授权

US08304192B2 Methods and compositions for assessing nucleic acids and alleles 有权
标题翻译：用于评估核酸和等位基因的方法和组合物
公开(公告)号：US08304192B2
公开(公告)日：2012-11-06
申请号：US11072700
申请日：2005-03-04
申请人： James C. Willey , Erin L. Crawford , David A. Weaver
发明人： James C. Willey , Erin L. Crawford , David A. Weaver
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q2563/155 , C12Q2537/143 , C12Q2535/131 , C12Q2565/537 , C12Q2565/627 , C12Q2545/107
摘要： The present invention is directed to methods and compositions for evaluating allelic variations with improved quality controls, methods of preparing such compositions, and applications employing such compositions and methods. In particular, the present invention provides methods and compositions for reducing false positives and/or false negatives in nucleic acid measurements.
摘要翻译：本发明涉及用于通过改进的质量控制来评估等位基因变异的方法和组合物，以及制备这种组合物的方法，以及使用这种组合物和方法的应用。特别地，本发明提供用于减少核酸测量中的假阳性和/或假阴性的方法和组合物。

7. 发明授权

US5543104A Method for molding a multi-pack container assembly 失效
标题翻译：用于模制多包装容器组件的方法
公开(公告)号：US5543104A
公开(公告)日：1996-08-06
申请号：US357665
申请日：1994-12-16
申请人： James T. Stratford , Alan H. Schoonveld , David A. Weaver
发明人： James T. Stratford , Alan H. Schoonveld , David A. Weaver
IPC分类号： B65D1/30 , B29C33/42 , B29C45/18
CPC分类号： B65D1/30
摘要： A method is provided of forming a multi-pack container assembly having at least four containers joined together by a cross or plus shaped frangible web. The method includes the steps of providing at least one male mold member and at least one female mold member, disposing the mold members so as to define at least four container cavities separated by a cross or plus shaped web cavity, injecting the cavities with a plastics material to form the multi-pack container assembly, and releasing the multi-pack container assembly from the mold members. Preferably, the method is used to form multi-peck containers, such as yogurt or pudding containers, where each individual container can be easily separated from the multi-pack container assembly.
摘要翻译：提供了一种形成具有至少四个容器的多包装容器组件的方法，所述至少四个容器通过交叉或加成形的易碎卷材连接在一起。该方法包括以下步骤：提供至少一个阳模构件和至少一个阴模构件，设置模具构件以限定由十字形或正型网状空腔分隔开的至少四个容器空腔，用塑料材料以形成多包装容器组件，以及将多包装容器组件从模具部件中释放出来。优选地，该方法用于形成多啄容器，例如酸奶或布丁容器，其中每个单独的容器可以容易地与多包装容器组件分离。

8. 发明授权

US5405160A Trailer hitch attachment apparatus 失效
标题翻译：拖车挂钩装置
公开(公告)号：US5405160A
公开(公告)日：1995-04-11
申请号：US898962
申请日：1992-06-10
申请人： David A. Weaver
发明人： David A. Weaver
IPC分类号： B60D1/38
CPC分类号： B60D1/38
摘要： An apparatus and method for attaching a trailer to a vehicle. An apparatus is provided having a winch attached to the trailer for pulling the trailer to the vehicle, a substantially flat strap connected to the winch at one end and having a flat attachment member with an aperture therethrough at the other end for placement over the ball portion of a hitch at the other end for connecting the trailer to the vehicle, and a multi-position arm attached to the trailer forward of the winch for lifting the receiver portion up and over the ball portion of the hitch when the strap is effectively shortened by winding it up on the winch. The arm is pivotally attached at one end by a block on the underside of the tongue of the trailer. A bearing member is disposed at the other end of the arm. The arm may be moved backward to a first-position and pinned in place so that it is tucked underneath the tongue for storage. To connect the trailer to or release it from the vehicle, the arm is locked into a second position so that it extends downward, the connector on the end of the strap is placed over the ball on the vehicle, and the winch is cranked so that the trailer is lifted up by the arm on the strap.
摘要翻译：一种用于将拖车附接到车辆的装置和方法。提供一种装置，其具有连接到拖车上用于将拖车拉到车辆上的绞盘，在一端连接到绞盘的基本平坦的带，并且具有平坦的附接构件，在另一端具有穿过其的孔，用于放置在球部分上在另一端用于将拖车连接到车辆上的连接装置;以及多个位置臂，其连接到绞盘前方的拖车，用于当带子被有效地缩短时，将接收器部分上下提升接合部分卷起绞车。臂在一端通过拖车舌头下侧的块枢轴连接。轴承构件设置在臂的另一端。手臂可以向后移动到第一位置并被固定在适当的位置，使得它被卷在舌头的下面用于存储。为了将拖车连接到车辆上或将其从车辆上拆下，臂被锁定在第二位置，使其向下延伸，带的端部上的连接器被放置在车辆上的球上，并且绞盘被起动，使得拖车由吊带上的手臂抬起。

9. 发明授权

US5409127A Multi-pack container assembly 失效
标题翻译：多包装容器组装
公开(公告)号：US5409127A
公开(公告)日：1995-04-25
申请号：US135255
申请日：1993-10-12
申请人： James T. Stratford , Alan H. Schoonveld , David A. Weaver
发明人： James T. Stratford , Alan H. Schoonveld , David A. Weaver
IPC分类号： B65D1/30 , B65D85/32
CPC分类号： B65D1/30
摘要： A multi-pack container assembly comprises a plurality of containers and webs joining the containers, each web configured to include an area of reduced structural integrity for tearing a plurality of frangible ribs interconnecting adjacent containers and traversing the tearing area.
摘要翻译：多包装容器组件包括连接容器的多个容器和腹板，每个腹板构造成包括具有减小的结构完整性的区域，用于撕开互连相邻容器并穿过撕裂区域的多个易碎肋条。

10. 发明授权

US4353515A Spool mounting assembly and brake 失效
标题翻译：阀芯安装组件和制动器
公开(公告)号：US4353515A
公开(公告)日：1982-10-12
申请号：US221026
申请日：1980-12-29
申请人： David A. Weaver , Gordon G. Bledsoe
发明人： David A. Weaver , Gordon G. Bledsoe
IPC分类号： B65H49/26 , B65H75/30 , B65H75/40
CPC分类号： B65H49/26
摘要： A mechanism for mounting a spool on a shaft is the subject of the present invention. First and second bearing means are provided which are designed to fit over the shaft and be received within the openings of a large wooden spool. Each bearing has a frusto-conical annular surface so that it can accommodate different sized openings in the spool. A sleeve member abuts one of the bearings and is comprised of first and second sleeve components which are complementally threaded. Means is provided for rotating the two sleeve components relative to each other whereby the effective length of the sleeve may be increased or decreased. This provides means for providing a lateral force acting against one of the bearings which in turn controls the speed of rotation of the spool. When it is desired to stop rotation of the spool, the two sleeve components are turned relative to each other a sufficient distance so as to apply a lateral force against the spool a sufficient magnitude to stop all rotation.
摘要翻译：用于将线轴安装在轴上的机构是本发明的主题。提供第一和第二轴承装置，其被设计成装配在轴上并被容纳在大型木制卷轴的开口内。每个轴承都有一个截头圆锥形的环形表面，使其可以容纳阀芯中不同尺寸的开口。套筒构件邻接其中一个轴承并且由互补螺纹的第一和第二套筒构件组成。提供了用于相对于彼此旋转两个套筒部件的装置，由此套筒的有效长度可以增加或减小。这提供了用于提供作用于轴承中的一个的横向力的装置，其进而控制滑阀的旋转速度。当需要停止卷轴的旋转时，两个套筒部件相对于彼此转动足够的距离，以便对卷筒施加足够大的程度的横向力以停止所有旋转。

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