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1. 发明授权

US5921244A Internal magnetic device to enhance drug therapy 失效
标题翻译：内部磁性装置增强药物治疗
公开(公告)号：US5921244A
公开(公告)日：1999-07-13
申请号：US873212
申请日：1997-06-11
申请人： James C. Chen , Brent Wiscombe , Brian D. Wilkerson , Darrin Huston , David J. Brown
发明人： James C. Chen , Brent Wiscombe , Brian D. Wilkerson , Darrin Huston , David J. Brown
IPC分类号： A61N2/02 , A61N2/06 , A61N5/06 , A61B19/00
CPC分类号： A61N5/062 , A61N2/02 , A61N2/06 , A61N5/0601
摘要： A magnet used for concentrating a medical substance carried by a magnetic fluid at an internal treatment site. The magnet is inserted through an opening in a patient's body and advanced to the internal treatment site. Although an electromagnet is used in one alternative embodiment, the magnet is preferably a super neodymium or other rare earth permanent magnet having a high field strength. A probe that includes the magnet is coated with a biologically inert material, such as a TEFLON.TM. polymer. Alternatively, a plurality of such magnets can be employed. In the preferred embodiment, a magnetic fluid that includes particles coated with a photoreactive agent is injected into the patient's body, preferably, immediately adjacent to or inside the treatment site. The particles in the magnetic fluid are attracted to the magnet at the treatment site, and the concentration of the photoreactive agent absorbed into the tissue around the magnet at the internal treatment site is enhanced. The photoreactive agent is used to provide a photodynamic therapy (PDT) to the treatment site that destroys cells that have absorbed the photoreactive agent when the internal treatment site is illuminated by light of an appropriate waveband. A PDT probe having a light source that emits light of the required waveband is inserted into the patient's body and advanced to the treatment site to effect the PDT. The magnet (or magnets) can also be disposed inside the PDT probe, which then carries the magnet(s) to the internal treatment site.
摘要翻译：用于在内部处理部位浓缩由磁性流体携带的医疗物质的磁体。磁体通过患者体内的开口插入并进入内部治疗部位。虽然在一个替代实施例中使用电磁体，但是磁体优选地是具有高场强的超钕或其它稀土永磁体。包括磁体的探针涂覆有生物惰性材料，例如TEFLON TM聚合物。或者，可以使用多个这样的磁体。在优选实施例中，将包含光反应剂的颗粒的磁性流体注射到患者体内，优选地在治疗部位附近或内部注射。磁性流体中的颗粒被吸引到处理部位的磁体，并且增强了吸收到内部处理部位的磁体周围的组织中的光反应剂的浓度。光反应剂用于向处理部位提供光动力学治疗（PDT），其在内部治疗部位被适当的波段的光照射时破坏已经吸收了光反应剂的细胞。将具有发出所需波段的光的光源的PDT探头插入到患者体内并前进到治疗部位以实现PDT。磁体（或磁体）也可以设置在PDT探针的内部，然后将磁体携带到内部处理部位。

2. 发明授权

US06580228B1 Flexible substrate mounted solid-state light sources for use in line current lamp sockets 失效
标题翻译：柔性基板安装固态光源，用于线路电流灯插座
公开(公告)号：US06580228B1
公开(公告)日：2003-06-17
申请号：US09644253
申请日：2000-08-22
申请人： James C. Chen , Darrin Huston , Brent Wiscombe
发明人： James C. Chen , Darrin Huston , Brent Wiscombe
IPC分类号： H05B3700
CPC分类号： H01L25/0753 , F21K9/232 , F21K9/90 , F21V3/06 , F21V3/061 , F21V3/062 , F21V23/02 , F21Y2107/30 , F21Y2115/10 , H01L2924/0002 , Y10S362/80 , H01L2924/00
摘要： A lamp using solid-state light emitting sources is configured to be used in a conventional socket. The lamp includes a flexible substrate on which are mounted a plurality of light emitting sources, such as light emitting diodes (LEDs) in spaced-apart array. In one embodiment, a flexible substrate configured as a generally rectangular panel formed into a cylindrical shape includes a plurality of conductive traces to which the LEDs are connected both mechanically and electrically. The flexible substrate is then enclosed within a light transmissive translucent cover that is attached to a base in which is disposed a power supply. The base is shaped and configured to be threaded into a conventional incandescent light socket and includes a center terminal through which AC line power is supplied to the power supply. The power supply provides an appropriate voltage and current to energize the light sources so that they produce a white light that is emitted radially outward around a longitudinal axis of the lamp. In a different embodiment, the light sources are mounted on a flexible substrate formed as a strand or thread that is wound in a helix around a cylindrical support. The light sources are also provided on a flap that covers the end of the cylinder so that light is emitted through the top or end of the cover. Also included is a solid-state lamp adapted to work in a conventional three-way socket.
摘要翻译：使用固态发光源的灯被配置为在常规插座中使用。该灯包括柔性基板，其上安装有多个发光源，例如间隔开阵列的发光二极管（LED）。在一个实施例中，被配置为形成为圆柱形的大致矩形面板的柔性基板包括多个导电迹线，LED均以机械和电气方式连接到该导电迹线。然后将柔性基板封闭在透光半透明盖中，透光半透明盖附接到设置有电源的基座。基座被成形并配置成螺纹连接到常规的白炽灯插座中，并且包括中心端子，通过该中心端子向电源供应AC线路电力。电源提供适当的电压和电流以激励光源，使得它们产生围绕灯的纵向轴线径向向外发射的白光。在不同的实施例中，光源安装在形成为绕圆柱形支撑件以螺旋形缠绕的线或线的柔性基底上。光源还设置在覆盖圆柱体的端部的翼片上，使得光通过盖的顶部或端部发射。还包括适于在常规三路插座中工作的固态灯。

3. 发明授权

US6096066A Conformal patch for administering light therapy to subcutaneous tumors 有权
标题翻译：用于对皮下肿瘤进行光疗的保形贴片
公开(公告)号：US6096066A
公开(公告)日：2000-08-01
申请号：US151844
申请日：1998-09-11
申请人： James C. Chen , Brent Wiscombe
发明人： James C. Chen , Brent Wiscombe
IPC分类号： A61N5/06 , A61N5/00
CPC分类号： A61N5/062 , A61N2005/0645 , A61N2005/0652
摘要： A flexible patch provided with a plurality of light sources mounted in spaced-apart array on its undersurface and covered with an optically transparent polymer material. The light sources are energized with an electrical current supplied by a flexible polymer battery, which is preferably rechargeable. Electrical current is conveyed through a lead that extends from the flexible battery to the flexible patch and then through an electrical circuit that includes a plurality of conductive traces formed using a conductive ink applied to the surface of a flexible substrate that supports the light sources. The thickness of the flexible patch at its maximum is less than 1.0 millimeters. The light sources can be separately grouped, and the electrical current supplied to each group individually controlled to achieve a desired light intensity and/or duration exposure to the light therapy over different portions of the undersurface of the flexible patch and different portions of the treatment site. An adhesive applied to the treatment site on the patient's body or on the undersurface of the flexible patch is used to mount the flexible patch to the treatment site. A plurality of slots that extend through the flexible substrate provide passages for air and moisture and enable the flexible substrate to freely and more readily conform to irregular, non-planar shapes of the treatment site. The flexible substrate can also be adhesively secured to a non-planar surface within a patient's body to render the light therapy internally.
摘要翻译：柔性贴片，其设置有多个光源，其间隔开地阵列安装在其下表面上，并被光学透明的聚合物材料覆盖。光源由柔性聚合物电池提供的电流通电，柔性聚合物电池优选是可再充电的。电流通过从柔性电池延伸到柔性贴片的引线传送，然后通过包括使用施加到支撑光源的柔性基板的表面的导电油墨形成的多个导电迹线的电路传送。柔性贴片最大厚度小于1.0毫米。光源可以分开分组，并且提供给每个组的电流被单独控制以实现对柔性贴片的下表面的不同部分和处理部位的不同部分的光疗的期望的光强度和/或持续时间。使用施加到患者身体或柔性贴片的下表面上的治疗部位的粘合剂将柔性贴片安装到治疗部位。延伸穿过柔性基底的多个槽提供用于空气和湿气的通道，并且使得柔性基底能够自由地且更容易地符合治疗部位的不规则的非平面形状。柔性基底还可以粘合地固定到患者体内的非平面表面以在内部进行光疗。

4. 发明授权

US5997569A Flexible and adjustable grid for medical therapy 失效
标题翻译：用于医疗治疗的灵活和可调电网
公开(公告)号：US5997569A
公开(公告)日：1999-12-07
申请号：US788451
申请日：1997-01-29
申请人： James C. Chen , Brent Wiscombe
发明人： James C. Chen , Brent Wiscombe
IPC分类号： A61N5/06 , A61N5/00
CPC分类号： A61N5/0601 , A61N5/062 , A61N2005/0645
摘要： Flexible probes are arranged to achieve a desired light distribution pattern for administering light therapy at a treatment site in a patient's body. The flexible probes (20, 20', 92) each include a flexible substrate on which are mounted light emitting devices (30) in spaced-apart array. An optically transparent, biocompatible envelope (36) encloses the flexible substrate and components mounted thereon. In one embodiment, a link (44) couples a pair of the flexible probes together in parallel alignment for insertion at the treatment site. Thereafter, the probes are moved relative to each other within the link to achieve the desired light distribution pattern. In another embodiment, the flexible probes include flexible leaders (70, 72) attached to their distal ends, which terminate in suture tabs (74) that can be affixed to tissue adjacent the treatment site. The flexible probes are inserted into the treatment site generally aligned in a compact bundle and then are arrayed in a grid and spaced apart using links (82) to secure them at points where the flexible probes cross each other transversely. A further embodiment includes a strip (90) having a longitudinal slot (96), that opens into a channel (98) for receiving balls (94) formed on the distal ends of the flexible probes. The strip maintains the flexible probes in a spaced-apart array. Finally, another embodiment includes a flexible sheet (100) on which the flexible probes are mounted using sutures (108) or staples (102) after the sheet and flexible probes have been introduced to the treatment site.
摘要翻译：柔性探针被布置成实现用于在患者体内的治疗部位施用光疗法的期望的光分布模式。柔性探针（20,20'，92）各自包括柔性基板，其上安装有间隔开阵列的发光器件（30）。光学透明的生物相容性封套（36）包围柔性基板和安装在其上的部件。在一个实施例中，连杆（44）将一对柔性探针并联对准，以便在治疗部位插入。此后，探针在链节内相对于彼此移动以实现期望的光分布模式。在另一个实施例中，柔性探针包括附接到其远端的柔性引导件（70,72），其终止于缝合片（74），缝合片可以固定到处理部位附近的组织。将柔性探针插入到处理部位中，该部位通常以致密的束束对准，然后使用连杆（82）排列成格栅并间隔开，以将它们固定在柔性探针横向交叉的点处。另一个实施例包括具有纵向狭槽（96）的条带（90），该条带通向通道（98），用于接收形成在柔性探针的远端上的滚珠（94）。条带将柔性探针保持在间隔开的阵列中。最后，另一个实施例包括柔性片材（100），在片材和柔性探针已经被引入到治疗部位之后，使用缝合线（108）或钉钉（102）在其上安装柔性探针。

5. 发明授权

US5827186A Method and PDT probe for minimizing CT and MRI image artifacts 失效
标题翻译：用于最小化CT和MRI图像伪像的方法和PDT探针
公开(公告)号：US5827186A
公开(公告)日：1998-10-27
申请号：US827832
申请日：1997-04-11
申请人： James C. Chen , Brent Wiscombe
发明人： James C. Chen , Brent Wiscombe
IPC分类号： A61B18/20 , A61B5/055 , A61B17/34 , A61B19/00 , A61N5/06 , G01R33/28 , H05K3/28 , H05K3/32 , A61B5/05
CPC分类号： A61N5/062 , A61N5/0601 , G01R33/285 , H05K3/321 , A61N2005/0652 , A61N2005/0653 , H05K2201/10106 , H05K2201/10636 , H05K2203/1311 , H05K3/284 , Y02P70/611
摘要： An implantable probe having a non-metallic insulating base, non-metallic conductive traces supported by the base, and a plurality of non-metallic light sources supported by the base and coupled to the conductive traces. The conductive traces and the light sources are fabricated from a conductive polymer, which does not cause any artifacts if the implantable probe is left at the treatment site while it is imaged. Further, the implantable probe includes an envelope that is transparent and hermetically encloses the base, the pair of conductive traces, and the light sources. At least a portion of the envelope is optically transparent, enabling light emitted by the light sources to illuminate an adjacent treatment site. The conductive traces and the base are substantially flexible, enabling the probe to be flexed without breaking when the implantable probe is advanced within the body to the treatment site. A non-metallic receiver coil implanted in a patient's body is energized by inductively coupling it to an external transmitter coil. The current from the receiver coil is conveyed to the implanted probe through non-metallic leads.
摘要翻译：具有非金属绝缘基底，由基底支撑的非金属导电迹线的可植入探针以及由基底支撑并耦合到导电迹线的多个非金属光源。导电迹线和光源由导电聚合物制成，如果可植入探针在成像时留在治疗部位，则不会引起任何伪影。此外，可植入探针包括透明的气密包封基底，一对导电迹线和光源。信封的至少一部分是光学透明的，使得由光源发射的光照亮相邻的处理部位。导电迹线和基部基本上是柔性的，使得当可植入探针在体内前进到治疗部位时，能够使探针弯曲而不断裂。植入患者体内的非金属接收器线圈通过电感耦合到外部发射器线圈来激励。来自接收器线圈的电流通过非金属引线传送到植入的探针。

6. 发明授权

US6080160A Use of shape memory alloy for internally fixing light emitting device at treatment site 失效
标题翻译：形状记忆合金用于在处理部位内部固定发光元件
公开(公告)号：US6080160A
公开(公告)日：2000-06-27
申请号：US760057
申请日：1996-12-04
申请人： James C. Chen , Brent Wiscombe
发明人： James C. Chen , Brent Wiscombe
IPC分类号： A61B17/00 , A61B17/34 , A61B19/00 , A61M25/04 , A61N5/06
CPC分类号： A61M25/04 , A61B17/3468 , A61N5/0601 , A61B2017/00867 , A61B2090/306 , A61B90/39
摘要： A method and apparatus for selectively engaging and disengaging an anchor to fix a medical device at a selected site within a patient's body. A shape memory alloy (SMA) such as Nitinol is used to fabricate one or more anchors for the medical device. The shape memory effect exhibited by the SMA is thermally activated. One embodiment of the anchor has a substantially circular shape when at its martensite temperature and reverts to an elliptical shape at its austenite temperature. Another embodiment is a substantially straight strip at its martensite temperature and has an end that curls to engage tissue when at its austenite temperature. Still another embodiment includes a pair of anchors that extend outwardly from each side of an elongate probe at their austenite temperature and retract inwardly against the sides of the probe at their martensite temperature. The change in the shape of the SMA elements tends to anchor the medical device or probe at the treatment site. To change the temperature of the SMA elements, an electrical current is selectively energized to provide heat, or thermal conduction between the SMA and a heat source or a heat sink is employed.
摘要翻译：一种用于选择性地接合和分离锚定器以将医疗装置固定在患者体内的选定部位的方法和装置。使用诸如镍钛诺的形状记忆合金（SMA）来制造用于医疗装置的一个或多个锚固件。 SMA表现出的形状记忆效应被热激活。锚固件的一个实施例在其马氏体温度下具有大致圆形形状并且在其奥氏体温度下回复到椭圆形状。另一个实施方案是其马氏体温度下的基本上直的条带，并且具有在其奥氏体温度时卷曲以接合组织的端部。另一个实施例包括一对锚定件，其在其奥氏体温度下从细长探针的每侧向外延伸并且在其马氏体温度下向内靠近探针的侧部。 SMA元件的形状变化倾向于将医疗器械或探针固定在治疗部位。为了改变SMA元件的温度，选择性地通电电流以提供热量，或者使用SMA与热源或散热器之间的热传导。

7. 发明授权

US5957960A Internal two photon excitation device for delivery of PDT to diffuse abnormal cells 失效
标题翻译：内部双光子激发装置用于传递PDT以扩散异常细胞
公开(公告)号：US5957960A
公开(公告)日：1999-09-28
申请号：US850909
申请日：1997-05-05
申请人： James C. Chen , Brent Wiscombe
发明人： James C. Chen , Brent Wiscombe
IPC分类号： A61K41/00 , A61K45/00 , A61N5/06 , A61P43/00
CPC分类号： A61N5/062 , A61K41/008 , A61N5/0601 , A61N2005/0645 , A61N2005/0652
摘要： A plurality of light sources that emit light having a long wavelength are energized for an extended period of time to increase the likelihood of two photon absorption by cells that have preferentially absorbed a photoreactive agent such as psoralen. The cells are preferably microscopic metastatic cancer cells that are diffusely distributed throughout a treatment site, for example, within an organ. The plurality of light sources are arranged in a spaced-apart array, mounted on a support plate that includes a plurality of conductive traces. A plurality of such arrays are preferably mounted to a flexible sheet that can conform to an outer surface of an organ being treated. Because the light emitted by the light sources is in the infrared or near infrared waveband, it penetrates deeply into the tissue at the treatment site. The duration of the treatment and the number of light sources employed for administering the therapy increases the likelihood of two photon absorption by the metastatic cancer cells, which has been shown to activate the photoreactive agent to destroy cancer cells in a tumor, even though the characteristic light absorption waveband of the photoreactive agent is in the ultraviolet waveband.
摘要翻译：发射长波长的光的多个光源被激励一段较长的时间，以增加优先吸收光活性剂如补骨脂素的细胞的双光子吸收的可能性。细胞优选是扩散分布在整个治疗部位，例如器官内的微观转移癌细胞。多个光源被布置成间隔开的阵列，安装在包括多个导电迹线的支撑板上。多个这样的阵列优选地安装到柔性片材上，该柔性片材可以符合被处理器官的外表面。由于光源发出的光线处于红外线或近红外线波段，所以在治疗部位深入到组织中。用于治疗的持续时间和用于治疗该治疗的光源的数量增加了转移癌细胞的两个光子吸收的可能性，已经显示活化光反应剂以破坏肿瘤中的癌细胞，即使特征光反应剂的光吸收波段处于紫外波段。

8. 发明授权

US5876427A Compact flexible circuit configuration 失效
标题翻译：紧凑型柔性电路配置
公开(公告)号：US5876427A
公开(公告)日：1999-03-02
申请号：US787775
申请日：1997-01-29
申请人： James C. Chen , Brent Wiscombe
发明人： James C. Chen , Brent Wiscombe
IPC分类号： A61N5/06 , H01L25/075 , H05K1/18 , A61N21/00
CPC分类号： A61N5/0601 , A61N5/062 , H01L2224/32225 , H01L2224/48091 , H01L2224/48227 , H01L2224/48465 , H01L2224/73265 , H01L25/0756 , H05K1/189
摘要： A flexible probe constructed using a flexible circuit having a small cross-sectional profile. In the various disclosed embodiments of the flexible circuit, a flexible substrate includes a plurality of conductive traces that extend along opposite surfaces of the substrate. Light emitting devices (or other electronic devices) are mounted at spaced-apart intervals along the length of the conductive traces using a conductive adhesive/solder. A conductor couples a terminal on the outwardly facing side of each of the light emitting devices to the conductive trace that is disposed on the opposite side of the substrate. In one embodiment, this conductor comprises a short conductive bar that extends between the terminals of pairs of the light emitting devices that are mounted on opposite sides of the flexible substrate so that the pair of light emitting devices are connected in series. In another embodiment, the flexible substrate includes an outwardly extending arm of the conductive trace that wraps around the edge of the flexible substrate to connect to the light emitting device mounted on the opposite side thereof. In each embodiment, a substantially smaller cross-sectional profile is achieved compared to a previous approach in which the conductive traces providing power to a light emitting device were located on the same side of the flexible substrate and fly wires were used to connect the light emitting devices to the conductive traces.
摘要翻译：使用具有小横截面轮廓的柔性电路构成的柔性探头。在柔性电路的各种公开的实施例中，柔性衬底包括沿衬底的相对表面延伸的多个导电迹线。发光器件（或其他电子器件）使用导电粘合剂/焊料沿着导电迹线的长度以间隔的间隔安装。导体将每个发光器件的面向外侧的端子连接到设置在衬底的相对侧上的导电迹线。在一个实施例中，该导体包括短导电棒，其在安装在柔性基板的相对侧上的成对的发光器件的端子之间延伸，使得该对发光器件串联连接。在另一个实施例中，柔性基板包括导电迹线的向外延伸的臂，其围绕柔性基板的边缘缠绕以连接到安装在其相对侧上的发光器件。在每个实施例中，与先前的方法相比，实现了基本上较小的横截面轮廓，其中向发光器件提供功率的导电迹线位于柔性基板的相同侧上，并且使用飞线将发光器件到导电迹线。

9. 发明授权

US5766234A Implanting and fixing a flexible probe for administering a medical therapy at a treatment site within a patient'body 失效
标题翻译：植入和固定用于在患者体内的治疗部位进行药物治疗的柔性探针
公开(公告)号：US5766234A
公开(公告)日：1998-06-16
申请号：US633171
申请日：1996-04-16
申请人： James C. Chen , Brent Wiscombe
发明人： James C. Chen , Brent Wiscombe
IPC分类号： A61B5/04 , A61B17/00 , A61B17/04 , A61B19/00 , A61N1/00 , A61N5/06 , A61N7/00
CPC分类号： A61B17/00234 , A61N5/0601 , A61N5/062 , A61B2017/00243 , A61B2017/00274 , A61B2017/0404 , A61B2017/0458 , A61B2018/00547 , A61N2005/061 , A61N2005/0645 , A61N2005/0652
摘要： A plurality of embodiments for a flexible probe used to provide photodynamic therapy (PDT) and to effect other medical procedures at an internal treatment site inside a patient's body. Each of the embodiments of the flexible probe (100, 108, 130, 158, 182, 190, 220, 280, 370, 390, 440, 460, 520) includes a flexible substrate (102, 184, 196, 222, 250, 282, 412, 462, 482, 502, 522) on which are disposed conductive traces (414, 466, 468, 488, 490, 504, 506, 524, 526) electrically connected to leads through which electrical current and signals are conveyed. A plurality of light sources (104, 192, 256, 286, 418, 436, 470, 492, 508, 542) or other micro-electronic circuits are connected to the conductive traces and mounted on the flexible substrate. Each of the embodiments of the flexible probes is enclosed within a transparent, biocompatible polymer envelope (106, 110, 464, 522). Due to the characteristic elastic properties of the flexible substrate, the flexible probe can readily be bent, folded, or rolled while being disposed at the internal treatment site. Thus, for example, a curved surgical needle (650) can be used to implant a flexible probe at the treatment site by drawing the flexible probe through tissue along a curved path to a desired position; one or more disk-shaped buttons (660, 670) that are attached to the ends of the flexible probe can be used to secure the flexible probe so that it does not move from the desired position.
摘要翻译：用于提供光动力治疗（PDT）的柔性探针的多个实施例，并且在患者体内的内部治疗部位进行其它医疗程序。柔性探针（100,108,130,158,182,190,220,280,370,390,440,460,520）的每个实施例包括柔性基底（102,184,196,222,250， 282,412,462,482,502,522），其上设置有电连接到通过其传送电流和信号的引线的导电迹线（414,466,468,48,490,504,506,524,526）。多个光源（104,192,256,286,418,436,470,492,504,542）或其它微电子电路连接到导电迹线并且安装在柔性基板上。柔性探针的每个实施例被封装在透明的生物相容性聚合物封套（106,110,464,522）内。由于柔性基板的特征弹性特性，柔性探针可以容易地弯曲，折叠或卷起，同时处于内部处理部位。因此，例如，弯曲外科手术针（650）可以用于通过将柔性探针通过组织沿弯曲路径拉伸到期望位置来在治疗部位植入柔性探针; 可以使用附接到柔性探针的端部的一个或多个盘形按钮（660,670）来固定柔性探针，使得其不会从期望的位置移动。

10. 发明授权

US5702432A Intracorporeal light treatment of blood 失效
标题翻译：体内光治疗血液
公开(公告)号：US5702432A
公开(公告)日：1997-12-30
申请号：US725578
申请日：1996-10-03
申请人： James C. Chen , Brent Wiscombe
发明人： James C. Chen , Brent Wiscombe
IPC分类号： A61M1/36 , A61N5/06 , A61N00/00
CPC分类号： A61N5/062 , A61N5/0601
摘要： A method and apparatus for administering intracorporeal photopheresis to blood flowing in a patient's body to destroy an undesirable component in the blood, where the undesirable component has absorbed a photoreactive agent having a characteristic light absorption waveband. The apparatus includes an implantable housing that is adapted to be placed transcutaneously within a patient's body. An inlet and outlet for a fluid path through the housing are provided and are coupled to a patient's circulatory system so that they convey blood into and out of the housing. Light sources disposed within the housing(or externally disposed and coupled to the housing by optical fibers) emit light having a waveband substantially equal to the absorption waveband of the photoreactive agent. A portion of the fluid path within the housing is optically transparent so that blood is irradiated with light from the light source. The fluid path can have one of several different configurations, including serpentine, planar coil, helical coil, and cross tubes coupling inlet and outlet header manifolds. The light source can comprise light emitting diodes (LEDs) or other types of light sources and may be coupled to the reactor through optical fibers. The power supply for the light source can be intracorporeal or extracorporeal.
摘要翻译：一种用于对在患者体内流动的血液进行体内光泳术以破坏血液中不期望的组分的方法和装置，其中不希望的组分已经吸收了具有特征性光吸收波段的光反应剂。该装置包括可植入的壳体，其适于经皮地放置在患者体内。提供了通过壳体的流体路径的入口和出口，并且连接到患者的循环系统，使得它们将血液输入和移出壳体。设置在壳体内（或者通过光纤外部设置并耦合到壳体）的光源发射具有基本上等于光反应剂的吸收波段的波段的光。壳体内的流体路径的一部分是光学透明的，从而用来自光源的光照射血液。流体路径可以具有几种不同构造中的一种，包括蛇形，平面线圈，螺旋线圈和耦合入口和出口集管歧管的交叉管。光源可以包括发光二极管（LED）或其他类型的光源，并且可以通过光纤耦合到反应器。光源的电源可以是体内或体外。

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