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1. 发明授权

US06657351B2 Contactless energy transfer apparatus 有权
标题翻译：非接触式能量传递装置
公开(公告)号：US06657351B2
公开(公告)日：2003-12-02
申请号：US09910364
申请日：2001-07-20
申请人： James C. Chen , Darrin Huston , Brian D. Wilkerson
发明人： James C. Chen , Darrin Huston , Brian D. Wilkerson
IPC分类号： H02K3300
CPC分类号： A61N1/08 , A47J36/02 , A47J36/26 , A61F2250/0001 , A61N1/3787 , H01F38/12 , H01F38/14 , H01M10/46 , H01M10/48 , H02K5/1282 , H02K7/1807 , H02K7/1876 , H02K21/12 , H02K21/24 , H02K35/02 , H05B6/1236 , Y02B40/123
摘要： A flux generator base unit electromagnetically coupled with a receiving unit to transfer energy into the receiving unit. The base unit includes one or more permanent magnets that produce a magnetic flux, which passes through a receiver coil in the receiving unit. The receiver coil is either disposed in a separate housing that is electrically connected with a portable device, or integrated into the housing of the portable device. Either the permanent magnets or a flux shunt is moved in the base unit to produce the varying magnetic flux that is coupled to the receiver coil. As a result of the varying magnetic field experienced by the receiver coil, an electric current is induced in the receiver coil, which is conditioned (e.g., rectified, filtered, and regulated) by a conditioning circuit to charge a battery or energize electronics contained in the portable device. Various embodiments of both the base unit and receiving unit are disclosed, including “universal” base units suitable for operation with different size receiving units.
摘要翻译：与接收单元电磁耦合以将能量传递到接收单元中的通量发生器基座单元。基座单元包括产生磁通的一个或多个永久磁铁，其通过接收单元中的接收器线圈。接收器线圈或者被布置在与便携式设备电连接或者集成到便携式设备的外壳中的分离的外壳中。永磁体或磁通分流器在基本单元中移动以产生耦合到接收器线圈的变化的磁通量。作为接收器线圈所经历的变化的磁场的结果，在接收器线圈中感应出电流，该接收器线圈由调节电路调节（例如，整流，滤波和调节），以对电池充电或激励包含在便携式设备。公开了基本单元和接收单元的各种实施例，包括适用于具有不同尺寸接收单元的操作的“通用”基本单元。

2. 发明授权

US5921244A Internal magnetic device to enhance drug therapy 失效
标题翻译：内部磁性装置增强药物治疗
公开(公告)号：US5921244A
公开(公告)日：1999-07-13
申请号：US873212
申请日：1997-06-11
申请人： James C. Chen , Brent Wiscombe , Brian D. Wilkerson , Darrin Huston , David J. Brown
发明人： James C. Chen , Brent Wiscombe , Brian D. Wilkerson , Darrin Huston , David J. Brown
IPC分类号： A61N2/02 , A61N2/06 , A61N5/06 , A61B19/00
CPC分类号： A61N5/062 , A61N2/02 , A61N2/06 , A61N5/0601
摘要： A magnet used for concentrating a medical substance carried by a magnetic fluid at an internal treatment site. The magnet is inserted through an opening in a patient's body and advanced to the internal treatment site. Although an electromagnet is used in one alternative embodiment, the magnet is preferably a super neodymium or other rare earth permanent magnet having a high field strength. A probe that includes the magnet is coated with a biologically inert material, such as a TEFLON.TM. polymer. Alternatively, a plurality of such magnets can be employed. In the preferred embodiment, a magnetic fluid that includes particles coated with a photoreactive agent is injected into the patient's body, preferably, immediately adjacent to or inside the treatment site. The particles in the magnetic fluid are attracted to the magnet at the treatment site, and the concentration of the photoreactive agent absorbed into the tissue around the magnet at the internal treatment site is enhanced. The photoreactive agent is used to provide a photodynamic therapy (PDT) to the treatment site that destroys cells that have absorbed the photoreactive agent when the internal treatment site is illuminated by light of an appropriate waveband. A PDT probe having a light source that emits light of the required waveband is inserted into the patient's body and advanced to the treatment site to effect the PDT. The magnet (or magnets) can also be disposed inside the PDT probe, which then carries the magnet(s) to the internal treatment site.
摘要翻译：用于在内部处理部位浓缩由磁性流体携带的医疗物质的磁体。磁体通过患者体内的开口插入并进入内部治疗部位。虽然在一个替代实施例中使用电磁体，但是磁体优选地是具有高场强的超钕或其它稀土永磁体。包括磁体的探针涂覆有生物惰性材料，例如TEFLON TM聚合物。或者，可以使用多个这样的磁体。在优选实施例中，将包含光反应剂的颗粒的磁性流体注射到患者体内，优选地在治疗部位附近或内部注射。磁性流体中的颗粒被吸引到处理部位的磁体，并且增强了吸收到内部处理部位的磁体周围的组织中的光反应剂的浓度。光反应剂用于向处理部位提供光动力学治疗（PDT），其在内部治疗部位被适当的波段的光照射时破坏已经吸收了光反应剂的细胞。将具有发出所需波段的光的光源的PDT探头插入到患者体内并前进到治疗部位以实现PDT。磁体（或磁体）也可以设置在PDT探针的内部，然后将磁体携带到内部处理部位。

3. 发明授权

US06986782B2 Ambulatory photodynamic therapy 有权
标题翻译：动态光动力疗法
公开(公告)号：US06986782B2
公开(公告)日：2006-01-17
申请号：US10211784
申请日：2002-08-01
申请人： James Chen , Brian Wilkerson , Dave Brown , Darrin Huston , Mike McQuade
发明人： James Chen , Brian Wilkerson , Dave Brown , Darrin Huston , Mike McQuade
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61B2018/2005 , A61B2018/2261 , A61N5/0601 , A61N2005/0645
摘要： Methods for delivering light to a treatment site of a patient to administer a light therapy thereto are provided. A method includes steps of providing a portable power source, and a light source configured to provide light suitable for the light therapy for a period of at least two hours, and an optical fiber; positioning a distal portion of the optical fiber that is adapted to be disposed at the treatment site within a patient's body, where the light generated by the light source and conveyed by the optical fiber exits from the distal portion of the optical fiber; energizing the light source with the portable power supply; and administering the light treatment to the treatment site with the light source, wherein the patient is ambulatory without interruption of the light therapy during the treatment.
摘要翻译：提供了将光传送到患者的治疗部位以给予光疗的方法。一种方法包括提供便携式电源的步骤和被配置为提供适合于光治疗的光至少两个小时的光的光源和光纤; 定位光纤的远端部分，其适于设置在患者体内的处理部位处，其中由光源产生并由光纤传送的光从光纤的远端部分出射; 用便携式电源为光源通电; 以及用所述光源将所述光处理施用于所述治疗部位，其中所述患者在所述治疗期间不中断所述光疗治疗。

4. 发明授权

US5945762A Movable magnet transmitter for inducing electrical current in an implanted coil 失效
公开(公告)号：US5945762A
公开(公告)日：1999-08-31
申请号：US21693
申请日：1998-02-10
申请人： James C. Chen , David J. Brown , Darrin Huston , Brian D. Wilkerson
发明人： James C. Chen , David J. Brown , Darrin Huston , Brian D. Wilkerson
IPC分类号： A61F2/02 , A61N1/08 , A61N1/378 , H02J17/00 , H05B6/12 , H02K33/00 , A61M37/00
CPC分类号： A61N1/3787 , A61N1/08 , A61F2250/0001
摘要： An external power head is energized by a motor causing movement of an element that produces a varying magnetic field, thereby inducing power in an implanted receiver coil within a patient's body. The external power head includes either one or more moving permanent magnets, or one or more moving elements that vary the magnetic flux coupled to the implanted receiver coil. As a result of the varying magnetic field experienced by the implanted receiver coil, an electric current flows from the implanted receiver coil to energize an implanted medical device.

5. 发明授权

US5741316A Electromagnetic coil configurations for power transmission through tissue 失效
标题翻译：用于通过组织传输电力的电磁线圈配置
公开(公告)号：US5741316A
公开(公告)日：1998-04-21
申请号：US756945
申请日：1996-12-02
申请人： James C. Chen , Brian D. Wilkerson , Darrin Huston , David J. Brown
发明人： James C. Chen , Brian D. Wilkerson , Darrin Huston , David J. Brown
IPC分类号： A61N1/362 , A61M1/12 , A61N1/378 , A61N2/04 , H02J17/00 , A61N1/00 , A61N1/36
CPC分类号： A61N1/3787
摘要： Several embodiments of relatively compact transmitter coils and receiver coils having an improved transcutaneous power transfer efficiency. The transmitter coils are preferably applied to the outer surface of a cutaneous layer on a patient's body and held in place using adhesive tape or other appropriate supporting material. Implanted within the patient's body is a receiver coil. To improve the power transfer efficiency of one embodiment, a transmitter coil and receiver coil include cores having pole faces with a substantially larger area than the cross section of the core at other locations. In addition, the core of the receiver coil is substantially shorter than that of the transmitter coil so that the lines of flux produced by the transmitter coil tend to pass through the pole faces of the receiver coil in greater density than they would if the pole faces of the transmitter and receiver cores were spaced identically. Relatively compact configurations for the transmitter core include an angled portion adjacent each of the pole faces so that the main portion of the transmitter core is disposed generally parallel and closely spaced to the surface of the cutaneous layer against which the transmitter core is placed. Further, two separate transmitter windings are provided on the transmitter core with an intermediate section joining the portions of the core on which these windings are disposed. This configuration provides enhanced power transfer capability compared to using a single winding around the intermediate section of the core.
摘要翻译：具有改进的经皮功率传递效率的相对紧凑的发射器线圈和接收器线圈的几个实施例。发射器线圈优选地应用于患者身体上的皮肤层的外表面并且使用粘合带或其它合适的支撑材料保持在适当的位置。植入患者体内的是接收线圈。为了提高一个实施例的功率传递效率，发射器线圈和接收器线圈包括具有比其它位置处的芯的横截面大得多的面积的极面的芯。此外，接收器线圈的芯部基本上短于发射器线圈的芯部，使得由发射器线圈产生的磁通线倾向于以比如果极面部分更大的密度穿过接收器线圈的极面发射机和接收机核心间隔相同。用于发射器芯的相对紧凑的构造包括邻近每个极面的成角度部分，使得发射器芯的主要部分大致平行并且与皮肤层的与发射器芯放置的表面紧密地间隔开。此外，两个单独的发射器绕组设置在发射机芯上，其中间部分连接在其上设置这些绕组的芯部分。与在芯的中间部分周围使用单个绕组相比，该配置提供增强的功率传递能力。

6. 发明授权

US06331744B1 Contactless energy transfer apparatus 失效
公开(公告)号：US06331744B1
公开(公告)日：2001-12-18
申请号：US09547700
申请日：2000-04-11
申请人： James C. Chen , Darrin Huston , Brian D. Wilkerson
发明人： James C. Chen , Darrin Huston , Brian D. Wilkerson
IPC分类号： H02K3300
CPC分类号： A61N1/08 , A47J36/02 , A47J36/26 , A61F2250/0001 , A61N1/3787 , H01F38/12 , H01F38/14 , H01M10/46 , H01M10/48 , H02K5/1282 , H02K7/1807 , H02K7/1876 , H02K21/12 , H02K21/24 , H02K35/02 , H05B6/1236 , Y02B40/123
摘要： A flux generator base unit electromagnetically coupled with a receiving unit to transfer energy into the receiving unit. The base unit includes one or more permanent magnets that produce a magnetic flux, which passes through a receiver coil in the receiving unit. The receiver coil is either disposed in a separate housing that is electrically connected with a portable device, or integrated into the housing of the portable device. Either the permanent magnets or a flux shunt is moved in the base unit to produce the varying magnetic flux that is coupled to the receiver coil. As a result of the varying magnetic field experienced by the receiver coil, an electric current is induced in the receiver coil, which is conditioned (e.g., rectified, filtered, and regulated) by a conditioning circuit to charge a battery or energize electronics contained in the portable device. Various embodiments of both the base unit and receiving unit are disclosed, including “universal” base units suitable for operation with different size receiving units.

7. 发明授权

US06273904B1 Polymer battery for internal light device 失效
标题翻译：用于内部照明装置的聚合物电池
公开(公告)号：US06273904B1
公开(公告)日：2001-08-14
申请号：US09260923
申请日：1999-03-02
申请人： James C. Chen , David J. Brown , Brian D. Wilkerson , Charles M. McQuade , Darrin Huston
发明人： James C. Chen , David J. Brown , Brian D. Wilkerson , Charles M. McQuade , Darrin Huston
IPC分类号： A61N506
CPC分类号： A61N5/062 , A61N1/3787 , A61N5/0601 , H01M2/1066 , H01M6/181
摘要： Several different embodiments of a flexible polymer battery are disclosed in connection with providing a medical therapy. For example, the electrical current from the polymer battery may be used to energize light sources for administering light therapy. In one embodiment, the polymer battery is formed as a substantially elongate structure having one end attached to an internal receiver coil, and the other end attached to a medical device such as a light probe that is adapted to be implanted within a patient's body. The polymer battery thus provides a conductive link between the internal receiver coil, which is electromagnetically coupled to an external transmitter coil for recharging the battery, and the light probe which is energized with current supplied by the flexible polymer battery. In another embodiment, the polymer battery is used to support a substrate on which a plurality of light sources are mounted in spaced-apart array. Yet other forms of the invention include polymer batteries within capsules or bead to energize light sources contained therein. The beads include receiver coils for recharging the polymer battery. Further, because of their small size, the beads or capsules are readily moved or held at a treatment site with an external magnet while therapy is rendered. Since a polymer battery includes very little metal, it is less likely to cause artifacts when the patient's body is imaged.
摘要翻译：结合提供医学疗法来公开柔性聚合物电池的若干不同实施方案。例如，可以使用来自聚合物电池的电流来激发用于施用光疗的光源。在一个实施例中，聚合物电池形成为具有附接到内部接收器线圈的一端的基本上细长的结构，另一端附接到医疗设备，例如适于植入患者体内的光探针。因此，聚合物电池在内部接收器线圈之间提供导电连接，内部接收器线圈电磁耦合到用于对电池充电的外部发射器线圈和由柔性聚合物电池供应的电流供电的光探针。在另一个实施例中，聚合物电池用于支撑其上安装有多个光源的衬底以间隔开的阵列。本发明的其它形式包括胶囊或珠粒内的聚合物电池，以激励其中所含的光源。珠子包括用于对聚合物电池充电的接收器线圈。此外，由于它们的小尺寸，在进行治疗时，珠或胶囊容易地与外部磁体移动或保持在治疗部位。由于聚合物电池包含非常少的金属，所以当患者的身体成像时不太可能引起伪影。

8. 发明授权

US6138681A Alignment of external medical device relative to implanted medical device 失效
标题翻译：外部医疗设备相对于植入医疗设备的对准
公开(公告)号：US6138681A
公开(公告)日：2000-10-31
申请号：US949308
申请日：1997-10-13
申请人： James C. Chen , Brian D. Wilkerson , Darrin Huston
发明人： James C. Chen , Brian D. Wilkerson , Darrin Huston
IPC分类号： A61B19/00 , A61B5/06 , A61F2/02 , A61N1/378 , H02J17/00
CPC分类号： A61B5/06 , A61F2250/0001
摘要： The alignment and positioning of an external device relative to an internal device is indicated on a display and/or by an acoustical signal. In the disclosed application, the external device transcutaneously transmits electromagnetic energy to an internal receiver to provide electrical power for an implanted medical device. To ensure optimal coupling between the external transmitter and the internal receiver, two permanent magnets are disposed at spaced-apart positions on the internal receiver. The magnetic field strength of the permanent magnets is sensed by a pair of correspondingly spaced-apart Hall effect sensor on the external transmitter. As the external transmitter is moved about over the internal receiver, the signals produced by the Hall effect sensors drive a display of light emitting diodes (LEDs) that indicates when the maximum magnetic field strength is achieved, i.e., when the Hall effect sensors on the external transmitter are each positioned directly opposite the corresponding permanent magnets on the internal receiver.
摘要翻译：外部设备相对于内部设备的对准和定位在显示器和/或声学信号上指示。在所公开的应用中，外部设备经常地将电磁能量传输到内部接收器以为植入的医疗设备提供电力。为了确保外部发射器和内部接收器之间的最佳耦合，两个永磁体设置在内部接收器上的间隔位置。永磁体的磁场强度由外部发射器上的一对相应间隔的霍尔效应传感器感测。当外部发射器在内部接收器上移动时，由霍尔效应传感器产生的信号驱动发光二极管（LED）的显示器，该发光二极管指示何时实现最大磁场强度，即当霍尔效应传感器外部发射器分别与内部接收器上相应的永久磁铁正好相对。

9. 发明授权

US07288106B2 System and method for excitation of photoreactive compounds in eye tissue 有权
标题翻译：用于激发眼组织中光反应性化合物的系统和方法
公开(公告)号：US07288106B2
公开(公告)日：2007-10-30
申请号：US10677645
申请日：2003-10-02
申请人： Gregory L. Heacock , Darrin Huston , James C. Chen , Steven R. Daly
发明人： Gregory L. Heacock , Darrin Huston , James C. Chen , Steven R. Daly
IPC分类号： A61N5/06
CPC分类号： A61F9/008 , A61F9/009 , A61F2009/00844 , A61F2009/00863 , A61F2009/00868 , A61F2009/00891 , A61N5/062 , A61N2005/0652
摘要： A system and method for excitation of photosensitizers is configured to provide desired illumination on targeted eye tissue. The excitation system includes an optical module that generates illumination and a controller to power the optical module and control the shape, intensity or energy level, and duration of the illumination. The optical module includes a contact portion for interfacing with the eye, a treatment beam portion including a light emitter array to generate shaped light patterns and optics to focus the light patterns onto the eye, and a visualization portion to provide visual feedback of treatment through a visualization interface coupled with a microscope. A typical treatment involves the optical module being placed on a diseased eye of a patient by a clinician to project illumination on a diseased portion of the eye. The clinician typically views the eye through the microscope and the optical module during treatment.
摘要翻译：用于激发光敏剂的系统和方法被配置为在目标眼睛组织上提供期望的照明。励磁系统包括产生照明的光学模块和用于为光学模块供电并控制形状，强度或能量水平以及照明持续时间的控制器。光学模块包括用于与眼睛接口的接触部分，包括光发射器阵列以产生成形光图案的光束部分和用于将光图案聚焦到眼睛上的光学元件，以及可视化部分，以通过以下方式提供治疗的视觉反馈：可视化界面与显微镜相结合。典型的治疗包括光学模块被临床医生放置在患者的患病眼睛上以在眼睛的患病部分上投影照明。临床医生通常在治疗期间通过显微镜和光学模块观察眼睛。

10. 发明授权

US06520669B1 Flexible substrate mounted solid-state light sources for exterior vehicular lighting 失效
标题翻译：用于室外照明的柔性基板安装固态光源
公开(公告)号：US06520669B1
公开(公告)日：2003-02-18
申请号：US09597931
申请日：2000-06-19
申请人： James C. Chen , Darrin Huston
发明人： James C. Chen , Darrin Huston
IPC分类号： F21W10114
CPC分类号： G09F9/301 , B60Q1/2696 , F21S41/143 , F21S43/14 , F21S43/315 , F21V7/0091 , F21Y2115/10 , H01L2224/48091 , H01L2224/48227 , H01L2224/48228 , H01L2224/73265 , H01L2224/85801 , H01L2224/8585 , Y10S362/80 , H01L2924/00014
摘要： Exterior lighting assemblies for use on vehicles include a flexible substrate on which are mounted a plurality of solid-state light emitting devices. Preferably, light emitting diodes (LEDs) are used for the solid-state light emitting devices, although other types of devices can alternatively be employed. The light emitting devices are connected to flexible conductive traces provided on the flexible substrate and leads are provided to connect to the power supply on the vehicle so that electrical current can be selectively supplied to energize the light emitting devices. The flexible substrate is adapted to be mounted on the exterior surface of a vehicle, for example, as a tail lamp assembly, or as a headlamp. Light emitting devices that emit different colored light can be used to provide red light to indicate slowing of the vehicle due to braking, amber light for turn signal indication, and white light to illuminate the surface over which the vehicle is traveling. A flexible optically transparent cover protects the light emitting devices. Due to their flexibility, the light assemblies can be conformed around a curved exterior surface of a vehicle.
摘要翻译：用于车辆的外部照明组件包括柔性基板，其上安装有多个固态发光装置。优选地，发光二极管（LED）用于固态发光器件，但是也可以采用其他类型的器件。发光器件连接到设置在柔性基板上的柔性导电迹线，并且提供引线以连接到车辆上的电源，使得可以选择性地提供电流以激励发光器件。柔性基板适于安装在车辆的外表面上，例如，作为尾灯组件或头灯。可以使用发射不同颜色的光的发光装置来提供红光，以指示由于制动而导致的车辆减速，用于转向信号指示的琥珀色光，以及照亮车辆行驶的表面的白光。柔性光学透明盖保护发光器件。由于它们的灵活性，灯组件可以围绕车辆的弯曲外表面。

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