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1. 发明申请

US20060115871A1 Protein interaction reporter agents and methods for using same 失效
公开(公告)号：US20060115871A1
公开(公告)日：2006-06-01
申请号：US11282403
申请日：2005-11-18
申请人： James Bruce , Xiaoting Tang , Gerhard Munske
发明人： James Bruce , Xiaoting Tang , Gerhard Munske
IPC分类号： C12Q1/37 , C07D498/02 , C07D403/02
CPC分类号： C12Q1/37 , C07D207/46 , C07D403/14 , C07D495/04 , G01N33/542 , G01N33/6848
摘要： Particular aspects provide novel protein interaction reporter (PIR) compounds (e.g., formulas I and II), comprising at least two protein reactive moieties (e.g., N-hydroxysuccinamide), each linked to a reporter moiety (e.g., mass reporter) by a covalent labile bond that is differentially cleavable with respect to peptide bonds (e.g., by a method such as collisional activation in a mass spectrometer, activation by electron capture dissociation (ECD), photoactivation, etc.), wherein the reporter moiety is operatively releasable from the PIR agent upon cleavage of the labile bonds, the released reporter moiety having a characteristic identifying property or label (e.g., m/z value). Particular PIRs comprise a mass reporter moiety, and further comprise an affinity group, (e.g., biotin), linked to the PIR (e.g., to the mass reporter moiety) by a selectively cleavable bone (e.g. photo-labile bond)). Additional aspects provide methods for characterizing intermolecular or intramolecular protein interactions using one or more inventive PIR compounds.

2. 发明申请

US20050032190A1 Beta-secretase substrates and uses thereof 有权
标题翻译： β-分泌酶底物及其用途
公开(公告)号：US20050032190A1
公开(公告)日：2005-02-10
申请号：US10480954
申请日：2002-05-17
申请人： Stephen Brady , James Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules Shafer , Xiaoting Tang
发明人： Stephen Brady , James Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules Shafer , Xiaoting Tang
IPC分类号： A61K38/00 , C07K5/107 , C07K5/11 , C07K5/113 , C07K7/06 , C07K14/47 , C07K16/18 , C12P21/06 , C12P21/08 , C12Q1/37 , G01N33/68 , C12N9/64 , C07K16/40 , G01N33/53 , G01N33/567
CPC分类号： C12Q1/37 , C07K7/06 , C07K14/4711 , C12P21/06 , G01N33/6896 , G01N2500/00
摘要： The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.
摘要翻译：本发明提供用于测量β-分泌酶活性的各种测定中的合成β-分泌酶肽底物。公开了在各种测定中识别合成底物和抗体应用的抗体。本文所公开的肽底物的水解速度明显快于从其中衍生出底物序列的瑞典突变体APP。

3. 发明申请

US20070184488A1 Beta-secretase substrates and uses thereof 失效
标题翻译： β-分泌酶底物及其用途
公开(公告)号：US20070184488A1
公开(公告)日：2007-08-09
申请号：US11523507
申请日：2006-09-19
申请人： Stephen Brady , James Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules Shafer , Xiaoting Tang
发明人： Stephen Brady , James Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules Shafer , Xiaoting Tang
IPC分类号： G01N33/53 , C07K16/40
CPC分类号： C12Q1/37 , C07K7/06 , C07K14/4711 , C12P21/06 , G01N33/6896 , G01N2500/00
摘要： The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.
摘要翻译：本发明提供用于测量β-分泌酶活性的各种测定中的合成β-分泌酶肽底物。公开了在各种测定中识别合成底物和抗体应用的抗体。本文所公开的肽底物的水解速度明显快于从其中衍生出底物序列的瑞典突变体APP。

4. 发明授权

US07814025B2 Methods and apparatus for title protocol, authentication, and sharing 有权
标题翻译：标题协议，认证和共享的方法和装置
公开(公告)号：US07814025B2
公开(公告)日：2010-10-12
申请号：US10439629
申请日：2003-05-15
申请人： Stefan Roever , Kevin Collins , Josh C. Ding , Alex F. Clark , James Bruce
发明人： Stefan Roever , Kevin Collins , Josh C. Ding , Alex F. Clark , James Bruce
IPC分类号： G06Q99/00
CPC分类号： G06Q50/184 , G06F21/10 , G06F21/6218 , G06F2221/07 , G06Q20/027 , G06Q20/0855 , G06Q20/367 , G06Q20/382 , G06Q20/401 , G06Q40/04
摘要： A title management apparatus resident on a first computer including a memory for storing a control program and data, and a processor for executing the control program and for managing the data. The apparatus includes a title object resident in the memory including a title structure, the title structure further comprising a content element, a set of attributes, and a set of title object security indicia. The apparatus further includes an authorization structure configured to selectively redeem the content element based at least in part on the user security indicia, and further configured to use a set of protocols. The apparatus also includes a title management structure configured to associate a user with the title object based at least in part on the user data and the title attributes.
摘要翻译：驻留在包括用于存储控制程序和数据的存储器的第一计算机上的标题管理装置，以及用于执行控制程序和用于管理数据的处理器。该装置包括驻留在存储器中的标题对象，其包括标题结构，标题结构还包括内容元素，一组属性以及一组标题对象安全标记。该装置还包括被配置为至少部分地基于用户安全标记来选择性地兑换内容元素的授权结构，并且还被配置为使用一组协议。该装置还包括标题管理结构，其被配置为至少部分地基于用户数据和标题属性将用户与标题对象相关联。

5. 发明申请

US20100161444A1 METHODS OF FACILITATING MERCHANT TRANSACTIONS USING A COMPUTERIZED SYSTEM INCLUDING A SET OF TITLES 有权
标题翻译：使用包含一组标题的计算机系统促进商业交易的方法
公开(公告)号：US20100161444A1
公开(公告)日：2010-06-24
申请号：US12716089
申请日：2010-03-02
申请人： Stefan Roever , Kevin Collins , Josh C. Ding , Alex F. Clark , James Bruce
发明人： Stefan Roever , Kevin Collins , Josh C. Ding , Alex F. Clark , James Bruce
IPC分类号： G06Q99/00 , G06Q30/00 , G06Q50/00
CPC分类号： G06Q30/0601 , G06Q20/04 , G06Q20/12 , G06Q20/123 , G06Q20/382 , G06Q30/06 , G06Q30/0641
摘要： A method of facilitating a transaction between a merchant and a buyer using a computerized system including a set of titles. The method includes storing the set of titles in a merchant site corresponding to a set of products for sale; browsing the merchant site using a client device and selecting a product for purchase; and generating a payment slip title for the product including information relating to a payment amount and a buyer identifier. The method further includes selecting a payment structure from a set of available payment structures; modifying the payment slip title to include information corresponding to the selected payment structure; releasing the product title to the buyer; and transmitting the payment amount to the merchant.
摘要翻译：一种使用包括一组标题的计算机化系统促进商家和买方之间的交易的方法。该方法包括：将一组标题存储在与要销售的一组产品相对应的商家站点中; 使用客户端设备浏览商家站点并选择要购买的产品; 并产生包括与支付金额和买方标识符有关的信息的产品的支付单标题。该方法还包括从一组可用支付结构中选择支付结构; 修改付款单标题以包括对应于所选择的支付结构的信息; 向买方发放产品标题; 并将支付金额发送给商家。

6. 发明申请

US20050038707A1 Methods and apparatus for enabling transactions in networks 审中-公开
标题翻译：实现网络交易的方法和设备
公开(公告)号：US20050038707A1
公开(公告)日：2005-02-17
申请号：US10873841
申请日：2004-06-21
申请人： Stefan Roever , Kevin Collins , James Bruce
发明人： Stefan Roever , Kevin Collins , James Bruce
IPC分类号： G06Q20/00 , G06Q30/00 , G06F17/60
CPC分类号： G06Q30/06 , G06Q20/12 , G06Q20/202
摘要： Methods and apparatus are described which enable transactions in electronic networks relating to digital assets, e.g., digital goods or services, through the use of title objects. A title object may have a number of elements and attributes which identify one or more digital assets and define access rights to the corresponding digital asset(s).
摘要翻译：描述了通过使用标题对象来实现与数字资产（例如数字商品或服务）相关的电子网络中的交易的方法和装置。标题对象可以具有多个元素和属性，其标识一个或多个数字资产并且定义对相应数字资产的访问权限。

7. 发明授权

US06180779B2 Release and isolation of O-glycans 失效
标题翻译：释放和分离O-聚糖
公开(公告)号：US06180779B2
公开(公告)日：2001-01-30
申请号：US08032166
申请日：1993-03-12
申请人： Rajesh Bhikhu Parekh , Anthony Hugh Merry , James Bruce
发明人： Rajesh Bhikhu Parekh , Anthony Hugh Merry , James Bruce
IPC分类号： C07H100
CPC分类号： G01N1/28 , B01L7/00 , C07H1/00 , C07H1/06 , G01N30/06 , G01N30/24 , G01N30/466 , G01N30/6043 , G01N30/6091 , G01N35/00712 , G01N2030/8881 , G01N2035/00376 , G01N2035/00415 , G01N30/30
摘要： O-glycan is released from a glycoconjugate with a substantially anhydrous hydrazine reagent, the glycoconjugate being substantially salt-free and substantially anhydrous. Released O-glycan is recovered in substantially unreduced and intact form using a chromatographic material.
摘要翻译： O-聚糖由具有基本上无水的肼试剂的糖缀合物释放，糖缀合物基本上是无盐且基本上无水的。使用色谱材料以基本上未还原和完整的形式回收释放的O-聚糖。

8. 发明授权

US5422079A Automated process equipment 失效
标题翻译：自动化工艺设备
公开(公告)号：US5422079A
公开(公告)日：1995-06-06
申请号：US159507
申请日：1993-11-30
申请人： Rajesh B. Parekh , Anthony H. Merry , James Bruce , Antonis C. Ioannides , Albert E. Platt
发明人： Rajesh B. Parekh , Anthony H. Merry , James Bruce , Antonis C. Ioannides , Albert E. Platt
IPC分类号： B01L7/00 , C07H1/00 , C07H1/06 , G01N1/28 , G01N30/06 , G01N30/24 , G01N30/46 , G01N30/60 , G01N30/88 , G01N35/00 , G01N33/00
CPC分类号： B01L7/00 , C07H1/00 , C07H1/06 , G01N1/28 , G01N30/24 , G01N35/00712 , G01N2030/8881 , G01N2035/00376 , G01N2035/00415 , G01N30/06 , G01N30/466 , G01N30/6043 , G01N30/6091
摘要： An instrument that is particularly designed for the automatic release and isolation saccharides from glycoconjugates comprises a source of inert gas that can be passed along a line, to bring together all the required reagents with the sample, heat the sample in the presence of the reagents for the required time and at the required temperature, pass the resultant mixtures through chromatographic columns, and deliver the separated material to a collection point. The release and separation can be conducted on two samples of glycoconjugate simultaneously, even when the samples are of different glycoconjugates requiring different processing parameters. The material of one sample can be prevented from mixing with or otherwise contaminating the material of the other sample.
摘要翻译：特别设计用于自动释放和分离来自糖缀合物的糖的仪器包括可以沿线通过的惰性气体源，以将所有所需的试剂与样品组合在一起，在样品存在下加热样品所需时间和所需温度，将所得混合物通过色谱柱，并将分离的物质输送到收集点。即使当样品具有不同的糖缀合物需要不同的加工参数时，也可以同时对两个糖缀合物样品进行释放和分离。可以防止一个样品的材料与另一个样品的材料混合或以其他方式污染另一个样品的材料。

9. 发明申请

US20100162408A1 METHODS AND APPARATUS FOR TITLE STRUCTURE AND MANAGEMENT 有权
标题翻译：标题结构与管理方法与装置
公开(公告)号：US20100162408A1
公开(公告)日：2010-06-24
申请号：US12717007
申请日：2010-03-03
申请人： Stefan Roever , Kevin Collins , Josh C. Ding , Alex F. Clark , James Bruce
发明人： Stefan Roever , Kevin Collins , Josh C. Ding , Alex F. Clark , James Bruce
IPC分类号： G06F21/00
CPC分类号： G06Q50/18 , G06F21/10 , G06Q10/10 , G06Q20/027 , G06Q20/0855 , G06Q20/12 , G06Q20/1235 , G06Q20/382 , G06Q20/401 , G06Q30/06
摘要： A title management apparatus resident on a first computer including a memory for storing a control program and data, and a processor for executing the control program and for managing the data. The apparatus includes user data resident in the memory including a set of user security indicia. The apparatus also includes a first title object resident in the memory including a title structure, the title structure further comprising a content element, a set of attributes, and a set of title object security indicia. The apparatus further includes a set of stub objects coupled to the title object, wherein the set of stub objects can further optimize the title structure; an authorization structure configured to selectively redeem the content element based at least in part of the user security indicia; and, a title management structure configured to associate a user with the first title object based at least in part of the user data and the title attributes.
摘要翻译：驻留在包括用于存储控制程序和数据的存储器的第一计算机上的标题管理装置，以及用于执行控制程序和用于管理数据的处理器。该装置包括驻留在存储器中的用户数据，包括一组用户安全标记。该装置还包括驻留在存储器中的第一标题对象，其包括标题结构，标题结构还包括内容元素，一组属性以及一组标题对象安全性标记。所述设备还包括耦合到所述标题对象的一组存根对象，其中所述一组存根对象可进一步优化所述标题结构; 授权结构，被配置为至少部分地根据所述用户安全标记选择性地兑换所述内容元素; 以及标题管理结构，被配置为至少部分地根据用户数据和标题属性将用户与第一标题对象相关联。

10. 发明申请

US20060036548A1 Methods and apparatus for title protocol, authentication, and sharing 有权
标题翻译：标题协议，认证和共享的方法和装置
公开(公告)号：US20060036548A1
公开(公告)日：2006-02-16
申请号：US10439629
申请日：2003-05-15
申请人： Stefan Roever , Kevin Collins , Josh Ding , Alex Clark , James Bruce
发明人： Stefan Roever , Kevin Collins , Josh Ding , Alex Clark , James Bruce
IPC分类号： G06Q99/00
CPC分类号： G06Q50/184 , G06F21/10 , G06F21/6218 , G06F2221/07 , G06Q20/027 , G06Q20/0855 , G06Q20/367 , G06Q20/382 , G06Q20/401 , G06Q40/04
摘要： A title management apparatus resident on a first computer including a memory for storing a control program and data, and a processor for executing the control program and for managing the data. The apparatus includes a title object resident in the memory including a title structure, the title structure further comprising a content element, a set of attributes, and a set of title object security indicia. The apparatus further includes an authorization structure configured to selectively redeem the content element based at least in part on the user security indicia, and further configured to use a set of protocols. The apparatus also includes a title management structure configured to associate a user with the title object based at least in part on the user data and the title attributes.
摘要翻译：驻留在包括用于存储控制程序和数据的存储器的第一计算机上的标题管理装置，以及用于执行控制程序和用于管理数据的处理器。该装置包括驻留在存储器中的标题对象，其包括标题结构，标题结构还包括内容元素，一组属性以及一组标题对象安全标记。该装置还包括被配置为至少部分地基于用户安全标记来选择性地兑换内容元素的授权结构，并且还被配置为使用一组协议。该装置还包括标题管理结构，其被配置为至少部分地基于用户数据和标题属性将用户与标题对象相关联。

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