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1. 发明申请

US20060115871A1 Protein interaction reporter agents and methods for using same 失效
公开(公告)号：US20060115871A1
公开(公告)日：2006-06-01
申请号：US11282403
申请日：2005-11-18
申请人： James Bruce , Xiaoting Tang , Gerhard Munske
发明人： James Bruce , Xiaoting Tang , Gerhard Munske
IPC分类号： C12Q1/37 , C07D498/02 , C07D403/02
CPC分类号： C12Q1/37 , C07D207/46 , C07D403/14 , C07D495/04 , G01N33/542 , G01N33/6848
摘要： Particular aspects provide novel protein interaction reporter (PIR) compounds (e.g., formulas I and II), comprising at least two protein reactive moieties (e.g., N-hydroxysuccinamide), each linked to a reporter moiety (e.g., mass reporter) by a covalent labile bond that is differentially cleavable with respect to peptide bonds (e.g., by a method such as collisional activation in a mass spectrometer, activation by electron capture dissociation (ECD), photoactivation, etc.), wherein the reporter moiety is operatively releasable from the PIR agent upon cleavage of the labile bonds, the released reporter moiety having a characteristic identifying property or label (e.g., m/z value). Particular PIRs comprise a mass reporter moiety, and further comprise an affinity group, (e.g., biotin), linked to the PIR (e.g., to the mass reporter moiety) by a selectively cleavable bone (e.g. photo-labile bond)). Additional aspects provide methods for characterizing intermolecular or intramolecular protein interactions using one or more inventive PIR compounds.

2. 发明申请

US20100047814A1 PROTEIN INTERACTION REPORTER AGENTS AND METHODS FOR USING SAME 审中-公开
标题翻译：蛋白质相互作用记录剂及其使用方法
公开(公告)号：US20100047814A1
公开(公告)日：2010-02-25
申请号：US12423459
申请日：2009-04-14
申请人： James E. Bruce , Xiaoting Tang , Gerhard Munske
发明人： James E. Bruce , Xiaoting Tang , Gerhard Munske
IPC分类号： G01N33/53
CPC分类号： C12Q1/37 , C07D207/46 , C07D403/14 , C07D495/04 , G01N33/542 , G01N33/6848
摘要： Particular aspects provide novel protein interaction reporter (PIR) compounds (e.g., formulas I and II), comprising at least two protein reactive moieties (e.g., N-hydroxysuccinamide), each linked to a reporter moiety (e.g., mass reporter) by a covalent labile bond that is differentially cleavable with respect to peptide bonds (e.g., by a method such as collisional activation in a mass spectrometer, activation by electron capture dissociation (ECD), photoactivation, etc.), wherein the reporter moiety is operatively releasable from the PIR agent upon cleavage of the labile bonds, the released reporter moiety having a characteristic identifying property or label (e.g., m/z value). Particular PIRs comprise a mass reporter moiety, and further comprise an affinity group, (e.g., biotin), linked to the PIR (e.g., to the mass reporter moiety) by a selectively cleavable bone (e.g. photo-labile bond)). Additional aspects provide methods for characterizing intermolecular or intramolecular protein interactions using one or more inventive PIR compounds.
摘要翻译：特别的方面提供新的蛋白质相互作用报告物（PIR）化合物（例如式I和II），其包含至少两个蛋白质反应性部分（例如，N-羟基琥珀酰胺），其各自通过共价键连接到报道部分（例如质量报告基团）相对于肽键可以差异地切割的不稳定键（例如，通过诸如质谱仪中的碰撞激活的方法，通过电子捕获解离的激活（ECD），光活化等），其中报道部分可操作地从裂解不稳定键时的PIR试剂，具有特征识别性质或标记的释放的报导部分（例如，m / z值）。具体的PIR包括质量报告基因部分，并且还包含通过可选择性切割的骨（例如光不稳定键）与PIR连接的亲和基团（例如，生物素）（例如与质量报告基团部分））。另外的方面提供了使用一种或多种本发明的PIR化合物表征分子间或分子内蛋白质相互作用的方法。

3. 发明授权

US07524925B2 Protein interaction reporter agents and methods for using same 失效
标题翻译：蛋白质相互作用记录剂及其使用方法
公开(公告)号：US07524925B2
公开(公告)日：2009-04-28
申请号：US11282403
申请日：2005-11-18
申请人： James E. Bruce , Xiaoting Tang , Gerhard Munske
发明人： James E. Bruce , Xiaoting Tang , Gerhard Munske
IPC分类号： C07K2/00 , C07K1/13 , C07C229/38
CPC分类号： C12Q1/37 , C07D207/46 , C07D403/14 , C07D495/04 , G01N33/542 , G01N33/6848
摘要： Particular aspects provide novel protein interaction reporter (PIR) compounds (e.g., formulas I and II), comprising at least two protein reactive moieties (e.g., N-hydroxysuccinamide), each linked to a reporter moiety (e.g., mass reporter) by a covalent labile bond that is differentially cleavable with respect to peptide bonds (e.g., by a method such as collisional activation in a mass spectrometer, activation by electron capture dissociation (ECD), photoactivation, etc.), wherein the reporter moiety is operatively releasable from the PIR agent upon cleavage of the labile bonds, the released reporter moiety having a characteristic identifying property or label (e.g., m/z value). Particular PIRs comprise a mass reporter moiety, and further comprise an affinity group, (e.g., biotin), linked to the PIR (e.g., to the mass reporter moiety) by a selectively cleavable bone (e.g. photo-labile bond)). Additional aspects provide methods for characterizing intermolecular or intramolecular protein interactions using one or more inventive PIR compounds.
摘要翻译：特别的方面提供新的蛋白质相互作用报告物（PIR）化合物（例如式I和II），其包含至少两个蛋白质反应性部分（例如，N-羟基琥珀酰胺），其各自通过共价键连接到报道部分（例如质量报告基团）相对于肽键可以差异地切割的不稳定键（例如，通过诸如质谱仪中的碰撞激活的方法，通过电子捕获解离的激活（ECD），光活化等），其中报道部分可操作地从裂解不稳定键时的PIR试剂，具有特征识别性质或标记的释放的报导部分（例如，m / z值）。具体的PIR包括质量报告基因部分，并且还包含通过可选择性切割的骨（例如光不稳定键）与PIR连接的亲和基团（例如，生物素）（例如与质量报告基团部分））。另外的方面提供了使用一种或多种本发明的PIR化合物表征分子间或分子内蛋白质相互作用的方法。

4. 发明申请

US20050032190A1 Beta-secretase substrates and uses thereof 有权
标题翻译： β-分泌酶底物及其用途
公开(公告)号：US20050032190A1
公开(公告)日：2005-02-10
申请号：US10480954
申请日：2002-05-17
申请人： Stephen Brady , James Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules Shafer , Xiaoting Tang
发明人： Stephen Brady , James Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules Shafer , Xiaoting Tang
IPC分类号： A61K38/00 , C07K5/107 , C07K5/11 , C07K5/113 , C07K7/06 , C07K14/47 , C07K16/18 , C12P21/06 , C12P21/08 , C12Q1/37 , G01N33/68 , C12N9/64 , C07K16/40 , G01N33/53 , G01N33/567
CPC分类号： C12Q1/37 , C07K7/06 , C07K14/4711 , C12P21/06 , G01N33/6896 , G01N2500/00
摘要： The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.
摘要翻译：本发明提供用于测量β-分泌酶活性的各种测定中的合成β-分泌酶肽底物。公开了在各种测定中识别合成底物和抗体应用的抗体。本文所公开的肽底物的水解速度明显快于从其中衍生出底物序列的瑞典突变体APP。

5. 发明申请

US20070184488A1 Beta-secretase substrates and uses thereof 失效
标题翻译： β-分泌酶底物及其用途
公开(公告)号：US20070184488A1
公开(公告)日：2007-08-09
申请号：US11523507
申请日：2006-09-19
申请人： Stephen Brady , James Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules Shafer , Xiaoting Tang
发明人： Stephen Brady , James Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules Shafer , Xiaoting Tang
IPC分类号： G01N33/53 , C07K16/40
CPC分类号： C12Q1/37 , C07K7/06 , C07K14/4711 , C12P21/06 , G01N33/6896 , G01N2500/00
摘要： The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.
摘要翻译：本发明提供用于测量β-分泌酶活性的各种测定中的合成β-分泌酶肽底物。公开了在各种测定中识别合成底物和抗体应用的抗体。本文所公开的肽底物的水解速度明显快于从其中衍生出底物序列的瑞典突变体APP。

6. 发明授权

US08086637B1 Access control for business process data 有权
标题翻译：业务流程数据访问控制
公开(公告)号：US08086637B1
公开(公告)日：2011-12-27
申请号：US11644340
申请日：2006-12-22
申请人： Kenwood Tsai , Harish Rawat , Xiaoting Tang , Payam Shahidi
发明人： Kenwood Tsai , Harish Rawat , Xiaoting Tang , Payam Shahidi
IPC分类号： G06F17/30 , G06F7/00
CPC分类号： G06F21/6245 , Y10S707/944 , Y10S707/955
摘要： Controlling access to business process data is disclosed. An instance of a business process object configured to contain business process data is created. An access control list that is determined based at least in part on a business process with which the business process data is associated is associated with the business process object instance.
摘要翻译：披露了对业务流程数据的访问控制。创建了一个配置为包含业务流程数据的业务流程对象的实例。至少部分地基于与业务流程数据相关联的业务流程确定的访问控制列表与业务流程对象实例相关联。

7. 发明授权

US07132401B2 Beta-secretase substrates and uses thereof 有权
公开(公告)号：US07132401B2
公开(公告)日：2006-11-07
申请号：US10480954
申请日：2002-05-17
申请人： Stephen F. Brady , James E. Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules A. Shafer , Xiaoting Tang
发明人： Stephen F. Brady , James E. Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules A. Shafer , Xiaoting Tang
IPC分类号： A61K38/08
CPC分类号： C12Q1/37 , C07K7/06 , C07K14/4711 , C12P21/06 , G01N33/6896 , G01N2500/00
摘要： The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.

8. 发明申请

US20120072461A1 ACCESS CONTROL FOR BUSINESS PROCESS DATA 审中-公开
标题翻译：业务流程数据访问控制
公开(公告)号：US20120072461A1
公开(公告)日：2012-03-22
申请号：US13302913
申请日：2011-11-22
申请人： Kenwood Tsai , Harish Rawat , Xiaoting Tang , Payam Shahidi
发明人： Kenwood Tsai , Harish Rawat , Xiaoting Tang , Payam Shahidi
IPC分类号： G06F17/30
CPC分类号： G06F21/6245 , Y10S707/944 , Y10S707/955
摘要： Controlling access to business process data is disclosed. An instance of a first business process object configured to contain business process data of a business process is created. An instance of a second business process object configured to contain business process data of the business process is created. A first access control list is associated with the instance of the first business process object and a second access control list is associated with the instance of the second business process object.
摘要翻译：披露了对业务流程数据的访问控制。创建配置为包含业务流程的业务流程数据的第一业务流程对象的实例。创建了配置为包含业务流程的业务流程数据的第二个业务流程对象的实例。第一访问控制列表与第一业务流程对象的实例相关联，并且第二访问控制列表与第二业务流程对象的实例相关联。

9. 发明授权

US07479372B2 Beta-secretase substrates and uses thereof 失效
标题翻译： β-分泌酶底物及其用途
公开(公告)号：US07479372B2
公开(公告)日：2009-01-20
申请号：US11523507
申请日：2006-09-19
申请人： Stephen F. Brady , James E. Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules A. Shafer , Xiaoting Tang
发明人： Stephen F. Brady , James E. Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules A. Shafer , Xiaoting Tang
IPC分类号： G01N33/53
CPC分类号： C12Q1/37 , C07K7/06 , C07K14/4711 , C12P21/06 , G01N33/6896 , G01N2500/00
摘要： The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.
摘要翻译：本发明提供用于测量β-分泌酶活性的各种测定中的合成β-分泌酶肽底物。公开了在各种测定中识别合成底物和抗体应用的抗体。本文所公开的肽底物的水解速度明显快于从其中衍生出底物序列的瑞典突变体APP。

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