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1. 发明授权

US09240002B2 Systems and methods for a graphical interface including a graphical representation of medical data 有权
标题翻译：图形界面的系统和方法，包括医疗数据的图形表示
公开(公告)号：US09240002B2
公开(公告)日：2016-01-19
申请号：US13588026
申请日：2012-08-17
申请人： James A. Hume , Robert M. Hume , Robert Mayer , Devy Amy Lee , Gabriele Ott , Candida Arvelo , Timothy L. Ruchti , Tamas Ban , Mohammad M. Khair , Nancy H. Hedlund
发明人： James A. Hume , Robert Mayer , Devy Amy Lee , Gabriele Ott , Candida Arvelo , Timothy L. Ruchti , Tamas Ban , Mohammad M. Khair , Nancy H. Hedlund
IPC分类号： G06F3/048 , G06Q10/10 , G06Q50/22 , G06F19/00
CPC分类号： G06Q10/10 , A61M2205/502 , A61M2205/52 , G06F19/00 , G06F19/3468 , G06Q50/22 , G16H10/60 , G16H15/00 , G16H40/63 , G16H50/20 , G16H50/70
摘要： This disclosure describes systems and methods for a graphical interface including a graphical representation of medical data. The graphical interface platform may receive medical data and provide medical safety reporting capabilities including reporting of history data and real-time visual monitoring data. The graphical interface platform may be configured to identify potential problems and corrections to medical devices in operation while a reporting cycle is underway through visual representation of performance metrics.
摘要翻译：本公开描述了用于包括医学数据的图形表示的图形界面的系统和方法。图形界面平台可以接收医疗数据并提供医疗安全报告功能，包括历史数据的报告和实时的可视化监视数据。图形界面平台可以被配置为在通过可视表示性能度量进行报告周期的同时，识别在操作中的医疗设备的潜在问题和修正。

2. 发明申请

US20130047113A1 Systems and Methods for a Graphical Interface including a Graphical Representation of Medical Data 有权
标题翻译：包括医学数据图形表示的图形界面的系统和方法
公开(公告)号：US20130047113A1
公开(公告)日：2013-02-21
申请号：US13588026
申请日：2012-08-17
申请人： Robert Mayer , Devy Amy Lee , Gabriele Ott , Candida Arvelo , Timothy L. Ruchti , Tamas Ban , Mohammad M. Khair , Nancy H. Hedlund , Robert M. Hume
发明人： James A. Hume , Robert Mayer , Devy Amy Lee , Gabriele Ott , Candida Arvelo , Timothy L. Ruchti , Tamas Ban , Mohammad M. Khair , Nancy H. Hedlund
IPC分类号： G06F3/048
CPC分类号： G06Q10/10 , A61M2205/502 , A61M2205/52 , G06F19/00 , G06F19/3468 , G06Q50/22 , G16H10/60 , G16H15/00 , G16H40/63 , G16H50/20 , G16H50/70
摘要： This disclosure describes systems and methods for a graphical interface including a graphical representation of medical data. The graphical interface platform may receive medical data and provide medical safety reporting capabilities including reporting of history data and real-time visual monitoring data. The graphical interface platform may be configured to identify potential problems and corrections to medical devices in operation while a reporting cycle is underway through visual representation of performance metrics.
摘要翻译：本公开描述了用于包括医学数据的图形表示的图形界面的系统和方法。图形界面平台可以接收医疗数据并提供医疗安全报告功能，包括历史数据的报告和实时的可视化监视数据。图形界面平台可以被配置为在通过可视表示性能度量进行报告周期的同时，识别在操作中的医疗设备的潜在问题和修正。

3. 发明申请

US20130158504A1 SYSTEM FOR MONITORING AND DELIVERING MEDICATION TO A PATIENT AND METHOD OF USING THE SAME TO MINIMIZE THE RISKS ASSOCIATED WITH AUTOMATED THERAPY 有权
标题翻译：用于监测和传递药物给患者的系统及其使用方法以最小化与自动治疗相关的风险
公开(公告)号：US20130158504A1
公开(公告)日：2013-06-20
申请号：US13714545
申请日：2012-12-14
申请人： Timothy L. Ruchti , Mohammad M. Khair
发明人： Timothy L. Ruchti , Mohammad M. Khair
IPC分类号： A61M5/172
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/4839 , G06F19/00 , G06F19/3468 , G16H20/17 , G16H50/30 , G16H50/50
摘要： A system and method for monitoring and delivering medication to a patient includes a controller that has a control algorithm and a closed loop control that monitors the control algorithm. A sensor is in communication with the controller and monitors a medical condition. A rule base application in the controller receives data from the sensor and the closed loop control and compares the data to predetermined medical information to determine the risk of automation of therapy to the patient. The controller then provides a predetermined risk threshold where below the predetermined risk threshold automated closed loop medication therapy is provided. If the predetermined risk threshold is met or exceeded, automated therapy adjustments may not occur and user/clinician intervention is requested.
摘要翻译：用于向患者监测和递送药物的系统和方法包括具有控制算法和控制算法的闭环控制的控制器。传感器与控制器通信并监测医疗状况。控制器中的规则库应用程序从传感器接收数据和闭环控制，并将数据与预定的医疗信息进行比较，以确定对患者的治疗自动化的风险。然后，控制器提供预定的风险阈值，其中低于预定风险阈值提供了自动闭环药物治疗。如果满足或超过预定风险阈值，则可能不会发生自动治疗调整，并且请求用户/临床医生干预。

4. 发明授权

US09498583B2 Froth detection system and method 有权
标题翻译：泡沫检测系统及方法
公开(公告)号：US09498583B2
公开(公告)日：2016-11-22
申请号：US13630031
申请日：2012-09-28
申请人： Kunal Sur , Paul T. Kotnik , Anatoly S. Belkin , John Hicks Dumas, III , Timothy L. Ruchti
发明人： Kunal Sur , Paul T. Kotnik , Anatoly S. Belkin , John Hicks Dumas, III , Timothy L. Ruchti
IPC分类号： A61M5/36 , A61M1/36 , G06F19/00 , A61M5/142
CPC分类号： A61M5/365 , A61M1/3626 , A61M5/142 , A61M2205/3375 , G06F19/00 , G06F19/3481
摘要： An infusion system includes a pump, a fluid delivery line, at least one sensor, a processor, and a memory. The fluid delivery line is connected to the pump for delivering fluid. The at least one sensor is connected to the fluid delivery line for emitting and receiving signals to detect whether there is air in the fluid delivery line. The processor is in electronic communication with the pump and the at least one sensor. The memory is in electronic communication with the processor. The memory comprises programming code for execution by the processor. The programming code is configured to determine a percentage of the air within an observed volume of the fluid delivery line.
摘要翻译：输液系统包括泵，流体输送管线，至少一个传感器，处理器和存储器。流体输送管线连接到泵以输送流体。所述至少一个传感器连接到所述流体输送管线，用于发出和接收信号以检测所述流体输送管线中是否存在空气。处理器与泵和至少一个传感器电子通信。存储器与处理器进行电子通信。存储器包括用于由处理器执行的编程代码。编程代码被配置为确定流体输送管线的观察体积内的空气的百分比。

5. 发明授权

US09114217B2 Pattern recognition system and method for the detection of stuck fluid droplets in a fluid delivery line of an infusion system 有权
标题翻译：用于检测输注系统的流体输送管线中粘滞的液滴的模式识别系统和方法
公开(公告)号：US09114217B2
公开(公告)日：2015-08-25
申请号：US13588049
申请日：2012-08-17
申请人： Kunal Sur , Paul T. Kotnik , Anatoly S. Belkin , John Hicks Dumas, III , Timothy L. Ruchti
发明人： Kunal Sur , Paul T. Kotnik , Anatoly S. Belkin , John Hicks Dumas, III , Timothy L. Ruchti
IPC分类号： G06F11/30 , A61M5/36 , A61M5/142
CPC分类号： A61M5/365 , A61M5/142 , A61M2205/18 , A61M2205/50
摘要： An infusion system includes a pump, a fluid delivery line, a sensor, a processor, and a memory. The fluid delivery line is connected to the pump for delivering fluid. The sensor is connected to the fluid delivery line for emitting and receiving signals to detect whether there is air in the fluid delivery line. The processor is in electronic communication with the pump and the sensor. The memory is in electronic communication with the processor. The memory includes programming code for execution by the processor. The programming code is configured to analyze the signals to determine if a stuck fluid droplet is stuck within the fluid delivery line at a location of the sensor.
摘要翻译：输液系统包括泵，流体输送管线，传感器，处理器和存储器。流体输送管线连接到泵以输送流体。传感器连接到流体输送管线，用于发出和接收信号，以检测流体输送管线中是否有空气。处理器与泵和传感器电子通信。存储器与处理器进行电子通信。存储器包括用于由处理器执行的编程代码。编程代码被配置为分析信号以确定在传感器的位置处的卡住的流体液滴是否粘附在流体输送管线内。

6. 再颁专利

USRE41333E1 Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction 失效
标题翻译：开发用于非侵入性血液分析物预测的局部校准模型的多层方法
公开(公告)号：USRE41333E1
公开(公告)日：2010-05-11
申请号：US11046673
申请日：2005-01-27
申请人： Thomas B. Blank , Stephen L. Monfre , Timothy L. Ruchti , Suresh N. Thennadill
发明人： Thomas B. Blank , Stephen L. Monfre , Timothy L. Ruchti , Suresh N. Thennadill
IPC分类号： A61B5/1455
CPC分类号： G01N21/274 , A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/7264 , A61B2560/0223 , A61B2560/0233 , G01N21/359 , G01N21/4785 , G01N21/49
摘要： A method of multi-tier classification and calibration in noninvasive blood analyte prediction minimizes prediction error by limiting co-varying spectral interferents. Tissue samples are categorized based on subject demographic and instrumental skin measurements, including in vivo near-IR spectral measurements. A multi-tier intelligent pattern classification sequence organizes spectral data into clusters having a high degree of internal consistency in tissue properties. In each tier, categories are successively refined using subject demographics, spectral measurement information and other device measurements suitable for developing tissue classifications.The multi-tier classification approach to calibration utilizes multivariate statistical arguments and multi-tiered classification using spectral features. Variables used in the multi-tiered classification can be skin surface hydration, skin surface temperature, tissue volume hydration, and an assessment of relative optical thickness of the dermis by the near-IR fat band. All tissue parameters are evaluated using the NIR spectrum signal along key wavelength segments.
摘要翻译：非侵入性血液分析物预测中的多层分类和校准方法通过限制共同变化的光谱干扰来最小化预测误差。组织样品根据受试者的人口统计学和仪器皮肤测量进行分类，包括体内近红外光谱测量。多层智能图案分类序列将光谱数据组织成具有组织性质内部高度一致性的簇。在每个层次中，使用主题人口统计学，光谱测量信息和适合于开发组织分类的其它装置测量法来连续地改进类别。校准的多层分类方法利用多变量统计学参数和使用光谱特征的多层次分类。用于多层次分类的变量可以是皮肤表面水合，皮肤表面温度，组织体积水合，以及近红外脂肪带对真皮的相对光学厚度的评估。使用沿关键波长段的NIR光谱信号评估所有组织参数。

7. 发明授权

US07317938B2 Method of adapting in-vitro models to aid in noninvasive glucose determination 失效
标题翻译：适应体外模型以帮助非侵入性葡萄糖测定的方法
公开(公告)号：US07317938B2
公开(公告)日：2008-01-08
申请号：US10978116
申请日：2004-10-29
申请人： Alexander D. Lorenz , Timothy L. Ruchti
发明人： Alexander D. Lorenz , Timothy L. Ruchti
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2560/0233 , G01N21/278 , G01N21/359
摘要： The invention relates to a noninvasive analyzer and a method of using information determined at least in part from in-vitro spectra of tissue phantoms or analyte solutions to aid in the development of a noninvasive glucose concentration analyzer and/or in the analysis of noninvasive spectra resulting in glucose concentration estimations in the body. The preferred apparatus is a spectrometer that includes a base module and a sample module that is semi-continuously in contact with a human subject and that collects spectral measurements which are used to determine a biological parameter in the sampled tissue, such as glucose concentration. Collection of in-vitro samples is, optionally, performed on a separate instrument from the production model allowing the measurement technology to be developed on a research grade instrument and used or transferred to a target product platform or production analyzer for noninvasive glucose concentration estimation.
摘要翻译：本发明涉及非侵入性分析仪和使用至少部分地从组织模型或分析物溶液的体外光谱确定的信息的方法，以帮助非侵入性葡萄糖浓度分析仪的开发和/或在非侵入性光谱的分析中得到在体内的葡萄糖浓度估计。优选的装置是一种光谱仪，其包括基本模块和与人类受试者半连续接触的样本模块，并收集用于确定采样组织中的生物学参数（如葡萄糖浓度）的光谱测量。体外样品的收集可选地在与生产模型分开的仪器上进行，允许在研究级仪器上开发测量技术，并将其用于或转移到用于非侵入性葡萄糖浓度估计的目标产物平台或生产分析仪。

8. 发明授权

US07233816B2 Optical sampling interface system for in vivo measurement of tissue 有权
公开(公告)号：US07233816B2
公开(公告)日：2007-06-19
申请号：US10917802
申请日：2004-08-12
申请人： Thomas B. Blank , George Acosta , Mutua Mattu , Marcy Makarewicz , Stephen L. Monfre , Alexander D. Lorenz , Timothy L. Ruchti
发明人： Thomas B. Blank , George Acosta , Mutua Mattu , Marcy Makarewicz , Stephen L. Monfre , Alexander D. Lorenz , Timothy L. Ruchti
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0071 , A61B5/0075 , A61B5/01 , A61B5/061 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/6824 , A61B5/6833 , A61B5/6843 , A61B2560/0233 , A61B2562/12 , A61B2562/146
摘要： An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement. Separate components of system can be individually deployed.

9. 发明授权

US07010336B2 Measurement site dependent data preprocessing method for robust calibration and prediction 失效
公开(公告)号：US07010336B2
公开(公告)日：2006-03-07
申请号：US10384023
申请日：2003-03-07
申请人： Alexander D. Lorenz , Timothy L. Ruchti , Thomas B. Blank , Kevin H. Hazen
发明人： Alexander D. Lorenz , Timothy L. Ruchti , Thomas B. Blank , Kevin H. Hazen
IPC分类号： A61B5/00
CPC分类号： G01N21/359 , A61B5/0075 , A61B5/14532 , A61B5/1455 , A61B5/1495 , G01N21/49
摘要： A solution for reducing interference in noninvasive spectroscopic measurements of tissue and blood analytes is provided. By applying a basis set representing various tissue components to a collected sample measurement, measurement interferences resulting from the heterogeneity of tissue, sampling site differences, patient-to-patient variation, physiological variation, and instrumental differences are reduced. Consequently, the transformed sample measurements are more suitable for developing calibrations that are robust with respect to sample-to-sample variation, variation through time, and instrument related differences. In the calibration phase, data associated with a particular tissue sample site is corrected using a selected subset of data within the same data set. This method reduces the complexity of the data and reduces the intra-subject, inter-subject, and inter-instrument variations by removing interference specific to the respective data subset. In the measurement phase, the basis set correction is applied using a minimal number of initial samples collected from the sample site(s) where future samples will be collected.

10. 发明授权

US06990364B2 Noninvasive measurement of glucose through the optical properties of tissue 有权
标题翻译：通过组织的光学性质对葡萄糖进行无创测量
公开(公告)号：US06990364B2
公开(公告)日：2006-01-24
申请号：US10297736
申请日：2002-01-25
申请人： Timothy L. Ruchti , Suresh N. Thennadil , Thomas B. Blank , Alexander Lorenz , Stephen L. Monfre
发明人： Timothy L. Ruchti , Suresh N. Thennadil , Thomas B. Blank , Alexander Lorenz , Stephen L. Monfre
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/1495 , A61B2560/0223 , G01N21/31 , G01N21/33 , G01N21/359 , G01N2021/3595
摘要： Methods and apparatus for noninvasive determination of blood analytes, such as glucose, through NIR spectroscopy utilize optical properties of tissue as reflected in key spectroscopic features to improve measurement accuracy and precision. Physiological conditions such as changes in water distribution among tissue compartments lead to complex alterations in the measured absorbance spectrum of skin and reflect a modification in the effective pathlength of light, leading to a biased noninvasive glucose measurement. Changes in the optical properties of tissue are detected by identifying key features responsive to physiological variations. Conditions not conducive to noninvasive measurement of glucose are detected. Noninvasive glucose measurements that are biased by physiological changes in tissue are compensated. In an alternate embodiment, glucose is measured indirectly based on natural physiological response of tissue to glucose concentration. A spectroscopic device capable of such measurements is provided.
摘要翻译：通过近红外光谱对血液分析物（如葡萄糖）进行无创测定的方法和设备利用关键光谱特征反映的组织光学性质来提高测量精度和精度。生理条件如组织间隔水分配变化导致测量的皮肤吸收光谱的复杂变化，并反映了有效光线长度的变化，导致偏向的非侵入性葡萄糖测量。通过识别响应于生理变化的关键特征来检测组织的光学性质的变化。检测不利于葡萄糖无创测量的条件。通过组织中的生理变化偏置的非侵入性葡萄糖测量被补偿。在替代实施方案中，基于组织对葡萄糖浓度的天然生理反应间接测量葡萄糖。提供能够进行这种测量的光谱装置。

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