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1. 发明申请

US20080063794A1 Mesoporous Permeation Layers for Use on Active Electronic Matrix Devices 有权
标题翻译：用于有源电子矩阵器件的介孔渗透层
公开(公告)号：US20080063794A1
公开(公告)日：2008-03-13
申请号：US11855374
申请日：2007-09-14
申请人： Jainamma Krotz , Daniel Smolko , Howard Reese , Thomas Onofrey , Daguang Wang , Theodore Winger , John Havens
发明人： Jainamma Krotz , Daniel Smolko , Howard Reese , Thomas Onofrey , Daguang Wang , Theodore Winger , John Havens
IPC分类号： B05D5/04 , B05D5/00
CPC分类号： C12Q1/002 , B01D67/003 , B01D69/125 , B01D2323/18 , B01D2323/34 , B01D2323/42 , C09D123/26 , C12Q1/003 , G01N33/5438 , G01N33/545
摘要： The present invention provides improved synthetic polymer hydrogel permeation layers for use on active electronic matrix devices for biological assays. The present invention includes methods for forming a permeation layer on an array of microelectrodes including the steps of attaching a linker to the surface of the array and providing a polymerization solution that includes a porogen. The surface of the array is then contacted with the polymerization solution and the polymerization solution is then polymerized on the surface of the array to form a permeation layer that is attached o the surface of the array through the linker. The porogen is then removed from the permeation layer, thereby creating void spaces in the permeation layer.
摘要翻译：本发明提供了用于生物测定的活性电子基质装置上的改进的合成聚合物水凝胶渗透层。本发明包括在微电极阵列上形成渗透层的方法，包括将接头连接到阵列的表面并提供包含致孔剂的聚合溶液的步骤。然后将阵列的表面与聚合溶液接触，然后聚合溶液在阵列的表面上聚合，形成通过接头连接在阵列表面上的渗透层。然后从渗透层除去致孔剂，从而在渗透层中产生空隙。

2. 发明申请

US20050164283A1 Mesoporous permeation layers for use on active electronic matrix devices 有权
标题翻译：用于有源电子矩阵器件的介孔渗透层
公开(公告)号：US20050164283A1
公开(公告)日：2005-07-28
申请号：US11082325
申请日：2005-03-16
申请人： Jainamma Krotz , Daniel Smolko , Howard Reese , Thomas Onofrey , Daguang Wang , Theodore Winger , John Havens
发明人： Jainamma Krotz , Daniel Smolko , Howard Reese , Thomas Onofrey , Daguang Wang , Theodore Winger , John Havens
IPC分类号： G01N33/53 , A61K20060101 , B01D29/00 , B01D39/14 , B01D63/08 , B01J19/00 , C08J5/12 , C12M1/34 , C12Q1/68 , G01N27/26 , G01N27/30 , G01N27/447 , G01N33/543 , G01N33/547 , G01N33/566
CPC分类号： C12Q1/002 , B01D67/003 , B01D69/125 , B01D2323/18 , B01D2323/34 , B01D2323/42 , C09D123/26 , C12Q1/003 , G01N33/5438 , G01N33/545
摘要： The present invention provides improved synthetic polymer hydrogel permeation layers for use on active electronic matrix devices for biological assays. The present invention includes methods for forming a permeation layer on an array of microelectrodes including the steps of attaching a linker to the surface of the array by treating the surface with a linker by vapor deposition and providing a polymerization solution that includes at least one monomer having a polymerizable moiety, a modified streptavidin, a surfactant or porogen, and a cross-linking agent. The surface of the array is then contacted with the polymerization solution and the polymerization solution is then polymerized on the surface of the array to form a permeation layer that is attached o the surface of the array through the linker.
摘要翻译：本发明提供了用于生物测定的活性电子基质装置上的改进的合成聚合物水凝胶渗透层。本发明包括在微电极阵列上形成渗透层的方法，包括以下步骤：通过气相沉积用接头处理该表面，并提供包含至少一种具有至少一个单体的聚合溶液，将接头连接到阵列的表面上可聚合部分，修饰的链霉抗生物素蛋白，表面活性剂或致孔剂和交联剂。然后将阵列的表面与聚合溶液接触，然后聚合溶液在阵列的表面上聚合，形成通过接头连接在阵列表面上的渗透层。

3. 发明授权

US07597932B2 Mesoporous permeation layers for use on active electronic matrix devices 有权
标题翻译：用于有源电子矩阵器件的介孔渗透层
公开(公告)号：US07597932B2
公开(公告)日：2009-10-06
申请号：US11855374
申请日：2007-09-14
申请人： Jainamma Krotz , Daniel Smolko , Howard R. Reese , Thomas J. Onofrey , Daguang Wang , Theodore M. Winger , John R. Havens
发明人： Jainamma Krotz , Daniel Smolko , Howard R. Reese , Thomas J. Onofrey , Daguang Wang , Theodore M. Winger , John R. Havens
IPC分类号： C23C16/00 , B01D29/00 , C12Q1/68 , C12M1/34
CPC分类号： C12Q1/002 , B01D67/003 , B01D69/125 , B01D2323/18 , B01D2323/34 , B01D2323/42 , C09D123/26 , C12Q1/003 , G01N33/5438 , G01N33/545
摘要： The present invention provides improved synthetic polymer hydrogel permeation layers for use on active electronic matrix devices for biological assays. The present invention includes methods for forming a permeation layer on an array of microelectrodes including the steps of attaching a linker to the surface of the array and providing a polymerization solution that includes a porogen. The surface of the array is then contacted with the polymerization solution and the polymerization solution is then polymerized on the surface of the array to form a permeation layer that is attached o the surface of the array through the linker. The porogen is then removed from the permeation layer, thereby creating void spaces in the permeation layer.
摘要翻译：本发明提供了用于生物测定的活性电子基质装置上的改进的合成聚合物水凝胶渗透层。本发明包括在微电极阵列上形成渗透层的方法，包括将接头连接到阵列的表面并提供包含致孔剂的聚合溶液的步骤。然后将阵列的表面与聚合溶液接触，然后聚合溶液在阵列的表面上聚合，形成通过接头连接在阵列表面上的渗透层。然后从渗透层除去致孔剂，从而在渗透层中产生空隙。

4. 发明授权

US06960298B2 Mesoporous permeation layers for use on active electronic matrix devices 有权
标题翻译：用于有源电子矩阵器件的介孔渗透层
公开(公告)号：US06960298B2
公开(公告)日：2005-11-01
申请号：US10014895
申请日：2001-12-10
申请人： Jainamma Krotz , Daniel Smolko , Howard R. Reese , Thomas J. Onofrey , Daguang Wang , Theodore M. Winger , John R. Havens
发明人： Jainamma Krotz , Daniel Smolko , Howard R. Reese , Thomas J. Onofrey , Daguang Wang , Theodore M. Winger , John R. Havens
IPC分类号： G01N33/53 , A61K20060101 , B01D29/00 , B01D39/14 , B01D63/08 , B01J19/00 , C08J5/12 , C12M1/34 , C12Q1/68 , G01N27/26 , G01N27/30 , G01N27/447 , G01N33/543 , G01N33/547 , G01N33/566
CPC分类号： C12Q1/002 , B01D67/003 , B01D69/125 , B01D2323/18 , B01D2323/34 , B01D2323/42 , C09D123/26 , C12Q1/003 , G01N33/5438 , G01N33/545
摘要： The present invention provides improved synthetic polymer hydrogel permeation layers for use on active electronic matrix devices for biological assays. The permeation layers have a defined porous character, with mesopores in a size range between about 100 nanometers and about 1000 nanometers, and may also have micropores in the micrometer size range. The mesoporous synthetic hydrogel permeation layers demonstrate improved signal intensity and linearity characteristics as compared to nanoporous synthetic hydrogel permeation layers on active electronic matrix devices. In addition, the present invention also provides synthetic polymer hydrogel permeation layers which contain copolymerized attachment sites for nucleic acid probes or other biomolecules.
摘要翻译：本发明提供了用于生物测定的活性电子基质装置上的改进的合成聚合物水凝胶渗透层。渗透层具有限定的多孔性质，其中介孔的尺寸范围在约100纳米至约1000纳米之间，并且也可以具有微米尺寸范围内的微孔。与有源电子矩阵器件上的纳米多孔合成水凝胶渗透层相比，介孔合成水凝胶渗透层显示出改进的信号强度和线性特性。此外，本发明还提供含有用于核酸探针或其他生物分子的共聚附着位点的合成聚合物水凝胶渗透层。

5. 发明授权

US07270850B2 Mesoporous permeation layers for use on active electronic matrix devices 有权
标题翻译：用于有源电子矩阵器件的介孔渗透层
公开(公告)号：US07270850B2
公开(公告)日：2007-09-18
申请号：US11082325
申请日：2005-03-16
申请人： Jainamma Krotz , Daniel J. Smolko , Howard R. Reese , Thomas J. Onofrey , Daguang Wang , Theodore M. Winger , John R. Havens
发明人： Jainamma Krotz , Daniel J. Smolko , Howard R. Reese , Thomas J. Onofrey , Daguang Wang , Theodore M. Winger , John R. Havens
IPC分类号： C23C16/00 , B01D29/00
CPC分类号： C12Q1/002 , B01D67/003 , B01D69/125 , B01D2323/18 , B01D2323/34 , B01D2323/42 , C09D123/26 , C12Q1/003 , G01N33/5438 , G01N33/545
摘要： The present invention provides improved synthetic polymer hydrogel permeation layers for use on active electronic matrix devices for biological assays. The present invention includes methods for forming a permeation layer on an array of microelectrodes including the steps of attaching a linker to the surface of the array by treating the surface with a linker by vapor deposition and providing a polymerization solution that includes at least one monomer having a polymerizable moiety, a modified streptavidin, a surfactant or porogen, and a cross-linking agent. The surface of the array is then contacted with the polymerization solution and the polymerization solution is then polymerized on the surface of the array to form a permeation layer that is attached o the surface of the array through the linker.
摘要翻译：本发明提供了用于生物测定的活性电子基质装置上的改进的合成聚合物水凝胶渗透层。本发明包括在微电极阵列上形成渗透层的方法，包括以下步骤：通过气相沉积用接头处理该表面，并提供包含至少一种具有至少一个单体的聚合溶液，将接头连接到阵列的表面上可聚合部分，修饰的链霉抗生物素蛋白，表面活性剂或致孔剂和交联剂。然后将阵列的表面与聚合溶液接触，然后聚合溶液在阵列的表面上聚合，形成通过接头连接在阵列表面上的渗透层。

6. 发明申请

US20060166285A1 Charged permeation layers for use on active electronic matrix devices 审中-公开
标题翻译：用于有源电子矩阵器件的充电渗透层
公开(公告)号：US20060166285A1
公开(公告)日：2006-07-27
申请号：US11044739
申请日：2005-01-26
申请人： Jainamma Krotz , David Wong , Kenny Nguyen
发明人： Jainamma Krotz , David Wong , Kenny Nguyen
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： C12Q1/001
摘要： An electronic device including at least one electrode on a substrate and a permeation layer overlaying the at least one electrode. The permeation layer comprises a polymer having a plurality of negatively-charged moieties. The negatively charged moieties may be carboxylates. In one embodiment, the negatively charged moieties are carboxylates from acrylic acids in the permeation layer. The amount of acrylic acid may be less than about 5 mol %. The permeation layer may also contain streptavidin and/or a surfactant. Methods of using the electronic device are also disclosed in which at least one of the selectively addressable electrodes are biased to at least partially neutralize the negatively charged moieties in the overlying permeation layer. Charged entities can then bind to the permeation layer over the biased electrode.
摘要翻译：一种电子器件，包括在衬底上的至少一个电极和覆盖所述至少一个电极的渗透层。渗透层包括具有多个带负电荷的部分的聚合物。带负电荷的部分可以是羧酸盐。在一个实施方案中，带负电荷的部分是在渗透层中来自丙烯酸的羧酸盐。丙烯酸的量可以小于约5mol％。渗透层还可以含有链霉亲和素和/或表面活性剂。还公开了使用电子器件的方法，其中至少一个选择性寻址电极被偏置以至少部分地中和上覆渗透层中的带负电荷的部分。然后，带电实体可以在偏置电极上结合渗透层。

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