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1. 发明申请

US20070203183A1 Diaryl piperidines as CB1 modulators 审中-公开
标题翻译：二芳基哌啶作为CB1调节剂
公开(公告)号：US20070203183A1
公开(公告)日：2007-08-30
申请号：US11652227
申请日：2007-01-11
申请人： Jack Scott , Jay Weinstein , Michael Miller , Andrew Stamford , Eric Gilbert , Yan Xia , William Greenlee , Sarah Li
发明人： Jack Scott , Jay Weinstein , Michael Miller , Andrew Stamford , Eric Gilbert , Yan Xia , William Greenlee , Sarah Li
IPC分类号： A61K31/454 , C07D211/54 , A61K31/445 , C07D401/02
CPC分类号： C07D211/18 , C07D211/22 , C07D211/26 , C07D211/28 , C07D211/30 , C07D211/32 , C07D211/58 , C07D211/60 , C07D211/76 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D471/10
摘要： A compound having the general structure of Formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, are useful in treating diseases, disorders, or conditions such as metabolic syndrome (e.g., obesity, waist circumference, lipid profile, and insulin sensitivity), neuroinflammatory disorders, cognitive disorders, psychosis, addictive behavior, gastrointestinal disorders, and cardiovascular conditions.
摘要翻译：具有式（I）的通式结构的化合物或其药学上可接受的盐，溶剂化物或酯可用于治疗疾病，病症或病症如代谢综合征（例如，肥胖，腰围，脂质分布和胰岛素敏感性），神经炎症性疾病，认知障碍，精神病，成瘾行为，胃肠道疾病和心血管疾病。

2. 发明申请

US20060241121A1 Substituted piperazines as CB1 antagonists 失效
标题翻译：取代的哌嗪作为CB1拮抗剂
公开(公告)号：US20060241121A1
公开(公告)日：2006-10-26
申请号：US11292264
申请日：2005-12-01
申请人： William Greenlee , Jay Weinstein , Eric Gilbert , Michael Miller , Jack Scott , Andrew Stamford
发明人： William Greenlee , Jay Weinstein , Eric Gilbert , Michael Miller , Jack Scott , Andrew Stamford
IPC分类号： A61K31/496 , A61K31/495 , C07D403/04 , C07D241/04
CPC分类号： C07D241/04 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/08 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/10
摘要： Compounds of Formula (I): or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.
摘要翻译：式（I）化合物或其药学上可接受的盐，溶剂合物或酯可用于治疗由CB1受体介导的疾病或病症，例如代谢综合征和肥胖症，神经炎症性疾病，认知障碍精神病，成瘾（如戒烟），胃肠道疾病和心血管疾病。

3. 发明申请

US20160009696A1 COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY 有权
公开(公告)号：US20160009696A1
公开(公告)日：2016-01-14
申请号：US14772290
申请日：2014-02-27
申请人： Michael MILLER , Kallol BASU , Duane DEMONG , Jack SCOTT , Wei LI , Joel HARRIS , Andrew STAMFORD , Marc POIRIER , Paul TEMPEST , MERCK SHARP & DOHME CORP.
发明人： Michael Miller , Kallol Basu , Duane DeMong , Jack Scott , Wei Li , Joel Harris , Andrew Stamford , Marc Poirier , Paul Tempest
IPC分类号： C07D403/14 , C07D401/14 , C07D491/107 , C07D417/14 , C07D471/10 , C07D413/14 , C07D498/08
CPC分类号： C07D403/14 , A61K31/505 , A61K31/506 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/10 , C07D491/107 , C07D498/08
摘要： The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

4. 发明申请

US20160009689A1 COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY 有权
公开(公告)号：US20160009689A1
公开(公告)日：2016-01-14
申请号：US14772295
申请日：2014-02-27
申请人： Michael MILLER , Kallol BASU , Duane DEMONG , Jack SCOTT , Wei LI , Andrew STAMFORD , Marc POIRIER , Paul TEMPEST , MERCK SHARP & DOHME CORP.
发明人： Michael Miller , Kallol Basu , Duane DeMong , Jack Scott , Wei Li , Andrew Stamford , Marc Poirer , Paul Tempest
IPC分类号： C07D403/04 , C07D413/14 , C07D401/14 , C07D471/10 , C07D491/107 , C07D498/10 , C07D487/10 , C07D405/14 , C07D498/04 , C07D487/04 , C07D409/14 , C07D403/14 , C07D498/08
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/107 , C07D498/04 , C07D498/08 , C07D498/10
摘要： The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

5. 发明申请

US20160009681A1 COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY 有权
标题翻译：化合物抑制富含重复激素激酶活性
公开(公告)号：US20160009681A1
公开(公告)日：2016-01-14
申请号：US14772525
申请日：2014-02-27
申请人： Michael MILLER , Kallol BASU , Duane MONG , Jack SCOTT , Hong LIU , Xing DAI , Andrew STAMFORD , Marc POIRIER , Paul TEMPEST , MERCK SHARP & DOHME CORP.
发明人： Michael Miller , Kallol Basu , Duane DeMong , Jack Scott , Hong Liu , Xing Dai , Andrew Stamford , Marc Poirier , Paul Tempest
IPC分类号： C07D401/04 , C07D498/08 , C07D401/14 , C07D495/08 , C07D498/04 , C07D487/04 , C07D413/14 , C07D405/14 , C07D417/14
CPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/08 , C07D495/08 , C07D498/04 , C07D498/08
摘要： The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK2 kinase is involved.
摘要翻译：本发明涉及作为LRRK2激酶的有效抑制剂的吲唑化合物，可用于治疗或预防其中涉及LRRK2激酶的疾病，例如帕金森病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及LRRK2激酶的疾病中的用途。

6. 发明授权

US09006228B2 Substituted cyclopropyl compounds, compositions containing such compounds, and methods of treatment 有权
标题翻译：取代的环丙基化合物，含有这些化合物的组合物和治疗方法
公开(公告)号：US09006228B2
公开(公告)日：2015-04-14
申请号：US14126685
申请日：2012-06-11
申请人： Michael Miller , Andrew Stamford , Kallol Basu , Harold B. Wood , Duane DeMong , Wanying Sun , Joie Garfunkle , Christopher Moyes , Zhiyong Hu , Ping Liu , Scott D. Edmondson , Xing Dai , Byron Gabriel DuBois
发明人： Michael Miller , Andrew Stamford , Kallol Basu , Harold B. Wood , Duane DeMong , Wanying Sun , Joie Garfunkle , Christopher Moyes , Zhiyong Hu , Ping Liu , Scott D. Edmondson , Xing Dai , Byron Gabriel DuBois
IPC分类号： C07D417/14 , C07D211/24 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D211/22
CPC分类号： C07D211/24 , C07D211/22 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了取代的式I的环丙基化合物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病症。该化合物可用作G蛋白偶联受体GPR-119的激动剂。还包括药物组合物和治疗方法。

7. 发明申请

US20140128368A1 SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT 有权
标题翻译：取代的环丙基化合物，包含这些化合物的组合物和处理方法
公开(公告)号：US20140128368A1
公开(公告)日：2014-05-08
申请号：US14126685
申请日：2012-06-11
申请人： Michael Miller , Andrew Stamford , Kallol Basu , Harold B. Wood , Duane DeMong , Wanying Sun , Joie Garfunkle , Christopher Moyes , Zhiyong Hu , Ping Liu , Scott D. Edmondson , Xing Dai , Byron Gabriel DuBois
发明人： Michael Miller , Andrew Stamford , Kallol Basu , Harold B. Wood , Duane DeMong , Wanying Sun , Joie Garfunkle , Christopher Moyes , Zhiyong Hu , Ping Liu , Scott D. Edmondson , Xing Dai , Byron Gabriel DuBois
IPC分类号： C07D417/14 , C07D211/24 , C07D405/14 , C07D413/04 , C07D413/14 , C07D401/14 , C07D401/04
CPC分类号： C07D211/24 , C07D211/22 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了取代的式I的环丙基化合物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病状。该化合物可用作G蛋白偶联受体GPR-119的激动剂。还包括药物组合物和治疗方法。

8. 发明申请

US20080095740A1 PIPERIDINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS 审中-公开
标题翻译：哌啶衍生物作为CCR5拮抗剂有用
公开(公告)号：US20080095740A1
公开(公告)日：2008-04-24
申请号：US11925119
申请日：2007-10-26
申请人： Michael Miller , Jack Scott
发明人： Michael Miller , Jack Scott
IPC分类号： A61K31/506 , A61K31/538 , A61K31/551 , A61K31/675 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K38/20 , A61P31/18
CPC分类号： C07D401/14
摘要： The present invention provides a compound of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein the various moieties are as defined in the specification. The present invention also provides pharmaceutical compositions containing the compound of this invention, and methods of treatment using the compound of this invention. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.
摘要翻译：本发明提供下式的化合物或其药学上可接受的盐或溶剂合物，其中各种部分如说明书中所定义。本发明还提供含有本发明化合物的药物组合物和使用本发明化合物的治疗方法。本发明还涉及本发明化合物与一种或多种可用于治疗人类免疫缺陷病毒（HIV）的抗病毒剂或其它药剂的组合的用途。本发明还涉及本发明化合物单独或与另一种药剂组合用于治疗实体器官移植排斥，移植物抗宿主病，关节炎，类风湿性关节炎，炎症性肠病，特应性皮炎，牛皮癣，哮喘，过敏或多发性硬化。

9. 发明申请

US20060025441A1 Bipiperidinyl derivatives useful as inhibitors of chemokine receptors 失效
标题翻译：可用作趋化因子受体抑制剂的二哌啶基衍生物
公开(公告)号：US20060025441A1
公开(公告)日：2006-02-02
申请号：US10979075
申请日：2004-11-01
申请人： Michael Miller , Jack Scott
发明人： Michael Miller , Jack Scott
IPC分类号： A61K31/4545 , C07D401/04
CPC分类号： C07D413/14 , C07D401/14
摘要： In its many embodiments, the present invention provides a novel class of bipiperidinyl compounds as inhibitors of the CCR5 receptors, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with CCR5 using such compounds or pharmaceutical compositions. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.
摘要翻译：在其许多实施方案中，本发明提供了作为CCR5受体的抑制剂的新类型的联哌啶化合物，制备这些化合物的方法，含有一种或多种这样的化合物的药物组合物，制备包含一种或多种这样的化合物的药物制剂的方法，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CCR5相关的一种或多种疾病的方法。本发明还涉及本发明化合物与一种或多种可用于治疗人类免疫缺陷病毒（HIV）的抗病毒剂或其它药剂的组合的用途。本发明还涉及本发明化合物单独或与另一种药剂组合用于治疗实体器官移植排斥，移植物抗宿主病，关节炎，类风湿性关节炎，炎症性肠病，特应性皮炎，牛皮癣，哮喘，过敏或多发性硬化。

10. 发明授权

US08791781B2 Spherical magnet 有权
标题翻译：球形磁铁
公开(公告)号：US08791781B2
公开(公告)日：2014-07-29
申请号：US13781019
申请日：2013-02-28
申请人： Michael Miller
发明人： Michael Miller
IPC分类号： H01F7/02
CPC分类号： H01F7/02 , F01K25/10 , F01K27/00 , H01F7/0221
摘要： A spherical magnet is formed as a hollow sphere having a fluid tight outer surface of a first magnetic pole and an inner surface having a second magnetic pole that is magnetically opposite the first pole. A plurality of individual thin flexible rectangular plate magnets are arranged as a continuous outer layer of the spherical magnet. Each individual plate magnet has four sides, an inner magnetic portion and an outer non-magnetic portion that extends around all four sides of the magnetic portion. Each inner magnetic portion includes a first face disposed on the outer surface and having the first pole and a second face opposite the first face, disposed on the inner surface and having the second pole.
摘要翻译：形成具有第一磁极的流体密封外表面的空心球体和具有与第一极磁性相对的第二磁极的内表面的球形磁体。多个单独的薄柔性矩形板磁体被布置为球形磁体的连续外层。每个单独的板状磁体具有四个侧面，内部磁性部分和外部非磁性部分，其围绕磁性部分的所有四个侧面延伸。每个内磁性部分包括设置在外表面上并且具有第一极和与第一面相对的第二面的第一面，设置在内表面上并具有第二极。

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