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1. 发明授权

US07981930B2 Compositions and kits for treating influenza 有权
标题翻译：用于治疗流感的组合物和试剂盒
公开(公告)号：US07981930B2
公开(公告)日：2011-07-19
申请号：US12040856
申请日：2008-02-29
申请人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
发明人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
IPC分类号： A61K31/7056 , A61K31/351 , A61K31/215 , A61K31/196 , A61K31/195 , A61K31/131 , C07H19/056 , C07D309/28 , C07C69/75 , C07C61/22 , C07C229/48 , C07C211/38
CPC分类号： A61K31/454 , A61K31/7056 , A61K2300/00
摘要： Kits comprising an M2 inhibitor selected from amantadine and rimantadine; ribavirin, and a neuraminidase inhibitor (NAi) in an amount that is antivirally effective in the combination, an oral dosage form containing 75-250 mg of the M2 inhibitor, an oral dosage form comprising 100-400 mg of ribavirin and a neuraminidase inhibitor are provided for the treatment of influenza. Some embodiments of the kits comprise an oral dosage form containing 75-250 mg of the M2 inhibitor, an oral dosage form comprising 100-400 mg of ribavirin, and a neuraminidase inhibitor.
摘要翻译：包含选自金刚胺和金刚乙胺的M2抑制剂的试剂盒; 利巴韦林和神经氨酸酶抑制剂（NAi），其组合中具有抗病毒效果的量，含有75-250mg的M2抑制剂的口服剂型，包含100-400mg的利巴韦林和神经氨酸酶抑制剂的口服剂型为规定用于治疗流行性感冒。试剂盒的一些实施方案包括含有75-250mg的M2抑制剂的口服剂型，包含100-400mg的利巴韦林的口服剂型和神经氨酸酶抑制剂。

2. 发明授权

US07858660B2 Compositions and kits for treating influenza 有权
标题翻译：用于治疗流感的组合物和试剂盒
公开(公告)号：US07858660B2
公开(公告)日：2010-12-28
申请号：US12477105
申请日：2009-06-02
申请人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
发明人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
IPC分类号： C07H19/056 , A61K31/215 , A61K31/166 , A61K31/16 , A61K31/7056 , A61K31/13 , C07D315/00 , C07D307/12 , C07C69/75 , C07C61/08 , C07C217/52
CPC分类号： A61K31/454 , A61K31/7056 , A61K2300/00
摘要： Compositions, kits and methods are provided for the treatment or prophylaxis of influenza.
摘要翻译：提供组合物，试剂盒和方法用于治疗或预防流行性感冒。

3. 发明申请

US20090326978A1 Emergency Preparations for an Epidemic 审中-公开
标题翻译：疫情紧急准备
公开(公告)号：US20090326978A1
公开(公告)日：2009-12-31
申请号：US12495793
申请日：2009-06-30
申请人： Timothy J. Fultz , Gregory T. Went , Jack Nguyen , Paul Spence , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
发明人： Timothy J. Fultz , Gregory T. Went , Jack Nguyen , Paul Spence , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
IPC分类号： G06Q50/00 , G06Q90/00 , G06Q10/00
CPC分类号： G06Q10/00 , G06Q50/22 , G06Q99/00
摘要： Stockpiles and methods of stockpiling a combination antiviral therapy for responding to an epidemic viral outbreak are described. Methods and systems of inventory control for co-deployment of drugs used in combination during a pandemic are described.
摘要翻译：描述了储存组合抗病毒治疗以应对流行性病毒爆发的库存和方法。描述了在大流行期间组合使用的药物共同部署的库存控制方法和系统。

4. 发明申请

US20090247481A1 Compositions and Kits for Treating Influenza 有权
标题翻译：治疗流感的成分和试剂盒
公开(公告)号：US20090247481A1
公开(公告)日：2009-10-01
申请号：US12477105
申请日：2009-06-02
申请人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
发明人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
IPC分类号： A61K31/708
CPC分类号： A61K31/454 , A61K31/7056 , A61K2300/00
摘要： Compositions, kits and methods are provided for the treatment or prophylaxis of influenza.
摘要翻译：提供组合物，试剂盒和方法用于治疗或预防流行性感冒。

5. 发明授权

US5900250A Monoglyceride/lactate ester permeation enhancer for oxybutnin 失效
标题翻译：羟丁酸甘油酯/乳酸酯渗透增强剂
公开(公告)号：US5900250A
公开(公告)日：1999-05-04
申请号：US070492
申请日：1998-04-30
申请人： Eun Soo Lee , Tyler Watanabe , Robert M. Gale , Terry L. Burkoth
发明人： Eun Soo Lee , Tyler Watanabe , Robert M. Gale , Terry L. Burkoth
IPC分类号： A61K9/00 , A61K9/70 , A61K31/216 , A61K47/14 , A61F13/02
CPC分类号： A61K9/7084 , A61K31/216 , A61K47/14 , A61K9/0014 , Y10S514/946
摘要： A composition of matter for application to a body surface or membrane to administer oxybutynin by permeation through the body surface or membrane, the composition comprising, in combination, the oxybutynin to be administered, in a therapeutically effective amount; and a permeation-enhancing mixture comprising a monoglyceride or a mixture of monoglycerides, and a lactic ester or a mixture of lactate esters; present in specific concentrations.
摘要翻译：一种用于施用于身体表面或膜的物质的组合物，以通过穿过身体表面或膜的渗透来施用奥昔布宁，所述组合物以治疗有效量组合包含待施用的奥昔布宁; 和包含单酸甘油酯或单酸甘油酯和乳酸酯或乳酸酯混合物的混合物的渗透增强混合物; 以特定浓度存在。

6. 发明授权

US5830501A Dosage form comprising hydrophilic polymer 失效
标题翻译：包含亲水性聚合物的剂型
公开(公告)号：US5830501A
公开(公告)日：1998-11-03
申请号：US964548
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. -L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. -L. Wong , Jerry D. Childers , Brian L. Barclay
IPC分类号： A61K9/00 , A61K9/24
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译：公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。

7. 发明授权

US5273752A Controlled release dispenser comprising beneficial agent 失效
标题翻译：控制释放分配器包括有益剂
公开(公告)号：US5273752A
公开(公告)日：1993-12-28
申请号：US763393
申请日：1991-09-19
申请人： Atul D. Ayer , Terry L. Burkoth , Anthony L. Kuczynski , Joseph C. Deters
发明人： Atul D. Ayer , Terry L. Burkoth , Anthony L. Kuczynski , Joseph C. Deters
IPC分类号： A61K9/00 , A23K1/18
CPC分类号： A61K9/0068 , A61K31/70 , A61K9/0004
摘要： A dispenser is disclosed for delivering a beneficial agent in a hydrophilic carrier formulation to an animal in a rate-controlled manner. The dispenser comprises (1) a semipermeable housing defining an internal space, (2) at least one composition comprising a beneficial agent and a pharmaceutically acceptable hydrophilic carrier in the space, (3) an expandable hydrophilic driving member in the space, (4) a density member in the space, and (5) one exit passageway or a multiplicity of exit passageways in the housing for delivering the beneficial agent from the dispenser, the diameter of each exit passageway being of a size to maximize release of the beneficial agent by osmotic pumping and to minimize release of the beneficial agent by diffusion or erosion to substantially avoid mechanical agitation-dependent release of the beneficial agent.
摘要翻译：公开了一种分配器，用于以速率控制的方式将亲水载体制剂中的有益剂递送给动物。所述分配器包括（1）限定内部空间的半透明壳体，（2）至少一种组合物，其包含所述空间中的有益剂和药学上可接受的亲水载体，（3）所述空间中的可膨胀亲水性驱动构件，（4）空间中的密度构件，以及（5）壳体中的一个出口通道或多个出口通道，用于从分配器输送有益物质，每个出口通道的直径具有使得有益剂释放最大化的大小渗透泵送并且通过扩散或侵蚀来最小化有益剂的释放，以基本上避免有益剂的机械搅动依赖性释放。

8. 发明授权

US5200195A Process for improving dosage form delivery kinetics 失效
标题翻译：改善剂型输送动力学的方法
公开(公告)号：US5200195A
公开(公告)日：1993-04-06
申请号：US804137
申请日：1991-12-06
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译：公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。

9. 发明授权

US5614211A Oxybutynin transdermal device having decreased delamination 失效
标题翻译：奥昔布宁经皮装置具有降低的分层
公开(公告)号：US5614211A
公开(公告)日：1997-03-25
申请号：US481544
申请日：1995-06-07
申请人： Robert M. Gale , Eun Soo Lee , Lina T. Taskovich , Terry L. Burkoth
发明人： Robert M. Gale , Eun Soo Lee , Lina T. Taskovich , Terry L. Burkoth
IPC分类号： A61M37/00 , A61K9/70 , A61F13/00
CPC分类号： A61K9/7084
摘要： A device for the transdermal administration of oxybutynin comprising a microporous tie layer located between the oxybutynin reservoir and the contact adhesive. The tie layer eliminates blooming and delamination and has no appreciable adverse effect on either the oxybutynin flux or release rate from the device.
摘要翻译：用于透皮给药奥昔布宁的装置，其包含位于奥昔布宁储库和接触粘合剂之间的微孔连接层。连结层消除了起霜和分层，并且对奥昔布宁通量或来自装置的释放速率没有明显的不利影响。

10. 发明授权

US5266332A Method for administering anti-Parkinson drug 失效
标题翻译：抗帕金森药物的施用方法
公开(公告)号：US5266332A
公开(公告)日：1993-11-30
申请号：US964162
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S.-L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S.-L. Wong , Jerry D. Childers , Brian L. Barclay
IPC分类号： A61K9/00 , A61K9/24
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译：公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。

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