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1. 发明授权

US5830501A Dosage form comprising hydrophilic polymer 失效
标题翻译：包含亲水性聚合物的剂型
公开(公告)号：US5830501A
公开(公告)日：1998-11-03
申请号：US964548
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. -L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. -L. Wong , Jerry D. Childers , Brian L. Barclay
IPC分类号： A61K9/00 , A61K9/24
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译：公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。

2. 发明授权

US5200195A Process for improving dosage form delivery kinetics 失效
标题翻译：改善剂型输送动力学的方法
公开(公告)号：US5200195A
公开(公告)日：1993-04-06
申请号：US804137
申请日：1991-12-06
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译：公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。

3. 发明授权

US5897878A Method for administering steroid 失效
标题翻译：施用类固醇的方法
公开(公告)号：US5897878A
公开(公告)日：1999-04-27
申请号：US963967
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S.-L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S.-L. Wong , Jerry D. Childers , Brian L. Barclay
IPC分类号： A61K9/00 , A61K9/24
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译：公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。

4. 发明授权

US5254349A Process for lessening irritation caused by drug 失效
标题翻译：降低药物刺激的方法
公开(公告)号：US5254349A
公开(公告)日：1993-10-19
申请号：US963962
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
IPC分类号： A61K9/00 , A61K9/24
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译：公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。

5. 发明授权

US5266332A Method for administering anti-Parkinson drug 失效
标题翻译：抗帕金森药物的施用方法
公开(公告)号：US5266332A
公开(公告)日：1993-11-30
申请号：US964162
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S.-L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S.-L. Wong , Jerry D. Childers , Brian L. Barclay
IPC分类号： A61K9/00 , A61K9/24
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译：公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。

6. 发明授权

US5348746A Method for administering drug 失效
标题翻译：给药方法
公开(公告)号：US5348746A
公开(公告)日：1994-09-20
申请号：US964538
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
IPC分类号： A61K9/00 , A61K9/24
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译：公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。

7. 发明授权

US5413572A Osmotic dosage system for liquid drug delivery 失效
标题翻译：用于液体药物输送的渗透剂量系统
公开(公告)号：US5413572A
公开(公告)日：1995-05-09
申请号：US203135
申请日：1994-02-18
申请人： Patrick S. L. Wong , Felix Theeuwes , Brian L. Barclay , Michael H. Dealey
发明人： Patrick S. L. Wong , Felix Theeuwes , Brian L. Barclay , Michael H. Dealey
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22 , A61K9/52 , A61K9/66
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic system comprises (a) an outside semipermeable wall, (b) a middle osmotically active layer, (c) a capsule comprising a beneficial agent, and (d) a passageway for dispensing the beneficial agent from the osmotic system.
摘要翻译：公开了用于将有益剂制剂递送到使用环境的渗透系统。渗透系统包括（a）外部半透壁，（b）中间渗透活性层，（c）包含有益剂的胶囊，和（d）用于从渗透系统分配有益剂的通道。

8. 发明授权

US5324280A Osmotic dosage system for delivering a formulation comprising liquid carrier and drug 失效
标题翻译：用于递送包含液体载体和药物的制剂的渗透剂量系统
公开(公告)号：US5324280A
公开(公告)日：1994-06-28
申请号：US502705
申请日：1990-04-02
申请人： Patrick S. L. Wong , Felix Theeuwes , Brian L. Barclay , Michael H. Dealey
发明人： Patrick S. L. Wong , Felix Theeuwes , Brian L. Barclay , Michael H. Dealey
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22 , A61K9/52 , A61K9/66
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic system comprises (a) an outside semipermeable wall, (b) a middle osmotically active layer, (c) a capsule comprising a beneficial agent, and (d) a passageway for dispensing the beneficial agent from the osmotic system.
摘要翻译：公开了用于将有益剂制剂递送到使用环境的渗透系统。渗透系统包括（a）外部半透壁，（b）中间渗透活性层，（c）包含有益剂的胶囊，和（d）用于从渗透系统分配有益剂的通道。

9. 发明授权

US5053032A Method of signalling a patient during buccal agent delivery 失效
标题翻译：信号交换中患者信号的方法
公开(公告)号：US5053032A
公开(公告)日：1991-10-01
申请号：US633590
申请日：1990-12-21
申请人： Brian L. Barclay , Jerry D. Childers , Jeri Wright , Virgil A. Place , Patrick S. L. Wong
发明人： Brian L. Barclay , Jerry D. Childers , Jeri Wright , Virgil A. Place , Patrick S. L. Wong
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： An osmotic device for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device comprises a wall surrounding a compartment housing a layer of an agent that is insoluble to very soluble in aqueous biological fluids, e.g., saliva, and a layer of a fluid swellable, hydrophilic polymer. A passageway in the wall connects the agent with the exterior of the device. The wall is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer. In one embodiment the beneficial agent has a different color than the hydrophilic polymer. The wall is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent remaining to be delivered. Marking lines may be provided on the wall indicating the amount of drug/agent which has been delivered and/or the amount remaining to be delivered.

10. 发明授权

US5021053A Oral osmotic device with hydrogel driving member 失效
标题翻译：具有水凝胶驱动构件的口腔渗透装置
公开(公告)号：US5021053A
公开(公告)日：1991-06-04
申请号：US380229
申请日：1989-07-14
申请人： Brian L. Barclay , Jerry D. Childers , Jeri Wright , Virgil A. Place , Patrick S. L. Wong
发明人： Brian L. Barclay , Jerry D. Childers , Jeri Wright , Virgil A. Place , Patrick S. L. Wong
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： An osmotic device for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device comprises a wall surrounding a compartment housing a layer of an agent that is insoluble to very soluble in aqueous biological fluid, e.g., saliva, and a layer of a fluid swellable, hydrophilic polymer. A passageway in the wall connects the agent with the exterior of the device. The wall is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer. In one embodiment the beneficial agent has a different color than the hydrophilic polymer. The wall is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent remaining to be delivered. Marking lines may be provided on the wall indicating the amount of drug/agent which has been delivered and/or the amount remaining to be delivered.
摘要翻译：公开了用于将有益药物（例如抗真菌）递送到人类患者的口腔中的渗透装置。该装置的尺寸和形状适应于舒适地保持在口中长时间。该装置包括一个围绕隔室的壁，该隔室容纳不溶于非常可溶于水生物流体例如唾液的一层试剂，以及一层流体可溶胀的亲水性聚合物。墙壁上的一个通道可将药剂与装置的外部连接起来。该壁对于水性生物流体的通道是可渗透的，但是对亲水性聚合物的通过基本上是不可渗透的。在一个实施方案中，有益剂具有与亲水性聚合物不同的颜色。该壁足够半透明以允许患者看到剩余的待传递的药物/有益剂的量。可以在墙上提供标记线，指示已经递送的药物/药剂的量和/或剩余的待传送量。

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