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1. 发明授权

US06210420B1 Apparatus and method for efficient blood sampling with lancet 有权
标题翻译：柳叶刀高效采血装置及方法
公开(公告)号：US06210420B1
公开(公告)日：2001-04-03
申请号：US09233298
申请日：1999-01-19
申请人： Ganapati R Mauze , J. Fleming Dias
发明人： Ganapati R Mauze , J. Fleming Dias
IPC分类号： A61B1714
CPC分类号： A61B5/15186 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150183 , A61B5/150213 , A61B5/150229 , A61B5/150412 , A61B5/150519 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15142 , A61B5/15194
摘要： A technique for efficiently sampling blood from body tissue by reducing pressure on the body tissue. In the present technique a body tissue is placed under reduced pressure to improve perfusion of blood in the body tissue before lancing. An embodiment of this apparatus includes a lancet carried by a piston slidable in a housing, a mechanism for transmitting mechanical energy internally in the apparatus for creating the reduced pressure on the body tissue. The apparatus also includes a driver that drives the lancet for lancing. The apparatus has a head in the housing for contacting the body tissue in an air-tight manner against suction forces. In the head facing the body tissue is a channel in which the air pressure can be reduced.
摘要翻译：一种通过减少身体组织上的压力来有效地从身体组织取样血液的技术。在本技术中，身体组织被放置在减压下以改善在穿刺之前身体组织中的血液灌注。该装置的一个实施例包括由可在壳体中滑动的活塞承载的刺血针，用于在用于在身体组织上产生减压的装置内部传递机械能的机构。该装置还包括驱动柳叶刀进行穿刺的驱动器。该装置在壳体中具有头部，用于以气密方式抵抗抽吸力使身体组织接触。在面向身体组织的头部是可以减小空气压力的通道。

2. 发明授权

US6113541A Noninvasive blood chemistry measurement method and system 失效
标题翻译：无创血液化学测定方法与系统
公开(公告)号：US6113541A
公开(公告)日：2000-09-05
申请号：US107304
申请日：1998-06-30
申请人： J. Fleming Dias , Ganapati R. Mauze
发明人： J. Fleming Dias , Ganapati R. Mauze
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/14532 , A61B5/1455 , A61B5/6826 , A61B5/6838 , A61B5/6843
摘要： A noninvasive blood chemistry measurement method and system isolate measurement contributions due to a patient's blood to accurately measure blood chemistry. In accordance with a first preferred embodiment of the present invention a noninvasive blood chemistry measurement method decreases the blood volume within a patient's body part relative to the normal blood volume in the body part and performs a baseline measurement. Blood volume is then increased and a second measurement is performed. Comparison of the second measurement to the baseline measurement isolates the measurement attributes of the patient's blood. In accordance with a second preferred embodiment of the present invention a noninvasive blood chemistry measurement system decreases blood volume by applying mechanical pressure to a body part. In accordance with a third preferred embodiment of the present invention, blood volume in the body part is decreased using a pressure cuff. In a fourth embodiment, a noninvasive probe accurately measures blood chemistry and uses a suction cup to increase blood volume at the blood chemistry measurement site.
摘要翻译：无创血液化学测量方法和系统分离由于患者的血液而准确测量血液化学物质的测量贡献。根据本发明的第一优选实施例，非侵入性血液化学测量方法相对于身体部位中的正常血液体积减少患者体内部分内的血容量并进行基线测量。然后增加血量并进行第二次测量。第二次测量与基线测量的比较将患者血液的测量属性隔离开来。根据本发明的第二优选实施例，非侵入性血液化学测量系统通过对身体部位施加机械压力来降低血液体积。根据本发明的第三优选实施例，使用压力袖带减少身体部位的血容量。在第四实施例中，非侵入性探针精确地测量血液化学物质并使用吸盘来增加血液化学测量部位的血液体积。

3. 发明授权

US5827181A Noninvasive blood chemistry measurement method and system 失效
公开(公告)号：US5827181A
公开(公告)日：1998-10-27
申请号：US813733
申请日：1997-03-07
申请人： J. Fleming Dias , Ganapati R. Mauze
发明人： J. Fleming Dias , Ganapati R. Mauze
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/0053 , A61B5/0055 , A61B5/14532 , A61B5/6826 , A61B5/6838 , A61B5/6843
摘要： A noninvasive blood chemistry measurement method and system isolate measurement contributions due to a patient's blood to accurately measure blood chemistry. In accordance with a first preferred embodiment of the present invention a noninvasive blood chemistry measurement method decreases the blood volume within a patient's body part relative to the normal blood volume in the body part and performs a baseline measurement. Blood volume is then increased and a second measurement is performed. Comparison of the second measurement to the baseline measurement isolates the measurement attributes of the patient's blood. In accordance with a second preferred embodiment of the present invention a noninvasive blood chemistry measurement system decreases blood volume by applying mechanical pressure to a body part. In accordance with a third preferred embodiment of the present invention, blood volume in the body part is decreased using a pressure cuff. In a fourth embodiment, a noninvasive probe accurately measures blood chemistry and uses a suction cup to increase blood volume at the blood chemistry measurement site.

4. 发明授权

US4482834A Acoustic imaging transducer 失效
标题翻译：声学成像传感器
公开(公告)号：US4482834A
公开(公告)日：1984-11-13
申请号：US052705
申请日：1979-06-28
申请人： J. Fleming Dias , H. Edward Karrer , John D. Larson, III , David A. Wilson , Amin M. Hanafy
发明人： J. Fleming Dias , H. Edward Karrer , John D. Larson, III , David A. Wilson , Amin M. Hanafy
IPC分类号： H04R1/46 , A61B8/00 , B06B1/06 , G01N29/24 , G01S7/521 , G10K11/00 , G10K11/02 , G10K11/26 , H04R17/00 , H01L41/08
CPC分类号： G01N29/2437 , B06B1/0622 , G10K11/002 , G10K11/02 , G10K11/26
摘要： The acoustic imaging transducer described herein incorporates an acoustic stack contained in an alumina housing which also provides structure for electrically connecting the transducer array elements to system signal processing electronics.
摘要翻译：本文所述的声学成像换能器包括包含在氧化铝壳体中的声学堆叠，其还提供用于将换能器阵列元件电连接到系统信号处理电子器件的结构。

5. 发明授权

US4064550A High fidelity pressure transducer 失效
标题翻译：高保真压力传感器
公开(公告)号：US4064550A
公开(公告)日：1977-12-20
申请号：US668760
申请日：1976-03-22
申请人： J. Fleming Dias , Henry E. Karrer , Alexander Tykulsky
发明人： J. Fleming Dias , Henry E. Karrer , Alexander Tykulsky
IPC分类号： G01L9/12 , G01L9/00 , H01G7/00 , H01G5/16
CPC分类号： G01L9/0075 , Y10T29/435 , Y10T403/479
摘要： The capacitive fluid pressure transducers described herein comprise quartz bodies and diaphragms having suitable electrodes deposited thereon to form both sensing and reference capacitors in appropriate configurations for high fidelity measurement of relative blood pressure, said transducers being substantially unaffected by temperature and other environment factors.
摘要翻译：本文所述的电容式流体压力传感器包括石英体和膜片，其中沉积有合适的电极，以形成适当配置的感测和参考电容器，用于相对血压的高保真度测量，所述换能器基本上不受温度和其它环境因素的影响。

6. 发明授权

US5713916A Method and system for coupling acoustic energy using shear waves 失效
标题翻译：使用剪切波耦合声能的方法和系统
公开(公告)号：US5713916A
公开(公告)日：1998-02-03
申请号：US608225
申请日：1996-02-28
申请人： J. Fleming Dias
发明人： J. Fleming Dias
IPC分类号： G10K11/24 , A61B17/32
CPC分类号： G10K11/24
摘要： A system and method for coupling acoustic energy within a waveguide provides highly efficient and sensitive acoustic energy generation and detection. In particular, an ultrasound angioplasty system is described which makes use of an end-fire array of ring transducers to produce highly directionalized sound within an acoustic waveguide. The transducers can be made circularly symmetric, and may be composed of multiple segments for generating sound waves in independent x and y spatial modes within the acoustic waveguide. Each ring transducer is optimally spaced 1/2.lambda..sub.L from its neighbor transducers, such that alternate transducers transduce 180-degrees out of phase, and may have their electrical end inverted for common drive, or for summing of transducer electrical outputs when the array is used as a detector. The phased array may also be used in a resonant acoustic energy system used to detect pressure variations or reflections from a substance, for example, for detecting the progress of chemical reactions, liquid level sensing, etc., imaging, or in various other ultrasound applications.
摘要翻译：用于耦合波导内的声能的系统和方法提供高效和灵敏的声能产生和检测。特别地，描述了利用环形换能器的端射阵列在声波导内产生高度方向化的声音的超声波血管成形术系统。换能器可以是圆形对称的，并且可以由用于在声波导内的独立的x和y空间模式中产生声波的多个段组成。每个环形换能器从其相邻的换能器最佳间隔+ E，fra 1/2 + EEλL，使得交替的换能器相位转换180度，并且可以使它们的电端反转用于公共驱动，或者用于求和当阵列用作检测器时的电气输出。相控阵列也可以用在用于检测物质的压力变化或反射的共振声能系统中，例如用于检测化学反应进程，液位感测等，成像，或在各种其他超声应用中。

7. 发明授权

US5488955A Magnetostriction transducer and an intraoperative probe for acoustic imaging 失效
标题翻译：磁致伸缩传感器和用于声学成像的术中探针
公开(公告)号：US5488955A
公开(公告)日：1996-02-06
申请号：US140902
申请日：1993-10-21
申请人： J. Fleming Dias
发明人： J. Fleming Dias
IPC分类号： A61B8/12 , A61B17/22 , G10K11/24
CPC分类号： A61B8/12 , A61B8/4461 , G10K11/24 , A61B2017/22017 , A61B8/4488
摘要： This invention is a magnetostriction transducer and an intraoperative probe for acoustic imaging. The magnetostriction transducer has a coil and a magnetostriction element deposited on a portion of the acoustic waveguide that is inserted inside the coil. The magnetic field of the coil threads into the magnetostriction element and, due to the alternating magnetic field, the magnetostriction element changes its length at a rate equal to the frequency of the magnetic field. These length changes excite, among others, longitudinal waves in the core of the acoustic waveguide. The intraoperative probe has an array of acoustic waveguides bonded together. Each acoustic waveguide in the intraoperative probe has a transducer, such as a magnetostriction transducer of a piezoelectric transducer, that couples acoustic signals into the acoustic waveguides. The intraoperative probe can image the body without the extra hardware needed to rotate an acoustic waveguide by stepping an acoustic beam across the aperture of the intraoperative probe. This invention has the advantage of imaging internal organs without exposing them to danger of leakage currents.
摘要翻译：本发明是用于声学成像的磁致伸缩换能器和术中探针。该磁致伸缩换能器具有一个线圈和一个磁致伸缩元件，它沉积在插入线圈内部的声波导的一部分上。线圈的磁场进入磁致伸缩元件，并且由于交变磁场，磁致伸缩元件以等于磁场频率的速率改变其长度。这些长度变化激发了声波导的芯中的纵波。术中探针具有结合在一起的声波导阵列。术中探针中的每个声波导具有将声信号耦合到声波导中的换能器，例如压电换能器的磁致伸缩换能器。术中探针可以对身体进行成像，而不需要通过将声束穿过术中探针的孔径来旋转声波导所需的额外的硬件。本发明具有成像内脏而不使其暴露于漏电流的危险的优点。

8. 发明授权

US5284148A Intracavity ultrasound diagnostic probe using fiber acoustic waveguides 失效
标题翻译：使用纤维声波导管的腔内超声诊断探头
公开(公告)号：US5284148A
公开(公告)日：1994-02-08
申请号：US918298
申请日：1992-07-22
申请人： J. Fleming Dias , Hewlett E. Melton, Jr.
发明人： J. Fleming Dias , Hewlett E. Melton, Jr.
IPC分类号： A61B5/00 , A61B8/06 , A61B8/08 , A61B8/12 , A61B17/22 , A61B19/00 , G02B6/26 , G10K11/24 , H03H9/145
CPC分类号： A61B8/12 , A61B5/1459 , A61B8/06 , A61B8/0833 , A61B8/4461 , A61B8/483 , G02B6/26 , G10K11/24 , A61B2017/22017 , A61B2034/2063 , A61B2090/3925 , A61B8/445 , A61B8/4488
摘要： An intracavity ultrasound diagnostic probe has a fiber acoustic waveguide that guides acoustic signals generated by a piezoelectric transducer located outside the body, through a body cavity and to an imaging site within the body where they reflect back into the ultrasound diagnostic probe that guides them back to the piezoelectric transducer located at the proximal end of the waveguide. The intracavity ultrasound diagnostic probe has one or more acoustic waveguides that could be optical fibers. The numerous advantages of placing the piezoelectric transducer outside the body include: electric power does not enter the body; a reusable piezoelectric transducer; the ability to use several acoustic signals at once including a mixture of doppler and imaging acoustic signals; the ability to adjust the frequency of each acoustic signal independently of the other acoustic signals to obtain the most desirable focus and resolution for a particular imaging site; and lower cost of complying with sterility regulations since they require discarding only the inexpensive fiber acoustic waveguide and the inexpensive catheter-radome.
摘要翻译：腔内超声诊断探针具有纤维声波导，其引导由位于身体外部的压电换能器产生的声信号，通过体腔和身体内的成像部位反射回超声诊断探针，引导他们回到位于波导近端的压电换能器。腔内超声诊断探针具有一个或多个可以是光纤的声波导。将压电传感器放置在身体外部的众多优点包括：电力不进入身体; 可重复使用的压电换能器; 能够一次使用多个声信号，包括多普勒和成像声信号的混合; 独立于其他声学信号调整每个声学信号的频率的能力，以获得特定成像部位最理想的焦点和分辨率; 并且降低了符合不育规定的成本，因为它们仅需要丢弃便宜的纤维声波导和廉价的导管天线罩。

9. 发明授权

US5271402A Turbine drive mechanism for steering ultrasound signals 失效
标题翻译：用于转向超声信号的涡轮驱动机构
公开(公告)号：US5271402A
公开(公告)日：1993-12-21
申请号：US892451
申请日：1992-06-02
申请人： King-Wah W. Yeung , J. Fleming Dias
发明人： King-Wah W. Yeung , J. Fleming Dias
IPC分类号： A61B8/12
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4461
摘要： An ultrasound probe includes an ultrasound emitter and a turbine. In one embodiment, the ultrasound emitter is a reflective surface which reflects ultrasound signals generated by a transmitter. The reflective surface reflects the ultrasound signals so that reflected ultrasound signals exit the ultrasound probe. The turbine is connected to the reflecting means. Fluid flowing through the turbine causes the turbine to rotate the reflecting means so that the reflected ultrasound signals sweep an area surrounding the ultrasound probe.
摘要翻译：超声波探头包括超声发射器和涡轮机。在一个实施例中，超声波发射器是反射由发射器产生的超声信号的反射表面。反射表面反射超声信号，使反射超声信号离开超声波探头。涡轮机连接到反射装置。流经涡轮的流体使涡轮旋转反射装置，使得反射的超声波信号扫描超声探头周围的区域。

10. 发明授权

US06658710B2 Method for fabricating an annular ring transducer 失效
标题翻译：制造环形环形换能器的方法
公开(公告)号：US06658710B2
公开(公告)日：2003-12-09
申请号：US09888742
申请日：2001-06-25
申请人： J. Fleming Dias , Richard D. Pering , Henry E. Karrer , Richard J. Pittaro
发明人： J. Fleming Dias , Richard D. Pering , Henry E. Karrer , Richard J. Pittaro
IPC分类号： H04R1700
CPC分类号： G01F1/667 , Y10T29/42 , Y10T29/49002 , Y10T29/49011
摘要： A method is provided for fabricating an annular ring transducers for determining the velocity of a fluid flow. A novel and accurate flow measurement system is fabricated for measuring transit time of a fluid flow using chirp signals, and a pneumotachometer with annular ring transducers is also disclosed.
摘要翻译：提供了一种用于制造用于确定流体流速度的环形换能器的方法。制造了一种新颖而精确的流量测量系统，用于测量使用啁啾信号的流体流动时间，并且还公开了一种具有环形环形换能器的气动测速计。

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