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1. 发明授权

US08981058B2 Gelatin sponge comprising an active ingredient, its preparation and use 有权
标题翻译：明胶海绵含有活性成分，其制备及用途
公开(公告)号：US08981058B2
公开(公告)日：2015-03-17
申请号：US13847898
申请日：2013-03-20
申请人： Israel Nur , Liliana Bar , Guy Tomer , Eyal Sheetrit
发明人： Israel Nur , Liliana Bar , Guy Tomer , Eyal Sheetrit
IPC分类号： A61K38/00 , A61K9/00 , A61K9/70 , A61L15/32 , A61L15/42 , A61L15/44 , A61K38/48
CPC分类号： A61L15/425 , A61K9/70 , A61K38/4833 , A61L15/32 , A61L15/325 , A61L15/44 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04
摘要： The present invention is directed to a method for manufacturing a cross-linked gelatin sponge having a surface by providing a cross-linked gelatin sponge, wetting the surface of the sponge by applying a sufficient amount of liquid comprising a protein or peptide active ingredient, wherein a sufficient amount of liquid is one that retains the flexibility of the sponge even after drying. The sponge is then dried the sponge to obtain a flexible, dry and ready to use cross linked gelatin sponge having a layer of protein or peptide active ingredient on the surface thereof.
摘要翻译：本发明涉及通过提供交联明胶海绵来制造具有表面的交联明胶海绵的方法，通过施加足量的包含蛋白质或肽活性成分的液体来润湿海绵的表面，其中足够量的液体即使在干燥后也保持海绵的柔韧性。然后将海绵干燥成海绵，以获得在其表面上具有蛋白质或肽活性成分层的柔性，干燥且准备使用的交联明胶海绵。

2. 发明授权

US08968724B2 Compositions suitable for treatment of spinal disease, disorder or condition 有权
标题翻译：适合治疗脊髓疾病，病症或病症的组合物
公开(公告)号：US08968724B2
公开(公告)日：2015-03-03
申请号：US12675234
申请日：2008-08-29
申请人： Edna Bechor , Liliana Bar , Israel Nur
发明人： Edna Bechor , Liliana Bar , Israel Nur
IPC分类号： A01N63/00 , A61L27/38 , A61L27/36 , C12N5/077 , A61K35/16
CPC分类号： A61K35/16 , A61K35/545 , A61K38/1709 , A61K38/363 , A61L27/3616 , A61L27/3804 , A61L27/3856 , A61L27/3878 , A61L2430/38 , C12N5/0655 , C12N2500/84 , A61K2300/00
摘要： The invention relates to the use of viral inactivated-plasma cryoprecipitate concentrate (VIPCC) comprising a suitable fibronectin/fibrinogen ratio for treating a spine disease, disorder or condition such as intervertebral disc degeneration.
摘要翻译：本发明涉及包含适当的纤连蛋白/纤维蛋白原比例的病毒灭活血浆冷沉淀物浓缩物（VIPCC）用于治疗脊椎疾病，病症或病症如椎间盘退变的用途。

3. 发明授权

US08563288B2 Removal of plasmin or plasminogen from cryoprecipitate 有权
标题翻译：从冷沉淀物中去除纤溶酶或纤溶酶原
公开(公告)号：US08563288B2
公开(公告)日：2013-10-22
申请号：US12289499
申请日：2008-10-29
申请人： Israel Nur , Liliana Bar , Malkit Azachi
发明人： Israel Nur , Liliana Bar , Malkit Azachi
IPC分类号： C12N9/66 , A61K35/16
CPC分类号： C12N9/6435 , C07K1/22 , C12Y304/21007
摘要： A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6-8 Angstroms, preferably about 7 Angstroms apart and the rigid amino acid is covalently bound to the support via the amino group of the amino acid.
摘要翻译：一种通过使混合物与刚性氨基酸接触的方法，其特征在于从含有纤维蛋白溶酶（ogen）或纤溶酶的混合物中除去或分离纤维蛋白原（纤维蛋白原）存在下的纤维蛋白溶酶或纤溶酶，其中氨基酸和羧基的氨基氨基酸约6-8埃，优选约7埃，刚性氨基酸通过氨基酸的氨基与载体共价结合。

4. 发明申请

US20110045034A1 Gelatin Sponge Comprising an Active Ingredient, Its Preparation and Use 有权
标题翻译：明胶海绵包含活性成分，其制备和用途
公开(公告)号：US20110045034A1
公开(公告)日：2011-02-24
申请号：US12920000
申请日：2009-03-02
申请人： Israel Nur , Eyal Sheetrit , Liliana Bar , Guy Tomer
发明人： Israel Nur , Eyal Sheetrit , Liliana Bar , Guy Tomer
IPC分类号： A61K9/00 , A61K38/48 , A61P7/04
CPC分类号： A61L15/425 , A61K9/70 , A61K38/4833 , A61L15/32 , A61L15/325 , A61L15/44 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04
摘要： The invention relates to an improved dry cross-linked gelatin sponge comprising a layer of an active ingredient, to methods of its preparation and uses thereof.
摘要翻译：本发明涉及包含活性成分层的改进的干交联明胶海绵，其制备方法及其用途。

5. 发明申请

US20100217231A1 Device for administering an at least two-component substance 审中-公开
标题翻译：用于施用至少两种组分物质的装置
公开(公告)号：US20100217231A1
公开(公告)日：2010-08-26
申请号：US12708453
申请日：2010-02-18
申请人： Erez Ilan , Moti Meron , Kfir Regev , Liliana Bar , Israel Nur
发明人： Erez Ilan , Moti Meron , Kfir Regev , Liliana Bar , Israel Nur
IPC分类号： A61M5/31 , A61B17/03 , A61M35/00
CPC分类号： A61M5/1582 , A61B17/00491 , A61B2017/00495 , A61M5/3297 , A61M2025/0039
摘要： The device for administering an at least two-component substance comprises a concentric lumen arrangement including (i) an inner cannula having a lumen with an inlet opening at a first end and a tip with an outlet opening at a second end opposite its first end, and (ii) an outer sheath having opposite first and second ends facing the respective first and second ends of the inner cannula, and surrounding the inner cannula along an axial length between the first and second ends of the inner cannula, wherein the outer sheath at its second end is sealingly and fixedly connected to the inner cannula and defining an outer lumen around the inner cannula, and wherein the inner cannula is provided with at least one opening for providing fluid communication between the outer lumen around the inner cannula and the lumen of the inner cannula.
摘要翻译：用于施用至少两种组分物质的装置包括同心的腔排列，其包括（i）具有在第一端具有入口开口的内腔和在其第一端相对的第二端处具有出口开口的末端的内套管，和（ii）外护套，其具有相对的第一和第二端面向所述内套管的相应的第一和第二端，并且沿着所述内套管的第一和第二端之间的轴向长度包围所述内套管，其中，其第二端密封地和固定地连接到内套管并且围绕内插管限定外腔，并且其中内插管设置有至少一个开口，用于提供围绕内插管的外腔与内套管之间的流体连通内套管。

6. 发明申请

US20090176293A1 Removal of plasmin(ogen) from protein solutions 有权
标题翻译：从蛋白质溶液中去除纤溶酶（ogen）
公开(公告)号：US20090176293A1
公开(公告)日：2009-07-09
申请号：US12289499
申请日：2008-10-29
申请人： Israel Nur , Liliana Bar , Malkit Azachi
发明人： Israel Nur , Liliana Bar , Malkit Azachi
IPC分类号： C12N9/68
CPC分类号： C12N9/6435 , C07K1/22 , C12Y304/21007
摘要： A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6-8 Angstroms, preferably about 7 Angstroms apart and the rigid amino acid is covalently bound to the support via the amino group of the amino acid.
摘要翻译：一种通过使混合物与刚性氨基酸接触的方法，其特征在于从含有纤维蛋白溶酶（ogen）或纤溶酶的混合物中除去或分离纤维蛋白原（纤维蛋白原）存在下的纤维蛋白溶酶或纤溶酶，其中氨基酸和羧基的氨基氨基酸约6-8埃，优选约7埃，刚性氨基酸通过氨基酸的氨基与载体共价结合。

7. 发明授权

US09328338B2 Method for removing a lytic enzyme from a heterogeneous mixture 有权
标题翻译：从异质混合物中除去裂解酶的方法
公开(公告)号：US09328338B2
公开(公告)日：2016-05-03
申请号：US13532997
申请日：2012-06-26
申请人： Roberto Meidler , Nina Raver-Shapira , Liliana Bar , Oleg Belyaev , Israel Nur
发明人： Roberto Meidler , Nina Raver-Shapira , Liliana Bar , Oleg Belyaev , Israel Nur
IPC分类号： C12N9/50 , C07K14/81 , C12N9/68 , C07K1/22
CPC分类号： C12N9/50 , C07K1/22 , C07K14/81 , C07K14/811 , C12N9/6435 , C12Y304/21007
摘要： The invention relates to purification of an intact, non-degraded macromolecule from a biological mixture comprising the macromolecule in the presence of its lytic enzyme. The method comprises providing the biological mixture as a heterogeneous mixture comprising the lytic enzyme, at least partially, in soluble form and the macromolecule, at least partially, in non-soluble form; batch-wise contacting the heterogeneous mixture with an immobilized inhibitor of the lytic enzyme; increasing the solubility of the macromolecule in the mixture; and removing the immobilized inhibitor from the mixture.
摘要翻译：本发明涉及在其溶解酶存在下从包含大分子的生物混合物中纯化完整的未降解的大分子。该方法包括提供生物混合物作为非均质混合物，其包含溶解酶，至少部分可溶形式和大分子，至少部分为非溶解形式; 将非均相混合物与溶解酶的固定化抑制剂分批接触; 增加大分子在混合物中的溶解度; 并从混合物中除去固定化的抑制剂。

8. 发明授权

US09213035B2 Protein assay 有权
标题翻译：蛋白质测定
公开(公告)号：US09213035B2
公开(公告)日：2015-12-15
申请号：US12298814
申请日：2008-05-22
申请人： Ashley De Anglis , Roberto Meidler , Anne Gorman , Liliana Bar , Israel Nur
发明人： Ashley De Anglis , Roberto Meidler , Anne Gorman , Liliana Bar , Israel Nur
IPC分类号： G01N33/86 , C12Q1/56 , G01N33/68
CPC分类号： C12Q1/56 , G01N33/68 , G01N33/86
摘要： A method is described for the measurement of thrombin activity in the presence of fibrinogen, or for the measurement of the functionality of fibrinogen in the presence of thrombin.
摘要翻译：描述了在纤维蛋白原存在下测量凝血酶活性或在凝血酶存在下测量纤维蛋白原的功能的方法。

9. 发明申请

US20130005947A1 METHOD FOR REMOVING A LYTIC ENZYME FROM A HETEROGENEOUS MIXTURE 有权
标题翻译：从异构混合物中除去乳酸酶的方法
公开(公告)号：US20130005947A1
公开(公告)日：2013-01-03
申请号：US13532997
申请日：2012-06-26
申请人： Roberto Meidler , Nina Raver-Shapira , Liliana Bar , Oleg Belyaev , Israel Nur
发明人： Roberto Meidler , Nina Raver-Shapira , Liliana Bar , Oleg Belyaev , Israel Nur
IPC分类号： C07K1/14 , B01D17/00 , C07K14/75
CPC分类号： C12N9/50 , C07K1/22 , C07K14/81 , C07K14/811 , C12N9/6435 , C12Y304/21007
摘要： The invention relates to purification of an intact, non-degraded macromolecule from a biological mixture comprising the macromolecule in the presence of its lytic enzyme. The method comprises providing the biological mixture as a heterogeneous mixture comprising the lytic enzyme, at least partially, in soluble form and the macromolecule, at least partially, in non-soluble form; batch-wise contacting the heterogeneous mixture with an immobilized inhibitor of the lytic enzyme; increasing the solubility of the macromolecule in the mixture; and removing the immobilized inhibitor from the mixture.
摘要翻译：本发明涉及在其溶解酶存在下从包含大分子的生物混合物中纯化完整的未降解的大分子。该方法包括提供生物混合物作为非均质混合物，其包含溶解酶，至少部分可溶形式和大分子，至少部分为非溶解形式; 将非均相混合物与溶解酶的固定化抑制剂分批接触; 增加大分子在混合物中的溶解度; 并从混合物中除去固定化的抑制剂。

10. 发明授权

US08322637B2 Method of micronization 有权
标题翻译：微粉化方法
公开(公告)号：US08322637B2
公开(公告)日：2012-12-04
申请号：US12312221
申请日：2007-10-30
申请人： Israel Nur , Liliana Bar
发明人： Israel Nur , Liliana Bar
IPC分类号： B02C19/06
CPC分类号： B02C19/061 , A61K9/14 , A61K9/19 , A61K38/363 , A61K38/4833
摘要： A method for micronization of a dispersion of particles including a protein having a predetermined level of biological activity, is provided. The method includes introducing the dispersion into a vortex chamber milling apparatus under milling conditions which result in a protein powder having a particle size distribution of 5 to 100 μm and/or exhibiting a 30 to 400 fold size reduction of the protein particle dispersion from its original size, and retaining at least 80% of the predetermined level of biological activity of the protein. The milling conditions include one or more parameters selected from the following: input pressure between 1 and 7 Bars; injector pressure between 0.2 and 5 Bars; loading rate between 0.1 and 5 kg/hour; and gas flow between 30 and 100 m3/hour.
摘要翻译：提供了包含具有预定水平生物活性的蛋白质的颗粒分散体的微粉化方法。该方法包括在研磨条件下将分散体引入涡流室研磨装置，其导致蛋白质粉末的粒度分布为5至100μm，和/或显示蛋白质颗粒分散体的原始尺寸为30至400倍大小的蛋白质粉末并且保留蛋白质的预定水平的生物活性的至少80％。研磨条件包括从以下选择的一个或多个参数：1和7条之间的输入压力; 注射器压力在0.2和5条之间; 装载速度在0.1到5公斤/小时之间; 气体流量在30到100立方米/小时之间。

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