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    • 3. 发明授权
    • Adaptive contrast agent medical imaging
    • 自适应造影剂医学成像
    • US07993273B2
    • 2011-08-09
    • US12129544
    • 2008-05-29
    • Patrick J. PhillipsIsmayil M. Guracar
    • Patrick J. PhillipsIsmayil M. Guracar
    • A61B8/14
    • A61B8/481A61B8/467
    • System parameters for contrast agent medical imaging are conveniently set. A simplified contrast agent configuration is provided where an appropriate contrast agent detection technique and/or contrast agent imaging parameters are achieved consistently and more often then exists with current methods. Examination workflow is improved for contrast agent studies by offering one contrast agent imaging mode or configuration that is dynamically determined and optimized based on the user's selected transmit level and/or a real-time measurement of the contrast agent signals. A simplified user interface provides one contrast agent imaging mode without a need to switch between multiple modes or contrast agent detection techniques and associated contrast agent imaging parameters. The contrast agent detection technique and imaging parameters are adjusting or selected based on changes in the transmit levels for contrast agent imaging. Either a single user input control or real time measurements are used to select a transmit level, resulting in automatic selection of adjustment of the detection technique and/or imaging parameters. Appropriate contrast agent detection techniques and imaging parameters are selected for each given transmit level without the user having to switch the mode or configuration of the system during an imaging session. As a result, contrast agent examinations are simplified while minimizing suboptimal selection by a user.
    • 造影剂医学成像的系统参数设置方便。 提供了一种简化的造影剂配置,其中一致地实现适当的造影剂检测技术和/或造影剂成像参数,并且随后以当前方法存在。 通过提供基于用户选择的发射电平和/或造影剂信号的实时测量动态确定和优化的一种造影剂成像模式或配置,对造影剂研究的检查工作流程得到改善。 简化的用户界面提供一种造影剂成像模式,而无需在多种模式或造影剂检测技术和相关的造影剂成像参数之间进行切换。 造影剂检测技术和成像参数根据造影剂成像的传输水平的变化进行调整或选择。 使用单个用户输入控制或实时测量来选择发射电平,导致自动选择检测技术和/或成像参数的调整。 为每个给定的传输级别选择适当的造影剂检测技术和成像参数,而用户不必在成像会话期间切换系统的模式或配置。 因此,简化了造影剂检查,同时使用户的次优选择最小化。
    • 7. 发明申请
    • Contrast Agent Imaging With Agent Specific Ultrasound Detection
    • 对比剂成像与特定特定超声检测
    • US20090012400A1
    • 2009-01-08
    • US12234448
    • 2008-09-19
    • Ismayil M. GuracarJames E. ChomasPatrick J. Phillips
    • Ismayil M. GuracarJames E. ChomasPatrick J. Phillips
    • A61B8/14
    • A61B8/481A61B8/483
    • Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence. Using cubic fundamental sensitive techniques with other motion estimation techniques, such as two-dimensional velocity estimation or speckle tracking, may operate better than using other contrast agent detection techniques because of substantially reduced clutter.
    • 可以通过处理立方基本信息来获得容器中诸如冠状动脉之间的流动的高度特异性测量。 通过显示具有高度对比组织特异性的血管中的流动,基于超声的基于3D造影剂的冠状动脉血管造影可能是可能的。 与三次基本能量的显示同时提供来自三次基本信号的试剂速度的测量和显示,例如提供由能量和速度两者分度的显示图。 结合长速度测量间隔的三次基波检测的高脉冲重复频率(PRF)可以提高低速度灵敏度和测量精度。 脉冲波(PW)多普勒可以通过使用立方基本敏感脉冲序列来改善。 使用三维基本敏感技术与其他运动估计技术(如二维速度估计或斑点跟踪)相比,使用其他造影剂检测技术的操作可能比实际上减少的杂波更好。
    • 10. 发明授权
    • Medical ultrasonic contrast agent imaging method and apparatus
    • 医用超声造影剂成像方法及装置
    • US06497666B1
    • 2002-12-24
    • US09696511
    • 2000-10-25
    • Patrick J. PhillipsIsmayil M. Guracar
    • Patrick J. PhillipsIsmayil M. Guracar
    • A61B814
    • A61B8/481A61B8/14G01S7/52034G01S7/52041G01S7/52046G01S7/5206G01S7/52074G01S15/8981
    • A medical ultrasonic imaging system transmits a set of two or more substantially identical transmit pulses into a tissue containing a contrast agent. The associated received pulses are filtered with a broadband filter that passes both the fundamental and at least one harmonic component of the echoes. The filtered received pulses are then applied to a clutter filter that suppresses harmonic and fundamental responses from slowly moving and stationary tissue, while clearly showing contrast agent response due to the loss of correlation effect. The disclosed system includes other signal paths for generating conventional B-mode images as well as combined images that include both components from the contrast-specific image as well as components from the B-mode image. An improved user interface allows the user to switch among these three images. Preferably the transmitter generates transmitted pulses having two or more spatially distinct focus zones, thereby improving the uniformity of contrast agent imaging over the imaged region.
    • 医疗超声成像系统将一组两个或更多基本相同的发射脉冲发送到包含造影剂的组织中。 相关联的接收脉冲用宽带滤波器滤波,该滤波器通过回波的基波和至少一个谐波分量。 滤波的接收脉冲然后被施加到杂波滤波器,其抑制来自缓慢移动和静止组织的谐波和基波响应,同时由于相关效应的损失而清楚地显示造影剂响应。 所公开的系统包括用于产生常规B模式图像的其他信号路径以及包括来自对比度特定图像的两个组件以及来自B模式图像的组件的组合图像。 改进的用户界面允许用户在这三个图像之间切换。 优选地,发射器产生具有两个或更多个空间上不同的聚焦区域的发射脉冲,从而改善造影剂成像在成像区域上的均匀性。