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    • 1. 发明授权
    • Soft contact lenses and process for preparation thereof
    • 软性隐形眼镜及其制备方法
    • US3983083A
    • 1976-09-28
    • US530119
    • 1974-12-06
    • Isao KaetsuMinoru KumakuraAkihiko ItoYuji Maeda
    • Isao KaetsuMinoru KumakuraAkihiko ItoYuji Maeda
    • G02C7/04C08F2/00C08F2/02C08F20/00C08F20/26G02B1/04B29D11/00C08F216/02C08F218/00C08G2/00
    • G02B1/043Y10S526/936
    • Soft contact lenses comprising a copolymer comprising at least one monomer of the general formula, ##EQU1## wherein X is H or CH.sub.3 and n is 2 or 3, at least one monomer of the general formula, ##EQU2## wherein X is H or CH.sub.3 and m is an integer of 4 to 13, and optionally at least one polymerizable monomer other than the monomers of the above-mentioned two groups are disclosed. These contact lenses are soft and flexible in the non-swollen state and are tougher and less susceptible to microbiological contamination than the hitherto known soft contact lenses. Also a novel process for preparation of these soft contact lenses is disclosed, which comprises cast-polymerizing a mixture of the above-mentioned monomers, cooling the resulting copolymer to a low temperature at which it stands rigid, and shaping the copolymer body into the lens form in the cooled rigid state.
    • 柔性隐形眼镜包含包含至少一种通式CH 2 = CX-CO-(CH 2)n OH的单体的共聚物,其中X为H或CH 3且n为2或3的PARALLEL O,至少一种通式 ,CH 2 = CX-CO-(CH 2)m OH,其中X为H或CH 3且m为4至13的整数的PARALLEL O,以及任选地至少一种除上述两个单体之外的可聚合单体 。 这些隐形眼镜在非肿胀状态下柔软且柔韧,比迄今为止已知的软性隐形眼镜更坚韧,更不易受微生物污染。 还公开了一种用于制备这些软性隐形眼镜的新方法,其包括将上述单体的混合物浇铸聚合,将所得共聚物冷却至其刚性的低温,并将共聚物体成形为透镜 形成冷却的刚性状态。
    • 4. 发明授权
    • Process for producing a contact lens
    • 隐形眼镜的制造方法
    • US4839109A
    • 1989-06-13
    • US886266
    • 1986-07-16
    • Isao KaetsuMinoru KumakuraHidenari SuyamaNobuo KamedaHideo Koyama
    • Isao KaetsuMinoru KumakuraHidenari SuyamaNobuo KamedaHideo Koyama
    • G02C7/04C08F230/08G02B1/04
    • C08F230/08G02B1/043
    • A mixture of a specified siloxanylalkyl ester monomer and a specified vinyl monomer is polymerized by exposure to an ionizing radiation at low temperatures and the resulting polymer is worked with a lathe cut to form a contact lens. The contact lens obtained is free from any optical distortion, has good dimensional stability and exhibits high oxygen permeability. In a preferred embodiment, a monomer mixture comprising a siloxanylalkyl ester, a methacrylate or acrylate, N-vinylpyrrolidone, and a small amount of a dimethacrylate or diacrylate is exposed to a total dose of 1.times.10.sup.5 -5.times.10.sup.6 roentgens at a low temperature (-80.degree. C. to -20.degree. C. and at a dose rate of 8.times.10.sup.4 -2.times.10.sup.6 roentgens per hour, and the resulting polymer is worked into a contact lens by a suitable forming process involving cutting, grinding and polishing operations.
    • 指定的硅氧烷基烷基酯单体和特定乙烯基单体的混合物通过在低温下暴露于电离辐射而聚合,并且所得聚合物用车床切割加工以形成隐形眼镜。 获得的隐形眼镜没有任何光学变形,具有良好的尺寸稳定性和显示出高的透氧性。 在优选的实施方案中,包含硅氧烷基烷基酯,甲基丙烯酸酯或丙烯酸酯,N-乙烯基吡咯烷酮和少量二甲基丙烯酸酯或二丙烯酸酯的单体混合物在低温(-80℃)下暴露于总量为1×105-5×10 6个 以-20℃,剂量率为8×10 4 -2×10 6个/小时,并且通过涉及切割,研磨和抛光操作的合适的成型方法将所得聚合物加工成隐形眼镜。
    • 5. 发明授权
    • Process for producing a slow release composite
    • 缓释复合材料的制备方法
    • US4582719A
    • 1986-04-15
    • US514026
    • 1983-07-15
    • Isao KaetsuMasaharu AsanoMinoru KumakuraMasaru Yoshida
    • Isao KaetsuMasaharu AsanoMinoru KumakuraMasaru Yoshida
    • A01N25/10A61K9/20A61K9/22A61K9/52B01J19/12B05D3/06
    • A01N25/10A61K9/2063
    • A process is, herein disclosed, for producing a slow release composite having a physiologically active substance encapsulated therein, which comprises preparing a system wherein one or more physiologically active substances are in contact with protein from one or more protein sources, and bringing said system into direct contact with steam at temperatures between 50.degree. C. and 100.degree. C. to denature the protein and make the same hydrophobic, to thereby make a slow release composite having the physiologically active substance dispersed, fixed and encapsulated therein. And a process is also disclosed for producing a slow release composite which comprises preparing a mixture of one or more hydrophilic polymerizable monomers containing the body fluid and/or isotonic solution, protein from one or more protein sources, and one or more physiologically active substances, subjecting the mixture to direct contact with steam and irradiation with light or ionizing radiation, said treatment with steam being performed either before or simultaneously with irradiation with light or ionizing radiation.
    • 本文公开了一种用于生产包含其中的生理活性物质的缓释复合物的方法,其包括制备其中一种或多种生理活性物质与来自一种或多种蛋白质来源的蛋白质接触的系统,并将所述系统引入 在50℃至100℃的温度下直接与蒸汽接触以使蛋白质变性并制成相同的疏水性,从而制备其生理活性物质分散,固定和包封的缓释复合物。 还公开了用于生产缓释复合物的方法,其包括制备含有体液和/或等渗溶液的一种或多种亲水性可聚合单体,来自一种或多种蛋白质来源的蛋白质和一种或多种生理活性物质的混合物, 使混合物与蒸汽直接接触并用光或电离辐射照射,所述用蒸汽进行的处理在用光或电离辐射照射之前或同时进行。