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    • 1. 发明授权
    • Process for producing a slow release composite
    • 缓释复合材料的制备方法
    • US4582719A
    • 1986-04-15
    • US514026
    • 1983-07-15
    • Isao KaetsuMasaharu AsanoMinoru KumakuraMasaru Yoshida
    • Isao KaetsuMasaharu AsanoMinoru KumakuraMasaru Yoshida
    • A01N25/10A61K9/20A61K9/22A61K9/52B01J19/12B05D3/06
    • A01N25/10A61K9/2063
    • A process is, herein disclosed, for producing a slow release composite having a physiologically active substance encapsulated therein, which comprises preparing a system wherein one or more physiologically active substances are in contact with protein from one or more protein sources, and bringing said system into direct contact with steam at temperatures between 50.degree. C. and 100.degree. C. to denature the protein and make the same hydrophobic, to thereby make a slow release composite having the physiologically active substance dispersed, fixed and encapsulated therein. And a process is also disclosed for producing a slow release composite which comprises preparing a mixture of one or more hydrophilic polymerizable monomers containing the body fluid and/or isotonic solution, protein from one or more protein sources, and one or more physiologically active substances, subjecting the mixture to direct contact with steam and irradiation with light or ionizing radiation, said treatment with steam being performed either before or simultaneously with irradiation with light or ionizing radiation.
    • 本文公开了一种用于生产包含其中的生理活性物质的缓释复合物的方法,其包括制备其中一种或多种生理活性物质与来自一种或多种蛋白质来源的蛋白质接触的系统,并将所述系统引入 在50℃至100℃的温度下直接与蒸汽接触以使蛋白质变性并制成相同的疏水性,从而制备其生理活性物质分散,固定和包封的缓释复合物。 还公开了用于生产缓释复合物的方法,其包括制备含有体液和/或等渗溶液的一种或多种亲水性可聚合单体,来自一种或多种蛋白质来源的蛋白质和一种或多种生理活性物质的混合物, 使混合物与蒸汽直接接触并用光或电离辐射照射,所述用蒸汽进行的处理在用光或电离辐射照射之前或同时进行。