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1. 发明申请

US20110117167A1 METHODS AND COMPOSITIONS FOR SOFT TISSUE REPAIR 失效
公开(公告)号：US20110117167A1
公开(公告)日：2011-05-19
申请号：US12949104
申请日：2010-11-18
申请人： Isaac Gilliam Sanford , Michelle Steffen Jansen , Paul Theodore Hamilton , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen , Martyn Kerry Darby , Hanne Gron , Ganesan Sathya
发明人： Isaac Gilliam Sanford , Michelle Steffen Jansen , Paul Theodore Hamilton , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen , Martyn Kerry Darby , Hanne Gron , Ganesan Sathya
IPC分类号： A61K9/00 , C07K14/00 , C07K7/08 , C07K14/78 , C12N5/071 , C12N5/078 , A61K35/12 , A61K35/32 , A61K35/28 , A61K35/14 , A61K35/16 , A61K35/48 , A61K35/50 , C07K19/00 , A61K38/16 , A61K38/10 , A61K38/39 , A61P17/02 , A61P19/04 , A61P21/00 , A61P19/00 , A61P9/00 , C07K9/00 , C08G63/91 , A61K38/14 , A61K31/765 , C12N5/077
CPC分类号： A61K47/48992 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/64 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

2. 发明授权

US08779089B2 Methods and compositions for soft tissue repair 失效
公开(公告)号：US08779089B2
公开(公告)日：2014-07-15
申请号：US12949104
申请日：2010-11-18
申请人： Isaac Gilliam Sanford , Michelle Steffen Jansen , Paul Theodore Hamilton , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen , Martyn Kerry Darby , Hanne Gron , Ganesan Sathya
发明人： Isaac Gilliam Sanford , Michelle Steffen Jansen , Paul Theodore Hamilton , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen , Martyn Kerry Darby , Hanne Gron , Ganesan Sathya
IPC分类号： A61K38/10 , C07K17/00 , C07K17/12 , C07K7/08 , C07K17/08 , C07K17/10 , A61K47/48 , A61K47/02 , A61K9/00 , A61L27/54 , A61L27/58 , A61K47/42 , A61L27/42
CPC分类号： A61K47/48992 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/64 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

3. 发明授权

US08691946B2 Methods and compositions for soft tissue repair 有权
标题翻译：软组织修复的方法和组成
公开(公告)号：US08691946B2
公开(公告)日：2014-04-08
申请号：US13109802
申请日：2011-05-17
申请人： Isaac Gilliam Sanford , Martyn Kerry Darby , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen , Paul Theodore Hamilton , Ganesan Sathya , Hanne Gron , Michelle Steffen Jansen
发明人： Isaac Gilliam Sanford , Martyn Kerry Darby , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen , Paul Theodore Hamilton , Ganesan Sathya , Hanne Gron , Michelle Steffen Jansen
IPC分类号： A61K38/04 , A61K38/00 , A61K38/03 , C07K17/12 , C07K17/04 , C07K17/08 , C07K17/10 , C07K7/08
CPC分类号： A61K47/48992 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/64 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.
摘要翻译：提供组织修复的组合物和方法，包括细胞结合肽和生长因子结合肽。细胞结合肽与干细胞，成纤维细胞或内皮细胞中的一种或多种结合。生长因子结合肽包括血小板衍生生长因子（PDGF）结合肽和生长分化因子（GDF）结合肽。用于修复的组织包括肌腱，肌肉，结缔组织，韧带，心脏组织，血管组织或真皮。提供用于组织修复的可植入装置，细胞和生长因子结合肽所连接的装置，例如具有连接结合肽的细胞外细胞基质。

4. 发明申请

US20110223142A1 METHODS AND COMPOSITIONS FOR SOFT TISSUE REPAIR 有权
标题翻译：软组织修复的方法和组合
公开(公告)号：US20110223142A1
公开(公告)日：2011-09-15
申请号：US13109802
申请日：2011-05-17
申请人： Isaac Gilliam Sanford , Martyn Kerry Darby , Shrikumar Ambujakshan Nair , Jonathan Allen Hodges , Yuchen Chen , Ganesan Sathya , Hanne Gron , Michelle Steffen Jansen , Paul Theodore Hamilton
发明人： Isaac Gilliam Sanford , Martyn Kerry Darby , Shrikumar Ambujakshan Nair , Jonathan Allen Hodges , Yuchen Chen , Ganesan Sathya , Hanne Gron , Michelle Steffen Jansen , Paul Theodore Hamilton
IPC分类号： A61K35/12 , C07K7/08 , C07K14/00 , A61K38/10 , A61K38/16 , A61K38/39 , C12N5/071 , A61P43/00
CPC分类号： A61K47/48992 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/64 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.
摘要翻译：提供组织修复的组合物和方法，包括细胞结合肽和生长因子结合肽。细胞结合肽与干细胞，成纤维细胞或内皮细胞中的一种或多种结合。生长因子结合肽包括血小板衍生生长因子（PDGF）结合肽和生长分化因子（GDF）结合肽。用于修复的组织包括肌腱，肌肉，结缔组织，韧带，心脏组织，血管组织或真皮。提供用于组织修复的可植入装置，细胞和生长因子结合肽所连接的装置，例如具有连接结合肽的细胞外细胞基质。

5. 发明申请

US20110117168A1 METHODS AND COMPOSITIONS FOR SOFT TISSUE REPAIR 审中-公开
公开(公告)号：US20110117168A1
公开(公告)日：2011-05-19
申请号：US12949149
申请日：2010-11-18
申请人： Ganesan Sathya , Michelle Steffen Jansen , Paul Theodore Hamilton , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Hanne Gron
发明人： Ganesan Sathya , Michelle Steffen Jansen , Paul Theodore Hamilton , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Hanne Gron
IPC分类号： A61K9/00 , C07K7/08 , C07K7/06 , C07K19/00 , C07K9/00 , C08G63/91 , A61K38/39 , A61K38/17 , A61K38/02 , A61K31/785 , A61F2/10 , A61F2/08 , A61F2/12 , A61P43/00 , A61P9/00 , A61P17/00 , A61P19/04
CPC分类号： A61K47/64 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

6. 发明申请

US20100098737A1 METHODS AND COMPOSITIONS FOR DELIVERY OF GLYCOPEPTIDE ANTIBIOTICS TO MEDICAL DEVICE SURFACES 审中-公开
标题翻译：用于向医疗装置表面递送糖尿病抗生素的方法和组合物
公开(公告)号：US20100098737A1
公开(公告)日：2010-04-22
申请号：US12253750
申请日：2008-10-17
申请人： Martyn Kerry Darby , Isaac Gilliam Sanford , Ray Edward Benson, III , Hanne Gron , Paul Theodore Hamilton , Shrikumar Ambujakshan Nair
发明人： Martyn Kerry Darby , Isaac Gilliam Sanford , Ray Edward Benson, III , Hanne Gron , Paul Theodore Hamilton , Shrikumar Ambujakshan Nair
IPC分类号： A61F2/00 , A61K38/16 , A61L33/12 , C07H21/04 , C12N15/64 , A61P31/04
CPC分类号： A61L27/34 , A61K38/16 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/252 , A61L2300/406 , C07K2319/20
摘要： The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.
摘要翻译：目前公开的主题涉及对糖肽抗生素具有结合亲和力的肽以及将糖肽抗生素递送到医疗器械表面的方法和组合物。肽组合物可以包含对与对糖肽抗生素具有结合亲和力的肽偶联的医疗器械的表面材料具有结合亲和力的肽。还提供了通过使肽组合物与医疗装置的表面接触来将肽组合物应用于医疗装置的方法。此外，提供了包含肽组合物的试剂盒。

7. 发明申请

US20060263357A1 Anti-CD19 antibody therapy for autoimmune disease 审中-公开
标题翻译：抗CD19抗体治疗自身免疫性疾病
公开(公告)号：US20060263357A1
公开(公告)日：2006-11-23
申请号：US11429545
申请日：2006-05-05
申请人： Thomas Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
发明人： Thomas Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
IPC分类号： A61K39/395
CPC分类号： C07K16/2887 , A61K2039/505 , A61K2039/507 , C07K16/2803 , C07K16/2896 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/77
摘要： The invention relates to immunotherapeutic compositions and methods for the treatment of autoimmune diseases and disorders in human subjects using therapeutic antibodies that bind to the human CD19 antigen and that preferably mediate human ADCC. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG1 or IgG3 human isotype. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG2 or IgG4 human isotype that preferably mediate human ADCC. The present invention also relates to pharmaceutical compositions comprising chimerized anti-CD19 antibodies of the IgG1, IgG2, IgG3, or IgG4 isotype that mediate human ADCC. In preferred embodiments, the present invention relates to pharmaceutical compositions comprising monoclonal human, humanized, or chimeric anti-CD19 antibodies.
摘要翻译：本发明涉及使用结合人CD19抗原并优选介导人ADCC的治疗性抗体治疗人受试者自身免疫性疾病和病症的免疫治疗组合物和方法。本发明涉及包含IgG1或IgG3人同种型的人或人源化抗CD19抗体的药物组合物。本发明涉及药物组合物，其包含优选介导人ADCC的IgG2或IgG4人同种型人或人源化抗CD19抗体。本发明还涉及包含介导人ADCC的IgG1，IgG2，IgG3或IgG4同种型的嵌合抗CD19抗体的药物组合物。在优选的实施方案中，本发明涉及包含单克隆人，人源化或嵌合抗-CD19抗体的药物组合物。

8. 发明申请

US20130084294A1 ANTI-CD19 ANTIBODIES AND USES IN B CELL DISORDERS 审中-公开
标题翻译：抗CD19抗体和B细胞病症中的用途
公开(公告)号：US20130084294A1
公开(公告)日：2013-04-04
申请号：US13603154
申请日：2012-09-04
申请人： Thomas F. Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
发明人： Thomas F. Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
IPC分类号： A61K39/395
CPC分类号： C07K16/2896 , A61K38/13 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/54 , C07K16/2803 , C07K16/2887 , C07K2317/73 , C07K2317/732 , C07K2317/77
摘要： The invention relates to immunotherapeutic compositions and methods for the treatment of B cell diseases and disorders in human subjects, such as, but not limited to, B cell malignancies and autoimmune diseases and disorders, using therapeutic antibodies that bind to the human CD19 antigen and that preferably mediate human ADCC. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG1 or IgG3 human isotype. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG2 or IgG4 human isotype that preferably mediate human ADCC. The present invention also relates to pharmaceutical compositions comprising chimerized anti-CD19 antibodies of the IgG1, IgG2, IgG3, or IgG4 isotype that mediate human ADCC. In preferred embodiments, the present invention relates to pharmaceutical compositions comprising monoclonal human, humanized, or chimeric anti-CD19 antibodies.
摘要翻译：本发明涉及使用结合人CD19抗原的治疗性抗体来治疗人受试者中B细胞疾病和病症的免疫治疗组合物和方法，例如但不限于B细胞恶性肿瘤和自身免疫疾病和病症，优选介导人ADCC。本发明涉及包含IgG1或IgG3人同种型的人或人源化抗CD19抗体的药物组合物。本发明涉及药物组合物，其包含优选介导人ADCC的IgG2或IgG4人同种型人或人源化抗CD19抗体。本发明还涉及包含介导人ADCC的IgG1，IgG2，IgG3或IgG4同种型的嵌合抗CD19抗体的药物组合物。在优选的实施方案中，本发明涉及包含单克隆人，人源化或嵌合抗-CD19抗体的药物组合物。

9. 发明申请

US20110104150A1 ANTI-CD19 ANTIBODIES AND USES IN B CELL DISORDERS 有权
标题翻译：抗CD19抗体和B细胞病症中的用途
公开(公告)号：US20110104150A1
公开(公告)日：2011-05-05
申请号：US12885341
申请日：2010-09-17
申请人： Thomas F. Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
发明人： Thomas F. Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
IPC分类号： A61K39/395
CPC分类号： C07K16/2896 , A61K38/13 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/54 , C07K16/2803 , C07K16/2887 , C07K2317/73 , C07K2317/732 , C07K2317/77
摘要： The invention relates to immunotherapeutic compositions and methods for the treatment of B cell diseases and disorders in human subjects, such as, but not limited to, B cell malignancies and autoimmune diseases and disorders, using therapeutic antibodies that bind to the human CD19 antigen and that preferably mediate human ADCC. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG1 or IgG3 human isotype. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG2 or IgG4 human isotype that preferably mediate human ADCC. The present invention also relates to pharmaceutical compositions comprising chimerized anti-CD19 antibodies of the IgG1, IgG2, IgG3, or IgG4 isotype that mediate human ADCC. In preferred embodiments, the present invention relates to pharmaceutical compositions comprising monoclonal human, humanized, or chimeric anti-CD19 antibodies.
摘要翻译：本发明涉及使用结合人CD19抗原的治疗性抗体来治疗人受试者中B细胞疾病和病症的免疫治疗组合物和方法，例如但不限于B细胞恶性肿瘤和自身免疫疾病和病症，优选介导人ADCC。本发明涉及包含IgG1或IgG3人同种型的人或人源化抗CD19抗体的药物组合物。本发明涉及药物组合物，其包含优选介导人ADCC的IgG2或IgG4人同种型人或人源化抗CD19抗体。本发明还涉及包含介导人ADCC的IgG1，IgG2，IgG3或IgG4同种型的嵌合抗CD19抗体的药物组合物。在优选的实施方案中，本发明涉及包含单克隆人，人源化或嵌合抗-CD19抗体的药物组合物。

10. 发明申请

US20090285808A1 ANTI-CD19 ANTIBODIES AND USES IN ONCOLOGY 审中-公开
标题翻译：抗CD19抗体及其在肿瘤学中的应用
公开(公告)号：US20090285808A1
公开(公告)日：2009-11-19
申请号：US12401310
申请日：2009-03-10
申请人： Thomas F. Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
发明人： Thomas F. Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
IPC分类号： A61K39/395
CPC分类号： C07K16/2803 , A61K2039/505 , A61K2039/54 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/77
摘要： The invention relates to immunotherapeutic compositions and methods for the treatment of B cell diseases and disorders in human subjects, such as, but not limited to, B cell malignancies, using therapeutic antibodies that bind to the human CD19 antigen and that preferably mediate human ADCC. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG1 or IgG3 human isotype. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG2 or IgG4 human isotype that preferably mediate human ADCC. The present invention also relates to pharmaceutical compositions comprising chimerized anti-CD19 antibodies of the IgG1, IgG2, IgG3, or IgG4 isotype that mediate human ADCC. In preferred embodiments, the present invention relates to pharmaceutical compositions comprising monoclonal human, humanized, or chimeric anti-CD19 antibodies.
摘要翻译：本发明涉及使用结合人CD19抗原并优选介导人ADCC的治疗性抗体来治疗人受试者中B细胞疾病和障碍的免疫治疗组合物和方法，所述B细胞疾病和病症例如但不限于B细胞恶性肿瘤。本发明涉及包含IgG1或IgG3人同种型的人或人源化抗CD19抗体的药物组合物。本发明涉及药物组合物，其包含优选介导人ADCC的IgG2或IgG4人同种型人或人源化抗CD19抗体。本发明还涉及包含介导人ADCC的IgG1，IgG2，IgG3或IgG4同种型的嵌合抗CD19抗体的药物组合物。在优选的实施方案中，本发明涉及包含单克隆人，人源化或嵌合抗-CD19抗体的药物组合物。

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