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    • 7. 发明授权
    • Mammalian myeloid progenitor cell subsets
    • 哺乳动物骨髓祖细胞亚群
    • US07618654B2
    • 2009-11-17
    • US11874841
    • 2007-10-18
    • Irving L. WeissmanDavid Jeffrey TraverKoichi AkashiMarkus Gabriel ManzToshihiro Miyamoto
    • Irving L. WeissmanDavid Jeffrey TraverKoichi AkashiMarkus Gabriel ManzToshihiro Miyamoto
    • A61K35/28G01N33/53
    • C12N5/0647C12N2501/125C12N2501/14C12N2501/145C12N2501/22C12N2501/23C12N2501/26C12N2503/00C12Q1/6881C12Q2600/158
    • A substantially enriched mammalian hematopoietic cell subpopulation is provided, which is characterized by progenitor cell activity for myeloid lineages, but lacking the potential to differentiate into lymphoid lineages. This population is further divided into specific myeloid progenitor subsets, including a common myeloid progenitor cells (CMP), megakaryocyte/erythroid progenitor cells (MEP) and granulocyte/monocyte lineage progenitor (GMP). Methods are provided for the isolation and culture of these subpopulations. The CMP population gives rise to all myeloid lineages, and can give rise to the two additional and isolatable progenitor populations that are exclusively committed to either the erythroid/megakaryocytic or myelomonocytic lineages. Tηε χελλ ενιχημεντ μετηoδσ εμπλoψεαγεντσ τηατ σπεχαλλψεψoγνιζε Tηψ-1; ανδIΛ-7 Pα, in conjunction with other markers expressed on lineage committed cells. These cells give rise to a variety of myeloid cells, including megakaryocytes, granulocytes, dendritic cells and erythroid cells, as evidenced by their growth and differentiation in vitro and in vivo.
    • 提供了基本上富集的哺乳动物造血细胞亚群,其特征在于骨髓谱系的祖细胞活性,但缺乏分化成淋巴谱系的潜力。 该群体进一步分为特定的骨髓祖细胞亚群,包括常见的髓系祖细胞(CMP),巨核细胞/红细胞祖细胞(MEP)和粒细胞/单核细胞谱系祖细胞(GMP)。 提供了用于分离和培养这些亚群体的方法。 CMP群体产生所有骨髓谱系,并且可以产生专门致力于红细胞/巨核细胞或骨髓单核细胞谱系的两个另外的和可分离的祖细胞群体。 “=”2.46mm“wi =”1.78mm“file =”US07618654-20091117-P00001.TIF“alt =”自定义字符“img-content =”character“ img-format =“tif”/> iotachietamuepsilonnutau muepsilontauetaodeltasigma epsilonmupilambdaopsi epsilonalphagammaepsilonnutausigma tauetaalphatau sigmapiepsilonchialphalambdalambdapsi epsilonpsiogammanuiotazetaepsilon Tetapsi-1; alphanudeltaILambda-7 Palpha,与在谱系确定的细胞上表达的其他标志物结合。 这些细胞产生各种骨髓细胞,包括巨核细胞,粒细胞,树突状细胞和红细胞,其体外和体内的生长和分化证明。