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1. 发明授权

US4973555A Human serine protease gene 失效
标题翻译：人丝氨酸蛋白酶基因
公开(公告)号：US4973555A
公开(公告)日：1990-11-27
申请号：US948248
申请日：1986-12-31
申请人： Irving L. Weissman , Howard K. Gershenfeld
发明人： Irving L. Weissman , Howard K. Gershenfeld
IPC分类号： A61K38/00 , C07K16/40 , C12N1/21 , C12N9/64 , C12N15/57
CPC分类号： C12N9/6467 , C07K16/40 , A61K38/00
摘要： Novel human serine proteases are provided characterized by expression in cytotoxic killer cells, being about 25.8kD, and having the amino acid residues of the serine protease charge-relay catalytic mechanism conserved. The proteases can be produced by recombinant DNA technology. The cDNA is also provided.
摘要翻译：提供了新的人丝氨酸蛋白酶，其特征在于在细胞毒性杀伤细胞中表达，约25.8kD，并且具有丝氨酸蛋白酶电荷 - 中继催化机制的氨基酸残基保守。蛋白酶可以通过重组DNA技术生产。还提供cDNA。

2. 发明授权

US5213977A Serine protease from cytotoxic killer cells 失效
标题翻译：来自细胞毒杀伤细胞的丝氨酸蛋白酶
公开(公告)号：US5213977A
公开(公告)日：1993-05-25
申请号：US917783
申请日：1992-07-20
申请人： Irving L. Weissman , Howard K. Gershenfeld
发明人： Irving L. Weissman , Howard K. Gershenfeld
IPC分类号： A61K38/00 , C07K16/40 , C12N9/64
CPC分类号： C12N9/6467 , C07K16/40 , A61K38/00
摘要： A human serine protease expressed in cytotoxic killer cells, having a mass of about 25.8kD, and having the amino acid residues of the serine protease charge-relay catalytic mechanism conserved is provided. The protease can be produced by recombinant DNA technology. The cDNA is also provided.
摘要翻译：提供了在细胞毒性杀伤细胞中表达的人丝氨酸蛋白酶，具有约25.8kD的质量，并且具有保守的丝氨酸蛋白酶电荷继电器催化机制的氨基酸残基。蛋白酶可以通过重组DNA技术生产。还提供cDNA。

3. 发明授权

US09151760B2 Isolation and use of melanoma cancer stem cells 有权
标题翻译：分离和使用黑色素瘤癌细胞
公开(公告)号：US09151760B2
公开(公告)日：2015-10-06
申请号：US13498876
申请日：2010-09-29
申请人： Irving L. Weissman , Alexander D. Boiko
发明人： Irving L. Weissman , Alexander D. Boiko
IPC分类号： A61K39/395 , A61P35/00 , A61K38/02 , G01N33/574 , C12N5/095 , A61K47/48
CPC分类号： G01N33/5743 , A61K39/39558 , A61K47/6843 , A61K47/6851 , A61K47/6879 , C12N5/0695
摘要： A set of markers for melanoma cancer stem cells are provided. The cells can be prospectively isolated or identified from primary tumor samples, and possess the unique properties of cancer stem cells in functional assays for tumor initiation, cancer stem cell self-renewal and differentiation. In addition, cancer stem cells can be used as a predictor for disease progression. The CSC have the phenotype of being positive for expression CD271.
摘要翻译：提供了一组用于黑素瘤癌干细胞的标记物。细胞可以从原发肿瘤样品前瞻性分离或鉴定，并且在肿瘤起始，癌症干细胞自我更新和分化的功能测定中具有癌症干细胞的独特性质。此外，癌症干细胞可用作疾病进展的预测因子。 CSC表达CD271表达阳性。

4. 发明授权

US08765390B2 Identification and isolation of squamous carcinoma stem cells 有权
标题翻译：鉴定和分离鳞状细胞癌干细胞
公开(公告)号：US08765390B2
公开(公告)日：2014-07-01
申请号：US12001336
申请日：2007-12-10
申请人： Laurie Ailles , Irving L. Weissman , Michael Clarke
发明人： Laurie Ailles , Irving L. Weissman , Michael Clarke
IPC分类号： G01N33/574 , G01N33/483
CPC分类号： C12N5/0695 , G01N33/5073 , G01N33/57407 , G01N33/57492
摘要： Squamous carcinoma stem cells (SCSC) are identified. The cells can be prospectively isolated or identified from primary tumor samples, and are shown to possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation, and to form unique histological microdomains useful in cancer diagnosis.
摘要翻译：鉴定鳞状细胞癌干细胞（SCSC）。这些细胞可以从原发性肿瘤样品前瞻性分离或鉴定，并且在癌症干细胞自我更新和分化的功能测定中显示具有癌干细胞的独特性质，并形成用于癌症诊断的独特组织学微结构域。

5. 发明授权

US07803783B2 Use of WNT inhibitors to augment therapeutic index of chemotherapy 失效
标题翻译：使用WNT抑制剂来增加化疗的治疗指数
公开(公告)号：US07803783B2
公开(公告)日：2010-09-28
申请号：US11707386
申请日：2007-02-16
申请人： Mark Lee , Calvin Jay Kuo , Tannishtha Reya , Irving L. Weissman
发明人： Mark Lee , Calvin Jay Kuo , Tannishtha Reya , Irving L. Weissman
IPC分类号： A61K31/713
CPC分类号： A61K38/17 , C07K2319/30
摘要： Methods and compositions are provided for the protection of normal cells from cytoreductive therapy that target proliferating cells, by administering an inhibitor of Wnt signaling pathways. Wnt signaling is critically important for homeostasis of the epithelial lining of the adult intestine and other proliferating normal adult tissues.
摘要翻译：提供了通过施用Wnt信号通路抑制剂来保护正常细胞免受靶向增殖细胞的细胞减灭治疗的方法和组合物。 Wnt信号对成年肠和其他增殖正常成人组织的上皮内皮的稳态至关重要。

6. 发明申请

US20100226927A1 SELECTIVE IMMUNODEPLETION OF ENDOGENOUS STEM CELL NICHE FOR ENGRAFTMENT 审中-公开
标题翻译：选择性免疫治疗内源性干细胞网络用于植入
公开(公告)号：US20100226927A1
公开(公告)日：2010-09-09
申请号：US12447634
申请日：2007-11-02
申请人： Irving L. Weissman , Agnieszka Czechowicz , Deepta Bhattacharya , Daniel Kraft
发明人： Irving L. Weissman , Agnieszka Czechowicz , Deepta Bhattacharya , Daniel Kraft
IPC分类号： A61K39/395 , A61K35/12 , A61P43/00
CPC分类号： C07K16/2896 , A61K35/28 , A61K39/3955 , A61K2039/505 , A61K2039/54 , C07K16/2803 , C07K16/2812 , C07K16/2815 , C07K16/2866 , C07K16/32 , C07K2317/73 , C07K2317/76
摘要： The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of GVHD or graft rejection. Aspects of the present invention are based on the discovery that the depletion of the endogenous stem cell niche facilitates efficient engraftment of stem cells into that niche. In particular, the present invention combines the use of selective ablation of endogenous stem cells, in combination with the administration to the recipient of exogenous stem cells, resulting in efficient, long-term engraftment and tolerance.
摘要翻译：本发明提供了一种临床适用的干细胞移植方法，其有助于移植并重建受体的免疫能力，而不需要放射治疗或化学疗法，并且不发展GVHD或移植物排斥反应。本发明的方面基于这样的发现：内源性干细胞生态位的消耗有助于将干细胞有效植入该生态位。特别地，本发明将内源性干细胞的选择性消融与对外源性干细胞受体的施用相结合，从而产生有效的长期植入和耐受。

7. 发明授权

US07618654B2 Mammalian myeloid progenitor cell subsets 有权
标题翻译：哺乳动物骨髓祖细胞亚群
公开(公告)号：US07618654B2
公开(公告)日：2009-11-17
申请号：US11874841
申请日：2007-10-18
申请人： Irving L. Weissman , David Jeffrey Traver , Koichi Akashi , Markus Gabriel Manz , Toshihiro Miyamoto
发明人： Irving L. Weissman , David Jeffrey Traver , Koichi Akashi , Markus Gabriel Manz , Toshihiro Miyamoto
IPC分类号： A61K35/28 , G01N33/53
CPC分类号： C12N5/0647 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/22 , C12N2501/23 , C12N2501/26 , C12N2503/00 , C12Q1/6881 , C12Q2600/158
摘要： A substantially enriched mammalian hematopoietic cell subpopulation is provided, which is characterized by progenitor cell activity for myeloid lineages, but lacking the potential to differentiate into lymphoid lineages. This population is further divided into specific myeloid progenitor subsets, including a common myeloid progenitor cells (CMP), megakaryocyte/erythroid progenitor cells (MEP) and granulocyte/monocyte lineage progenitor (GMP). Methods are provided for the isolation and culture of these subpopulations. The CMP population gives rise to all myeloid lineages, and can give rise to the two additional and isolatable progenitor populations that are exclusively committed to either the erythroid/megakaryocytic or myelomonocytic lineages. Tηε χελλ ενιχημεντ μετηoδσ εμπλoψεαγεντσ τηατ σπεχαλλψεψoγνιζε Tηψ-1; ανδIΛ-7 Pα, in conjunction with other markers expressed on lineage committed cells. These cells give rise to a variety of myeloid cells, including megakaryocytes, granulocytes, dendritic cells and erythroid cells, as evidenced by their growth and differentiation in vitro and in vivo.
摘要翻译：提供了基本上富集的哺乳动物造血细胞亚群，其特征在于骨髓谱系的祖细胞活性，但缺乏分化成淋巴谱系的潜力。该群体进一步分为特定的骨髓祖细胞亚群，包括常见的髓系祖细胞（CMP），巨核细胞/红细胞祖细胞（MEP）和粒细胞/单核细胞谱系祖细胞（GMP）。提供了用于分离和培养这些亚群体的方法。 CMP群体产生所有骨髓谱系，并且可以产生专门致力于红细胞/巨核细胞或骨髓单核细胞谱系的两个另外的和可分离的祖细胞群体。 “=”2.46mm“wi =”1.78mm“file =”US07618654-20091117-P00001.TIF“alt =”自定义字符“img-content =”character“ img-format =“tif”/> iotachietamuepsilonnutau muepsilontauetaodeltasigma epsilonmupilambdaopsi epsilonalphagammaepsilonnutausigma tauetaalphatau sigmapiepsilonchialphalambdalambdapsi epsilonpsiogammanuiotazetaepsilon Tetapsi-1; alphanudeltaILambda-7 Palpha，与在谱系确定的细胞上表达的其他标志物结合。这些细胞产生各种骨髓细胞，包括巨核细胞，粒细胞，树突状细胞和红细胞，其体外和体内的生长和分化证明。

8. 发明授权

US06991939B2 Optical array device and methods of use thereof for screening, analysis and manipulation of particles 失效
公开(公告)号：US06991939B2
公开(公告)日：2006-01-31
申请号：US10199341
申请日：2002-07-19
申请人： David R. Walt , Irving L. Weissman , Israel Biran , Jenny Tam
发明人： David R. Walt , Irving L. Weissman , Israel Biran , Jenny Tam
IPC分类号： G01N21/64
CPC分类号： G21K1/006 , Y10T436/25375
摘要： Methods and devices are provided for the trapping, including optical trapping; analysis; and selective manipulation of particles on an optical array. A multi-channel device parcels a light source into many points of light transmitted through an optical array of fibers or conduits, preferably where the individual points of light are individually controllable through a light controlling device. Optical properties of the particles may be determined by interrogation with light focused through the optical array. The particles may be manipulated by immobilizing or releasing specific particles, separating types of particles, etc.

9. 发明授权

US06761883B2 Mammalian myeloid progenitor cell subsets 有权
公开(公告)号：US06761883B2
公开(公告)日：2004-07-13
申请号：US09956279
申请日：2001-09-17
申请人： Irving L. Weissman , David Jeffrey Traver , Koichi Akashi , Markus Gabriel Manz , Toshihiro Miyamoto
发明人： Irving L. Weissman , David Jeffrey Traver , Koichi Akashi , Markus Gabriel Manz , Toshihiro Miyamoto
IPC分类号： A01N6300
CPC分类号： C12N5/0647 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/22 , C12N2501/23 , C12N2501/26 , C12N2503/00 , C12Q1/6881 , C12Q2600/158
摘要： A substantially enriched mammalian hematopoietic cell subpopulation is provided, which is characterized by progenitor cell activity for myeloid lineages, but lacking the potential to differentiate into lymphoid lineages. This population is further divided into specific myeloid progenitor subsets, including a common myeloid progenitor cells (CMP), megakaryocyte/erythroid progenitor cells (MEP) and granulocyte/monocyte lineage progenitor (GMP). Methods are provided for the isolation and culture of these subpopulations. The CMP population gives rise to all myeloid lineages, and can give rise to the two additional and isolatable progenitor populations that are exclusively committed to either the erythroid/megakaryocytic or myelomonocytic lineages. The cell enrichment methods employ reagents that specifically recognize Thy-1; and IL-7R&agr;, in conjunction with other markers expressed on lineage committed cells. These cells give rise to a variety of myeloid cells, including megakaryocytes, granulocytes, dendritic cells and erythroid cells, as evidenced by their growth and differentiation in vitro and in vivo.

10. 发明申请

US20140271683A1 Therapeutic and Diagnostic Methods for Manipulating Phagocytosis Through Calreticulin and Low Density Lipoprotein-Related Receptor 审中-公开
标题翻译：通过钙网蛋白和低密度脂蛋白相关受体操纵吞噬作用的治疗和诊断方法
公开(公告)号：US20140271683A1
公开(公告)日：2014-09-18
申请号：US13996390
申请日：2011-12-21
申请人： Mark P. Chao , Rachel Weissman-Tsukamoto , Siddhartha Jaiswal , Ravindra Majeti , Irving L. Weissman
发明人： Mark P. Chao , Rachel Weissman-Tsukamoto , Siddhartha Jaiswal , Ravindra Majeti , Irving L. Weissman
IPC分类号： A61K39/395 , G01N33/68 , C12Q1/68 , A61K35/28 , G01N33/574
CPC分类号： C07K16/2803 , A61K35/28 , A61K39/3955 , A61K2039/505 , C07K16/2896 , C07K2317/73 , C07K2317/76 , C12Q1/6886 , G01N33/56966 , G01N33/57492 , G01N33/57496 , G01N33/6872 , G01N2333/47 , G01N2333/4722 , G01N2800/52
摘要： Therapeutic and diagnostic methods are provided, which methods relate to the expression of calreticulin on cancer cells and hematopoietic cells.
摘要翻译：提供了治疗和诊断方法，该方法涉及钙网蛋白在癌细胞和造血细胞上的表达。

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