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1. 发明申请

US20090238875A1 Chitosan or Hyaluronic Acid-Poly(Ethylene Oxide)-and Chitosan-Hyaluronic Acid-Poly(Ethylene Oxide)-Based Hydrogel and Manufacturing Method Therefor 审中-公开
标题翻译：壳聚糖或透明质酸 - 聚（环氧乙烷）和壳聚糖 - 透明质酸 - 聚（环氧乙烷）基水凝胶及其制备方法
公开(公告)号：US20090238875A1
公开(公告)日：2009-09-24
申请号：US12083705
申请日：2006-08-28
申请人： Insup Noh , Yongdoo Park , Kyuback Lee , Soonjung Hwang , Kyung Sun , Gunwoo Kim
发明人： Insup Noh , Yongdoo Park , Kyuback Lee , Soonjung Hwang , Kyung Sun , Gunwoo Kim
IPC分类号： A61K9/14 , C07H5/06
CPC分类号： C08B37/003 , C08B37/0072 , C08L5/08
摘要： Disclosed are a chitosan-chitosan-polyethylene oxide hydrogel formed via covalent bonding between chitosan derivatives crosslinked with an acrylate or methacrylate functional group-containing substance and a thiol functional group-containing substance and hydrogel microbeads thereof; a hyaluronic acid-hyaluronic acid-polyethylene oxide hydrogel formed via covalent bonding between hyaluronic acid derivatives crosslinked with an acrylate or methacrylate functional group-containing substance and a thiol functional group-containing substance and hydrogel microbeads thereof; and a chitosan-hyaluronic acid-polyethylene oxide hydrogel formed via covalent bonding between a chitosan derivative crosslinked with a (meth)acrylate functional group-containing substance as well as a hyaluronic acid derivative crosslinked with a (meth) acrylate functional group-containing substance and a thiol functional group-containing substance and hydrogel microbeads thereof.
摘要翻译：公开了通过与含丙烯酸酯或甲基丙烯酸酯官能团的物质和含硫醇官能团的物质和水凝胶微珠交联的壳聚糖衍生物之间的共价键而形成的壳聚糖 - 壳聚糖 - 聚环氧乙烷水凝胶; 通过与含丙烯酸酯或甲基丙烯酸酯官能团的物质交联的透明质酸衍生物与含硫醇官能团的物质和水凝胶微珠之间的共价键合形成的透明质酸 - 透明质酸 - 聚环氧乙烷水凝胶; 和通过与（甲基）丙烯酸酯官能团含有物质交联的壳聚糖衍生物和与（甲基）丙烯酸酯官能团物质交联的透明质酸衍生物之间的共价键而形成的壳聚糖 - 透明质酸 - 聚环氧乙烷水凝胶，以及含硫醇官能团的物质及其水凝胶微珠。

2. 发明授权

US08742013B2 Synthesis of lipoamide-grafted high molecular compound and method therefor 有权
标题翻译：脂酰胺接枝高分子化合物的合成及其制备方法
公开(公告)号：US08742013B2
公开(公告)日：2014-06-03
申请号：US12608126
申请日：2009-10-29
申请人： Insup Noh , Seongyeun Jo , Doyeon Kim , Junghoon Woo
发明人： Insup Noh , Seongyeun Jo , Doyeon Kim , Junghoon Woo
IPC分类号： A61K38/18 , A61K47/36 , A61K47/38 , C08B15/06 , C08B37/02 , C08B37/04 , C08B37/08 , C08B37/10
CPC分类号： C08H1/00 , C08B37/0021 , C08B37/003 , C08B37/0069 , C08B37/0072 , C08B37/0075
摘要： The present disclosure provides polymer compounds binding with lipoamide produced by the reaction of the primary amine group of lipoamide with the carboxy group of polysaccharide compounds such as chondroitin sulfates, carboxymethyl celluloses, or hyaluronic acids; functional compounds such as peptides, proteins, growth factors; or drugs; or biocompatible polymers such as poly(ethylene oxide), poly(vinyl alcohol), or poly(vinyl pyrrolidone). The present disclosure also provides their synthesis methods, products of hydrogels and films using the same as and methods for manufacturing the products.
摘要翻译：本公开提供了通过脂酰胺的伯胺基与多糖化合物的羧基如硫酸软骨素，羧甲基纤维素或透明质酸的反应产生的与脂酰胺结合的聚合物化合物; 功能化合物如肽，蛋白质，生长因子; 或药物; 或生物相容性聚合物如聚（环氧乙烷），聚（乙烯醇）或聚（乙烯基吡咯烷酮））。本公开还提供了它们的合成方法，水凝胶的产物和使用其的方法和制造产品的方法。

3. 发明申请

US20050152813A1 Method of chemical surface modification of polytetrafluoroethylene materials 审中-公开
标题翻译：聚四氟乙烯材料化学表面改性方法
公开(公告)号：US20050152813A1
公开(公告)日：2005-07-14
申请号：US10504709
申请日：2003-02-19
申请人： Insup Noh
发明人： Insup Noh
IPC分类号： A61M1/16 , A61F2/06 , A61F2/18 , A61F2/24 , A61L27/00 , A61L27/16 , A61L29/00 , A61L29/04 , A61L31/00 , A61L31/04 , A61M1/10 , A61M25/00 , B01D67/00 , B01D71/36 , C02F1/44 , C08F8/26 , C08J7/00 , C08J7/12 , B01J10/00
CPC分类号： B01D67/0093 , A61L27/16 , A61L29/041 , A61L31/048 , B01D71/36 , C08F8/26 , C08J7/12 , C08J2327/18 , C08L27/18
摘要： Disclosed is a method for chemically modifying the surface of polytetrafluoroethylene materials, which allows biocompatibility of the materials to be improved. The method comprises the steps of: mixing a hydrogen compound, such as sodium hydroborate, with a cyclic compound, such as anthraquinone or derivatives thereof, in an organic solvent, such as dichloromethane, so as to produce a reactant solution; adding polytetrafluoroethylene materials, such as ePTFE artificial blood vessels, PTFE films or porous PTFE membranes, to the reactant solution; applying heat or ultraviolet energy to the mixture containing the polytetrafluoroethylene materials, so as to remove fluorine from the surface of the polytetrafluoroethylene materials by electron exchange reaction; removing the remaining reactants from the polytetrafluoroethylene materials; and drying the polytetrafluoroethylene materials. The expanded polytetrafluoroethylene artificial blood vessels and the like, whose surface were modified according to the present invention, have a hydrophilic surface changed from a hydrophobic surface, a remarkably reduced fluorine content, and increased cell adhesion. Furthermore, the surface-modified ePTFE artificial blood vessels may be coated with a biodegradable polymer, such as cell adhesion proteins or polylactide, etc. Also, the surface-modified ePTFE films exhibit remarkably increased permeability.
摘要翻译：公开了一种对聚四氟乙烯材料的表面进行化学改性的方法，其允许改善材料的生物相容性。该方法包括以下步骤：将氢化合物如硼氢化钠与诸如蒽醌或其衍生物的环状化合物在有机溶剂如二氯甲烷中混合，以产生反应物溶液; 向反应物溶液中加入诸如ePTFE人造血管，PTFE膜或多孔PTFE膜的聚四氟乙烯材料; 对含有聚四氟乙烯材料的混合物施加热或紫外线能量，以通过电子交换反应从聚四氟乙烯材料的表面除去氟; 从聚四氟乙烯材料中除去剩余的反应物; 并干燥聚四氟乙烯材料。其表面根据本发明改性的膨体聚四氟乙烯人造血管等具有从疏水性表面变化的亲水性表面，显着降低的氟含量和增加的细胞粘附性。此外，表面改性的ePTFE人造血管可以涂覆有可生物降解的聚合物，例如细胞粘附蛋白或聚丙交酯等。此外，表面改性的ePTFE膜显示出显着增加的渗透性。

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