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1. 发明申请

US20120009257A1 Galenical Formulations of a Fixed Dose Combination of Valsartan and Aliskiren 审中-公开
标题翻译：缬沙坦和阿利吉仑的固定剂量组合的Galenical制剂
公开(公告)号：US20120009257A1
公开(公告)日：2012-01-12
申请号：US13256454
申请日：2010-03-18
申请人： Indrajit Ghosh , Shoufeng Li , Wei-Qin Tong , Sudha Vippagunta , Hong Wen
发明人： Indrajit Ghosh , Shoufeng Li , Wei-Qin Tong , Sudha Vippagunta , Hong Wen
IPC分类号： A61K9/20 , A61P13/12 , A61P9/12 , A61K31/41
CPC分类号： A61K9/2086 , A61K9/209 , A61K31/165 , A61K31/41 , A61K2300/00
摘要： The invention provides a pharmaceutical oral fixed dose combination of aliskiren and valsartan. Aliskiren is shown to slow the dissolution rate of valsartan and the resultant undesirable gelling of valsartan in the presence of aliskiren is overcome by the use of disintegrants.
摘要翻译：本发明提供阿利吉仑和缬沙坦的药物口服固定剂量组合。阿利吉仑被证明可以减缓缬沙坦的溶解速度，并且在使用崩解剂的情况下克服了阿利吉仑存在下不希望的缬沙坦凝胶化。

2. 发明申请

US20100209480A1 GALENICAL FORMULATIONS OF ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的制剂配方
公开(公告)号：US20100209480A1
公开(公告)日：2010-08-19
申请号：US12678877
申请日：2008-09-24
申请人： Ralf Altenburger , Maggy B. Saunier , Nicole Bargenda , Michael A. Bock , Sabine Adler , Bruno Buss , Catherine Curdy , Indrajit Ghosh , Stefan Hirsch , Patrice F. Keller , Charu Kochhar , Shoufeng Li , Nicoletta Loggia , Amol S. Matharu , Julien Taillemite , Wei-Qin Tong , Sudha Vippagunta , Hong Wen , Marie-Christine Wolf , Jay P. Lakshman , James Kowalski
发明人： Ralf Altenburger , Maggy B. Saunier , Nicole Bargenda , Michael A. Bock , Sabine Adler , Bruno Buss , Catherine Curdy , Indrajit Ghosh , Stefan Hirsch , Patrice F. Keller , Charu Kochhar , Shoufeng Li , Nicoletta Loggia , Amol S. Matharu , Julien Taillemite , Wei-Qin Tong , Sudha Vippagunta , Hong Wen , Marie-Christine Wolf , Jay P. Lakshman , James Kowalski
IPC分类号： A61K31/41 , A61K9/70 , A61K9/48 , A61K9/24 , A61K9/14 , A61P13/12 , A61P9/10 , A61P9/04 , A61P9/12 , B29B9/06
CPC分类号： A61K9/209 , A61K9/4808 , A61K9/5084 , A61K31/165 , A61K31/41 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a pharmaceutical oral fixed dose combination comprising a) a therapeutically effective amount of Aliskiren, or a pharmaceutically acceptable salt thereof, b) a therapeutically effective amount of Valsartan, or a pharmaceutically acceptable salt thereof, wherein the pharmaceutical oral fixed dose combination shows an in vitro dissolution of component a) of 80% or less after 10 minutes and 98% or less after 20 minutes, and a dissolution profile of component b) of 25% or more after 30 minutes, and 40% or more after 60 minutes at pH 4.5.
摘要翻译：本发明涉及药物口服固定剂量组合，其包含a）治疗有效量的阿利吉仑或其药学上可接受的盐，b）治疗有效量的缬沙坦或其药学上可接受的盐，其中药物口服固定剂量 10分钟后组分a）的体外溶出度为80％以下，20分钟后为98％以下，30分钟后组分b）的溶出曲线为25％以上，40％以上 pH 4.5时60分钟。

3. 发明申请

US20120003308A1 Pharmaceutical Composition Comprising Aliskiren 审中-公开
标题翻译：包含阿利吉仑的药物组合物
公开(公告)号：US20120003308A1
公开(公告)日：2012-01-05
申请号：US13256462
申请日：2010-03-18
申请人： Sonali Bose , Shoufeng Li , Hong Wen
发明人： Sonali Bose , Shoufeng Li , Hong Wen
IPC分类号： A61K9/20 , A61P9/12 , B29C43/36 , A61K31/41
CPC分类号： A61K31/165 , A61K9/2009 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/209 , A61K31/41 , A61K2300/00
摘要： The invention provides a pharmaceutical oral fixed dose combination of aliskiren and valsartan. It provides compressed bilayer tablets with both a high drug load and suitable physical properties, which can be produced using conventional equipment.
摘要翻译：本发明提供阿利吉仑和缬沙坦的药物口服固定剂量组合。它提供具有高药物负载和合适物理性质的压缩双层片剂，其可以使用常规设备制备。

4. 发明授权

US08800075B2 Spring loaded docking mechanism 有权
标题翻译：弹簧加载对接机制
公开(公告)号：US08800075B2
公开(公告)日：2014-08-12
申请号：US13205201
申请日：2011-08-08
申请人： Jan Christopher van Leyen , Shoufeng Li
发明人： Jan Christopher van Leyen , Shoufeng Li
IPC分类号： E03D1/04
CPC分类号： E03C1/0404 , E03C2001/0415
摘要： An improved docking assembly for faucets having a pull-down sprayhead extendable from a spout. The docking assembly generally comprises a receptacle fitted into the spout which is formed with chamfered interior walls. A spring-loaded flexible collet is contained within the receptacle with a degree of sliding freedom for spring-biased travel along the chamfered interior walls of the receptacle, from a first position that allows generous radial expansion of the collet to a second position in which radial expansion is restricted. A quick-connect fitting attached to the pull-down sprayhead moves the collet into its first position allowing radial expansion of the collet. Removal of the quick-connect fitting moves the collet to its second position which restricts radial expansion, inhibiting said removal. Consequently, the pulldown sprayhead may be docked to the spout with considerably less insertion force than the opposite removal force needed to undock the pulldown sprayhead from the spout.
摘要翻译：一种用于水龙头的改进的对接组件，其具有可从喷口延伸的下拉喷头。对接组件通常包括装配到喷口中的插座，其形成有倒角的内壁。弹簧加载的弹性夹头容纳在容器内，具有一定程度的滑动自由度，用于沿着插座的倒角内壁的弹簧偏置行进，从允许夹头大幅度径向膨胀到第二位置的第一位置，其中径向扩张受到限制连接到下拉式喷头的快速连接配件将夹头移动到其第一位置，允许夹头径向膨胀。快速连接配件的拆卸将夹头移动到其限制径向膨胀的第二位置，从而阻止所述拆卸。因此，下拉式喷头可以以比相对于从喷口拆下下拉喷头所需的相反的移除力相对更小的插入力对接到喷口。

5. 发明申请

US20130230593A1 Orally Dosed Pharmaceutical Compositions Comprising a Delivery Agent in Micronized Form 有权
标题翻译：口服药物组合物，包含微粉形式的递送剂
公开(公告)号：US20130230593A1
公开(公告)日：2013-09-05
申请号：US13862811
申请日：2013-04-15
申请人： Shoufeng Li , Anasuya Ashok Ghosh , Simon D. Bateman , Moise Azria , Alan E. Royce
发明人： Shoufeng Li , Anasuya Ashok Ghosh , Simon D. Bateman , Moise Azria , Alan E. Royce
IPC分类号： A61K47/18
CPC分类号： A61K47/18 , A61K9/1617 , A61K9/2013 , A61K38/23 , A61K47/183
摘要： Solid pharmaceutical compositions and methods of their use suitable for the oral delivery of pharmacologically active agents, e.g. peptides, comprising a therapeutically-effective amount of a pharmacologically active agent; a crospovidone or povidone; and a delivery agent for said pharmacologically active agent are disclosed. The compositions utilize micronized forms of the delivery agent which provides enhanced bioavailability of pharmacologically active agents, particularly calcitonin.
摘要翻译：固体药物组合物及其用途的方法适用于药物活性剂的口服递送，例如，肽，包含治疗有效量的药理活性剂; 交聚维酮或聚维酮; 并公开了所述药理活性剂的递送剂。组合物使用微粒化形式的递送剂，其提供药理活性剂，特别是降钙素的增强的生物利用度。

6. 发明申请

US20130037626A1 SPRING LOADED DOCKING MECHANISM 有权
标题翻译：弹簧装载机构
公开(公告)号：US20130037626A1
公开(公告)日：2013-02-14
申请号：US13205201
申请日：2011-08-08
申请人： Jan Christopher van Leyen , Shoufeng Li
发明人： Jan Christopher van Leyen , Shoufeng Li
IPC分类号： A62C33/00
CPC分类号： E03C1/0404 , E03C2001/0415
摘要： An improved docking assembly for faucets having a pull-down sprayhead extendable from a spout. The docking assembly generally comprises a receptacle fitted into the spout which is formed with chamfered interior walls. A spring-loaded flexible collet is contained within the receptacle with a degree of sliding freedom for spring-biased travel along the chamfered interior walls of the receptacle, from a first position that allows generous radial expansion of the collet to a second position in which radial expansion is restricted. A quick-connect fitting attached to the pull-down sprayhead moves the collet into its first position allowing radial expansion of the collet. Removal of the quick-connect fitting moves the collet to its second position which restricts radial expansion, inhibiting said removal. Consequently, the pulldown sprayhead may be docked to the spout with considerably less insertion force than the opposite removal force needed to undock the pulldown sprayhead from the spout.
摘要翻译：一种用于水龙头的改进的对接组件，其具有可从喷口延伸的下拉喷头。对接组件通常包括装配到喷口中的插座，其形成有倒角的内壁。弹簧加载的弹性夹头容纳在容器内，具有一定程度的滑动自由度，用于沿着插座的倒角内壁的弹簧偏置行进，从允许夹头大幅度径向膨胀到第二位置的第一位置，其中径向扩张受到限制连接到下拉式喷头的快速连接配件将夹头移动到其第一位置，允许夹头径向膨胀。快速连接配件的拆卸将夹头移动到其限制径向膨胀的第二位置，从而阻止所述拆卸。因此，下拉式喷头可以以比相对于从喷口拆下下拉喷头所需的相反的移除力相对更小的插入力对接到喷口。

7. 发明申请

US20060194722A1 Use of calcitonin in osteoarthritis 失效
标题翻译：降钙素在骨关节炎中的使用
公开(公告)号：US20060194722A1
公开(公告)日：2006-08-31
申请号：US10565455
申请日：2004-07-22
申请人： Moise Azria , Claus Christiansen , Simon Bateman , Shoufeng Li
发明人： Moise Azria , Claus Christiansen , Simon Bateman , Shoufeng Li
IPC分类号： A61K38/23 , C08G63/91
CPC分类号： A61K38/23 , A61K9/0031 , A61K9/0043 , A61K9/2013 , A61K9/2054 , A61K45/06 , A61K47/16 , A61K47/183 , A61K47/48169 , A61K47/56
摘要： The present invention relates to a novel use of calcitonin in osteoarthritis, and to methods of treating and/or preventing osteoarthritis in mammals, particularly humans.
摘要翻译：本发明涉及降钙素在骨关节炎中的新用途，以及哺乳动物，特别是人中治疗和/或预防骨关节炎的方法。

8. 发明申请

US20150273070A1 MODIFIED RELEASE OF 4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]-N-[5-(4-METHYL-1H-IMIDAZOL-1-YL)-3-(TRIFLOUOROMETHYL)PHENYL] BENZAMIDE SOLUBILIZED USING ORGANIC ACIDS 审中-公开
标题翻译： 4-甲基-3 - [[4-（3-吡啶基）-2-嘧啶基]氨基] -N- [5-（4-甲基-1H-咪唑-1-基）-3-（三氟甲磺酰））的改性释放苯基]苯甲酸溶解使用有机酸
公开(公告)号：US20150273070A1
公开(公告)日：2015-10-01
申请号：US14126219
申请日：2012-06-13
申请人： Shoufeng Li , Saran Kumar , Nikhil Javant Kavimandan , Enxian Lu
发明人： Shoufeng Li , Saran Kumar , Nikhil Javant Kavimandan , Enxian Lu
IPC分类号： A61K47/22 , A61K31/506 , A61K47/12 , C07D401/14
CPC分类号： A61K47/22 , A61K31/506 , A61K47/12 , C07D401/14
摘要： Soluble pharmaceutical compositions of nilotinib or a pharmaceutically acceptable salt thereof were invented using one or more organic acids that function as a solubilizing agent, increasing the bioavailability of nilotinib and supressing the food effect associated with certain compositions of nilotinib. The pharmaceutical compositions are in the form of solid oral dosage forms, including capsules and tablets.
摘要翻译：使用一种或多种有机酸发挥尼洛替尼或其药学上可接受的盐的可溶性药物组合物，其作为增溶剂起作用，提高尼罗替尼的生物利用度，并抑制与尼罗替尼的某些组合物相关的食物效应。药物组合物是固体口服剂型的形式，包括胶囊和片剂。

9. 发明申请

US20130245061A1 PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物
公开(公告)号：US20130245061A1
公开(公告)日：2013-09-19
申请号：US13989250
申请日：2011-12-01
申请人： Yu Cao , Wolfgang Hackl , Ping Li , Shoufeng Li , Tahseen Mirza , Hartmut Zehender , Jiahao Zhu
发明人： Yu Cao , Wolfgang Hackl , Ping Li , Shoufeng Li , Tahseen Mirza , Hartmut Zehender , Jiahao Zhu
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1694 , A61K31/00
摘要： A pharmaceutical composition for the oral administration of a therapeutic compound of formula (I), comprising granules that comprise at least therapeutic compound of formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt, or a hydrate or solvate thereof; at least one non-ionic surfactant that is Vitamin E-TPGS in an amount ranging from about 15 to about 80% by weight of the composition; and at least one a dissolution enhancing agent selected from polyethylene glycol, polyethylene oxide, and any combination of the foregoing; processes for making such pharmaceutical compositions; a kit comprising such pharmaceutical composition and the instructions for administration thereof; and related uses and methods of treatment.
摘要翻译：口服给药式（I）治疗性化合物的药物组合物，其包含至少包含治疗性式（I）化合物或其互变异构体或其药学上可接受的盐或其水合物或溶剂合物的颗粒剂; 至少一种非离子表面活性剂，其量为所述组合物的约15至约80重量％的量的维生素E-TPGS; 和至少一种选自聚乙二醇，聚环氧乙烷和前述的任何组合的溶解增强剂; 制备这种药物组合物的方法; 包含该药物组合物的试剂盒及其施用说明书; 及相关用途及治疗方法。

10. 发明申请

US20100278881A1 USE OF CALCITONIN IN OSTEOARTHRITIS 失效
标题翻译：钙离子在OSTEOARTHRITIS中的使用
公开(公告)号：US20100278881A1
公开(公告)日：2010-11-04
申请号：US12819583
申请日：2010-06-21
申请人： Moise AZRIA , Claus Christiansen , Simon David Bateman , Shoufeng Li
发明人： Moise AZRIA , Claus Christiansen , Simon David Bateman , Shoufeng Li
IPC分类号： A61K38/23 , A61K9/00 , A61P19/02 , A61P19/08
CPC分类号： A61K38/23 , A61K9/0031 , A61K9/0043 , A61K9/2013 , A61K9/2054 , A61K45/06 , A61K47/16 , A61K47/183 , A61K47/48169 , A61K47/56
摘要： The present invention relates to a novel use of calcitonin in osteoarthritis, and to methods of treating and/or preventing osteoarthritis in mammals, particularly humans.
摘要翻译：本发明涉及降钙素在骨关节炎中的新用途，以及哺乳动物，特别是人类中治疗和/或预防骨关节炎的方法。

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