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1. 发明授权

US09040572B2 Method of preparing benzoimidazole derivatives 有权
标题翻译：苯并咪唑衍生物的制备方法
公开(公告)号：US09040572B2
公开(公告)日：2015-05-26
申请号：US13821067
申请日：2011-09-27
申请人： In Woo Kim , Ji Duck Kim , Hong Chul Yoon , Hee Kyoon Yoon , Byung Goo Lee , Joon Hwan Lee , Young Mook Lim , Soo Jin Choi
发明人： In Woo Kim , Ji Duck Kim , Hong Chul Yoon , Hee Kyoon Yoon , Byung Goo Lee , Joon Hwan Lee , Young Mook Lim , Soo Jin Choi
IPC分类号： C07D401/14 , C07D235/18 , C07D471/04 , C07D401/10 , C07D413/14 , C07B37/04
CPC分类号： C07D401/10 , C07B37/04 , C07D235/18 , C07D401/14 , C07D413/14 , C07D471/04
摘要： This invention relates to a method of preparing a benzoimidazole derivative at high purity and high yield so as to enable the production of the benzoimidazole derivative compound as an antagonist against a vanilloid reactor-1, and particularly to a method of preparing a benzoimidazole derivative at high purity and high yield, wherein the benzoimidazole derivative is synthesized using a novel intermediate, namely, benzaldehyde, and thereby the preparation process is simple so that it can be applied to production.
摘要翻译：本发明涉及以高纯度和高收率制备苯并咪唑衍生物的方法，以便能够制备苯并咪唑衍生物化合物作为抗香草酸反应器-1的拮抗剂，特别涉及一种制备高浓度苯并咪唑衍生物的方法纯度和高产率，其中苯并咪唑衍生物是使用新型中间体即苯甲醛合成的，因此制备方法简单，从而可以应用于生产。

2. 发明申请

US20130231477A1 NOVEL METHOD OF PREPARING BENZOIMIDAZOLE DERIVATIVES 有权
标题翻译：制备苯甲酰胺衍生物的新方法
公开(公告)号：US20130231477A1
公开(公告)日：2013-09-05
申请号：US13821067
申请日：2011-09-27
申请人： In Woo Kim , Ji Duck Kim , Hong Chul Yoon , Hee Kyoon Yoon , Byung Goo Lee , Joon Hwan Lee , Young Mook Lim , Soo Jin Choi
发明人： In Woo Kim , Ji Duck Kim , Hong Chul Yoon , Hee Kyoon Yoon , Byung Goo Lee , Joon Hwan Lee , Young Mook Lim , Soo Jin Choi
IPC分类号： C07D401/10 , C07D413/14 , C07D401/14 , C07D235/18 , C07D471/04
CPC分类号： C07D401/10 , C07B37/04 , C07D235/18 , C07D401/14 , C07D413/14 , C07D471/04
摘要： This invention relates to a method of preparing a benzoimidazole derivative at high purity and high yield so as to enable the production of the benzoimidazole derivative compound as an antagonist against a vanilloid reactor-1, and particularly to a method of preparing a benzoimidazole derivative at high purity and high yield, wherein the benzoimidazole derivative is synthesized using a novel intermediate, namely, benzaldehyde, and thereby the preparation process is simple so that it can be applied to production.
摘要翻译：本发明涉及以高纯度和高收率制备苯并咪唑衍生物的方法，以便能够制备苯并咪唑衍生物化合物作为抗香草酸反应器-1的拮抗剂，特别涉及一种制备高浓度苯并咪唑衍生物的方法纯度和高产率，其中苯并咪唑衍生物是使用新型中间体即苯甲醛合成的，因此制备方法简单，从而可以应用于生产。

3. 发明申请

US20120065392A1 METHOD FOR PREPARING MEROPENEM USING ZINC POWDER 有权
标题翻译：使用锌粉制备烯烃的方法
公开(公告)号：US20120065392A1
公开(公告)日：2012-03-15
申请号：US13256178
申请日：2010-03-11
申请人： Yoon Seok Song , Sung Woo Park , Yeon Jung Yoon , Hee Kyoon Yoon , Seong Cheol Moon , Byung Goo Lee , Soo Jin Choi , Sun Ah Jun
发明人： Yoon Seok Song , Sung Woo Park , Yeon Jung Yoon , Hee Kyoon Yoon , Seong Cheol Moon , Byung Goo Lee , Soo Jin Choi , Sun Ah Jun
IPC分类号： C07D477/20
CPC分类号： C07D477/08 , C07D477/04 , C07D477/10 , C07D477/20
摘要： The present invention relates to an improved method for synthesizing meropenem trihydrate [(1R,5S,6S)-2-[((2′S,4′S)-2′-dimethylaminocarbozyl)pyrrolidin-4′-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid, trihydrate], which is a novel carbapenem antibiotic.
摘要翻译：本发明涉及一种用于合成美罗培南三水合物[（1R，5S，6S）-2 - [（（2'S，4'S）-2'-二甲基氨基羰基）吡咯烷-4'-基硫代] [（R）-1-羟乙基] -1-甲基碳代青霉-2-烯-3-羧酸三水合物]，它是一种新型的碳青霉烯类抗生素。

4. 发明授权

US09233963B2 Method for preparing meropenem using zinc powder 有权
标题翻译：使用锌粉制备美罗培南的方法
公开(公告)号：US09233963B2
公开(公告)日：2016-01-12
申请号：US13256178
申请日：2010-03-11
申请人： Yoon Seok Song , Sung Woo Park , Yeon Jung Yoon , Hee Kyoon Yoon , Seong Cheol Moon , Byung Goo Lee , Soo Jin Choi , Sun Ah Jun
发明人： Yoon Seok Song , Sung Woo Park , Yeon Jung Yoon , Hee Kyoon Yoon , Seong Cheol Moon , Byung Goo Lee , Soo Jin Choi , Sun Ah Jun
IPC分类号： C07D477/08 , C07D477/04 , C07D477/10 , C07D477/20
CPC分类号： C07D477/08 , C07D477/04 , C07D477/10 , C07D477/20
摘要： The present invention relates to an improved method for synthesizing meropenem trihydrate[(1R,5S,6S)-2-[((2′S,4′S)-2′-dimethylaminocarbozyl)pyrrolidin-4′-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid, trihydrate], which is a novel carbapenem antibiotic.
摘要翻译：本发明涉及一种用于合成美罗培南三水合物[（1R，5S，6S）-2 - [（（2'S，4'S）-2'-二甲基氨基羰基）吡咯烷-4'-基硫代] [（R）-1-羟乙基] -1-甲基碳代青霉-2-烯-3-羧酸三水合物]，它是一种新型的碳青霉烯类抗生素。

5. 发明申请

US20120101273A1 NOVEL CRYSTAL FORMS OF ADEFOVIR DIPIVOXIL AND PROCESSES FOR PREPARING THE SAME 审中-公开
标题翻译：新型水杨酸的新型水晶形式及其制备方法
公开(公告)号：US20120101273A1
公开(公告)日：2012-04-26
申请号：US13256197
申请日：2010-03-26
申请人： Soo Jin Choi , Byung Goo Lee , Seong Soo Oh , Yong Tae Kim , Kwang Joo Kim , Hye Jin Kim
发明人： Soo Jin Choi , Byung Goo Lee , Seong Soo Oh , Yong Tae Kim , Kwang Joo Kim , Hye Jin Kim
IPC分类号： C07F9/6561
CPC分类号： C07D473/34 , C07F9/65616
摘要： The present invention relates to novel Forms A, B, C, D, E, F and G of crystalline 9-[2-[phosphonomethoxy]ethyl]adenine bis-pivaloyloxymethyl ester, i.e., adefovir dipivoxil, and processes for preparing them. According to the present invention, said novel crystal forms having a high purity can be obtained by a simple method and in a high yield.
摘要翻译：本发明涉及结晶9- [2- [膦基甲氧基]乙基]腺嘌呤双新戊酰氧基甲酯（即阿德福韦酯）的新型形式A，B，C，D，E，F和G及其制备方法。根据本发明，可以通过简单的方法和高产率获得具有高纯度的所述新型晶体形式。

6. 发明授权

US09169257B2 Crystal forms of adefovir dipivoxil and processes for preparing the same 有权
标题翻译：阿德福韦酯的晶体形式及其制备方法
公开(公告)号：US09169257B2
公开(公告)日：2015-10-27
申请号：US13256197
申请日：2010-03-26
申请人： Soo Jin Choi , Byung Goo Lee , Seong Soo Oh , Yong Tae Kim , Kwang Joo Kim , Hye Jin Kim
发明人： Soo Jin Choi , Byung Goo Lee , Seong Soo Oh , Yong Tae Kim , Kwang Joo Kim , Hye Jin Kim
IPC分类号： C07D473/34 , C07F9/6561
CPC分类号： C07D473/34 , C07F9/65616
摘要： The present invention relates to novel Forms A, B, C, D, E, F and G of crystalline 9-[2-[phosphonomethoxy]ethyl]adenine bis-pivaloyloxymethyl ester, i.e., adefovir dipivoxil, and processes for preparing them. According to the present invention, said novel crystal forms having a high purity can be obtained by a simple method and in a high yield.
摘要翻译：本发明涉及结晶9- [2- [膦基甲氧基]乙基]腺嘌呤双新戊酰氧基甲酯（即阿德福韦酯）的新型形式A，B，C，D，E，F和G及其制备方法。根据本发明，可以通过简单的方法和高产率获得具有高纯度的所述新型晶体形式。

7. 发明申请

US20120250124A1 SCANNING MICROMIRROR 有权
标题翻译：扫描微型计算机
公开(公告)号：US20120250124A1
公开(公告)日：2012-10-04
申请号：US13383375
申请日：2010-08-26
申请人： Dong June Choi , Byung Goo Lee , Tae Sik Kim , Tae Sun Lim
发明人： Dong June Choi , Byung Goo Lee , Tae Sik Kim , Tae Sun Lim
IPC分类号： G02B26/10
CPC分类号： G02B26/0841 , G02B26/105
摘要： The present invention may relate to a scanning micromirror. The scanning micromirror can include a substrate having an open region; a micro plate provided in the open region; a first gimbal provided between the substrate and the mirror plate, and including a first curvature curved toward the mirror plate along an X-axis of the open region; a second gimbal including a second curvature formed along the first curvature of the first gimbal; a first elastic body configured to connect the substrate with the first curvature of the first gimbal; a second elastic body configured to connect the first gimbal with the second gimbal along a Y-axis of the open region; and a third elastic body configured to connect the second gimbal with the mirror plate along the Y-axis of the open region.
摘要翻译：本发明可以涉及扫描微镜。扫描微镜可以包括具有开放区域的基板; 设置在开放区域中的微板; 设置在所述基板和所述镜板之间的第一万向节，并且包括沿着所述开放区域的X轴朝向所述镜板弯曲的第一曲率; 包括沿着第一万向架的第一曲率形成的第二曲率的第二万向节; 第一弹性体，其构造成将所述基板与所述第一万向架的所述第一曲率连接; 第二弹性体，其构造成沿着所述开放区域的Y轴将所述第一万向架与所述第二万向节连接; 以及第三弹性体，其构造成沿着所述开放区域的Y轴将所述第二万向架与所述镜板连接。

8. 发明授权

US08675270B2 Scanning micromirror 有权
标题翻译：扫描微镜
公开(公告)号：US08675270B2
公开(公告)日：2014-03-18
申请号：US13383375
申请日：2010-08-26
申请人： Dong June Choi , Byung Goo Lee , Tae Sik Kim , Tae Sun Lim
发明人： Dong June Choi , Byung Goo Lee , Tae Sik Kim , Tae Sun Lim
IPC分类号： G02B26/08
CPC分类号： G02B26/0841 , G02B26/105
摘要： The present invention may relate to a scanning micromirror. The scanning micromirror can include a substrate having an open region; a micro plate provided in the open region; a first gimbal provided between the substrate and the mirror plate, and including a first curvature curved toward the mirror plate along an X-axis of the open region; a second gimbal including a second curvature formed along the first curvature of the first gimbal; a first elastic body configured to connect the substrate with the first curvature of the first gimbal; a second elastic body configured to connect the first gimbal with the second gimbal along a Y-axis of the open region; and a third elastic body configured to connect the second gimbal with the mirror plate along the Y-axis of the open region.
摘要翻译：本发明可以涉及扫描微镜。扫描微镜可以包括具有开放区域的基板; 设置在开放区域中的微板; 设置在所述基板和所述镜板之间的第一万向节，并且包括沿着所述开放区域的X轴朝向所述镜板弯曲的第一曲率; 包括沿着第一万向架的第一曲率形成的第二曲率的第二万向节; 第一弹性体，其构造成将所述基板与所述第一万向架的所述第一曲率连接; 第二弹性体，其构造成沿着所述开放区域的Y轴将所述第一万向架与所述第二万向节连接; 以及第三弹性体，其构造成沿着所述开放区域的Y轴将所述第二万向架与所述镜板连接。

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