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1. 发明申请

US20120101273A1 NOVEL CRYSTAL FORMS OF ADEFOVIR DIPIVOXIL AND PROCESSES FOR PREPARING THE SAME 审中-公开
标题翻译：新型水杨酸的新型水晶形式及其制备方法
公开(公告)号：US20120101273A1
公开(公告)日：2012-04-26
申请号：US13256197
申请日：2010-03-26
申请人： Soo Jin Choi , Byung Goo Lee , Seong Soo Oh , Yong Tae Kim , Kwang Joo Kim , Hye Jin Kim
发明人： Soo Jin Choi , Byung Goo Lee , Seong Soo Oh , Yong Tae Kim , Kwang Joo Kim , Hye Jin Kim
IPC分类号： C07F9/6561
CPC分类号： C07D473/34 , C07F9/65616
摘要： The present invention relates to novel Forms A, B, C, D, E, F and G of crystalline 9-[2-[phosphonomethoxy]ethyl]adenine bis-pivaloyloxymethyl ester, i.e., adefovir dipivoxil, and processes for preparing them. According to the present invention, said novel crystal forms having a high purity can be obtained by a simple method and in a high yield.
摘要翻译：本发明涉及结晶9- [2- [膦基甲氧基]乙基]腺嘌呤双新戊酰氧基甲酯（即阿德福韦酯）的新型形式A，B，C，D，E，F和G及其制备方法。根据本发明，可以通过简单的方法和高产率获得具有高纯度的所述新型晶体形式。

2. 发明授权

US09169257B2 Crystal forms of adefovir dipivoxil and processes for preparing the same 有权
标题翻译：阿德福韦酯的晶体形式及其制备方法
公开(公告)号：US09169257B2
公开(公告)日：2015-10-27
申请号：US13256197
申请日：2010-03-26
申请人： Soo Jin Choi , Byung Goo Lee , Seong Soo Oh , Yong Tae Kim , Kwang Joo Kim , Hye Jin Kim
发明人： Soo Jin Choi , Byung Goo Lee , Seong Soo Oh , Yong Tae Kim , Kwang Joo Kim , Hye Jin Kim
IPC分类号： C07D473/34 , C07F9/6561
CPC分类号： C07D473/34 , C07F9/65616
摘要： The present invention relates to novel Forms A, B, C, D, E, F and G of crystalline 9-[2-[phosphonomethoxy]ethyl]adenine bis-pivaloyloxymethyl ester, i.e., adefovir dipivoxil, and processes for preparing them. According to the present invention, said novel crystal forms having a high purity can be obtained by a simple method and in a high yield.
摘要翻译：本发明涉及结晶9- [2- [膦基甲氧基]乙基]腺嘌呤双新戊酰氧基甲酯（即阿德福韦酯）的新型形式A，B，C，D，E，F和G及其制备方法。根据本发明，可以通过简单的方法和高产率获得具有高纯度的所述新型晶体形式。

3. 发明授权

US06228291B1 Process for preparing controlled-released chitosan microcapsule 有权
标题翻译：制备受控释放的壳聚糖微胶囊的方法
公开(公告)号：US06228291B1
公开(公告)日：2001-05-08
申请号：US09342070
申请日：1999-06-29
申请人： Jung-min Lee , Choong Kyun Yeom , Chul Ung Kim , Beom Sik Kim , Kwang Joo Kim , Sang Bong Oh
发明人： Jung-min Lee , Choong Kyun Yeom , Chul Ung Kim , Beom Sik Kim , Kwang Joo Kim , Sang Bong Oh
IPC分类号： B01J1302
CPC分类号： B01J13/16 , Y10S514/963 , Y10T428/2984
摘要： The present invention relates to a process for preparing the controlled-release chitosan microcapsule, more specifically to a process for preparing the sustained-release chitosan microcapsule capable of releasing at an appropriate rate for a long time, which is characterized by: a) Biodegradable chitosan polymer is used for the capsule material; b) The capsule is kept stable during the release time by the rapid and effective crosslinking reaction between the chitosan polymer and the double crosslinking agent on the surface of tiny particles formed by a new emulsion interface reaction method using a double crosslinking agent of sulfuric acid and glutaraldehyde; and c) The microcapsule which is smaller than several &mgr;m s can be easily formed and the capsule is kept stable for a long release time because an insoluble polymer film whose source material is biodegradable is formed after the release.
摘要翻译：本发明涉及一种制备控制释放壳聚糖微胶囊的方法，更具体地涉及能够长时间以适当速率释放的缓释壳聚糖微胶囊的制备方法，其特征在于：a）可生物降解的壳聚糖聚合物用于胶囊材料; b）胶囊在释放时间内通过壳聚糖聚合物和双交联剂之间的快速有效的交联反应在通过新的乳液界面反应方法形成的微小颗粒的表面上保持稳定，该方法使用硫酸和戊二醛的双交联剂; 和）可以容易地形成小于几个微米的微胶囊，并且由于在释放后形成源材料是可生物降解的不溶性聚合物膜，所以胶囊保持稳定的长时间释放时间。

4. 发明授权

US6045675A Method for concentrating aqueous tetrafluoroethylene emulsion by electrodialysis and its apparatus 失效
标题翻译：通过电渗析浓缩四氟乙烯水溶液的方法及其设备
公开(公告)号：US6045675A
公开(公告)日：2000-04-04
申请号：US43548
申请日：1998-03-19
申请人： Jung Min Lee , Jae Cheon Koh , Sang Jin Moon , Kwang Joo Kim , Hang Kyo Jin , Chul Ung Kim , Won Uook So
发明人： Jung Min Lee , Jae Cheon Koh , Sang Jin Moon , Kwang Joo Kim , Hang Kyo Jin , Chul Ung Kim , Won Uook So
IPC分类号： B01D57/02 , B01D61/42 , B01D61/46 , B01D71/10 , C08F6/20 , C08F14/26 , B01D61/44
CPC分类号： B01D61/422 , B01D57/02 , C08F6/20
摘要： The present invention relates to a method and an apparatus for concentrating an aqueous PTFE emulsion in which a raw, aqueous PTFE emulsion containing fluorinated surfactants is concentrated by an electrodialysis technique using at least one nonionic surfactant as an anti-flocculation agent and a volatile electrolyte such that the formation of floccules is prevented.
摘要翻译： PCT No.PCT / KR97 / 00142 Sec。 371日期：1998年3月19日 102（e）1998年3月19日PCT PCT 1997年7月18日PCT公布。第WO98 / 03561号公报日本1998年1月29日本发明涉及一种浓缩PTFE水性乳液的方法和装置，其中通过电渗析技术使含至少一种非离子表面活性剂作为抗絮凝剂的含氟表面活性剂的原料含水PTFE乳液浓缩和挥发性电解质，使得防止絮凝物的形成。

5. 发明授权

US06335202B1 Method and apparatus for on-line measurement of the permeation characteristics of a permeant through dense nonporous membrane 失效
标题翻译：用于在线测量渗透物通过致密无孔膜的渗透特性的方法和装置
公开(公告)号：US06335202B1
公开(公告)日：2002-01-01
申请号：US09329492
申请日：1999-06-10
申请人： Jung Min Lee , Choong Kyun Yeom , Chul Ung Kim , Beom Sik Kim , Kwang Joo Kim
发明人： Jung Min Lee , Choong Kyun Yeom , Chul Ung Kim , Beom Sik Kim , Kwang Joo Kim
IPC分类号： G01N3002
CPC分类号： G01N15/0826 , G01N30/82 , G01N2030/025
摘要： This invention relates to a method and apparatus for on-line measurement of permeation characteristics (transmitting chemicals) through dense nonporous membrane. This invention is intended to facilitate various research activities, such as simultaneous analyses of diffusion coefficient, solubility coefficient, permeation rate and permeant composition, and presentation of new analysis about the permeation behavior, kinetics and so on. The object of this invention is to provide the method and apparatus for measurement of permeation characteristics of permeants in liquid, vapor or gas phase through dense nonporous membrane and more practicuraly, to provide permeation apparatus for measurement of permeation characteristics by analyzing permeation rate and permeation concentration of permeants through an on-line type dense porous membrane with time, not only for a steady state but also for an unsteady state in an accurate and reliable manner.
摘要翻译：本发明涉及通过致密无孔膜在线测量渗透特性（透射化学品）的方法和设备。本发明旨在促进各种研究活动，例如扩散系数的同时分析，溶解度系数，渗透速率和渗透物组成，以及关于渗透行为，动力学等的新分析的呈现。本发明的目的是提供用于通过致密无孔膜测量渗透液渗透特性的方法和装置，并且更实用，以便通过分析渗透速率和渗透浓度来提供用于测量渗透特性的渗透装置的渗透剂通过在线型致密多孔膜随时间而变化，不仅用于稳定状态，而且以准确可靠的方式进行非稳态。

6. 发明授权

US06325218B1 Polyion complex separation membrane with a double structure 失效
标题翻译： Polyion复合分离膜具有双重结构
公开(公告)号：US06325218B1
公开(公告)日：2001-12-04
申请号：US09486238
申请日：2000-02-24
申请人： Jung Min Lee , Choong Kyun Yeom , Chul Ung Kim , Beom Sik Kim , Kwang Joo Kim
发明人： Jung Min Lee , Choong Kyun Yeom , Chul Ung Kim , Beom Sik Kim , Kwang Joo Kim
IPC分类号： B01D2905
CPC分类号： B01D71/80 , B01D61/02 , B01D69/12 , B01D69/125 , C02F1/441
摘要： This invention relates to a polyion complex separation membrane with a double structure, which is applicable in the separation process of a water-soluble mixture having ionic molecules or particles by means of reverse osmotic pressure for the purposes of recovering expensive ionic organic materials such as anionic emulsifiers from the waste water. More particularly, this invention relates to said membrane having anionic polymers, as substrate, which is immersed into a cationic polymer solution containing a multivalent ion cross-linking agent, by which a cross-linkage within the internal of the separation membrane is achieved, thereby forming an ion complex between ionic polymers of opposite ion at the surface of the separation membrane to yield a stable separation membrane of a double structure.
摘要翻译：本发明涉及具有双重结构的聚离子络合物分离膜，其可应用于具有离子分子或颗粒的水溶性混合物通过反渗透压力的分离过程，用于回收昂贵的离子有机材料如阴离子来自废水的乳化剂。更具体地说，本发明涉及具有阴离子聚合物作为底物的所述膜，其被浸入含有多价离子交联剂的阳离子聚合物溶液中，由此实现了分离膜内部的交联，由此在分离膜表面的相对离子的离子聚合物之间形成离子络合物，得到双重结构的稳定的分离膜。

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