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1. 发明申请

US20070260285A1 HEART FAILURE MANAGEMENT SYSTEM 有权
标题翻译：心脏失败管理系统
公开(公告)号：US20070260285A1
公开(公告)日：2007-11-08
申请号：US11382128
申请日：2006-05-08
申请人： Imad Libbus , Krzysztof Siejko , Marina Brockway , Robert Sweeney
发明人： Imad Libbus , Krzysztof Siejko , Marina Brockway , Robert Sweeney
IPC分类号： A61N1/00
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/0215 , A61B5/02158 , A61B5/0402 , A61B5/0488 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36139 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/372 , A61N1/37288
摘要： Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括适于递送用于心力衰竭治疗的刺激信号的刺激器，适于提供心力衰竭状态的至少第一测量和心力衰竭状态的第二测量的多个传感器以及控制器。控制器连接到刺激器和传感器的数量。控制器适于使用第一和第二测量来创建心力衰竭状态指数，并且使用该索引来控制刺激器来调制信号。本文提供了其它方面和实施例。

2. 发明申请

US20060276849A1 Sensing rate of change of pressure in the left ventricle with an implanted device 有权
公开(公告)号：US20060276849A1
公开(公告)日：2006-12-07
申请号：US11142851
申请日：2005-06-01
申请人： Gerrard Carlson , Krzysztof Siejko , Ramesh Wariar , Marina Brockway
发明人： Gerrard Carlson , Krzysztof Siejko , Ramesh Wariar , Marina Brockway
IPC分类号： A61N1/00
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.

3. 发明申请

US20060282000A1 Ischemia detection using a heart sound sensor 有权
标题翻译：使用心脏声音传感器进行缺血检测
公开(公告)号：US20060282000A1
公开(公告)日：2006-12-14
申请号：US11148107
申请日：2005-06-08
申请人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina Brockway , Krzysztof Siejko
发明人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina Brockway , Krzysztof Siejko
IPC分类号： A61B5/02
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/024 , A61B5/0452 , A61B5/0456 , A61B7/04 , A61N1/36578 , A61N1/395
摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.
摘要翻译：包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。心脏声音与患者心脏的机械活动有关。另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。

4. 发明申请

US20060270939A1 Systems and methods for multi-axis cardiac vibration measurements 有权
标题翻译：用于多轴心脏振动测量的系统和方法
公开(公告)号：US20060270939A1
公开(公告)日：2006-11-30
申请号：US11135985
申请日：2005-05-24
申请人： Ramesh Wariar , Krzysztof Siejko , Gerrard Carlson , Jeffrey Stahmann
发明人： Ramesh Wariar , Krzysztof Siejko , Gerrard Carlson , Jeffrey Stahmann
IPC分类号： A61B5/02
CPC分类号： A61B7/00 , A61N1/08
摘要： A system to monitor heart sounds, such as to detect a worsening condition of heart failure decompensation. The system comprises a medical device that includes an implantable multi-axis heart sound sensor, operable to produce, for each of at least two nonparallel axes, an electrical signal representative of at least one heart sound, the heart sound associated with mechanical activity of a patient's heart. The device further includes a controller circuit coupled to the heart sound sensor. The controller circuit measures components of the heart sound that respectively correspond to each of the axes.
摘要翻译：监测心脏声音的系统，例如检测心力衰竭代偿失调的恶化情况。该系统包括医疗装置，其包括可植入的多轴心音传感器，可操作以针对至少两个不平行的轴中的每一个产生代表至少一个心脏声音的电信号，所述心脏声音与病人的心。该装置还包括耦合到心脏声音传感器的控制器电路。控制器电路测量分别对应于每个轴的心音的分量。

5. 发明申请

US20060253159A1 Trending of systolic murmur intensity for monitoring cardiac disease with implantable device 有权
标题翻译：用植入式装置监测心脏病的收缩期杂音强度的趋势
公开(公告)号：US20060253159A1
公开(公告)日：2006-11-09
申请号：US11122749
申请日：2005-05-05
申请人： Krzysztof Siejko , Richard Fogoros
发明人： Krzysztof Siejko , Richard Fogoros
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61B7/023 , A61N1/3627
摘要： Described is an implantable device configured to monitor for changes in the intensity and/or duration of a systolic murmur such as mitral regurgitation by means of an acoustic sensor. Such changes may be taken to indicate a change in a patient's heart failure status. Upon detection of a worsening in the patient's heart failure statue, the device may be programmed to alert clinical personnel over a patient management network and/or make appropriate adjustments to pacing therapy.
摘要翻译：描述了被配置为通过声学传感器监测收缩期杂音如二尖瓣反流的强度和/或持续时间的变化的可植入装置。可以采取这种改变来指示患者心力衰竭状态的变化。当检测到患者的心力衰竭雕像恶化时，该装置可以被编程以通过患者管理网络警告临床人员和/或对起搏治疗进行适当的调整。

6. 发明授权

US08229557B2 Estimating acute response to cardiac resynchronization therapy 有权
标题翻译：估计对心脏再同步治疗的急性反应
公开(公告)号：US08229557B2
公开(公告)日：2012-07-24
申请号：US11729453
申请日：2007-03-29
申请人： Abhilash Patangay , Krzysztof Siejko , Mohan Krishnan , Gerrard M. Carlson
发明人： Abhilash Patangay , Krzysztof Siejko , Mohan Krishnan , Gerrard M. Carlson
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/029 , A61B5/0422 , A61B5/0535 , A61B5/0538 , A61B5/1102 , A61B5/7267 , A61B7/00 , A61N1/3684 , A61N1/3704
摘要： Systolic timing intervals are measured in response to delivering pacing energy to a pacing site of a patient's heart. An estimate of a patient's acute response to cardiac resynchronization therapy (CRT) for the pacing site is determined using the measured systolic timing intervals. The estimate is compared to a threshold. The threshold preferably distinguishes between acute responsiveness and non-responsiveness to CRT for a patient population. An indication of acute responsiveness to CRT for the pacing site may be produced in response to the comparison.
摘要翻译：响应于将起搏能量递送到患者心脏的起搏部位来测量收缩时间间隔。使用测量的收缩时间间隔来确定对于起搏部位的患者对心脏再同步治疗（CRT）的急性反应的估计。将估计值与阈值进行比较。该阈值优选地区分对于患者群体的急性反应性和对CRT的无反应性。响应于比较可以产生针对起搏部位对CRT的急性反应性的指示。

7. 发明申请

US20070078491A1 THIRD HEART SOUND ACTIVITY INDEX FOR HEART FAILURE MONITORING 有权
标题翻译：心脏失败监测的第三心音活动指标
公开(公告)号：US20070078491A1
公开(公告)日：2007-04-05
申请号：US11465878
申请日：2006-08-21
申请人： Krzysztof Siejko , Laura Green , Gerrard Carlson
发明人： Krzysztof Siejko , Laura Green , Gerrard Carlson
IPC分类号： A61N1/00
CPC分类号： A61B7/006 , A61B5/02028 , A61B5/024 , A61B5/02438 , A61B5/4836 , A61B5/6847 , A61B5/7275 , A61B7/04 , A61B2562/0204 , A61B2562/0219 , A61N1/36514 , A61N1/37 , A61N1/3987
摘要： A cardiac rhythm management system provides for the trending of a third heart sound (S3) index. The S3 index is a ratio, or an estimate of the ratio, of the number of S3 beats to the number of all heart beats, where the S3 beats are each a heart beat during which an occurrence of S3 is detected. An implantable sensor such as an accelerometer or a microphone senses an acoustic signal indicative heart sounds including S3. An S3 detector detects occurrences of S3 from the acoustic signal. A heart sound processing system trends the S3 index on a periodic basis to allow continuous monitoring of the S3 activity level, which is indicative of conditions related to heart failure.
摘要翻译：心律管理系统提供第三心音（S3）指数的趋势。 S3指数是S3跳动次数与所有心跳次数的比率或比率的估计，其中S3跳动各自是检测到S3的发生的心跳。诸如加速度计或麦克风的可植入传感器感测到包括S3的指示心音的声信号。 S3检测器从声信号检测出S3的发生。心脏声音处理系统周期性地推动S3指数，以允许连续监测S3活动水平，这表明与心力衰竭有关的病症。

8. 发明申请

US20070066913A1 METHOD AND APPARATUS FOR DETECTING ATRIAL FILLING PRESSURE 有权
标题翻译：用于检测心律灌注压的方法和装置
公开(公告)号：US20070066913A1
公开(公告)日：2007-03-22
申请号：US11558967
申请日：2006-11-13
申请人： Abhilash Patangay , Krzysztof Siejko
发明人： Abhilash Patangay , Krzysztof Siejko
IPC分类号： A61B5/02
CPC分类号： A61B5/02028 , A61B7/00 , A61N1/36514 , A61N1/36528
摘要： A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.
摘要翻译：心律管理系统基于用于诊断和治疗目的的心音相关参数的定量测量，提供对血液动力学性能的动态监测。监测这种心脏声音相关参数允许心律管理系统基于心脏的情况来确定递送治疗和/或治疗参数调整的需要。该监测还允许医师观察或评估用于诊断和作出治疗决定的血液动力学性能。由于心脏的状况可能波动，并且可能在医师访问之间显着恶化，所以在连续或周期性的基础上进行的动态监测可确保心律管理系统能够节省生命，预防住院或进一步防止心律失常的迅速反应心脏恶化

9. 发明申请

US20070213599A1 PHYSIOLOGICAL EVENT DETECTION SYSTEMS AND METHODS 有权
标题翻译：生理事件检测系统和方法
公开(公告)号：US20070213599A1
公开(公告)日：2007-09-13
申请号：US11276735
申请日：2006-03-13
申请人： Krzysztof Siejko , John Hatlestad
发明人： Krzysztof Siejko , John Hatlestad
IPC分类号： A61B5/00 , G08B1/08
CPC分类号： A61B5/00 , A61B5/053 , A61B5/746 , A61B7/023 , A61N1/3627 , A61N1/36514
摘要： Systems and methods using constant false alarm rate techniques for event detection. One example of an event detection method includes collecting a first distribution of measurements for a first physiological parameter. In another example, the first distribution of measurements includes only non-event measurements. One or more values are determined corresponding to at least a first tail area of the first distribution from at least one measurement of the first physiological parameter toward an end point of the distribution. A threshold is established based on a specified false alarm rate. The one or more values are compared to the threshold. The method includes determining if the measurement is representative of a detected event using the comparison.
摘要翻译：用于事件检测的常数误报率技术的系统和方法。事件检测方法的一个示例包括收集第一生理参数的测量的第一分布。在另一示例中，测量的第一分布仅包括非事件测量。从第一生理参数的至少一个测量到分布的终点，确定对应于第一分布的至少第一尾区的一个或多个值。基于指定的虚警率建立阈值。将一个或多个值与阈值进行比较。该方法包括使用比较来确定测量是否表示检测到的事件。

10. 发明申请

US20060025699A1 Determining a patient's posture from mechanical vibrations of the heart 有权
公开(公告)号：US20060025699A1
公开(公告)日：2006-02-02
申请号：US10900570
申请日：2004-07-28
申请人： Keith Maile , Krzysztof Siejko
发明人： Keith Maile , Krzysztof Siejko
IPC分类号： A61B5/02
CPC分类号： A61N1/36542 , A61B7/00 , A61N1/36535 , A61N1/36578
摘要： A system for determining a patient's posture by monitoring heart sounds. The system comprises an implantable medical device that includes a sensor operable to produce an electrical signal representative of heart sounds, a sensor interface circuit coupled to the sensor to produce a heart sound signal, and a controller circuit coupled to the sensor interface circuit. The heart sounds are associated with mechanical activity of a patient's heart and the controller circuit is operable to detect a posture of the patient from a heart sound signal.

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