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1. 发明申请

US20120232607A1 ESTIMATING ACUTE RESPONSE TO CARDIAC RESYNCHRONIZATION THERAPY 失效
标题翻译：估计对心脏康复治疗的急性反应
公开(公告)号：US20120232607A1
公开(公告)日：2012-09-13
申请号：US13479979
申请日：2012-05-24
申请人： Abhilash Patangay , Krzysztof Siejko , Mohan Krishnan , Gerrard M. Carlson
发明人： Abhilash Patangay , Krzysztof Siejko , Mohan Krishnan , Gerrard M. Carlson
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/029 , A61B5/0422 , A61B5/0535 , A61B5/0538 , A61B5/1102 , A61B5/7267 , A61B7/00 , A61N1/3684 , A61N1/3704
摘要： Systolic timing intervals are measured in response to delivering pacing energy to a pacing site of a patient's heart. An estimate of a patient's acute response to cardiac resynchronization therapy (CRT) for the pacing site is determined using the measured systolic timing intervals. The estimate is compared to a threshold. The threshold preferably distinguishes between acute responsiveness and non-responsiveness to CRT for a patient population. An indication of acute responsiveness to CRT for the pacing site may be produced in response to the comparison.
摘要翻译：响应于将起搏能量递送到患者心脏的起搏部位来测量收缩时间间隔。使用测量的收缩时间间隔来确定对于起搏部位的患者对心脏再同步治疗（CRT）的急性反应的估计。将估计值与阈值进行比较。该阈值优选地区分对于患者群体的急性反应性和对CRT的无反应性。响应于比较可以产生针对起搏部位对CRT的急性反应性的指示。

2. 发明申请

US20080243202A1 Estimating acute response to cardiac resynchronization therapy 有权
标题翻译：估计对心脏再同步治疗的急性反应
公开(公告)号：US20080243202A1
公开(公告)日：2008-10-02
申请号：US11729453
申请日：2007-03-29
申请人： Abhilash Patangay , Krzysztof Siejko , Mohan Krishnan , Gerrard M. Carlson
发明人： Abhilash Patangay , Krzysztof Siejko , Mohan Krishnan , Gerrard M. Carlson
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/029 , A61B5/0422 , A61B5/0535 , A61B5/0538 , A61B5/1102 , A61B5/7267 , A61B7/00 , A61N1/3684 , A61N1/3704
摘要： Systolic timing intervals are measured in response to delivering pacing energy to a pacing site of a patient's heart. An estimate of a patient's acute response to cardiac resynchronization therapy (CRT) for the pacing site is determined using the measured systolic timing intervals. The estimate is compared to a threshold. The threshold preferably distinguishes between acute responsiveness and non-responsiveness to CRT for a patient population. An indication of acute responsiveness to CRT for the pacing site may be produced in response to the comparison.
摘要翻译：响应于将起搏能量递送到患者心脏的起搏部位来测量收缩时间间隔。使用测量的收缩时间间隔来确定对于起搏部位的患者对心脏再同步治疗（CRT）的急性反应的估计。将估计值与阈值进行比较。该阈值优选地区分对于患者群体的急性反应性和对CRT的无反应性。响应于比较可以产生针对起搏部位对CRT的急性反应性的指示。

3. 发明授权

US08229557B2 Estimating acute response to cardiac resynchronization therapy 有权
标题翻译：估计对心脏再同步治疗的急性反应
公开(公告)号：US08229557B2
公开(公告)日：2012-07-24
申请号：US11729453
申请日：2007-03-29
申请人： Abhilash Patangay , Krzysztof Siejko , Mohan Krishnan , Gerrard M. Carlson
发明人： Abhilash Patangay , Krzysztof Siejko , Mohan Krishnan , Gerrard M. Carlson
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/029 , A61B5/0422 , A61B5/0535 , A61B5/0538 , A61B5/1102 , A61B5/7267 , A61B7/00 , A61N1/3684 , A61N1/3704
摘要： Systolic timing intervals are measured in response to delivering pacing energy to a pacing site of a patient's heart. An estimate of a patient's acute response to cardiac resynchronization therapy (CRT) for the pacing site is determined using the measured systolic timing intervals. The estimate is compared to a threshold. The threshold preferably distinguishes between acute responsiveness and non-responsiveness to CRT for a patient population. An indication of acute responsiveness to CRT for the pacing site may be produced in response to the comparison.
摘要翻译：响应于将起搏能量递送到患者心脏的起搏部位来测量收缩时间间隔。使用测量的收缩时间间隔来确定对于起搏部位的患者对心脏再同步治疗（CRT）的急性反应的估计。将估计值与阈值进行比较。该阈值优选地区分对于患者群体的急性反应性和对CRT的无反应性。响应于比较可以产生针对起搏部位对CRT的急性反应性的指示。

4. 发明授权

US08700149B2 Estimating acute response to cardiac resynchronization therapy 失效
标题翻译：估计对心脏再同步治疗的急性反应
公开(公告)号：US08700149B2
公开(公告)日：2014-04-15
申请号：US13479979
申请日：2012-05-24
申请人： Abhilash Patangay , Krzysztof Z. Siejko , Mohan Krishnan , Gerrard M. Carlson
发明人： Abhilash Patangay , Krzysztof Z. Siejko , Mohan Krishnan , Gerrard M. Carlson
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/029 , A61B5/0422 , A61B5/0535 , A61B5/0538 , A61B5/1102 , A61B5/7267 , A61B7/00 , A61N1/3684 , A61N1/3704
摘要： Systolic timing intervals are measured in response to delivering pacing energy to a pacing site of a patient's heart. An estimate of a patient's acute response to cardiac resynchronization therapy (CRT) for the pacing site is determined using the measured systolic timing intervals. The estimate is compared to a threshold. The threshold preferably distinguishes between acute responsiveness and non-responsiveness to CRT for a patient population. An indication of acute responsiveness to CRT for the pacing site may be produced in response to the comparison.
摘要翻译：响应于将起搏能量递送到患者心脏的起搏部位来测量收缩时间间隔。使用测量的收缩时间间隔来确定对于起搏部位的患者对心脏再同步治疗（CRT）的急性反应的估计。将估计值与阈值进行比较。该阈值优选地区分对于患者群体的急性反应性和对CRT的无反应性。响应于比较可以产生针对起搏部位对CRT的急性反应性的指示。

5. 发明授权

US08401636B2 Monitoring of chronobiological rhythms for disease and drug management using one or more implantable device 有权
标题翻译：使用一个或多个可植入装置监测疾病和药物管理的计时生理节律
公开(公告)号：US08401636B2
公开(公告)日：2013-03-19
申请号：US13209938
申请日：2011-08-15
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61N1/18
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译：使用至少一个可植入装置自动评价或预测受试者的健康状况。在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。也可以使用昼夜节律以外的其他时间生理节律。可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。

6. 发明申请

US20110301530A1 MONITORING OF CHRONOBIOLOGICAL RHYTHMS FOR DISEASE AND DRUG MANAGEMENT USING ONE OR MORE IMPLANTABLE DEVICE 有权
标题翻译：使用一个或多个可植入装置监测疾病和药物管理的血液生殖系统
公开(公告)号：US20110301530A1
公开(公告)日：2011-12-08
申请号：US13209938
申请日：2011-08-15
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61N1/08 , A61N1/365 , A61M5/142
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译：使用至少一个可植入装置自动评价或预测受试者的健康状况。在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。也可以使用昼夜节律以外的其他时间生理节律。可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。

7. 发明申请

US20080125820A1 ADAPTIVE SAMPLING OF HEART SOUNDS 有权
标题翻译：自适应采样心音
公开(公告)号：US20080125820A1
公开(公告)日：2008-05-29
申请号：US11564637
申请日：2006-11-29
申请人： Jeffrey E. Stahmann , Krzysztof Z. Siejko , Carlos Haro , Abhilash Patangay , Gerrard M. Carlson , Andres Belalcazar
发明人： Jeffrey E. Stahmann , Krzysztof Z. Siejko , Carlos Haro , Abhilash Patangay , Gerrard M. Carlson , Andres Belalcazar
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61B5/0031 , A61B5/021 , A61B5/024 , A61B5/053 , A61B5/08 , A61B5/0816 , A61B5/1116 , A61B5/4806 , A61B5/686 , A61B5/7275 , A61B7/04 , A61N1/36578
摘要： A system and method to sense heart sounds with one or more implantable medical devices according to one or more parameters. The system alters one or more of the parameters as a function of one or more triggering events. The system then senses heart sounds with the one or more implantable medical devices according to at least the one or more altered parameters.
摘要翻译：根据一个或多个参数用一个或多个可植入医疗装置感测心脏声音的系统和方法。系统根据一个或多个触发事件改变一个或多个参数。该系统然后根据至少一个或多个改变的参数用一个或多个可植入医疗装置感测心脏声音。

8. 发明申请

US20130096451A1 HEART SOUND TRACKING SYSTEM AND METHOD 审中-公开
公开(公告)号：US20130096451A1
公开(公告)日：2013-04-18
申请号：US13708196
申请日：2012-12-07
申请人： Abhilash Patangay , Krzysztof Z. Siejko , Gerrard M. Carlson
发明人： Abhilash Patangay , Krzysztof Z. Siejko , Gerrard M. Carlson
IPC分类号： A61B7/00
CPC分类号： A61B7/04 , A61B7/00 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36585 , A61N1/368
摘要： A system and method provide heart sound tracking, including an input circuit, configured to receive heart sound information, and a heart sound recognition circuit. The heart sound recognition circuit can be coupled to the input circuit and can be configured to recognize, within a particular heart sound of a particular heart sound waveform, a first intra heart sound energy indication and a corresponding first intra heart sound time indication using the heart sound information from the particular heart sound waveform and the heart sound information from at least one other heart sound waveform. The particular heart sound can include at least a portion of one of S1, S2, S3, and S4. Further, the first intra heart sound energy indication and the corresponding first intra heart sound time indication can correspond to the at least a portion of one of S1, S2, S3, and S4, respectively.

9. 发明授权

US08332034B2 Heart sound tracking system and method 有权
标题翻译：心音跟踪系统及方法
公开(公告)号：US08332034B2
公开(公告)日：2012-12-11
申请号：US12964902
申请日：2010-12-10
申请人： Abhilash Patangay , Krzysztof Z. Siejko , Gerrard M. Carlson
发明人： Abhilash Patangay , Krzysztof Z. Siejko , Gerrard M. Carlson
IPC分类号： A61N1/365
CPC分类号： A61B7/04 , A61B7/00 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36585 , A61N1/368
摘要： A system and method provide heart sound tracking, including an input circuit, configured to receive heart sound information, and a heart sound recognition circuit. The heart sound recognition circuit can be coupled to the input circuit and can be configured to recognize, within a particular heart sound of a particular heart sound waveform, a first intra heart sound energy indication and a corresponding first intra heart sound time indication using the heart sound information from the particular heart sound waveform and the heart sound information from at least one other heart sound waveform. The particular heart sound can include at least a portion of one of S1, S2, S3, and S4. Further, the first intra heart sound energy indication and the corresponding first intra heart sound time indication can correspond to the at least a portion of one of S1, S2, S3, and S4, respectively.
摘要翻译：一种系统和方法提供心脏跟踪，包括被配置为接收心脏声音信息的输入电路和心脏声音识别电路。心脏声音识别电路可以耦合到输入电路，并且可以被配置为在特定心脏声音波形的特定心脏声音内识别第一心脏心脏声能指示和使用心脏的对应的第一心脏心脏音频指示来自特定心脏声音波形的声音信息和来自至少一个其他心脏声音波形的心脏声音信息。特定的心音可以包括S1，S2，S3和S4中的一个的至少一部分。此外，第一心内心音能量指示和对应的第一心脏心音时间指示可以分别对应于S1，S2，S3和S4中的一个的至少一部分。

10. 发明申请

US20120089040A1 ADAPTIVE SAMPLING OF HEART SOUNDS 审中-公开
标题翻译：自适应采样心音
公开(公告)号：US20120089040A1
公开(公告)日：2012-04-12
申请号：US13325654
申请日：2011-12-14
申请人： Jeffrey E. Stahmann , Krzysztof Z. Siejko , Carlos Haro , Abhilash Patangay , Gerrard M. Carlson , Andres Belalcazar
发明人： Jeffrey E. Stahmann , Krzysztof Z. Siejko , Carlos Haro , Abhilash Patangay , Gerrard M. Carlson , Andres Belalcazar
IPC分类号： A61B7/00
CPC分类号： A61N1/36514 , A61B5/0031 , A61B5/021 , A61B5/024 , A61B5/053 , A61B5/08 , A61B5/0816 , A61B5/1116 , A61B5/4806 , A61B5/686 , A61B5/7275 , A61B7/04 , A61N1/36578
摘要： A system and method to sense heart sounds with one or more implantable medical devices according to one or more signal processing parameters. The method alters one or more of the parameters as a function of one or more physiologic triggering events. The method then senses heart sounds with the one or more implantable medical devices according to at least the one or more altered signal processing parameters.
摘要翻译：根据一个或多个信号处理参数用一个或多个可植入医疗装置感测心脏声音的系统和方法。该方法将一个或多个参数改变为一个或多个生理触发事件的函数。该方法然后根据至少一个或多个改变的信号处理参数用一个或多个可植入医疗装置感测心脏声音。

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