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1. 发明申请

US20130017169A1 MULTIMERIC FORMS OF THERAPEUTIC PROTEINS AND USES THEREOF 审中-公开
标题翻译：多种治疗性蛋白质及其用途
公开(公告)号：US20130017169A1
公开(公告)日：2013-01-17
申请号：US13582464
申请日：2011-03-02
申请人： Ilya Ruderfer , Orit Shilovittzky , Avidor Shulman , Joseph Shaaltiel , Tehila Ben-Moshe , Talia Shekhter , Yaniv Azulay
发明人： Ilya Ruderfer , Orit Shilovittzky , Avidor Shulman , Joseph Shaaltiel , Tehila Ben-Moshe , Talia Shekhter , Yaniv Azulay
IPC分类号： C07K14/525 , C07K14/475 , C07K16/00 , C07K14/54 , A61K38/19 , A61K38/20 , A61K38/17 , A61K38/18 , C07K2/00 , A61K38/24 , A61K38/44 , C07K1/113 , A61K39/395 , A61P35/00 , A61P27/02 , A61P29/00 , A61P19/02 , A61P17/02 , C07K14/49 , C07K14/725 , C07K14/715 , C12N9/06 , A61K38/02 , C07K14/59
CPC分类号： C07K14/525
摘要： Multimeric protein structures are disclosed herein, as well a process for preparing same, and methods employing same for treating various diseases or disorders. The multimeric protein structures comprise at least two monomers of a therapeutic protein, including a TNF-alpha, a luteinizing hormone, an immunoglobin, a TNF-alpha receptor, a CTLA-4, a urate oxidase, a VEGF, a PDGF, a VEGF receptor, a PDGF receptor, an interleukin-17, and/or fragments thereof, the monomers being covalently linked to one another via a linking moiety. The multimeric protein structures exhibit improved performance as compared to the corresponding native proteins, including a longer lasting activity in vivo.
摘要翻译：本文公开了多聚体蛋白质结构，以及其制备方法，以及使用它们治疗各种疾病或病症的方法。多聚体蛋白质结构包含治疗性蛋白质的至少两种单体，包括TNF-α，促黄体激素，免疫球蛋白，TNF-α受体，CTLA-4，尿酸氧化酶，VEGF，PDGF，VEGF 受体，PDGF受体，白细胞介素-17和/或其片段，所述单体通过连接部分彼此共价连接。与相应的天然蛋白质相比，多聚体蛋白质结构表现出改善的性能，包括在体内更持久的活性。

2. 发明授权

US09194011B2 Stabilized alpha-galactosidase and uses thereof 有权
标题翻译：稳定的α-半乳糖苷酶及其用途
公开(公告)号：US09194011B2
公开(公告)日：2015-11-24
申请号：US13582482
申请日：2011-03-02
申请人： Avidor Shulman , Ilya Ruderfer , Tehila Ben-Moshe , Talia Shekhter , Yaniv Azulay , Yoseph Shaaltiel , Tali Kizhner
发明人： Avidor Shulman , Ilya Ruderfer , Tehila Ben-Moshe , Talia Shekhter , Yaniv Azulay , Yoseph Shaaltiel , Tali Kizhner
IPC分类号： A61K38/54 , C12N9/96 , C12N9/40 , C07H21/04 , C07K1/00
CPC分类号： C12N9/2465 , A61K38/00 , C12Y302/01022
摘要： Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.
摘要翻译：本文公开了包含通过连接部分彼此共价连接的至少两个α-半乳糖苷酶单体的多聚体蛋白质结构，以及其制备方法，以及通过施用多聚体蛋白质结构治疗法布里病的方法。根据在溶酶体条件和血清环境中增强的活性和/或更持久的活性方面，所公开的多聚体蛋白质结构表现出改进的性能。

3. 发明申请

US20120328592A1 STABILIZED ALPHA-GALACTOSIDASE AND USES THEREOF 有权
标题翻译：稳定的阿尔法胶质糖苷酶及其用途
公开(公告)号：US20120328592A1
公开(公告)日：2012-12-27
申请号：US13582482
申请日：2011-03-02
申请人： Avidor Shulman , Llya Ruderfer , Tehila Ben-Moshe , Talia Sheckhter , Yaniv Azulay , Yoseph Shaaltiel , Tali Kizhner
发明人： Avidor Shulman , Llya Ruderfer , Tehila Ben-Moshe , Talia Sheckhter , Yaniv Azulay , Yoseph Shaaltiel , Tali Kizhner
IPC分类号： A61K38/47 , A61P3/00 , C12N9/96
CPC分类号： C12N9/2465 , A61K38/00 , C12Y302/01022
摘要： Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.
摘要翻译：本文公开了包含通过连接部分彼此共价连接的至少两个α-半乳糖苷酶单体的多聚体蛋白质结构，以及其制备方法，以及通过施用多聚体蛋白质结构治疗法布里病的方法。根据在溶酶体条件和血清环境中增强的活性和/或更持久的活性方面，所公开的多聚体蛋白质结构表现出改进的性能。

4. 发明授权

US08742079B2 Saccharide-containing protein conjugates and uses thereof 有权
标题翻译：含糖蛋白质共轭物及其用途
公开(公告)号：US08742079B2
公开(公告)日：2014-06-03
申请号：US12673987
申请日：2008-08-20
申请人： Avidor Shulman , Ilya Ruderfer
发明人： Avidor Shulman , Ilya Ruderfer
IPC分类号： C07H23/00 , C07H17/02 , A61K38/14 , A01N43/04 , A61K31/70 , C07K1/00 , C07K17/00
CPC分类号： A61K47/48092 , A61K47/54 , A61K47/549
摘要： Conjugates of a saccharide and a biomolecule, covalently linked therebetween via a non-hydrophobic linker and methods of preparing same are disclosed. Also disclosed are medical uses utilizing such conjugates. Glycosylation reagents for use in preparing these conjugates are also disclosed. Glycosylated proteins, characterized by improved performance, are also disclosed.
摘要翻译：公开了通过非疏水性接头及其制备方法共价连接的糖和生物分子的缀合物。还公开了利用这种缀合物的医学用途。还公开了用于制备这些缀合物的糖基化试剂。还公开了以改进的性能为特征的糖基化蛋白质。

5. 发明申请

US20110105379A1 SACCHARIDE-CONTAINING PROTEIN CONJUGATES AND USES THEREOF 有权
标题翻译：含有蛋白质的蛋白质结合物及其用途
公开(公告)号：US20110105379A1
公开(公告)日：2011-05-05
申请号：US12673987
申请日：2008-08-20
申请人： Avidor Shulman , Ilya Ruderfer
发明人： Avidor Shulman , Ilya Ruderfer
IPC分类号： A61K38/02 , C07K14/00 , C12N9/96 , C07K14/59 , C07H15/08 , A61P3/00 , C12Q1/02
CPC分类号： A61K47/48092 , A61K47/54 , A61K47/549
摘要： Conjugates of a saccharide and a biomolecule, covalently linked therebetween via a non-hydrophobic linker and methods of preparing same are disclosed. Also disclosed are medical uses utilizing such conjugates. Glycosylation reagents for use in preparing these conjugates are also disclosed. Glycosylated proteins, characterized by improved performance, are also disclosed.
摘要翻译：公开了通过非疏水性接头及其制备方法共价连接的糖和生物分子的缀合物。还公开了利用这种缀合物的医学用途。还公开了用于制备这些缀合物的糖基化试剂。还公开了以改进的性能为特征的糖基化蛋白质。

6. 发明申请

US20120328589A1 GLUCOCEREBROSIDASE MULTIMERS AND USES THEREOF 审中-公开
标题翻译：葡萄糖苷酶多聚体及其用途
公开(公告)号：US20120328589A1
公开(公告)日：2012-12-27
申请号：US13582441
申请日：2011-03-02
申请人： Ilya Ruderfer , Tali Kizhner , Avidor Shulman , Yoseph Shaaltiel
发明人： Ilya Ruderfer , Tali Kizhner , Avidor Shulman , Yoseph Shaaltiel
IPC分类号： A61K38/47 , A61P3/00 , C12N9/96
CPC分类号： C07K14/525
摘要： Multimeric protein structures comprising at least two glucocerebrosidase molecules being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and uses thereof in the treatment of Gaucher disease. The multimeric protein structures are characterized by longer-lasting activity as compared to native glucocerebrosidase both in serum and in lysosomes.
摘要翻译：本文公开了包含通过连接部分彼此共价连接的至少两种葡糖脑苷脂酶分子的多聚体蛋白质结构，以及其制备方法及其在治疗戈谢病中的用途。与血浆和溶酶体中的天然葡糖脑苷脂酶相比，多聚体蛋白质结构的特征在于持久的活性。

7. 发明授权

US08772270B2 Treatment methods requiring phyto-ingredients 有权
标题翻译：需要植物成分的处理方法
公开(公告)号：US08772270B2
公开(公告)日：2014-07-08
申请号：US11673726
申请日：2007-02-12
申请人： Avidor Shulman , Dori Pelled , Tzafra Cohen , Orly Farkash
发明人： Avidor Shulman , Dori Pelled , Tzafra Cohen , Orly Farkash
IPC分类号： A61K31/56 , A61K47/00 , A23D9/013 , A23L1/30
CPC分类号： A23D9/013 , A23L33/11 , A23L33/12 , A23V2002/00 , A61K31/20 , A61K31/23 , A61K31/56 , A61K31/575 , A61K2300/00 , A23V2200/332 , A23V2200/3262 , A23V2250/182 , A23V2250/2136
摘要： The invention provides methods for treatment of conditions which require phytosterol therapy without adversely affecting the bioavailability of lipophilic vitamins or lipophilic drugs. The method includes administering a mixture of phytosterol ester(s) (PS-E) and 1,3-diglyceride(s) (DAG) dissolved in an edible oil or fat. The invention also provides a method of improving weight management and a method of treating metabolic conditions that result in overweight. Dietary nutrients, food supplements and food articles containing the mixture are also provided.
摘要翻译：本发明提供了治疗需要植物甾醇治疗而不会不利地影响亲脂维生素或亲脂性药物的生物利用度的条件的方法。该方法包括施用溶解在食用油或脂肪中的植物甾醇酯（PS-E）和1,3-二甘油酯（DAG）的混合物。本发明还提供了改善体重管理的方法和治疗导致超重的代谢病症的方法。还提供膳食营养素，食品添加剂和含有混合物的食品。

8. 发明授权

US08507466B2 Oils enriched with diacylglycerols and phytosterol esters and unit dosage forms thereof for use in therapy 有权
标题翻译：富含二酰基甘油和植物甾醇酯的油和其单位剂型用于治疗
公开(公告)号：US08507466B2
公开(公告)日：2013-08-13
申请号：US12655240
申请日：2009-12-23
申请人： Dorit Plat , Dori Pelled , Avidor Shulman , Gal Ben-Dror
发明人： Dorit Plat , Dori Pelled , Avidor Shulman , Gal Ben-Dror
IPC分类号： A61K31/56 , A61P3/00
CPC分类号： A61K31/22 , A23D9/013 , A23L33/11 , A23L33/12 , A23V2002/00 , A61K31/20 , A61K31/23 , A61K31/56 , A61K31/575 , A61K45/06 , A61K2300/00 , A23V2250/182 , A23V2250/2136
摘要： Described herein are various lipid mixtures, more particularly special mixtures of fatty acids esters, which may be phytosterol esters and/or glyceride esters. Said mixtures are evaluated in the context of their ability to, upon consumption, affect the levels of circulating LDL and HDL particles, and their therapeutic effect on conditions associated with lipid metabolism, such as atherosclerosis, diabetes, metabolic disorders, etc. Compositions, dietary nutrients, food supplements and nutraceuticals comprising the herein described mixtures are also described.
摘要翻译：本文描述的是各种脂质混合物，更特别的是脂肪酸酯的特殊混合物，其可以是植物甾醇酯和/或甘油酯。所述混合物在其消耗后能够影响循环LDL和HDL颗粒的水平及其对与脂质代谢相关的病症（例如动脉粥样硬化，糖尿病，代谢紊乱等）的治疗效果的上下文中进行评估。组合物，饮食还描述了包含本文所述混合物的营养物，食物补充剂和营养制品。

9. 发明申请

US20090011075A1 Polar Lipid Mixtures, their Preparation and Uses 审中-公开
标题翻译：极性脂质混合物，其制备和用途
公开(公告)号：US20090011075A1
公开(公告)日：2009-01-08
申请号：US11912925
申请日：2006-04-27
申请人： Avidor Shulman , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
发明人： Avidor Shulman , Rassan Zuabi , Gai Ben Dror , Yoni Twito , Dori Pelled , Yael Herzog
IPC分类号： A23L1/30
CPC分类号： A23J7/00 , A23L33/115 , A23V2002/00 , A23V2250/185 , A23V2250/1852 , A23V2250/1848
摘要： Disclosed herein are polar lipid mixtures, comprising glycerophospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidyl-inositol (PI), and sphingolipids such as sphyngomyelin (SM). Most importantly, the ratio of phospholipids in said mixture is comparable to that of HMF, and is represented by SM>PC>PE>PS>PI or SM=PC>PE>PS>PI. Processes for the preparation of said mixtures and uses thereof are also described herein.
摘要翻译：本文公开了包含甘油磷脂如磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰丝氨酸（PS）和磷脂酰肌醇（PI）以及鞘脂如鞘氨醇（SM）的极性脂质混合物。最重要的是，所述混合物中磷脂的比例与HMF的比例相当，并且由SM> PC> PE> PS> PI或SM = PC> PE> PS> PI表示。本文还描述了制备所述混合物的方法及其用途。

10. 发明申请

US20080058415A1 Lipid Preparation for Enhancing Mineral Absorption 有权
标题翻译：用于增强矿物吸收的脂质制备
公开(公告)号：US20080058415A1
公开(公告)日：2008-03-06
申请号：US10576239
申请日：2004-10-21
申请人： Avidor Shulman , Gai Ben Dror , Dori Pelled
发明人： Avidor Shulman , Gai Ben Dror , Dori Pelled
IPC分类号： A61K31/20 , A23D9/00 , A23L1/29 , A61P19/10 , A61P19/08 , A23L1/30
CPC分类号： A21D2/165 , A23C11/04 , A23D7/001 , A23D9/00 , A23G3/346 , A23G2200/08 , A23G2200/12 , C11C3/08
摘要： Disclosed is a dietary ingredient comprising at least one edible lipid which does not inhibit mineral absorption, enhances mineral absorption and intake, particularly a chemically or enzymatically synthesized synthetic oil, particularly glyceride-based lipid with high levels of mono- or polyunsaturated fatty acids at positions sn-1 and sn-3 of the glycerol backbone, vegetable- and plant-derived oil, such as flax and canola oils, short and medium chains lipid, preferably MCT and an oil mimicking the triglyceride composition of human mother's milk fat and its various uses.The dietary ingredient is particularly intended for use in enhancing calcium absorption and in the prevention and/or treatment of disorders associated with depletion of bone calcium and bone density, prevention and treatment of osteoporosis, for the enhancement of bone formation and bone mass maximization and for the enhancement of bone formation in infants and young children.
摘要翻译：公开了包含至少一种不抑制矿物质吸收的可食用脂质，增强矿物质吸收和摄入的膳食成分，特别是化学或酶合成的合成油，特别是甘油酯类脂质，其具有高水平的单不饱和脂肪酸或多不饱和脂肪酸甘油骨架的sn-1和sn-3，植物和植物来源的油，例如亚麻和低芥酸菜子油，短链和中链脂质，优选MCT和模仿人母乳脂肪的甘油三酯组合物的油及其各种用途。膳食成分特别用于增强钙的吸收，以及预防和/或治疗与骨钙素和骨密度消耗相关的疾病，预防和治疗骨质疏松症，用于增强骨形成和骨量最大化以及增强婴幼儿骨骼形成。

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