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1. 发明授权

US06630124B1 Combination therapy with VIP antagonist 失效
标题翻译： VIP拮抗剂联合治疗
公开(公告)号：US06630124B1
公开(公告)日：2003-10-07
申请号：US09807557
申请日：2002-01-09
申请人： Illana Gozes , Mati Fridkin , Edgar Gelber , Terry W. Moody , Douglas C. Brenneman
发明人： Illana Gozes , Mati Fridkin , Edgar Gelber , Terry W. Moody , Douglas C. Brenneman
IPC分类号： A61K5100
CPC分类号： A61K31/427 , A61K31/351 , A61K33/24 , A61K38/14 , A61K38/2278 , A61K45/06 , A61K2300/00
摘要： The present invention relates to combination therapy using a pharmaceutical composition comprising a polypeptide which is an antagonist of the vasoactive intestinal polypeptide (VIP) and a chemotherapeutic agent. Methods of using the pharmaceutical composition are also disclosed.
摘要翻译：本发明涉及使用包含作为血管活性肠多肽（VIP）的拮抗剂的多肽和化学治疗剂的药物组合物的组合疗法。还公开了使用该药物组合物的方法。

2. 发明授权

US06649411B2 Methods of inhibiting cancer cells with ADNF III antisense oligonucleotides 失效
标题翻译：用ADNF III反义寡核苷酸抑制癌细胞的方法
公开(公告)号：US06649411B2
公开(公告)日：2003-11-18
申请号：US09364609
申请日：1999-07-30
申请人： Illana Gozes , Douglas E. Brenneman , Rachel Zamostiano , Edgar Gelber , Albert Pinhasov , Merav Bassan
发明人： Illana Gozes , Douglas E. Brenneman , Rachel Zamostiano , Edgar Gelber , Albert Pinhasov , Merav Bassan
IPC分类号： C12N500
CPC分类号： C12N15/1136 , C12N2310/111 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12Q1/6886 , C12Q2600/136 , C12N2310/3521
摘要： The present invention provides methods of using antisense ADNF III oligonucleotides to inhibit the growth of pathologically proliferating cells. The invention also provides methods and kits for using ADNF III nucleic acid probes to detect the presence of pathologically proliferating cells in human tissues.
摘要翻译：本发明提供了使用反义ADNF III寡核苷酸抑制病理增殖细胞生长的方法。本发明还提供了使用ADNF III核酸探针来检测人组织中病理性增殖细胞的存在的方法和试剂盒。

3. 发明授权

US5565424A Superactive VIP antagonists 失效
标题翻译：超活性VIP拮抗剂
公开(公告)号：US5565424A
公开(公告)日：1996-10-15
申请号：US194591
申请日：1994-02-07
申请人： Illana Gozes , Douglas E. Brenneman , Matityahu Fridkin , Terry W. Moody
发明人： Illana Gozes , Douglas E. Brenneman , Matityahu Fridkin , Terry W. Moody
IPC分类号： A61K38/00 , A61P9/00 , A61P35/00 , A61P43/00 , C07K7/08 , C07K14/00 , C07K14/47 , C07K14/575 , A61K38/16
CPC分类号： C07K7/083 , C07K14/57563 , A61K38/00
摘要： The present invention relates to a family of peptides encoding antagonists of the vasoactive intestinal peptide (VIP) designed to distinguish multiple receptors that mediate VIP neurotransmission, neurotrophism and cell division. The invention also relates to methods of using these peptides to antagonize VIP-associated activity and function. The invention further relates to pharmaceutical compositions dsigned to inhibit VIP-associated activity.
摘要翻译：本发明涉及编码血管活性肠肽（VIP）的拮抗剂的肽家族，其设计用于区分介导VIP神经传递，神经营养和细胞分裂的多种受体。本发明还涉及使用这些肽拮抗VIP相关活性和功能的方法。本发明还涉及抑制VIP相关活性的药物组合物。

4. 发明授权

US08067369B2 Protection of the retina against laser injury by NAP and related peptides 有权
标题翻译：保护视网膜免受NAP和相关肽的激光损伤
公开(公告)号：US08067369B2
公开(公告)日：2011-11-29
申请号：US12280471
申请日：2006-04-20
申请人： Illana Gozes , Michael Belkin
发明人： Illana Gozes , Michael Belkin
IPC分类号： A61K38/18 , A61K38/08
CPC分类号： A61K38/18 , G01N2800/40
摘要： This invention relates to the use of ADNF polypeptides in the treatment of laser-induced retinal damage and related conditions.
摘要翻译：本发明涉及ADNF多肽在治疗激光诱导的视网膜损伤和相关病症中的应用。

5. 发明授权

US08017578B2 Orally active peptides that prevent cell damage and death 有权
标题翻译：口服活性肽，可防止细胞损伤和死亡
公开(公告)号：US08017578B2
公开(公告)日：2011-09-13
申请号：US12102760
申请日：2008-04-14
申请人： Douglas Brenneman , Illana Gozes , Catherine Y. Spong , Albert Pinhasov , Eliezer Giladi
发明人： Douglas Brenneman , Illana Gozes , Catherine Y. Spong , Albert Pinhasov , Eliezer Giladi
IPC分类号： A61K38/08 , C07K7/06
CPC分类号： A61K38/04 , A61K38/185
摘要： This invention provides an ADNF polypeptide comprising an active core site, the active core site comprising at least one D-amino acid. The invention also provides a pharmaceutical composition comprising an ADNF polypeptide comprising an active core site, the active core site comprising at least one D-amino acid. In particular, the pharmaceutical composition of the invention is orally active. The invention further provides methods for reducing neuronal cell death, methods for reducing oxidative stress, and methods for reducing a condition associated with fetal alcohol syndrome using the ADNF polypeptides and the pharmaceutical compositions of the invention.
摘要翻译：本发明提供了包含活性核心位点的ADNF多肽，所述活性核心位点包含至少一个D-氨基酸。本发明还提供了包含包含活性核心位点的ADNF多肽的药物组合物，所述活性核心位点包含至少一个D-氨基酸。特别地，本发明的药物组合物是口服活性的。本发明还提供了使用ADNF多肽和本发明的药物组合物减少神经元细胞死亡的方法，用于降低氧化应激的方法以及用于降低与胎儿酒精综合征相关的病症的方法。

6. 发明申请

US20070054847A1 Use of adnf polypeptides for treating anxiety and depression 有权
标题翻译：使用adnf多肽治疗焦虑和抑郁
公开(公告)号：US20070054847A1
公开(公告)日：2007-03-08
申请号：US10547986
申请日：2004-03-11
申请人： Illana Gozes , Roy Alcalay , Inna Divinski , Eliezer Giladi
发明人： Illana Gozes , Roy Alcalay , Inna Divinski , Eliezer Giladi
IPC分类号： A61K38/17 , A61K38/10
CPC分类号： A61K38/18
摘要： This invention relates to the use of ADNF polypeptides in the treatment of anxiety and/or depression. The present invention also relates to drug discovery assays using the ADNF polypeptide mechanism of action and target interaction, as well as the manufacture of medicaments, methods of application and formulation therefor. Embodiments of the invention provide methods for preventing and/or treating anxiety and depression disorders in a subject by administering a NAP, an 8-amino-acid peptide derived from Activity Dependent Neurotrophic Factor (ADNF III), in an amount sufficient to improve postnatal performance. The ADNF polypeptides include ADNF I and ADNF III (also referred to as ADNP) polypeptides, analogs, subsequences, and D-amino acid versions (either wholly D-amino acid peptides or mixed D- and L-amino acid peptides), and combinations thereof which contain their respective active core sites and provide neuroprotective and anti-anxiety functions.
摘要翻译：本发明涉及ADNF多肽在治疗焦虑和/或抑郁症中的应用。本发明还涉及使用ADNF多肽作用和靶相互作用机制的药物发现测定，以及药物的制备，应用方法和制剂。本发明的实施方案通过以足以改善出生后表现的量施用NAP（衍生自活性依赖性神经营养因子（ADNF III）的8-氨基酸肽）来提供预防和/或治疗受试者的焦虑和抑郁症的方法。 ADNF多肽包括ADNF I和ADNF III（也称为ADNP）多肽，类似物，亚序列和D-氨基酸形式（完全D-氨基酸肽或混合D-和L-氨基酸肽）和组合其含有它们各自的活性核心位点并提供神经保护和抗焦虑功能。

7. 发明授权

US5217953A Vasoactive intestinal peptide antagonist 失效
标题翻译：血管活性肠肽拮抗剂
公开(公告)号：US5217953A
公开(公告)日：1993-06-08
申请号：US620410
申请日：1990-11-30
申请人： Illana Gozes , Douglas E. Brenneman , Mati M. Fridkin , Terry Moody
发明人： Illana Gozes , Douglas E. Brenneman , Mati M. Fridkin , Terry Moody
IPC分类号： A61K38/00 , C07K7/08 , C07K14/575
CPC分类号： C07K7/083 , C07K14/57563 , A61K38/00 , Y10S930/17
摘要： The present invention relates to a peptide encoding an antagonist of VIP. The invention also relates to a method of using said peptide to antagonize VIP function. The invention further relates to a pharmaceutical composition.
摘要翻译：本发明涉及编码VIP拮抗剂的肽。本发明还涉及使用所述肽拮抗VIP功能的方法。本发明还涉及药物组合物。

8. 发明授权

US5147855A Conjugates of VIP and active fragments thereof with hydrophobic moieties and topical compositions for male impotence 失效
标题翻译：贵宾及其主要片段与疏水性动物和用于男性不良的局部组合物的结合
公开(公告)号：US5147855A
公开(公告)日：1992-09-15
申请号：US376559
申请日：1989-07-07
申请人： Illana Gozes , Matityahu Fridkin
发明人： Illana Gozes , Matityahu Fridkin
IPC分类号： A61K9/06 , A61K38/00 , A61P13/02 , A61P15/00 , A61P15/10 , C07K1/02 , C07K14/00 , C07K14/47 , C07K14/575
CPC分类号： A61K47/48061 , C07K14/57563 , A61K38/00
摘要： There are provided pharmaceutical compositions for topical transdermal application for the treatment of male impotence. The active ingredients of such compositions are selected from vasoactive intestinal peptide (VIP), effective derivatives thereof and effective fragments thereof. In the compositions for the treatment of male impotence a transdermally effective conjugate of VIP, its derivatives or fragments coupled to a hydrophogic moiety, is used.

9. 发明授权

US08618043B2 Use of ADNF polypeptides for treating anxiety and depression 有权
标题翻译：使用ADNF多肽治疗焦虑和抑郁
公开(公告)号：US08618043B2
公开(公告)日：2013-12-31
申请号：US13080412
申请日：2011-04-05
申请人： Illana Gozes , Roy N. Alcalay , Inna Divinski , Eliezer Giladi
发明人： Illana Gozes , Roy N. Alcalay , Inna Divinski , Eliezer Giladi
IPC分类号： A61K38/00 , A61K51/00
CPC分类号： A61K38/18
摘要： This invention relates to the use of ADNF polypeptides in the treatment of anxiety and/or depression. The present invention also relates to drug discovery assays using the ADNF polypeptide mechanism of action and target interaction, as well as the manufacture of medicaments, methods of application and formulation therefor. Embodiments of the invention provide methods for preventing and/or treating anxiety and depression disorders in a subject by administering a NAP, an 8-amino-acid peptide derived from Activity Dependent Neurotrophic Factor (ADNF III), in an amount sufficient to improve postnatal performance. The ADNF polypeptides include ADNF I and ADNF III (also referred to as ADNP) polypeptides, analogs, subsequences, and D-amino acid versions (either wholly D-amino acid peptides or mixed D- and L-amino acid peptides), and combinations thereof which contain their respective active core sites and provide neuroprotective and anti-anxiety functions.
摘要翻译：本发明涉及ADNF多肽在治疗焦虑和/或抑郁症中的应用。本发明还涉及使用ADNF多肽作用和靶相互作用机制的药物发现测定，以及药物的制备，应用方法和制剂。本发明的实施方案通过以足以改善出生后表现的量施用NAP（衍生自活性依赖性神经营养因子（ADNF III）的8-氨基酸肽）来提供预防和/或治疗受试者的焦虑和抑郁症的方法。 ADNF多肽包括ADNF I和ADNF III（也称为ADNP）多肽，类似物，亚序列和D-氨基酸形式（完全D-氨基酸肽或混合D-和L-氨基酸肽）和组合其含有它们各自的活性核心位点并提供神经保护和抗焦虑功能。

10. 发明申请

US20120015878A1 USE OF ADNF POLYPEPTIDES FOR TREATING ANXIETY AND DEPRESSION 有权
标题翻译： ADNF多肽用于治疗恶心和呕吐的用途
公开(公告)号：US20120015878A1
公开(公告)日：2012-01-19
申请号：US13080412
申请日：2011-04-05
申请人： Illana Gozes , Roy N. Alcalay , Inna Divinski , Eliezer Giladi
发明人： Illana Gozes , Roy N. Alcalay , Inna Divinski , Eliezer Giladi
IPC分类号： A61K38/18 , A61K38/10 , A61K31/7088 , G01N33/567 , A61P25/22 , A61P25/24 , A61K49/00 , C40B30/04 , A61K38/08 , C07K7/06
CPC分类号： A61K38/18
摘要： This invention relates to the use of ADNF polypeptides in the treatment of anxiety and/or depression. The present invention also relates to drug discovery assays using the ADNF polypeptide mechanism of action and target interaction, as well as the manufacture of medicaments, methods of application and formulation therefor. Embodiments of the invention provide methods for preventing and/or treating anxiety and depression disorders in a subject by administering a NAP, an 8-amino-acid peptide derived from Activity Dependent Neurotrophic Factor (ADNF III), in an amount sufficient to improve postnatal performance. The ADNF polypeptides include ADNF I and ADNF III (also referred to as ADNP) polypeptides, analogs, subsequences, and D-amino acid versions (either wholly D-amino acid peptides or mixed D- and L-amino acid peptides), and combinations thereof which contain their respective active core sites and provide neuroprotective and anti-anxiety functions.
摘要翻译：本发明涉及ADNF多肽在治疗焦虑和/或抑郁症中的应用。本发明还涉及使用ADNF多肽作用和靶相互作用机制的药物发现测定，以及药物的制备，应用方法和制剂。本发明的实施方案通过以足以改善出生后表现的量施用NAP（衍生自活性依赖性神经营养因子（ADNF III）的8-氨基酸肽）来提供预防和/或治疗受试者的焦虑和抑郁症的方法。 ADNF多肽包括ADNF I和ADNF III（也称为ADNP）多肽，类似物，亚序列和D-氨基酸形式（完全D-氨基酸肽或混合D-和L-氨基酸肽）和组合其含有它们各自的活性核心位点并提供神经保护和抗焦虑功能。

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