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1. 发明授权

US5147855A Conjugates of VIP and active fragments thereof with hydrophobic moieties and topical compositions for male impotence 失效
标题翻译：贵宾及其主要片段与疏水性动物和用于男性不良的局部组合物的结合
公开(公告)号：US5147855A
公开(公告)日：1992-09-15
申请号：US376559
申请日：1989-07-07
申请人： Illana Gozes , Matityahu Fridkin
发明人： Illana Gozes , Matityahu Fridkin
IPC分类号： A61K9/06 , A61K38/00 , A61P13/02 , A61P15/00 , A61P15/10 , C07K1/02 , C07K14/00 , C07K14/47 , C07K14/575
CPC分类号： A61K47/48061 , C07K14/57563 , A61K38/00
摘要： There are provided pharmaceutical compositions for topical transdermal application for the treatment of male impotence. The active ingredients of such compositions are selected from vasoactive intestinal peptide (VIP), effective derivatives thereof and effective fragments thereof. In the compositions for the treatment of male impotence a transdermally effective conjugate of VIP, its derivatives or fragments coupled to a hydrophogic moiety, is used.

2. 发明授权

US05998368A Derivatives of structurally modified VIP and pharmaceutical compositions containing them 失效
标题翻译：结构改性的VIP衍生物和含有它们的药物组合物
公开(公告)号：US05998368A
公开(公告)日：1999-12-07
申请号：US897624
申请日：1997-07-21
申请人： Illana Gozes , Matityahu Fridkin
发明人： Illana Gozes , Matityahu Fridkin
IPC分类号： A61K38/00 , A61P15/10 , C07K14/575 , C07K5/00 , C07K7/00
CPC分类号： C07K14/57563 , A61K38/00
摘要： There are provided novel compounds for the treatment of male impotence. The compounds are derived from vasoactive intestinal peptide (VIP) in which the natural amino acid sequence is modified by replacement of any of the 5, 17 and 19 amino acid residues by other natural or non-natural amino acids, and they bear at least one terminal lipophilic group.The modified VIP sequences are prepared by conventional peptide chain assembling methods.The novel compounds and compositions containing them are suitable for transdermal application for treating male impotence.
摘要翻译：提供了用于治疗男性阳provided的新型化合物。该化合物衍生自血管活性肠肽（VIP），其中天然氨基酸序列被其他天然或非天然氨基酸替代5,17和19个氨基酸残基中的任何一个被修饰，并且它们至少具有一个末端亲脂基团。经修饰的VIP序列通过常规肽链组装方法制备。含有它们的新化合物和组合物适用于经皮施用以治疗男性阳。。

3. 发明授权

US5972883A Method for the treatment of neurodegenerative diseases by administering VIP, an analogue, fragment or a conjugate thereof 失效
标题翻译：通过给予VIP，其类似物，片段或缀合物治疗神经变性疾病的方法
公开(公告)号：US5972883A
公开(公告)日：1999-10-26
申请号：US413708
申请日：1995-03-30
申请人： Illana Gozes , Matityahu Fridkin
发明人： Illana Gozes , Matityahu Fridkin
IPC分类号： A61K38/00 , C07K14/575
CPC分类号： C07K14/57563 , A61K38/00
摘要： A method for the treatment of neurodegenerative diseases comprising administering to a patient in need of such treatment a therapeutically effective amount of a peptide compound selected from the group consisting of:(i) vasoactive intestinal peptide (VIP);(ii) analogues of vasoactive intestinal peptide (VIP) in which one or more amino acids has been replaced, added or deleted without substantially altering the biological properties of the parent peptide;(iii) a conjugate being a peptide compound according to either of (i) and (ii) coupled to a lipophilic moiety;(iv) a physiologically active fragment of (i), (ii) and (iii); and(v) a functional derivative of any of (i), (ii), (iii) and (iv);optionally in combination with a pharmaceutically acceptable carrier.
摘要翻译：一种治疗神经变性疾病的方法，包括向需要这种治疗的患者施用治疗有效量的选自以下的肽化合物：（i）血管活性肠肽（VIP）; （ii）其中一个或多个氨基酸被替换，添加或缺失而不显着改变母体肽的生物学性质的血管活性肠肽（VIP）的类似物; （iii）缀合物，其是与亲脂性部分偶联的根据（i）和（ii）中任一项的肽化合物; （iv）（i），（ii）和（iii）的生理活性片段; （v）（i），（ii），（iii）和（iv）中任一项的功能性衍生物; 任选地与药学上可接受的载体组合。

4. 发明授权

US06239107B1 Conjugates of lipophilic moieties and fragments of vasoactive intestinal peptide (VIP) 失效
标题翻译：亲脂性部分和血管活性肠肽（VIP）片段的结合物
公开(公告)号：US06239107B1
公开(公告)日：2001-05-29
申请号：US09171654
申请日：1999-04-29
申请人： Illana Gozes , Matityahu Fridkin
发明人： Illana Gozes , Matityahu Fridkin
IPC分类号： A61K3806
CPC分类号： C07K14/57563 , A61K38/00
摘要： The invention concerns novel conjugates of peptide fragments of vasoactive intestinal peptide (VIP) or analogues thereof having 3-12 amino acid residues, and lipophilic moieties, which may be present at the N- or C-terminus. The invention further concerns pharmaceutical compositions containing these novel conjugates which may be used for treatment of male impotence or for the treatment of neurodegenerative diseases.
摘要翻译：本发明涉及具有3-12个氨基酸残基的血管活性肠肽（VIP）或其类似物的肽片段的新缀合物和可存在于N-或C-末端的亲脂性部分。本发明还涉及含有这些新型缀合物的药物组合物，其可用于治疗男性阳ence或用于治疗神经变性疾病。

5. 发明授权

US5565424A Superactive VIP antagonists 失效
标题翻译：超活性VIP拮抗剂
公开(公告)号：US5565424A
公开(公告)日：1996-10-15
申请号：US194591
申请日：1994-02-07
申请人： Illana Gozes , Douglas E. Brenneman , Matityahu Fridkin , Terry W. Moody
发明人： Illana Gozes , Douglas E. Brenneman , Matityahu Fridkin , Terry W. Moody
IPC分类号： A61K38/00 , A61P9/00 , A61P35/00 , A61P43/00 , C07K7/08 , C07K14/00 , C07K14/47 , C07K14/575 , A61K38/16
CPC分类号： C07K7/083 , C07K14/57563 , A61K38/00
摘要： The present invention relates to a family of peptides encoding antagonists of the vasoactive intestinal peptide (VIP) designed to distinguish multiple receptors that mediate VIP neurotransmission, neurotrophism and cell division. The invention also relates to methods of using these peptides to antagonize VIP-associated activity and function. The invention further relates to pharmaceutical compositions dsigned to inhibit VIP-associated activity.
摘要翻译：本发明涉及编码血管活性肠肽（VIP）的拮抗剂的肽家族，其设计用于区分介导VIP神经传递，神经营养和细胞分裂的多种受体。本发明还涉及使用这些肽拮抗VIP相关活性和功能的方法。本发明还涉及抑制VIP相关活性的药物组合物。

6. 发明申请

US20050075284A1 Pharmaceutical compositions comprising vip-related peptides for the treatment of sexual disorders 审中-公开
标题翻译：包含用于治疗性障碍的vip相关肽的药物组合物
公开(公告)号：US20050075284A1
公开(公告)日：2005-04-07
申请号：US10240392
申请日：2001-05-22
申请人： Illana Gozes , Matityahu Fridkin
发明人： Illana Gozes , Matityahu Fridkin
IPC分类号： A61K9/06 , A61K9/08 , A61K9/10 , A61K9/127 , A61K38/22 , A61K47/48 , A61P15/02 , A61P15/08 , C07K14/47
CPC分类号： A61K38/2278 , A61K47/54 , A61K47/542 , A61K47/64
摘要： The present invention relates to pharmaceutical compositions for the treatment of female sexual dysfunction, for vaginal relaxation and/or for modulation of sperm motility. The composition comprises as active ingredient (i) a peptide analogue or conjugate of vasoactive intestinal peptide (VIP) as defined in the specification and is preferably formulated for topical application in the vaginal, vulvar and/or clitorial area. The invention also relates to the use of the VIP peptide analogue or conjugate for the preparation of a pharmaceutical composition for the treatment of female sexual dysfunction, for vaginal relaxation and/or for modulation of sperm motility. Yet further, the invention provides a method of treatment of female sexual dysfunctions and/or vaginal relaxation by the use of said peptide analogue and/or conjugate.
摘要翻译：本发明涉及用于治疗女性性功能障碍，阴道松弛和/或调节精子活力的药物组合物。组合物包含作为活性成分（i）如说明书中定义的血管活性肠肽（VIP）的肽类似物或缀合物，并且优选配制用于阴道，外阴和/或阴蒂区域的局部应用。本发明还涉及VIP肽类似物或缀合物用于制备用于治疗女性性功能障碍，用于阴道松弛和/或调节精子活力的药物组合物的用途。此外，本发明提供了通过使用所述肽类似物和/或缀合物来治疗女性性功能障碍和/或阴道松弛的方法。

7. 发明授权

US08067369B2 Protection of the retina against laser injury by NAP and related peptides 有权
标题翻译：保护视网膜免受NAP和相关肽的激光损伤
公开(公告)号：US08067369B2
公开(公告)日：2011-11-29
申请号：US12280471
申请日：2006-04-20
申请人： Illana Gozes , Michael Belkin
发明人： Illana Gozes , Michael Belkin
IPC分类号： A61K38/18 , A61K38/08
CPC分类号： A61K38/18 , G01N2800/40
摘要： This invention relates to the use of ADNF polypeptides in the treatment of laser-induced retinal damage and related conditions.
摘要翻译：本发明涉及ADNF多肽在治疗激光诱导的视网膜损伤和相关病症中的应用。

8. 发明授权

US08017578B2 Orally active peptides that prevent cell damage and death 有权
标题翻译：口服活性肽，可防止细胞损伤和死亡
公开(公告)号：US08017578B2
公开(公告)日：2011-09-13
申请号：US12102760
申请日：2008-04-14
申请人： Douglas Brenneman , Illana Gozes , Catherine Y. Spong , Albert Pinhasov , Eliezer Giladi
发明人： Douglas Brenneman , Illana Gozes , Catherine Y. Spong , Albert Pinhasov , Eliezer Giladi
IPC分类号： A61K38/08 , C07K7/06
CPC分类号： A61K38/04 , A61K38/185
摘要： This invention provides an ADNF polypeptide comprising an active core site, the active core site comprising at least one D-amino acid. The invention also provides a pharmaceutical composition comprising an ADNF polypeptide comprising an active core site, the active core site comprising at least one D-amino acid. In particular, the pharmaceutical composition of the invention is orally active. The invention further provides methods for reducing neuronal cell death, methods for reducing oxidative stress, and methods for reducing a condition associated with fetal alcohol syndrome using the ADNF polypeptides and the pharmaceutical compositions of the invention.
摘要翻译：本发明提供了包含活性核心位点的ADNF多肽，所述活性核心位点包含至少一个D-氨基酸。本发明还提供了包含包含活性核心位点的ADNF多肽的药物组合物，所述活性核心位点包含至少一个D-氨基酸。特别地，本发明的药物组合物是口服活性的。本发明还提供了使用ADNF多肽和本发明的药物组合物减少神经元细胞死亡的方法，用于降低氧化应激的方法以及用于降低与胎儿酒精综合征相关的病症的方法。

9. 发明申请

US20070054847A1 Use of adnf polypeptides for treating anxiety and depression 有权
标题翻译：使用adnf多肽治疗焦虑和抑郁
公开(公告)号：US20070054847A1
公开(公告)日：2007-03-08
申请号：US10547986
申请日：2004-03-11
申请人： Illana Gozes , Roy Alcalay , Inna Divinski , Eliezer Giladi
发明人： Illana Gozes , Roy Alcalay , Inna Divinski , Eliezer Giladi
IPC分类号： A61K38/17 , A61K38/10
CPC分类号： A61K38/18
摘要： This invention relates to the use of ADNF polypeptides in the treatment of anxiety and/or depression. The present invention also relates to drug discovery assays using the ADNF polypeptide mechanism of action and target interaction, as well as the manufacture of medicaments, methods of application and formulation therefor. Embodiments of the invention provide methods for preventing and/or treating anxiety and depression disorders in a subject by administering a NAP, an 8-amino-acid peptide derived from Activity Dependent Neurotrophic Factor (ADNF III), in an amount sufficient to improve postnatal performance. The ADNF polypeptides include ADNF I and ADNF III (also referred to as ADNP) polypeptides, analogs, subsequences, and D-amino acid versions (either wholly D-amino acid peptides or mixed D- and L-amino acid peptides), and combinations thereof which contain their respective active core sites and provide neuroprotective and anti-anxiety functions.
摘要翻译：本发明涉及ADNF多肽在治疗焦虑和/或抑郁症中的应用。本发明还涉及使用ADNF多肽作用和靶相互作用机制的药物发现测定，以及药物的制备，应用方法和制剂。本发明的实施方案通过以足以改善出生后表现的量施用NAP（衍生自活性依赖性神经营养因子（ADNF III）的8-氨基酸肽）来提供预防和/或治疗受试者的焦虑和抑郁症的方法。 ADNF多肽包括ADNF I和ADNF III（也称为ADNP）多肽，类似物，亚序列和D-氨基酸形式（完全D-氨基酸肽或混合D-和L-氨基酸肽）和组合其含有它们各自的活性核心位点并提供神经保护和抗焦虑功能。

10. 发明授权

US5217953A Vasoactive intestinal peptide antagonist 失效
标题翻译：血管活性肠肽拮抗剂
公开(公告)号：US5217953A
公开(公告)日：1993-06-08
申请号：US620410
申请日：1990-11-30
申请人： Illana Gozes , Douglas E. Brenneman , Mati M. Fridkin , Terry Moody
发明人： Illana Gozes , Douglas E. Brenneman , Mati M. Fridkin , Terry Moody
IPC分类号： A61K38/00 , C07K7/08 , C07K14/575
CPC分类号： C07K7/083 , C07K14/57563 , A61K38/00 , Y10S930/17
摘要： The present invention relates to a peptide encoding an antagonist of VIP. The invention also relates to a method of using said peptide to antagonize VIP function. The invention further relates to a pharmaceutical composition.
摘要翻译：本发明涉及编码VIP拮抗剂的肽。本发明还涉及使用所述肽拮抗VIP功能的方法。本发明还涉及药物组合物。

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