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1. 发明申请

US20120205306A1 MULTI-LAYERED BLOOD COMPONENT EXCHANGE DEVICES, SYSTEMS, AND METHODS 审中-公开
标题翻译：多层血液成分交换装置，系统和方法
公开(公告)号：US20120205306A1
公开(公告)日：2012-08-16
申请号：US13392519
申请日：2010-08-27
申请人： Ilan K. Reich , Edward F. Leonard , Michael Hill , John Howard
发明人： Ilan K. Reich , Edward F. Leonard , Michael Hill , John Howard
IPC分类号： B01D17/00
CPC分类号： B01D61/18 , A61M1/3472 , A61M2205/0244 , B01D63/081 , B01D2313/12
摘要： A microfluidic separation device suitable for high throughput applications such as medical treatments, and associated methods and systems, are described. Embodiments are suitable for treatment of end stage renal disease.
摘要翻译：描述了适用于诸如医疗处理和相关方法和系统的高通量应用的微流体分离装置。实施方案适用于治疗终末期肾病。

2. 发明授权

US08496606B2 Fluid separation devices, systems and methods 有权
标题翻译：流体分离装置，系统和方法
公开(公告)号：US08496606B2
公开(公告)日：2013-07-30
申请号：US12866017
申请日：2009-02-04
申请人： Edward F. Leonard , Ilan K. Reich , Stanley Cortell
发明人： Edward F. Leonard , Ilan K. Reich , Stanley Cortell
IPC分类号： A61M1/14 , A61M1/16 , A61M1/34 , A61M1/36 , B01D61/24 , B01D61/58
CPC分类号： A61M1/14 , A61M1/3482 , A61M2206/11
摘要： A membraneless separation device can be applied to a variety of treatments, such as the ultrafiltration of blood for a patient with end stage renal disease. An ultrafiltration device can include a membraneless separation device, which separates an incoming blood flow into a substantially cytoplasmic body-free plasma flow and remaining fraction, and a dialysate-free second stage, which selectively removes excess fluid, toxins and other substances from the plasma flow and returns the processed plasma to the membraneless separation device. A treatment protocol can include ultrafiltering blood of a patient using the ultrafiltration device and performing a secondary treatment on the blood of the patient at a reduced frequency compared to the ultrafiltering. The membraneless separation device can also be applied to treatment, analysis, and/or exchange of plasma from blood, or combined with conventional dialyzers to perform dialysis on a cytoplasmic body-free plasma fraction.
摘要翻译：无膜分离装置可用于各种治疗，例如用于终末期肾病的患者的血液超滤。超滤装置可以包括无膜分离装置，其将进入的血流分离成基本上不含细胞质的无体质血浆流和剩余部分，以及无透析液的第二阶段，其从血浆中选择性地除去多余的流体，毒素和其他物质流动并将处理的等离子体返回到无膜分离装置。治疗方案可以包括使用超滤装置对患者的超滤血液，并且与超滤相比以更低的频率对患者的血液进行二次治疗。无膜分离装置也可以应用于来自血液的血浆的治疗，分析和/或交换，或与常规透析器组合以在不含细胞质的体外血浆级分上进行透析。

3. 发明申请

US20130102948A1 PORTABLE BLOOD FILTRATION DEVICES, SYSTEMS, AND METHODS 审中-公开
标题翻译：便携式血液过滤装置，系统和方法
公开(公告)号：US20130102948A1
公开(公告)日：2013-04-25
申请号：US13641559
申请日：2011-03-24
申请人： Ilan K. Reich , Edward F. Leonard , Fred Mermelstein
发明人： Ilan K. Reich , Edward F. Leonard , Fred Mermelstein
IPC分类号： A61M1/36
CPC分类号： A61M1/3621 , A61M1/16 , A61M1/3472 , A61M1/3482 , A61M1/3486 , A61M2202/20 , A61M2202/203 , A61M2202/206 , A61M2205/8206
摘要： A blood filtration device, system, and method that can and selectively remove or reduce an unwanted, in certain cases unknown, substance from a patient's blood stream. More specifically, a specific size or size range of unwanted substance is selectively removed. The unwanted substance includes one or more of a pathogen, a toxin, an activated cell, and an administered drug. The device and system employ a microfluidic separation device that minimizes thrombogenesis and can permit the use of anticoagulants to be avoided. The device or system can be portable and can include its own power supply. Sensors in the system may monitor for the presence and/or concentration of unwanted species including pathogens or drugs and invoke a blood cleansing process responsively to the sensor signals in closed loop control process. The control may combine the infusion of therapeutic agents into the blood of a patient as well.
摘要翻译：血液过滤装置，系统和方法，其可以并且选择性地从患者的血液流中去除或减少在某些情况下不需要的物质。更具体地，选择性地去除不需要的物质的具体尺寸或尺寸范围。不想要的物质包括病原体，毒素，活化的细胞和给药的药物中的一种或多种。该装置和系统采用使血栓形成最小化的微流体分离装置，并且可以允许避免使用抗凝剂。该设备或系统可以是便携式的并且可以包括其自己的电源。系统中的传感器可以监测不想要的物质（包括病原体或药物）的存在和/或浓度，并且在闭环控制过程中响应于传感器信号调节血液清洁过程。该对照可以将治疗剂的输注组合到患者的血液中。

4. 发明申请

US20120294742A1 PERISTALTIC PUMP DEVICES, METHODS, AND SYSTEMS 审中-公开
标题翻译：超声波泵装置，方法和系统
公开(公告)号：US20120294742A1
公开(公告)日：2012-11-22
申请号：US13514490
申请日：2010-12-08
申请人： Ilan K. Reich , Keith McCord , Edward F. Leonard
发明人： Ilan K. Reich , Keith McCord , Edward F. Leonard
IPC分类号： F04B43/08
CPC分类号： F04B43/1292
摘要： A peristaltic pump with a removable pump race module has guiding channels for receiving at least a portion of a flexible fluid-carrying tubing and an adjusting device for displacing a flexible inner portion of the removable pump race module to change the compression on the fluid-carrying tubing. The arrangement of the various elements makes it particularly suitable in configurations where compactness and convenience are important considerations.
摘要翻译：具有可拆卸泵座模块的蠕动泵具有用于接收柔性流体输送管道的至少一部分的引导通道和用于移动可移除泵座组件的柔性内部部分的调节装置，以改变流体承载管道。各种元件的布置使其特别适用于紧凑性和方便性是重要考虑的构造。

5. 发明申请

US20110105982A1 FLUID SEPARATION DEVICES, SYSTEMS AND METHODS 有权
标题翻译：流体分离装置，系统和方法
公开(公告)号：US20110105982A1
公开(公告)日：2011-05-05
申请号：US12866017
申请日：2009-02-04
申请人： Edward F. Leonard , Ilan K. Reich , Stanley Cortell
发明人： Edward F. Leonard , Ilan K. Reich , Stanley Cortell
IPC分类号： A61M5/00
CPC分类号： A61M1/14 , A61M1/3482 , A61M2206/11
摘要： A membraneless separation device can be applied to a variety of treatments, such as the ultrafiltration of blood for a patient with end stage renal disease. An ultrafiltration device can include a membraneless separation device, which separates an incoming blood flow into a substantially cytoplasmic body-free plasma flow and remaining fraction, and a dialysate-free second stage, which selectively removes excess fluid, toxins and other substances from the plasma flow and returns the processed plasma to the membraneless separation device. A treatment protocol can include ultrafiltering blood of a patient using the ultrafiltration device and performing a secondary treatment on the blood of the patient at a reduced frequency compared to the ultrafiltering. The membraneless separation device can also be applied to treatment, analysis, and/or exchange of plasma from blood, or combined with conventional dialyzers to perform dialysis on a cytoplasmic body-free plasma fraction.
摘要翻译：无膜分离装置可用于各种治疗，例如用于终末期肾病的患者的血液超滤。超滤装置可以包括无膜分离装置，其将进入的血流分离成基本上不含细胞质的无体质血浆流和剩余部分，以及无透析液的第二阶段，其从血浆中选择性地除去多余的流体，毒素和其他物质流动并将处理的等离子体返回到无膜分离装置。治疗方案可以包括使用超滤装置对患者的超滤血液，并且与超滤相比以更低的频率对患者的血液进行二次治疗。无膜分离装置也可以应用于来自血液的血浆的治疗，分析和/或交换，或与常规透析器组合以在不含细胞质的体外血浆级分上进行透析。

6. 发明申请

US20120103903A1 METHODS, APPARATUS, AND SYSTEMS FOR SEPARATING FLUIDS 审中-公开
标题翻译：用于分离流体的方法，装置和系统
公开(公告)号：US20120103903A1
公开(公告)日：2012-05-03
申请号：US13265201
申请日：2010-04-19
申请人： Michael Hill , Edward F. Leonard
发明人： Michael Hill , Edward F. Leonard
IPC分类号： B01D29/00
CPC分类号： B01D61/147
摘要： A device for separating fluids includes a microfluidic channel with one or more wall filters or membranes through which portions of the flow in the microfluidic channel can be removed. The wall filters can have precisely defined pores therein which restrict the removal of certain particles while allowing other particles and/or fluids to freely flow therethrough. Because of the high and uniform pore density and low flow resistance of these filters, the pressure drop along the microfluidic channel may result in a negative trans-filter pressure, thereby causing reverse flow of extracted fluid back through the filter and into the microfluidic channel. Precise design of the microfluidic channel and control of flow characteristics can minimize and/or eliminate this reverse flow while allowing for sufficient sweeping of the filter surface to inhibit clogging with particles.
摘要翻译：用于分离流体的装置包括具有一个或多个壁过滤器或膜的微流体通道，通过该流体可以去除微流体通道中的流动的部分。壁过滤器可以在其中具有精确定义的孔，其限制某些颗粒的去除，同时允许其它颗粒和/或流体自由地流过其中。由于这些过滤器具有高且均匀的孔密度和低流动阻力，沿着微流体通道的压力降可能导致负的反式过滤器压力，从而导致提取的流体反向流过过滤器并进入微流体通道。微流体通道的精确设计和流动特性的控制可以最大限度地减少和/或消除这种反向流动，同时允许过滤表面的充分清扫以抑制颗粒堵塞。

7. 发明申请

US20120234746A1 FILTER BLOOD FLUID CHANNEL METHODS, DEVICES, AND SYSTEMS 审中-公开
标题翻译：过滤血液通道方法，设备和系统
公开(公告)号：US20120234746A1
公开(公告)日：2012-09-20
申请号：US13496084
申请日：2010-09-14
申请人： John Howard , Edward F. Leonard , Thomas Qin
发明人： John Howard , Edward F. Leonard , Thomas Qin
IPC分类号： B01D63/06
CPC分类号： B01D63/02 , A61M1/1627 , A61M2206/16 , B01D65/00 , B01D2313/08 , B01D2313/21
摘要： A risk of thrombogenesis is minimized in a tubular fiber membrane filter by flowing blood or other fluid through a header manifold that ensures a minimum shear rate on the wetted surfaces without flow reversal, stagnation volumes, or a shear rate that is too high. In an embodiment, fluid is conveyed into a header space and into a manifold face at a perimeter of the header space. The header space has a progressively decreasing clearance that is minimal to provide for substantial shear rate and decreasing toward a minimum clearance in a region that is remote from the perimeter and vented by openings to the microtubular membrane fibers. Other features and embodiments are described.
摘要翻译：在管状纤维膜过滤器中通过使血液或其它流体流过集管歧管来确保在润湿表面上的最小剪切速率而没有流动反转，停滞体积或过高的剪切速率，使血栓形成的风险最小化。在一个实施例中，流体被传送到集管空间并进入集管面在集管空间的周边。头部空间具有逐渐减小的间隙，其最小化以提供显着的剪切速率并且在远离周边的区域中朝向最小间隙减小并且通过开口排出到微管膜纤维。描述其他特征和实施例。

8. 发明申请

US20110021966A1 SYSTEMS, METHODS, AND DEVICES FOR BLOOD TREATMENT 有权
标题翻译：用于血液治疗的系统，方法和装置
公开(公告)号：US20110021966A1
公开(公告)日：2011-01-27
申请号：US12747785
申请日：2008-12-12
申请人： Edward F. Leonard
发明人： Edward F. Leonard
IPC分类号： A61M1/36
CPC分类号： A61M37/00 , A61M1/3681 , A61M1/3683 , A61M2205/053 , A61M2206/11
摘要： A blood treatment device provides a photopheresis treatment using a microfluidic separation channel to separate blood components into layers The layering caused by laminar flow in the microfluidic separation channel allows light to be projected through plasma onto leukocytes without hindrance by erythrocytes
摘要翻译：血液处理装置使用微流体分离通道提供光泳处理以将血液成分分离成层。由微流体分离通道中的层流引起的分层使得能够通过血浆将光投射到白细胞上而不受红细胞的阻碍

9. 发明申请

US20100004578A1 APPARATUS AND SYSTEMS FOR MEMBRANELESS SEPARATION OF FLUIDS 失效
标题翻译：用于液体无菌分离的装置和系统
公开(公告)号：US20100004578A1
公开(公告)日：2010-01-07
申请号：US12499038
申请日：2009-07-07
申请人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
发明人： Edward F. Leonard , Alan C. West , Nina C. Shapley , Zhongliang Tang
IPC分类号： A61M1/14
CPC分类号： A61M1/14 , A61M2206/11 , B01D11/0288 , B01D11/0492 , B01D11/0496 , B01L3/5027
摘要： The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of small molecules, middle molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
摘要翻译：本发明涉及通过与第二流体接触从样品流体中除去不需要的材料的装置，系统和方法。样品流体作为与第二流体的同时流动的层相邻或相邻的薄层流动，而没有中间膜。在各种实施方案中，使用次级分离器来限制所需物质的去除并且实现从血液中除去不需要的物质。本发明可用于各种情况，其中样品液体经由针对抽提流体的扩散机制进行纯化。此外，本发明可用于从尺寸变化的样品流体中除去组分。例如，当血液是样品液体时，这可能包括从血液样品到提取液中去除小分子，中分子，大分子，大分子聚集体和细胞。

10. 发明授权

US06890755B1 Recovery of fetal cells from maternal blood using chaotic advection 失效
标题翻译：使用混沌平流从母体血液回收胎儿细胞
公开(公告)号：US06890755B1
公开(公告)日：2005-05-10
申请号：US08986552
申请日：1997-12-08
申请人： Edward F. Leonard , Rene Chevray
发明人： Edward F. Leonard , Rene Chevray
IPC分类号： C12N5/08 , G01N33/50
CPC分类号： G01N33/5044
摘要： To extract fetal cells from a sample of maternal blood or a fluid derived from maternal blood, sample liquid is moved over a collector surface bearing a ligand for the fetal cells. Chaotic advection in the liquid enhances the efficiency of cell collection.
摘要翻译：为了从母体血液样本或母体血液中提取胎儿细胞，将样品液体移动到带有胎儿细胞配体的收集器表面上。液体中的混沌平流增强了细胞收集的效率。

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